Q02297 (NRG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pro-neuregulin-1, membrane-bound isoform
Short name=Pro-NRG1

Cleaved into the following chain:

1. Neuregulin-1
   Alternative name(s):
   Acetylcholine receptor-inducing activity
   Short name=ARIA
   Breast cancer cell differentiation factor p45
   Glial growth factor
   Heregulin
   Short name=HRG
   Neu differentiation factor
   Sensory and motor neuron-derived factor

Gene names

Name:	NRG1
Synonyms:	GGF, HGL, HRGA, NDF, SMDF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Ref.14 Ref.15
Subunit structure	The cytoplasmic domain interacts with the LIM domain region of LIMK1 By similarity. Interacts with ERBB3 and ERBB4. Ref.15 Ref.18
Subcellular location	Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note: Does not seem to be active. Neuregulin-1: Secreted. Isoform 8: Nucleus. Note: May be nuclear. Isoform 9: Secreted. Note: Has a signal peptide. Isoform 10: Membrane; Single-pass type I membrane protein. Note: May possess an internal uncleaved signal sequence.
Tissue specificity	Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. Ref.10
Developmental stage	Detectable at early embryonic ages. Isoform 10 is highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons. Type IV isoforms are expressed in fetal brain. Ref.10
Domain	The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization By similarity. ERBB receptor binding is elicited entirely by the EGF-like domain.
Post-translational modification	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage By similarity. Ref.14
Involvement in disease	A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.
Sequence similarities	Belongs to the neuregulin family. Contains 1 EGF-like domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Sequence caution	The sequence AAA19955.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part. The sequence AAC51756.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Nucleus Secreted
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	EGF-like domain Immunoglobulin domain Transmembrane Transmembrane helix
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	ERBB signaling pathway Inferred from direct assay PubMed 11389077. Source: BHF-UCL MAPK cascade Inferred from electronic annotation. Source: Compara cardiac conduction system development Inferred from electronic annotation. Source: Compara cardiac muscle cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL cardiac muscle cell myoblast differentiation Inferred from direct assay PubMed 17336907. Source: BHF-UCL cell migration Inferred from electronic annotation. Source: Compara cell morphogenesis Inferred from electronic annotation. Source: Compara cell proliferation Inferred from direct assay PubMed 11389077. Source: BHF-UCL cellular protein complex disassembly Inferred from genetic interaction PubMed 15155732. Source: MGI embryo development Inferred from electronic annotation. Source: InterPro endocardial cell differentiation Inferred from direct assay PubMed 17336907. Source: BHF-UCL glial cell differentiation Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara mammary gland development Traceable author statement PubMed 17432114. Source: BHF-UCL negative regulation of cardiac muscle cell apoptotic process Inferred from direct assay PubMed 9553078. Source: BHF-UCL negative regulation of protein catabolic process Inferred from electronic annotation. Source: Compara negative regulation of secretion Inferred from direct assay PubMed 10559227. Source: BHF-UCL negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 15073182. Source: MGI nervous system development Traceable author statement PubMed 17432114. Source: BHF-UCL neural crest cell development Traceable author statement PubMed 17432114. Source: BHF-UCL neuron fate commitment Inferred from electronic annotation. Source: Compara neurotransmitter receptor metabolic process Inferred from electronic annotation. Source: Compara peripheral nervous system development Inferred from electronic annotation. Source: Compara positive regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell proliferation Inferred from direct assay PubMed 9553078. Source: BHF-UCL positive regulation of cell adhesion Inferred from direct assay PubMed 7556068. Source: BHF-UCL positive regulation of cell growth Inferred from direct assay PubMed 9553078. Source: BHF-UCL positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of striated muscle cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL regulation of protein heterodimerization activity Inferred from direct assay PubMed 10559227. Source: BHF-UCL regulation of protein homodimerization activity Traceable author statement PubMed 16412517. Source: BHF-UCL synapse assembly Inferred from electronic annotation. Source: Compara transmembrane receptor protein tyrosine kinase signaling pathway Inferred from direct assay PubMed 7514177. Source: BHF-UCL ventricular cardiac muscle cell differentiation Inferred from direct assay PubMed 9553078. Source: BHF-UCL ventricular trabecula myocardium morphogenesis Inferred from direct assay PubMed 17336907. Source: BHF-UCL wound healing Inferred from direct assay PubMed 12646923. Source: BHF-UCL
Cellular_component	apical plasma membrane Inferred from direct assay PubMed 12646923. Source: BHF-UCL cytoplasm Inferred from electronic annotation. Source: Compara extracellular region Non-traceable author statement Ref.14Ref.1Ref.3. Source: UniProtKB extracellular space Inferred from direct assay PubMed 11389077PubMed 12646923PubMed 11389077. Source: BHF-UCL integral to plasma membrane Inferred from electronic annotation. Source: Compara membrane Non-traceable author statement Ref.3. Source: UniProtKB neuromuscular junction Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ErbB-3 class receptor binding Inferred from direct assay PubMed 7556068. Source: BHF-UCL cytokine activity Traceable author statement PubMed 10372964. Source: BHF-UCL growth factor activity Inferred from direct assay PubMed 11389077. Source: BHF-UCL protein tyrosine kinase activator activity Inferred from direct assay PubMed 7556068. Source: BHF-UCL receptor tyrosine kinase binding Non-traceable author statement Ref.14Ref.1. Source: UniProtKB transcription cofactor activity Inferred from direct assay PubMed 15073182. Source: MGI transmembrane receptor protein tyrosine kinase activator activity Inferred by curator PubMed 9553078. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ERBB2	P04626	2	EBI-2460927,EBI-641062
ERBB3	P21860	3	EBI-2460927,EBI-720706

