##gff-version 3 Q02297 UniProtKB Propeptide 1 19 . . . ID=PRO_0000019462;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7689552;Dbxref=PMID:7689552 Q02297 UniProtKB Chain 20 640 . . . ID=PRO_0000019463;Note=Pro-neuregulin-1%2C membrane-bound isoform Q02297 UniProtKB Chain 20 241 . . . ID=PRO_0000019464;Note=Neuregulin-1 Q02297 UniProtKB Topological domain 20 242 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q02297 UniProtKB Transmembrane 243 265 . . . Note=Helical%3B Note%3DInternal signal sequence;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q02297 UniProtKB Topological domain 266 640 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q02297 UniProtKB Domain 37 128 . . . Note=Ig-like C2-type Q02297 UniProtKB Domain 178 222 . . . Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 Q02297 UniProtKB Region 1 53 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q02297 UniProtKB Region 334 360 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q02297 UniProtKB Region 375 399 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q02297 UniProtKB Region 433 461 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q02297 UniProtKB Region 524 588 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q02297 UniProtKB Compositional bias 375 389 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q02297 UniProtKB Compositional bias 559 573 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q02297 UniProtKB Site 34 34 . . . Note=Breakpoint for translocation to form gamma-heregulin Q02297 UniProtKB Glycosylation 120 120 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q02297 UniProtKB Glycosylation 126 126 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q02297 UniProtKB Glycosylation 164 164 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q02297 UniProtKB Disulfide bond 57 112 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q02297 UniProtKB Disulfide bond 182 196 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8639490;Dbxref=PMID:8639490 Q02297 UniProtKB Disulfide bond 190 210 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8639490;Dbxref=PMID:8639490 Q02297 UniProtKB Disulfide bond 212 221 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8639490;Dbxref=PMID:8639490 Q02297 UniProtKB Alternative sequence 1 166 . . . ID=VSP_037562;Note=In isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7782315;Dbxref=PMID:14702039,PMID:15489334,PMID:7782315 Q02297 UniProtKB Alternative sequence 1 33 . . . ID=VSP_003425;Note=In isoform 9. MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP->MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRC;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8096067;Dbxref=PMID:8096067 Q02297 UniProtKB Alternative sequence 1 21 . . . ID=VSP_037563;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17565985;Dbxref=PMID:17565985 Q02297 UniProtKB Alternative sequence 22 33 . . . ID=VSP_037564;Note=In isoform 11. KKPESAAGSQSP->MGKGRAGRVGTT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17565985;Dbxref=PMID:17565985 Q02297 UniProtKB Alternative sequence 134 168 . . . ID=VSP_003426;Note=In isoform 9 and isoform 11. EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS->A;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17565985,ECO:0000303|PubMed:8096067;Dbxref=PMID:17565985,PMID:8096067 Q02297 UniProtKB Alternative sequence 167 167 . . . ID=VSP_037565;Note=In isoform 10. S->MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCACLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKL;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7782315;Dbxref=PMID:14702039,PMID:15489334,PMID:7782315 Q02297 UniProtKB Alternative sequence 213 241 . . . ID=VSP_003429;Note=In isoform 8%2C isoform 9 and isoform 10. QPGFTGARCTENVPMKVQNQEKAEELYQK->PNEFTGDRCQNYVMASFYSTSTPFLSLPE;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1350381,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7509448,ECO:0000303|PubMed:7782315,ECO:0000303|PubMed:8096067;Dbxref=PMID:1350381,PMID:14702039,PMID:15489334,PMID:7509448,PMID:7782315,PMID:8096067 Q02297 UniProtKB Alternative sequence 213 234 . . . ID=VSP_003428;Note=In isoform 6 and isoform 11. QPGFTGARCTENVPMKVQNQEK->PNEFTGDRCQNYVMASFYKHLGIEFME;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1350381,ECO:0000303|PubMed:17565985,ECO:0000303|PubMed:7509448;Dbxref=PMID:1350381,PMID:17565985,PMID:7509448 Q02297 UniProtKB Alternative sequence 213 233 . . . ID=VSP_003427;Note=In isoform 7 and isoform 12. QPGFTGARCTENVPMKVQNQE->PNEFTGDRCQNYVMASFY;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1350381,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:7509448;Dbxref=PMID:1350381,PMID:14702039,PMID:7509448 Q02297 UniProtKB Alternative sequence 234 247 . . . ID=VSP_003432;Note=In isoform 4. KAEELYQKRVLTIT->SAQMSLLVIAAKTT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7509448;Dbxref=PMID:7509448 Q02297 UniProtKB Alternative sequence 234 234 . . . ID=VSP_003431;Note=In isoform 