ID   PLAK_MOUSE              Reviewed;         745 AA.
AC   Q02257; Q8CGD3;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 3.
DT   03-NOV-2009, entry version 81.
DE   RecName: Full=Junction plakoglobin;
DE   AltName: Full=Desmoplakin-3;
DE   AltName: Full=Desmoplakin III;
GN   Name=Jup;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NOD;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 125-745.
RX   MEDLINE=92376536; PubMed=1509266; DOI=10.1126/science.257.5073.1142-a;
RA   Butz S., Stappert J., Weissig H., Kemler R.;
RT   "Plakoglobin and beta-catenin: distinct but closely related.";
RL   Science 257:1142-1144(1992).
RN   [4]
RP   SEQUENCE REVISION TO 418 AND 420.
RA   Butz S.;
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665, AND MASS
RP   SPECTROMETRY.
RX   PubMed=18973353; DOI=10.1021/pr800599n;
RA   Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,
RA   Faessler R., Mann M.;
RT   "Solid tumor proteome and phosphoproteome analysis by high resolution
RT   mass spectrometry.";
RL   J. Proteome Res. 7:5314-5326(2008).
CC   -!- FUNCTION: Common junctional plaque protein. The membrane-
CC       associated plaques are architectural elements in an important
CC       strategic position to influence the arrangement and function of
CC       both the cytoskeleton and the cells within the tissue. The
CC       presence of plakoglobin in both the desmosomes and in the
CC       intermediate junctions suggests that it plays a central role in
CC       the structure and function of submembranous plaques.
CC   -!- SUBUNIT: Homodimer. Interacts with MUC1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell
CC       junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral
CC       membrane protein. Note=Cytoplasmic in a soluble and membrane-
CC       associated form.
CC   -!- SIMILARITY: Belongs to the beta-catenin family.
CC   -!- SIMILARITY: Contains 9 ARM repeats.
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DR   EMBL; AK170934; BAE42126.1; -; mRNA.
DR   EMBL; BC040757; AAH40757.1; -; mRNA.
DR   EMBL; BC094461; AAH94461.1; -; mRNA.
DR   EMBL; M90365; AAB02885.1; -; mRNA.
DR   IPI; IPI00229475; -.
DR   PIR; S35092; S35092.
DR   RefSeq; NP_034723.1; -.
DR   UniGene; Mm.299774; -.
DR   HSSP; Q02248; 2BCT.
DR   SMR; Q02257; 142-653.
DR   STRING; Q02257; -.
DR   PhosphoSite; Q02257; -.
DR   PRIDE; Q02257; -.
DR   Ensembl; ENSMUST00000001592; ENSMUSP00000001592; ENSMUSG00000001552; Mus musculus.
DR   Ensembl; ENSMUST00000107403; ENSMUSP00000103026; ENSMUSG00000001552; Mus musculus.
DR   GeneID; 16480; -.
DR   KEGG; mmu:16480; -.
DR   UCSC; uc007lkz.1; mouse.
DR   CTD; 16480; -.
DR   MGI; MGI:96650; Jup.
DR   HOGENOM; Q02257; -.
DR   HOVERGEN; Q02257; -.
DR   OMA; DDMDATY; -.
DR   NextBio; 289775; -.
DR   ArrayExpress; Q02257; -.
DR   Bgee; Q02257; -.
DR   CleanEx; MM_JUP; -.
DR   Genevestigator; Q02257; -.
DR   GermOnline; ENSMUSG00000001552; Mus musculus.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0030057; C:desmosome; IDA:MGI.
DR   GO; GO:0019898; C:extrinsic to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IDA:MGI.
DR   GO; GO:0042153; F:RPTP-like protein binding; IPI:MGI.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR013284; Beta-catenin.
DR   InterPro; IPR000357; HEAT.
DR   Gene3D; G3DSA:1.25.10.10; ARM-like; 1.
DR   Pfam; PF00514; Arm; 6.
DR   Pfam; PF02985; HEAT; 1.
DR   PRINTS; PR01869; BCATNINFAMLY.
DR   SMART; SM00185; ARM; 12.
DR   PROSITE; PS50176; ARM_REPEAT; 9.
PE   1: Evidence at protein level;
KW   Acetylation; Cell adhesion; Cell junction; Cytoplasm; Cytoskeleton;
KW   Membrane; Phosphoprotein; Repeat.
FT   CHAIN         1    745       Junction plakoglobin.
FT                                /FTId=PRO_0000064279.
FT   REPEAT      132    171       ARM 1.
FT   REPEAT      216    255       ARM 2.
FT   REPEAT      258    297       ARM 3.
FT   REPEAT      342    381       ARM 4.
FT   REPEAT      383    420       ARM 5.
FT   REPEAT      423    464       ARM 6.
FT   REPEAT      470    510       ARM 7.
FT   REPEAT      512    551       ARM 8.
FT   REPEAT      574    613       ARM 9.
FT   MOD_RES       1      1       N-acetylmethionine (By similarity).
FT   MOD_RES      20     20       Phosphotyrosine (By similarity).
FT   MOD_RES     182    182       Phosphoserine (By similarity).
FT   MOD_RES     660    660       Phosphotyrosine (By similarity).
FT   MOD_RES     665    665       Phosphoserine.
SQ   SEQUENCE   745 AA;  81801 MW;  9609619D94052FC5 CRC64;
     MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GIMDEDDACG RQYTLKKTTT
     YTQGVPQNQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQT TNLQRLAEPS
     QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM
     GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE
     SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
     ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH
     LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC
     NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY
     GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR
     HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
     QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY
     RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT YRPMYSSDVP LDPLDMHMDL
     DGDYPMDTYS DGLRPPYPTA DHMLA
//