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Q02286 (PHEA_ENTAG) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P-protein

Including the following 2 domains:

  1. Chorismate mutase
    Short name=CM
    EC=5.4.99.5
  2. Prephenate dehydratase
    Short name=PDT
    EC=4.2.1.51
Gene names
Name:pheA
OrganismEnterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Taxonomic identifier549 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePantoea

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Phenylalanine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
Lyase
   Technical termMultifunctional enzyme
Gene Ontology (GO)
   Biological processL-phenylalanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionchorismate mutase activity

Inferred from electronic annotation. Source: EC

prephenate dehydratase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387P-protein
PRO_0000119187

Regions

Domain1 – 9292Chorismate mutase
Domain105 – 285181Prephenate dehydratase
Region286 – 387102Regulatory (Phe-binding)

Sites

Site2781Essential for prephenate dehydratase activity Potential

Experimental info

Sequence conflict3011I → K in AAA24853. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q02286 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 8C4F29C5678E42C6

FASTA38743,183
        10         20         30         40         50         60 
MNPDNPLLAL RDKISAVDKK LLTLLAERRL LAVEVAQAKL ATHRPIRDVE RERALLENLI 

        70         80         90        100        110        120 
VLGKAHNLDA HYITRLFQLV IEDSVLTQQA LLQKNLNHPH AHAARIAFLG PKGSYSHLAA 

       130        140        150        160        170        180 
RNYASRHFDS MVECGCLKFH DIIKQVENGV ADYAVMPIEN TSSGSINDVY DLLQQTSLSI 

       190        200        210        220        230        240 
VGELTLPIDH CVLVNGPTDL QQIETVYSHP QPFQQCSQFI NRFPHWKIEY TESTAAAMEK 

       250        260        270        280        290        300 
VAALNSPKVA ALGSEAGGEL YQLQVLERNL ANQQQNHTRF IVLARKAIEV SDQVPAKTTL 

       310        320        330        340        350        360 
IMATGQQAGA LVDALLVLRQ HNLIMSKLES RPINGNPWEE MFYIDVQGNL QSERMQQALQ 

       370        380 
ELQTMTRSLK VLGCYPSENV VPAEPGR 

« Hide

References

[1]"A monofunctional prephenate dehydrogenase created by cleavage of the 5' 109 bp of the tyrA gene from Erwinia herbicola."
Xia T., Zhao G., Fischer R.S., Jensen R.A.
J. Gen. Microbiol. 138:1309-1316(1992) [PubMed: 1512561] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Loss of allosteric control but retention of the bifunctional catalytic competence of a fusion protein formed by excision of 260 base pairs from the 3' terminus of pheA from Erwinia herbicola."
Xia T., Zhao G., Jensen R.A.
Appl. Environ. Microbiol. 58:2792-2798(1992) [PubMed: 1444388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60420 Genomic DNA. Translation: CAA42949.1.
M74134 Genomic DNA. Translation: AAA24853.1.
PIRS26053.

3D structure databases

ProteinModelPortalQ02286.
SMRQ02286. Positions 6-97.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008242. Chor_mutase/pphenate_deHydtase.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR010952. CM_P_1.
IPR001086. Preph_deHydtase.
IPR018528. Preph_deHydtase_CS.
[Graphical view]
Gene3DG3DSA:1.20.59.10. Chorismate_mutase. 1 hit.
PfamPF01817. CM_2. 1 hit.
PF00800. PDT. 1 hit.
[Graphical view]
PIRSFPIRSF001500. Chor_mut_pdt_Ppr. 1 hit.
SMARTSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMSSF48600. Chorismate_mut. 1 hit.
TIGRFAMsTIGR01797. CM_P_1. 1 hit.
PROSITEPS51168. CHORISMATE_MUT_2. 1 hit.
PS00857. PREPHENATE_DEHYDR_1. 1 hit.
PS00858. PREPHENATE_DEHYDR_2. 1 hit.
PS51171. PREPHENATE_DEHYDR_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHEA_ENTAG
AccessionPrimary (citable) accession number: Q02286
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 21, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families