2. K->KHLGIEFIE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7509448;Dbxref=PMID:7509448 Q02297 UniProtKB Alternative sequence 242 640 . . . ID=VSP_003430;Note=In isoform 8%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1350381,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7509448,ECO:0000303|PubMed:7782315,ECO:0000303|PubMed:8096067;Dbxref=PMID:1350381,PMID:14702039,PMID:15489334,PMID:7509448,PMID:7782315,PMID:8096067 Q02297 UniProtKB Alternative sequence 248 640 . . . ID=VSP_003433;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7509448;Dbxref=PMID:7509448 Q02297 UniProtKB Alternative sequence 424 640 . . . ID=VSP_046417;Note=In isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q02297 UniProtKB Alternative sequence 424 462 . . . ID=VSP_003434;Note=In isoform 3. YVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVS->HNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7509448;Dbxref=PMID:7509448 Q02297 UniProtKB Alternative sequence 463 640 . . . ID=VSP_003435;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7509448;Dbxref=PMID:7509448 Q02297 UniProtKB Natural variant 38 38 . . . ID=VAR_009307;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17565985;Dbxref=dbSNP:rs3924999,PMID:17565985 Q02297 UniProtKB Natural variant 289 289 . . . ID=VAR_053531;Note=M->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17565985;Dbxref=dbSNP:rs10503929,PMID:14702039,PMID:17565985 Q02297 UniProtKB Natural variant 463 463 . . . ID=VAR_009308;Note=M->K Q02297 UniProtKB Mutagenesis 181 181 . . . Note=Defective in integrin-binding and in inducing ERBB3 phosphorylation%3B when associated with or without E-185 or E-187. No effect on ERBB3-binding%2C defective in integrin-binding and in ternary complex formation with ERBB3 and integrins%2C and defective in inducing NRG1-ERBB signaling%3B when associated with E-185 and E-187. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20682778;Dbxref=PMID:20682778 Q02297 UniProtKB Mutagenesis 185 185 . . . Note=Defective in integrin-binding and in inducing ERBB3 phosphorylation%3B when associated with or without E-181 or E-187. No effect on ERBB3-binding%2C defective in integrin-binding and in ternary complex formation with ERBB3 and integrins%2C and defective in inducing NRG1-ERBB signaling%3B when associated with E-181 and E-187. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20682778;Dbxref=PMID:20682778 Q02297 UniProtKB Mutagenesis 187 187 . . . Note=Defective in integrin-binding and in inducing ERBB3 phosphorylation%3B when associated with or without E-181 or E-185. No effect on ERBB3-binding%2C defective in integrin-binding and in ternary complex formation with ERBB3 and integrins%2C and defective in inducing NRG1-ERBB signaling%3B when associated with E-181 and E-185. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20682778;Dbxref=PMID:20682778 Q02297 UniProtKB Sequence conflict 94 94 . . . Note=K->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q02297 UniProtKB Sequence conflict 107 107 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q02297 UniProtKB Sequence conflict 261 261 . . . Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q02297 UniProtKB Sequence conflict 414 414 . . . Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q02297 UniProtKB Sequence conflict 535 535 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q02297 UniProtKB Beta strand 45 48 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Beta strand 51 61 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Beta strand 67 72 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Turn 79 81 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Beta strand 86 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Beta strand 94 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Helix 104 106 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Beta strand 108 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Beta strand 120 130 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SJL Q02297 UniProtKB Beta strand 179 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U7U Q02297 UniProtKB Turn 185 189 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U7U Q02297 UniProtKB Beta strand 190 193 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1HRE Q02297 UniProtKB Beta strand 195 199 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U7U Q02297 UniProtKB Beta strand 200 204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1HRE Q02297 UniProtKB Beta strand 208 212 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U7U Q02297 UniProtKB Beta strand 216 218 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3U7U Q02297 UniProtKB Beta strand 233 235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1HAF Q02297 UniProtKB Natural variant 46 46 . . . ID=VAR_082866;Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305;Dbxref=dbSNP:rs3735774 Q02297 UniProtKB Natural variant 127 127 . . . ID=VAR_082867;Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305;Dbxref=dbSNP:rs34822181