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. Isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9), type III NRGs (isoforms with a Cys-rich domain, isoform 10) and type IV NRGs (isoforms with additional 5' exons, isoform 11). All these isoforms perform distinct tissue-specific functions.

Isoform 1 (identifier: Q02297-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q02297-2)

Also known as: Alpha1A;

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: K → KHLGIEFIE

Isoform 3 (identifier: Q02297-3)

Also known as: Alpha2B;

The sequence of this isoform differs from the canonical sequence as follows:
     424-462: YVSAMTTPAR...SPPVSSMTVS → HNLIAELRRN...SSIPHLGFIL
     463-640: Missing.

Isoform 4 (identifier: Q02297-4)

Also known as: Alpha3;

The sequence of this isoform differs from the canonical sequence as follows:
     234-247: KAEELYQKRVLTIT → SAQMSLLVIAAKTT
     248-640: Missing.

Isoform 6 (identifier: Q02297-6)

Also known as: Beta1; Beta1A;

The sequence of this isoform differs from the canonical sequence as follows:
     213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

Isoform 7 (identifier: Q02297-7)

Also known as: Beta2;

The sequence of this isoform differs from the canonical sequence as follows:
     213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY

Isoform 8 (identifier: Q02297-8)

Also known as: Beta3; GGFHFB1;

The sequence of this isoform differs from the canonical sequence as follows:
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Isoform 9 (identifier: Q02297-9)

Also known as: GGF2; GGFHPP2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP → MRWRRAPRRS...EVSRVLCKRC
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Isoform 10 (identifier: Q02297-10)

Also known as: SMDF;

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     167-167: S → MEIYSPDMSE...ETNLQTAPKL
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Note: Potential internal signal sequence at positions 76-100.

Isoform 11 (identifier: Q02297-11)

Also known as: Type IV-beta1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-33: KKPESAAGSQSP → MGKGRAGRVGTT
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

Isoform 12 (identifier: Q02297-12)

The sequence of this isoform differs from the canonical sequence as follows:
     213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY
     424-640: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed

Propeptide

2 – 19

18

PRO_0000019462

Chain

20 – 640

621

Pro-neuregulin-1, membrane-bound isoform

PRO_0000019463

Chain

20 – 241

222

Neuregulin-1

PRO_0000019464

Regions

Topological domain

20 – 242

223

Extracellular Potential

Transmembrane

243 – 265

23

Helical; Note=Internal signal sequence; Potential

Topological domain

266 – 640

375

Cytoplasmic Potential

Domain

37 – 128

92

Ig-like C2-type

Domain

178 – 222

45

EGF-like

Compositional bias

165 – 177

13

Ser/Thr-rich

Sites

Site

34

1

Breakpoint for translocation to form gamma-heregulin

Amino acid modifications

Glycosylation

120

1

N-linked (GlcNAc...) Potential

Glycosylation

126

1

N-linked (GlcNAc...) Potential

Glycosylation

164

1

N-linked (GlcNAc...) Potential

Disulfide bond

57 ↔ 112

By similarity

Disulfide bond

182 ↔ 196

Ref.20

Disulfide bond

190 ↔ 210

Ref.20

Disulfide bond

212 ↔ 221

Ref.20

Natural variations

Alternative sequence

1 – 166

166

Missing in isoform 10.

VSP_037562

Alternative sequence

1 – 33

33

MSERK…GSQSP → MRWRRAPRRSGRPGPRAQRP GSAARSSPPLPLLPLLLLLG TAALAPGAAAGNEAAPAGAS VCYSSPPSVGSVQELAQRAA VVIEGKVHPQRRQQGALDRK AAAAAGEAGAWGGDREPPAA GPRALGPPAEEPLLAANGTV PSWPTAPVPSAGEPGEEAPY LVKVHQVWAVKAGGLKKDSL LTVRLGTWGHPAFPSCGRLK EDSRYIFFMEPDANSTSRAP AAFRASFPPLETGRNLKKEV SRVLCKRC in isoform 9.

VSP_003425

Alternative sequence

1 – 21

21

Missing in isoform 11.

VSP_037563

Alternative sequence

22 – 33

12

KKPES…GSQSP → MGKGRAGRVGTT in isoform 11.

VSP_037564

Alternative sequence

134 – 168

35

EIITG…NTSSS → A in isoform 9 and isoform 11.

VSP_003426

Alternative sequence

167

1

S → MEIYSPDMSEVAAERSSSPS TQLSADPSLDGLPAAEDMPE PQTEDGRTPGLVGLAVPCCA CLEAERLRGCLNSEKICIVP ILACLVSLCLCIAGLKWVFV DKIFEYDSPTHLDPGGLGQD PIISLDATAASAVWVSSEAY TSPVSRAQSESEVQVTVQGD KAVVSFEPSAAPTPKNRIFA FSFLPSTAPSFPSPTRNPEV RTPKSATQPQTTETNLQTAP KL in isoform 10.

VSP_037565

Alternative sequence

213 – 241

29

QPGFT…ELYQK → PNEFTGDRCQNYVMASFYST STPFLSLPE in isoform 8, isoform 9 and isoform 10.

VSP_003429

Alternative sequence

213 – 234

22

QPGFT…QNQEK → PNEFTGDRCQNYVMASFYKH LGIEFME in isoform 6 and isoform 11.

VSP_003428

Alternative sequence

213 – 233

21

QPGFT…VQNQE → PNEFTGDRCQNYVMASFY in isoform 7 and isoform 12.

VSP_003427

Alternative sequence

234 – 247

14

KAEEL…VLTIT → SAQMSLLVIAAKTT in isoform 4.

VSP_003432

Alternative sequence

234

1

K → KHLGIEFIE in isoform 2.

VSP_003431

Alternative sequence

242 – 640

399

Missing in isoform 8, isoform 9 and isoform 10.

VSP_003430

Alternative sequence

248 – 640

393

Missing in isoform 4.

VSP_003433

Alternative sequence

424 – 640

217

Missing in isoform 12.

VSP_046417

Alternative sequence

424 – 462

39

YVSAM…SMTVS → HNLIAELRRNKAHRSKCMQI QLSATHLRSSSIPHLGFIL in isoform 3.

VSP_003434

Alternative sequence

463 – 640

178

Missing in isoform 3.

VSP_003435

Natural variant

38

1

R → Q. Ref.10
Corresponds to variant rs3924999 [ dbSNP | Ensembl ].

VAR_009307

Natural variant

289

1

M → T. Ref.5 Ref.10
Corresponds to variant rs10503929 [ dbSNP | Ensembl ].

VAR_053531

Natural variant

463

1

M → K.

VAR_009308

Isoform 10:

Natural variant

46

1

G → R.
Corresponds to variant rs3735774 [ dbSNP | Ensembl ].

