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Protein

T-protein

Gene

tyrA

Organism
Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. T-protein (tyrA), T-protein (SAMN03097723_2546), T-protein (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. Chorismate mutase (AL522_03350), P-protein (pheA), Chorismate mutase (SAMN03097723_3661), T-protein (tyrA), Monofunctional chorismate mutase (aroQ), T-protein (SAMN03097723_2546), T-protein (tyrA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Oxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
OrganismiEnterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Taxonomic identifieri549 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaePantoeaPantoea agglomerans group

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191961 – 373T-proteinAdd BLAST373

Proteomic databases

PRIDEiQ02287.

Structurei

3D structure databases

ProteinModelPortaliQ02287.
SMRiQ02287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90Chorismate mutasePROSITE-ProRule annotationAdd BLAST90
Domaini99 – 361Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST263

Sequence similaritiesi

In the C-terminal section; belongs to the prephenate/arogenate dehydrogenase family.Curated

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
PfamiView protein in Pfam
PF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiView protein in SMART
SM00830. CM_2. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiView protein in PROSITE
PS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAELTALRD QIDSVDKALL DLLAKRLELV AEVGEVKSRY GLPIYVPERE
60 70 80 90 100
ASMLASRRKE AEALGVPPDL IEDVLRRVMR ESYTSENDKG FKTLCPELRP
110 120 130 140 150
VVIVGGKGQM GRLFEKMLGL SGYTVKTLDK EDWPQAETLL SDAGMVIISV
160 170 180 190 200
PIHLTEQVIA QLPPLPEDCI LVDLASVKNR PLQAMLAAHN GPVLGLHPMF
210 220 230 240 250
GPDSGSLAKQ VVVWCDGRQP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA
260 270 280 290 300
FIQALRHFAT FAYGLHLAEE NVNLDQLLAL SSPIYRLELA MVGRLFAQDP
310 320 330 340 350
QLYADIIMSS ESNLALIKRY YQRFGEAIAL LEQGDKQAFI ASFNRVEQWF
360 370
GDHAKRFLVE SRSLLRSAND SRP
Length:373
Mass (Da):41,847
Last modified:April 1, 1993 - v1
Checksum:iC6E3C3B877A0628C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60420 Genomic DNA. Translation: CAA42950.1.
M74135 Genomic DNA. Translation: AAA24868.1.
PIRiS29934.
RefSeqiWP_010248465.1. NZ_LIME01000008.1.

Genome annotation databases

GeneIDi31703945.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTYRA_ENTAG
AccessioniPrimary (citable) accession number: Q02287
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 7, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families