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Q02287

- TYRA_ENTAG

UniProt

Q02287 - TYRA_ENTAG

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Protein
T-protein
Gene
tyrA
Organism
Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

GO - Molecular functioni

  1. chorismate mutase activity Source: UniProtKB-EC
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. chorismate metabolic process Source: InterPro
  2. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
OrganismiEnterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Taxonomic identifieri549 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePantoea

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373T-protein
PRO_0000119196Add
BLAST

Proteomic databases

PRIDEiQ02287.

Structurei

3D structure databases

ProteinModelPortaliQ02287.
SMRiQ02287. Positions 90-368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9090Chorismate mutase
Add
BLAST
Domaini99 – 361263Prephenate/arogenate dehydrogenase
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02287-1 [UniParc]FASTAAdd to Basket

« Hide

MVAELTALRD QIDSVDKALL DLLAKRLELV AEVGEVKSRY GLPIYVPERE    50
ASMLASRRKE AEALGVPPDL IEDVLRRVMR ESYTSENDKG FKTLCPELRP 100
VVIVGGKGQM GRLFEKMLGL SGYTVKTLDK EDWPQAETLL SDAGMVIISV 150
PIHLTEQVIA QLPPLPEDCI LVDLASVKNR PLQAMLAAHN GPVLGLHPMF 200
GPDSGSLAKQ VVVWCDGRQP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA 250
FIQALRHFAT FAYGLHLAEE NVNLDQLLAL SSPIYRLELA MVGRLFAQDP 300
QLYADIIMSS ESNLALIKRY YQRFGEAIAL LEQGDKQAFI ASFNRVEQWF 350
GDHAKRFLVE SRSLLRSAND SRP 373
Length:373
Mass (Da):41,847
Last modified:April 1, 1993 - v1
Checksum:iC6E3C3B877A0628C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60420 Genomic DNA. Translation: CAA42950.1.
M74135 Genomic DNA. Translation: AAA24868.1.
PIRiS29934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60420 Genomic DNA. Translation: CAA42950.1 .
M74135 Genomic DNA. Translation: AAA24868.1 .
PIRi S29934.

3D structure databases

ProteinModelPortali Q02287.
SMRi Q02287. Positions 90-368.
ModBasei Search...

Proteomic databases

PRIDEi Q02287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00120 ; UER00203 .
UPA00122 ; UER00961 .

Family and domain databases

Gene3Di 1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTi SM00830. CM_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsi TIGR01799. CM_T. 1 hit.
PROSITEi PS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A monofunctional prephenate dehydrogenase created by cleavage of the 5' 109 bp of the tyrA gene from Erwinia herbicola."
    Xia T., Zhao G., Fischer R.S., Jensen R.A.
    J. Gen. Microbiol. 138:1309-1316(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTYRA_ENTAG
AccessioniPrimary (citable) accession number: Q02287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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