Natural variant

127

1

A → P.
Corresponds to variant rs34822181 [ dbSNP | Ensembl ].

Experimental info

Sequence conflict

94

1

K → A in AAA19953. Ref.2

Sequence conflict

107

1

S → P in ABQ53539. Ref.10

Sequence conflict

261

1

V → L in ABQ53540. Ref.10

Sequence conflict

414

1

S → F in AAA19953. Ref.2

Sequence conflict

535

1

Q → R in AAA19951. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

640

Helix Strand Turn

Details...

Beta strand

179 – 181

3

Turn

185 – 189

5

Beta strand

190 – 193

4

Beta strand

195 – 199

5

Beta strand

200 – 204

5

Beta strand

208 – 212

5

Beta strand

216 – 218

3

Beta strand

233 – 235

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C30D3F614AADFF62	FASTA	640	70,392
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ 250 260 270 280 290 300 KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 310 320 330 340 350 360 PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT 370 380 390 400 410 420 ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH 430 440 450 460 470 480 SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL 490 500 510 520 530 540 VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK 550 560 570 580 590 600 LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE 610 620 630 640 ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV
	Isoform 2 (Alpha1A) [UniParc]. Checksum: 775329E1F5FED358	FASTA	648	71,331
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKHLGIEF 250 260 270 280 290 300 IEAEELYQKR VLTITGICIA LLVVGIMCVV AYCKTKKQRK KLHDRLRQSL RSERNNMMNI 310 320 330 340 350 360 ANGPHHPNPP PENVQLVNQY VSKNVISSEH IVEREAETSF STSHYTSTAH HSTTVTQTPS 370 380 390 400 410 420 HSWSNGHTES ILSESHSVIV MSSVENSRHS SPTGGPRGRL NGTGGPRECN SFLRHARETP 430 440 450 460 470 480 DSYRDSPHSE RYVSAMTTPA RMSPVDFHTP SSPKSPPSEM SPPVSSMTVS MPSMAVSPFM 490 500 510 520 530 540 EEERPLLLVT PPRLREKKFD HHPQQFSSFH HNPAHDSNSL PASPLRIVED EEYETTQEYE 550 560 570 580 590 600 PAQEPVKKLA NSRRAKRTKP NGHIANRLEV DSNTSSQSSN SESETEDERV GEDTPFLGIQ 610 620 630 640 NPLAASLEAT PAFRLADSRT NPAGRFSTQE EIQARLSSVI ANQDPIAV
	Isoform 3 (Alpha2B) [UniParc]. Checksum: 00F513509DED3269	FASTA	462	50,879
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ 250 260 270 280 290 300 KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 310 320 330 340 350 360 PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT 370 380 390 400 410 420 ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH 430 440 450 460 SERHNLIAEL RRNKAHRSKC MQIQLSATHL RSSSIPHLGF IL
	Isoform 4 (Alpha3) [UniParc]. Checksum: 8D44247649C60C67	FASTA	247	26,590
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQESAQMSLL VIAAKTT
	Isoform 6 (Beta1) (Beta1A) [UniParc]. Checksum: D61555DF50325386	FASTA	645	71,157
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA 250 260 270 280 290 300 EELYQKRVLT ITGICIALLV VGIMCVVAYC KTKKQRKKLH DRLRQSLRSE RNNMMNIANG 310 320 330 340 350 360 PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REAETSFSTS HYTSTAHHST TVTQTPSHSW 370 380 390 400 410 420 SNGHTESILS ESHSVIVMSS VENSRHSSPT GGPRGRLNGT GGPRECNSFL RHARETPDSY 430 440 450 460 470 480 RDSPHSERYV SAMTTPARMS PVDFHTPSSP KSPPSEMSPP VSSMTVSMPS MAVSPFMEEE 490 500 510 520 530 540 RPLLLVTPPR LREKKFDHHP QQFSSFHHNP AHDSNSLPAS PLRIVEDEEY ETTQEYEPAQ 550 560 570 580 590 600 EPVKKLANSR RAKRTKPNGH IANRLEVDSN TSSQSSNSES ETEDERVGED TPFLGIQNPL 610 620 630 640 AASLEATPAF RLADSRTNPA GRFSTQEEIQ ARLSSVIANQ DPIAV
	Isoform 7 (Beta2) [UniParc]. Checksum: D92B25445628869D	FASTA	637	70,200
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV 250 260 270 280 290 300 LTITGICIAL LVVGIMCVVA YCKTKKQRKK LHDRLRQSLR SERNNMMNIA NGPHHPNPPP 310 320 330 340 350 360 ENVQLVNQYV SKNVISSEHI VEREAETSFS TSHYTSTAHH STTVTQTPSH SWSNGHTESI 370 380 390 400 410 420 LSESHSVIVM SSVENSRHSS PTGGPRGRLN GTGGPRECNS FLRHARETPD SYRDSPHSER 430 440 450 460 470 480 YVSAMTTPAR MSPVDFHTPS SPKSPPSEMS PPVSSMTVSM PSMAVSPFME EERPLLLVTP 490 500 510 520 530 540 PRLREKKFDH HPQQFSSFHH NPAHDSNSLP ASPLRIVEDE EYETTQEYEP AQEPVKKLAN 550 560 570 580 590 600 SRRAKRTKPN GHIANRLEVD SNTSSQSSNS ESETEDERVG EDTPFLGIQN PLAASLEATP 610 620 630 AFRLADSRTN PAGRFSTQEE IQARLSSVIA NQDPIAV
