Reviewed, UniProtKB/Swiss-Prot Q02287 (TYRA_ENTAG)

Names and origin

Protein names

Recommended name:
    T-protein
Including the following 2 domains:
    1- Recommended name:
            Chorismate mutase
                Short name=CM
              EC=5.4.99.5
    2- Recommended name:
            Prephenate dehydrogenase
                Short name=PDH
              EC=1.3.1.12

Gene names

Name:

tyrA

Organism

Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)

Taxonomic identifier

549 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pantoea

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Chorismate = prephenate. Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1. Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.
Subcellular location	Cytoplasm.
Sequence similarities	Contains 1 chorismate mutase domain. Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Isomerase Oxidoreductase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro chorismate mutase activity Inferred from electronic annotation. Source: EC prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	T-protein		PRO_0000119196
Regions
	Domain	1 – 90	90	Chorismate mutase
	Domain	99 – 361	263	Prephenate/arogenate dehydrogenase

Sequences

	Sequence		Length	Mass (Da)
	Q02287-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: C6E3C3B877A0628C	FASTA	373	41,847
	10 20 30 40 50 60 MVAELTALRD QIDSVDKALL DLLAKRLELV AEVGEVKSRY GLPIYVPERE ASMLASRRKE 70 80 90 100 110 120 AEALGVPPDL IEDVLRRVMR ESYTSENDKG FKTLCPELRP VVIVGGKGQM GRLFEKMLGL 130 140 150 160 170 180 SGYTVKTLDK EDWPQAETLL SDAGMVIISV PIHLTEQVIA QLPPLPEDCI LVDLASVKNR 190 200 210 220 230 240 PLQAMLAAHN GPVLGLHPMF GPDSGSLAKQ VVVWCDGRQP EAYQWFLEQI QVWGARLHRI 250 260 270 280 290 300 SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVNLDQLLAL SSPIYRLELA MVGRLFAQDP 310 320 330 340 350 360 QLYADIIMSS ESNLALIKRY YQRFGEAIAL LEQGDKQAFI ASFNRVEQWF GDHAKRFLVE 370 SRSLLRSAND SRP

References

[1]	"A monofunctional prephenate dehydrogenase created by cleavage of the 5' 109 bp of the tyrA gene from Erwinia herbicola." Xia T., Zhao G., Fischer R.S., Jensen R.A. J. Gen. Microbiol. 138:1309-1316(1992) [PubMed: 1512561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X60420 Genomic DNA. Translation: CAA42950.1. M74135 Genomic DNA. Translation: AAA24868.1.
PIR	S29934.
3D structure databases
SMR	Q02287. Positions 1-93, 90-368.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.1.12. 3054. 5.4.99.5. 3054.
Family and domain databases
InterPro	IPR008244. Chor_mut/prephenate_DH_T. IPR002701. Chorismate_mutase. IPR020822. Chorismate_mutase_type_II. IPR011277. CM_T. IPR016040. NAD(P)-bd_dom. IPR003099. Prephen_DH. [Graphical view]
PANTHER	PTHR21363. Prephen_DH. 1 hit.
Pfam	PF01817. CM_2. 1 hit. PF02153. PDH. 1 hit. [Graphical view]
PIRSF	PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMART	SM00830. CM_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01799. CM_T. 1 hit.
PROSITE	PS51168. CHORISMATE_MUT_2. 1 hit. PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_ENTAG

Accession

Primary (citable) accession number: Q02287

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	February 9, 2010
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)