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Q02284

- 5HT1F_MOUSE

UniProt

Q02284 - 5HT1F_MOUSE

Protein

5-hydroxytryptamine receptor 1F

Gene

Htr1f

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

    GO - Molecular functioni

    1. serotonin binding Source: MGI
    2. serotonin receptor activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 1F
    Short name:
    5-HT-1F
    Short name:
    5-HT1F
    Alternative name(s):
    5-HT-1E-beta
    Serotonin receptor 1F
    Gene namesi
    Name:Htr1f
    Synonyms:5ht1f, Htr1eb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:99842. Htr1f.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3663665-hydroxytryptamine receptor 1FPRO_0000068938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ02284.

    PTM databases

    PhosphoSiteiQ02284.

    Expressioni

    Tissue specificityi

    Detected in hippocampus.1 Publication

    Gene expression databases

    BgeeiQ02284.
    CleanExiMM_HTR1F.
    GenevestigatoriQ02284.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000063136.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02284.
    SMRiQ02284. Positions 20-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularBy similarityAdd
    BLAST
    Topological domaini51 – 6010CytoplasmicBy similarity
    Topological domaini84 – 9714ExtracellularBy similarityAdd
    BLAST
    Topological domaini119 – 14022CytoplasmicBy similarityAdd
    BLAST
    Topological domaini162 – 17817ExtracellularBy similarityAdd
    BLAST
    Topological domaini202 – 29089CytoplasmicBy similarityAdd
    BLAST
    Topological domaini312 – 32918ExtracellularBy similarityAdd
    BLAST
    Topological domaini351 – 36616CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1By similarityAdd
    BLAST
    Transmembranei61 – 8323Helical; Name=2By similarityAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3By similarityAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4By similarityAdd
    BLAST
    Transmembranei179 – 20123Helical; Name=5By similarityAdd
    BLAST
    Transmembranei291 – 31121Helical; Name=6By similarityAdd
    BLAST
    Transmembranei330 – 35021Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni99 – 10810Agonist bindingBy similarity
    Regioni306 – 3105Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi120 – 1223DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi343 – 3475NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ02284.
    KOiK04153.
    OMAiVVNVCEK.
    OrthoDBiEOG7NCV3Q.
    PhylomeDBiQ02284.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000450. 5HT1F_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00515. 5HT1FRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02284-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLNASDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV    50
    TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVLCDIWL 100
    SVDIICCTCS ILHLSAIALD RYRAITDAVE YARKRTPRHA GIMITIVWVI 150
    SVFISMPPLF WRHQGTSRDD ECVIKHDHIV STIYSTFGAF YIPLVLILIL 200
    YYKIYRAART LYHKRQASRM IKEELNGQVF LESGEKSIKL VSTSYMLEKS 250
    LSDPSTDFDR IHSTVKSPRS ELKHEKSWRR QKISGTRERK AATTLGLILG 300
    AFVICWLPFF VKELVVNVCE KCKISEEMSN FLAWLGYLNS LINPLIYTIF 350
    NEDFKKAFQK LVRCRY 366
    Length:366
    Mass (Da):41,977
    Last modified:April 1, 1993 - v1
    Checksum:i69EC1CD6F22BD93F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z14224 mRNA. Translation: CAA78593.1.
    CCDSiCCDS28267.1.
    PIRiS26048.
    RefSeqiNP_032336.1. NM_008310.3.
    UniGeneiMm.5040.

    Genome annotation databases

    EnsembliENSMUST00000063076; ENSMUSP00000063136; ENSMUSG00000050783.
    GeneIDi15557.
    KEGGimmu:15557.
    UCSCiuc007zqg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z14224 mRNA. Translation: CAA78593.1 .
    CCDSi CCDS28267.1.
    PIRi S26048.
    RefSeqi NP_032336.1. NM_008310.3.
    UniGenei Mm.5040.

    3D structure databases

    ProteinModelPortali Q02284.
    SMRi Q02284. Positions 20-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000063136.

    Chemistry

    BindingDBi Q02284.
    GuidetoPHARMACOLOGYi 5.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q02284.

    Proteomic databases

    PRIDEi Q02284.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063076 ; ENSMUSP00000063136 ; ENSMUSG00000050783 .
    GeneIDi 15557.
    KEGGi mmu:15557.
    UCSCi uc007zqg.2. mouse.

    Organism-specific databases

    CTDi 3355.
    MGIi MGI:99842. Htr1f.

    Phylogenomic databases

    eggNOGi NOG249628.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q02284.
    KOi K04153.
    OMAi VVNVCEK.
    OrthoDBi EOG7NCV3Q.
    PhylomeDBi Q02284.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 288496.
    PROi Q02284.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02284.
    CleanExi MM_HTR1F.
    Genevestigatori Q02284.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000450. 5HT1F_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF34. PTHR24247:SF34. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00515. 5HT1FRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a mouse '5HT1E-like' serotonin receptor expressed predominantly in hippocampus."
      Amlaiky N., Ramboz S., Boschert U., Plassat J.-L., Hen R.
      J. Biol. Chem. 267:19761-19764(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry namei5HT1F_MOUSE
    AccessioniPrimary (citable) accession number: Q02284
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3