	Isoform 8 (Beta3) (GGFHFB1) [UniParc]. Checksum: D2450DB340E6B64D	FASTA	241	26,143
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY STSTPFLSLP E
	Isoform 9 (GGF2) (GGFHPP2) [UniParc]. Checksum: 3535A1E4AB8EEA8E	FASTA	422	45,141
	10 20 30 40 50 60 MRWRRAPRRS GRPGPRAQRP GSAARSSPPL PLLPLLLLLG TAALAPGAAA GNEAAPAGAS 70 80 90 100 110 120 VCYSSPPSVG SVQELAQRAA VVIEGKVHPQ RRQQGALDRK AAAAAGEAGA WGGDREPPAA 130 140 150 160 170 180 GPRALGPPAE EPLLAANGTV PSWPTAPVPS AGEPGEEAPY LVKVHQVWAV KAGGLKKDSL 190 200 210 220 230 240 LTVRLGTWGH PAFPSCGRLK EDSRYIFFME PDANSTSRAP AAFRASFPPL ETGRNLKKEV 250 260 270 280 290 300 SRVLCKRCAL PPRLKEMKSQ ESAAGSKLVL RCETSSEYSS LRFKWFKNGN ELNRKNKPQN 310 320 330 340 350 360 IKIQKKPGKS ELRINKASLA DSGEYMCKVI SKLGNDSASA NITIVESNAT STSTTGTSHL 370 380 390 400 410 420 VKCAEKEKTF CVNGGECFMV KDLSNPSRYL CKCPNEFTGD RCQNYVMASF YSTSTPFLSL PE
	Isoform 10 (SMDF) [UniParc]. Checksum: 8D41743217F7EB02	FASTA	296	31,686
	10 20 30 40 50 60 MEIYSPDMSE VAAERSSSPS TQLSADPSLD GLPAAEDMPE PQTEDGRTPG LVGLAVPCCA 70 80 90 100 110 120 CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD 130 140 150 160 170 180 PIISLDATAA SAVWVSSEAY TSPVSRAQSE SEVQVTVQGD KAVVSFEPSA APTPKNRIFA 190 200 210 220 230 240 FSFLPSTAPS FPSPTRNPEV RTPKSATQPQ TTETNLQTAP KLSTSTSTTG TSHLVKCAEK 250 260 270 280 290 EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYSTSTP FLSLPE
	Isoform 11 (Type IV-beta1a) [UniParc]. Checksum: B4DCA7D49EE8117B	FASTA	590	65,460
	10 20 30 40 50 60 MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN 70 80 90 100 110 120 KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNATSTSTTG 130 140 150 160 170 180 TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI 190 200 210 220 230 240 EFMEAEELYQ KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM 250 260 270 280 290 300 NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 310 320 330 340 350 360 PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE 370 380 390 400 410 420 TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP 430 440 450 460 470 480 FMEEERPLLL VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE 490 500 510 520 530 540 YEPAQEPVKK LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG 550 560 570 580 590 IQNPLAASLE ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV
	Isoform 12 [UniParc]. Checksum: BE6F4EBA41F043A9	FASTA	420	46,226
	10 20 30 40 50 60 MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS 70 80 90 100 110 120 SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 130 140 150 160 170 180 DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV 190 200 210 220 230 240 KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV 250 260 270 280 290 300 LTITGICIAL LVVGIMCVVA YCKTKKQRKK LHDRLRQSLR SERNNMMNIA NGPHHPNPPP 310 320 330 340 350 360 ENVQLVNQYV SKNVISSEHI VEREAETSFS TSHYTSTAHH STTVTQTPSH SWSNGHTESI 370 380 390 400 410 420 LSESHSVIVM SSVENSRHSS PTGGPRGRLN GTGGPRECNS FLRHARETPD SYRDSPHSER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of heregulin, a specific activator of p185erbB2." Holmes W.E., Sliwkowski M.X., Akita R.W., Henzel W.J., Lee J., Park J.W., Yansura D., Abadi N., Raab H., Lewis G.D., Shepard H.M., Kuang W.-J., Wood W.I., Goeddel D.V., Vandlen R.L. Science 256:1205-1210(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6; 7 AND 8), PARTIAL PROTEIN SEQUENCE.
[2]	"Structural and functional aspects of the multiplicity of Neu differentiation factors." Wen D., Suggs S.V., Karunagaran D., Liu N., Cupples R.L., Luo Y., Janssen A.M., Ben-Baruch N., Trollinger D.B., Jacobsen V.L., Meng S.-Y., Lu H.S., Hu S., Chang D., Yang W., Yanigahara D., Koski R.A., Yarden Y. Mol. Cell. Biol. 14:1909-1919(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 6; 7 AND 8). Tissue: Kidney adenocarcinoma and Pituitary.
[3]	"Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system." Marchionni M.A., Goodearl A.D.J., Chen M.S., Bermingham-McDonogh O., Kirk C., Hendricks M., Danehy F., Misumi D., Sudhalter J., Kobayashi K., Wroblewski D., Lynch C., Baldasarre M., Hiles I., Davis J.B., Hsuan J.J., Totty N.F., Otsu M. , McBurney R.N., Waterfield M.D., Stroobant P., Gwynne D. Nature 362:312-318(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9). Tissue: Brain.
[4]	"Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons." Ho W.-H., Armanini M.P., Nuijens A., Phillips H.S., Osheroff P.L. J. Biol. Chem. 270:14523-14532(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10). Tissue: Brain stem and Cerebellum.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 10 AND 12), VARIANT THR-289. Tissue: Hippocampus.
[6]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175." Schaefer G., Fitzpatrick V.D., Sliwkowski M.X. Oncogene 15:1385-1394(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF GAMMA-HEREGULIN FUSION PROTEIN. Tissue: Mammary cancer.
[9]	"Neuregulin 1 and susceptibility to Schizophrenia." Stefansson H., Sigurdsson E., Steinthorsdottir V., Bjornsdottir S., Sigmundsson T., Ghosh S., Brynjolfsson J., Gunnarsdottir S., Ivarsson O., Chou T.T., Hjaltason O., Birgisdottir B., Jonsson H., Gudnadottir V.G., Gudmundsdottir E., Bjornsson A., Ingvarsson B., Ingason A. , Sigfusson S., Hardardottir H., Harvey R.P., Brunner D., Mutel V., Gonzalo A., Lemke G., Sainz J., Johannesson G., Andresson T., Gudbjartsson D., Manolescu A., Frigge M.L., Gurney M.E., Kong A., Gulcher J.R., Petursson H., Stefansson K. Am. J. Hum. Genet. 71:877-892(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 8 AND 9), SUSCEPTIBILITY TO SCHIZOPHRENIA.
[10]	"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia." Tan W., Wang Y., Gold B., Chen J., Dean M., Harrison P.J., Weinberger D.R., Law A.J. J. Biol. Chem. 282:24343-24351(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11), ALTERNATIVE SPLICING, VARIANTS GLN-38 AND THR-289, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Hippocampus and Prefrontal cortex.
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 10). Tissue: Brain and Duodenum.
[12]	Schoumacher F., Herzer S., Flury N., Kueng W., Mueller H., Eppenberger U. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-211 (ISOFORM 1).
[13]	"Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor." Culouscou J.-M., Plowman G.D., Carlton G.W., Green J.M., Shoyab M. J. Biol. Chem. 268:18407-18410(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-28.
[14]	"Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells." Peles E., Bacus S.S., Koski R.A., Lu H.S., Wen D., Ogden S.G., Levy R.B., Yarden Y. Cell 69:205-216(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE (ISOFORM 1), FUNCTION, GLYCOSYLATION.
[15]	"Heregulin induces tyrosine phosphorylation of HER4/p180erbB4." Plowman G.D., Green J.M., Culouscou J.M., Carlton G.W., Rothwell V.M., Buckley S. Nature 366:473-475(1993) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ERBB4, FUNCTION.
[16]	"Gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line." Wang X.-Z., Jolicoeur E.M., Conte N., Chaffanet M., Zhang Y., Mozziconacci M.-J., Feiner H., Birnbaum D., Pebusque M.-J., Ron D. Oncogene 18:5718-5721(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION.
[17]	"Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation." Liu X., Baker E., Eyre H.J., Sutherland G.R., Zhou M. Oncogene 18:7110-7114(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION.
[18]	"Ligand discrimination in signaling through an ErbB4 receptor homodimer." Sweeney C., Lai C., Riese D.J. II, Diamonti A.J., Cantley L.C., Carraway K.L. III J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ERBB4.
[19]	"Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4." Nagata K., Kohda D., Hatanaka H., Ichikawa S., Matsuda S., Yamamoto T., Suzuki A., Inagaki F. EMBO J. 13:3517-3523(1994) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 175-241 (ISOFORM 1).
[20]	"High-resolution solution structure of the EGF-like domain of heregulin-alpha." Jacobsen N.E., Abadi N., Sliwkowski M.X., Reilly D., Skelton N.J., Fairbrother W.J. Biochemistry 35:3402-3417(1996) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 177-239 (ISOFORM 1), DISULFIDE BONDS.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Tipping the mind - Issue 129 of June 2011

