SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q02284

- 5HT1F_MOUSE

UniProt

Q02284 - 5HT1F_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

5-hydroxytryptamine receptor 1F

Gene
Htr1f, 5ht1f, Htr1eb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

GO - Molecular functioni

  1. serotonin binding Source: MGI
  2. serotonin receptor activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1F
Short name:
5-HT-1F
Short name:
5-HT1F
Alternative name(s):
5-HT-1E-beta
Serotonin receptor 1F
Gene namesi
Name:Htr1f
Synonyms:5ht1f, Htr1eb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:99842. Htr1f.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Extracellular By similarityAdd
BLAST
Transmembranei30 – 5021Helical; Name=1; By similarityAdd
BLAST
Topological domaini51 – 6010Cytoplasmic By similarity
Transmembranei61 – 8323Helical; Name=2; By similarityAdd
BLAST
Topological domaini84 – 9714Extracellular By similarityAdd
BLAST
Transmembranei98 – 11821Helical; Name=3; By similarityAdd
BLAST
Topological domaini119 – 14022Cytoplasmic By similarityAdd
BLAST
Transmembranei141 – 16121Helical; Name=4; By similarityAdd
BLAST
Topological domaini162 – 17817Extracellular By similarityAdd
BLAST
Transmembranei179 – 20123Helical; Name=5; By similarityAdd
BLAST
Topological domaini202 – 29089Cytoplasmic By similarityAdd
BLAST
Transmembranei291 – 31121Helical; Name=6; By similarityAdd
BLAST
Topological domaini312 – 32918Extracellular By similarityAdd
BLAST
Transmembranei330 – 35021Helical; Name=7; By similarityAdd
BLAST
Topological domaini351 – 36616Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3663665-hydroxytryptamine receptor 1FPRO_0000068938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 172 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ02284.

PTM databases

PhosphoSiteiQ02284.

Expressioni

Tissue specificityi

Detected in hippocampus.1 Publication

Gene expression databases

BgeeiQ02284.
CleanExiMM_HTR1F.
GenevestigatoriQ02284.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063136.

Structurei

3D structure databases

ProteinModelPortaliQ02284.
SMRiQ02284. Positions 20-363.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 10810Agonist binding By similarity
Regioni306 – 3105Agonist binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi120 – 1223DRY motif; important for ligand-induced conformation changes By similarity
Motifi343 – 3475NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ02284.
KOiK04153.
OMAiVVNVCEK.
OrthoDBiEOG7NCV3Q.
PhylomeDBiQ02284.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02284-1 [UniParc]FASTAAdd to Basket

« Hide

MDFLNASDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV    50
TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVLCDIWL 100
SVDIICCTCS ILHLSAIALD RYRAITDAVE YARKRTPRHA GIMITIVWVI 150
SVFISMPPLF WRHQGTSRDD ECVIKHDHIV STIYSTFGAF YIPLVLILIL 200
YYKIYRAART LYHKRQASRM IKEELNGQVF LESGEKSIKL VSTSYMLEKS 250
LSDPSTDFDR IHSTVKSPRS ELKHEKSWRR QKISGTRERK AATTLGLILG 300
AFVICWLPFF VKELVVNVCE KCKISEEMSN FLAWLGYLNS LINPLIYTIF 350
NEDFKKAFQK LVRCRY 366
Length:366
Mass (Da):41,977
Last modified:April 1, 1993 - v1
Checksum:i69EC1CD6F22BD93F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z14224 mRNA. Translation: CAA78593.1.
CCDSiCCDS28267.1.
PIRiS26048.
RefSeqiNP_032336.1. NM_008310.3.
UniGeneiMm.5040.

Genome annotation databases

EnsembliENSMUST00000063076; ENSMUSP00000063136; ENSMUSG00000050783.
GeneIDi15557.
KEGGimmu:15557.
UCSCiuc007zqg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z14224 mRNA. Translation: CAA78593.1 .
CCDSi CCDS28267.1.
PIRi S26048.
RefSeqi NP_032336.1. NM_008310.3.
UniGenei Mm.5040.

3D structure databases

ProteinModelPortali Q02284.
SMRi Q02284. Positions 20-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000063136.

Chemistry

BindingDBi Q02284.
GuidetoPHARMACOLOGYi 5.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q02284.

Proteomic databases

PRIDEi Q02284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063076 ; ENSMUSP00000063136 ; ENSMUSG00000050783 .
GeneIDi 15557.
KEGGi mmu:15557.
UCSCi uc007zqg.2. mouse.

Organism-specific databases

CTDi 3355.
MGIi MGI:99842. Htr1f.

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q02284.
KOi K04153.
OMAi VVNVCEK.
OrthoDBi EOG7NCV3Q.
PhylomeDBi Q02284.
TreeFami TF316350.

Miscellaneous databases

NextBioi 288496.
PROi Q02284.
SOURCEi Search...

Gene expression databases

Bgeei Q02284.
CleanExi MM_HTR1F.
Genevestigatori Q02284.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF34. PTHR24247:SF34. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a mouse '5HT1E-like' serotonin receptor expressed predominantly in hippocampus."
    Amlaiky N., Ramboz S., Boschert U., Plassat J.-L., Hen R.
    J. Biol. Chem. 267:19761-19764(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry namei5HT1F_MOUSE
AccessioniPrimary (citable) accession number: Q02284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi