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Protein

Homeobox-leucine zipper protein HAT5

Gene

HAT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription activator involved in leaf development. Binds to the DNA sequence 5'-CAAT[AT]ATTG-3'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi65 – 124HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • protein homodimerization activity Source: TAIR
  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • leaf morphogenesis Source: TAIR
  • positive regulation of transcription, DNA-templated Source: TAIR
  • response to blue light Source: TAIR
  • response to salt stress Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox-leucine zipper protein HAT5
Alternative name(s):
HD-ZIP protein ATHB-1
Homeodomain transcription factor ATHB-1
Homeodomain-leucine zipper protein HAT5
Short name:
HD-ZIP protein 5
Gene namesi
Name:HAT5
Synonyms:ATHB-1
Ordered Locus Names:At3g01470
ORF Names:F4P13.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G01470.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi119R → K: Abolishes DNA-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489021 – 272Homeobox-leucine zipper protein HAT5Add BLAST272

Proteomic databases

PaxDbiQ02283.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevisibleiQ02283. AT.

Interactioni

Subunit structurei

Interacts with DNA as homodimer (PubMed:9405140). Interacts with TBP2 (PubMed:24531799).2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: TAIR

Protein-protein interaction databases

BioGridi6471. 4 interactors.
MINTiMINT-8060197.
STRINGi3702.AT3G01470.1.

Structurei

3D structure databases

ProteinModelPortaliQ02283.
SMRiQ02283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 160Leucine-zipperAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 63Asp/Glu-rich (acidic)Add BLAST25
Compositional biasi211 – 243Asp-rich (acidic)Add BLAST33

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0483. Eukaryota.
ENOG410Z2UE. LUCA.
HOGENOMiHOG000006025.
InParanoidiQ02283.
KOiK09338.
OMAiQETANEP.
OrthoDBiEOG09360JSX.
PhylomeDBiQ02283.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003106. Leu_zip_homeo.
[Graphical view]
PfamiPF02183. HALZ. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNSFFFDP SASHGNSMFF LGNLNPVVQG GGARSMMNME ETSKRRPFFS
60 70 80 90 100
SPEDLYDDDF YDDQLPEKKR RLTTEQVHLL EKSFETENKL EPERKTQLAK
110 120 130 140 150
KLGLQPRQVA VWFQNRRARW KTKQLERDYD LLKSTYDQLL SNYDSIVMDN
160 170 180 190 200
DKLRSEVTSL TEKLQGKQET ANEPPGQVPE PNQLDPVYIN AAAIKTEDRL
210 220 230 240 250
SSGSVGSAVL DDDAPQLLDS CDSYFPSIVP IQDNSNASDH DNDRSCFADV
260 270
FVPTTSPSHD HHGESLAFWG WP
Length:272
Mass (Da):30,933
Last modified:July 1, 1993 - v1
Checksum:iB85ACCA20EDFA094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58821 mRNA. Translation: CAA41625.1.
AC009325 Genomic DNA. Translation: AAF01532.1.
CP002686 Genomic DNA. Translation: AEE73670.1.
AY058188 mRNA. Translation: AAL25601.1.
AY098972 mRNA. Translation: AAM19982.1.
M90416 mRNA. Translation: AAA32816.1.
PIRiS16325.
RefSeqiNP_186796.1. NM_111013.4.
UniGeneiAt.41275.
At.47815.

Genome annotation databases

EnsemblPlantsiAT3G01470.1; AT3G01470.1; AT3G01470.
GeneIDi821138.
GrameneiAT3G01470.1; AT3G01470.1; AT3G01470.
KEGGiath:AT3G01470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58821 mRNA. Translation: CAA41625.1.
AC009325 Genomic DNA. Translation: AAF01532.1.
CP002686 Genomic DNA. Translation: AEE73670.1.
AY058188 mRNA. Translation: AAL25601.1.
AY098972 mRNA. Translation: AAM19982.1.
M90416 mRNA. Translation: AAA32816.1.
PIRiS16325.
RefSeqiNP_186796.1. NM_111013.4.
UniGeneiAt.41275.
At.47815.

3D structure databases

ProteinModelPortaliQ02283.
SMRiQ02283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi6471. 4 interactors.
MINTiMINT-8060197.
STRINGi3702.AT3G01470.1.

Proteomic databases

PaxDbiQ02283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G01470.1; AT3G01470.1; AT3G01470.
GeneIDi821138.
GrameneiAT3G01470.1; AT3G01470.1; AT3G01470.
KEGGiath:AT3G01470.

Organism-specific databases

TAIRiAT3G01470.

Phylogenomic databases

eggNOGiKOG0483. Eukaryota.
ENOG410Z2UE. LUCA.
HOGENOMiHOG000006025.
InParanoidiQ02283.
KOiK09338.
OMAiQETANEP.
OrthoDBiEOG09360JSX.
PhylomeDBiQ02283.

Miscellaneous databases

PROiQ02283.

Gene expression databases

GenevisibleiQ02283. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003106. Leu_zip_homeo.
[Graphical view]
PfamiPF02183. HALZ. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAT5_ARATH
AccessioniPrimary (citable) accession number: Q02283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.