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M94165 mRNA. Translation: AAA58638.1.
M94166 mRNA. Translation: AAA58639.1.
M94167 mRNA. Translation: AAA58640.1.
M94168 mRNA. Translation: AAA58641.1.
U02325 mRNA. Translation: AAA19950.1.
U02326 mRNA. Translation: AAA19951.1.
U02327 mRNA. Translation: AAA19952.1.
U02328 mRNA. Translation: AAA19953.1.
U02329 mRNA. Translation: AAA19954.1.
U02330 mRNA. Translation: AAA19955.1. Sequence problems.
L12260 mRNA. Translation: AAB59622.1.
L12261 mRNA. Translation: AAB59358.1.
L41827 mRNA. Translation: AAC41764.1.
AK289927 mRNA. Translation: BAF82616.1.
AK298132 mRNA. Translation: BAH12729.1.
AC021909 Genomic DNA. No translation available.
AC022833 Genomic DNA. No translation available.
AC022850 Genomic DNA. No translation available.
AC023948 Genomic DNA. No translation available.
AC068359 Genomic DNA. No translation available.
AC068931 Genomic DNA. No translation available.
AC083977 Genomic DNA. No translation available.
AC103675 Genomic DNA. No translation available.
AC104000 Genomic DNA. No translation available.
AC104029 Genomic DNA. No translation available.
AC113209 Genomic DNA. No translation available.
AF009227 mRNA. Translation: AAC51756.1. Different initiation.
AF491780 Genomic DNA. Translation: AAM71137.1.
AF491780 Genomic DNA. Translation: AAM71139.1.
AF491780 Genomic DNA. Translation: AAM71140.1.
EF372273 mRNA. Translation: ABQ53539.1.
EF372274 mRNA. Translation: ABQ53540.1.
CH471080 Genomic DNA. Translation: EAW63411.1.
BC064587 mRNA. Translation: AAH64587.1.
BC073871 mRNA. Translation: AAH73871.1.
AF026146 mRNA. Translation: AAD01795.1.
BK000383 Genomic DNA. Translation: DAA00044.1.
BK000383 Genomic DNA. Translation: DAA00045.1.
BK000383 Genomic DNA. Translation: DAA00046.1.
BK000383 Genomic DNA. Translation: DAA00047.1.

IPI

IPI00004473.
IPI00017547.
IPI00221375.
IPI00221376.
IPI00221378.
IPI00296902.
IPI00307737.
IPI00394936.
IPI00641213.
IPI00930509.
IPI01012594.

PIR

A43273.
A56943.
B43273.
C43273.
D43273.
I38403.
I38404.
I38408.
S32357.

RefSeq

NP_001153467.1. NM_001159995.1.
NP_001153471.1. NM_001159999.1.
NP_001153473.1. NM_001160001.1.
NP_001153477.1. NM_001160005.1.
NP_039250.2. NM_013956.3.
NP_039251.2. NM_013957.3.
NP_039252.2. NM_013958.3.
NP_039253.1. NM_013959.3.
NP_039254.1. NM_013960.3.
NP_039256.2. NM_013962.2.
NP_039258.1. NM_013964.3.

UniGene

Hs.453951.
Hs.668810.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HAE	NMR	-	A	177-238	[»]
1HAF	NMR	-	A	177-238	[»]
1HRE	NMR	-	A	175-241	[»]
1HRF	NMR	-	A	175-241	[»]
3U7U	X-ray	3.03	G/H/I/J/K/L	175-221	[»]

ProteinModelPortal

Q02297.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-355N.

IntAct

Q02297. 4 interactions.

PTM databases

PhosphoSite

Q02297.

Polymorphism databases

DMDM

9297018.

Proteomic databases

PaxDb

Q02297.

PRIDE

Q02297.

Protocols and materials databases

DNASU

3084.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000287840; ENSP00000287840; ENSG00000157168.
ENST00000287842; ENSP00000287842; ENSG00000157168.
ENST00000341377; ENSP00000340497; ENSG00000157168.
ENST00000356819; ENSP00000349275; ENSG00000157168.
ENST00000405005; ENSP00000384620; ENSG00000157168.
ENST00000519301; ENSP00000429582; ENSG00000157168.
ENST00000520407; ENSP00000434640; ENSG00000157168.
ENST00000520502; ENSP00000433289; ENSG00000157168.
ENST00000521670; ENSP00000428828; ENSG00000157168.
ENST00000523079; ENSP00000430120; ENSG00000157168.

GeneID

3084.

KEGG

hsa:3084.

UCSC

uc003xip.3. human.
uc003xis.3. human.
uc003xit.2. human.
uc003xiu.2. human.
uc003xiv.2. human.
uc003xiw.2. human.
uc003xix.3. human.
uc003xiy.3. human.
uc003xja.2. human.
uc010lvp.2. human.

Organism-specific databases

CTD

3084.

GeneCards

GC08P031554.

HGNC

HGNC:7997. NRG1.

HPA

HPA010964.

MIM

142445. gene.

neXtProt

NX_Q02297.

PharmGKB

PA31776.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG47801.

HOVERGEN

HBG006531.

KO

K05455.

Enzyme and pathway databases

Pathway_Interaction_DB

glypican_1pathway. Glypican 1 network.

Reactome

REACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q02297.

Bgee

Q02297.

CleanEx

HS_NRG1.

Genevestigator

Q02297.

GermOnline

ENSG00000157168. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR018250. Neuregulin.
IPR002154. Neuregulin_1_C.
[Graphical view]

Pfam

PF12661. hEGF. 1 hit.
PF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]

PRINTS

PR01089. NEUREGULIN.

SMART

SM00181. EGF. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]

PROSITE

PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

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Other

ChiTaRS

NRG1. human.

EvolutionaryTrace

Q02297.

GenomeRNAi

3084.

NextBio

12227.

PMAP-CutDB

Q02297.

SOURCE

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Entry information

Entry name

NRG1_HUMAN

Accession

Primary (citable) accession number: Q02297
Secondary accession number(s): A5YAK4 , A5YAK5, A8K1L2, B7Z4Z3, E9PHH4, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q15491, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 160 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.