Reviewed, UniProtKB/Swiss-Prot Q02257 (PLAK_MOUSE)

Names and origin

Protein names

Recommended name:
    Junction plakoglobin
Alternative name(s):
    Desmoplakin-3
    Desmoplakin III

Gene names

Name:

Jup

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
Subunit structure	Homodimer. Interacts with MUC1 By similarity.
Subcellular location	Cell junction › adherens junction. Cell junction › desmosome. Cytoplasm › cytoskeleton. Membrane; Peripheral membrane protein. Note: Cytoplasmic in a soluble and membrane-associated form.
Sequence similarities	Belongs to the beta-catenin family. Contains 9 ARM repeats.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cytoplasm Cytoskeleton Membrane
Domain	Repeat
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Cellular component	Z disc Inferred from direct assay. Source: MGI cytosol Inferred from direct assay. Source: MGI desmosome Inferred from direct assay. Source: MGI
Molecular function	RPTP-like protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 745	745	Junction plakoglobin		PRO_0000064279
Regions
	Repeat	132 – 171	40	ARM 1
	Repeat	216 – 255	40	ARM 2
	Repeat	258 – 297	40	ARM 3
	Repeat	342 – 381	40	ARM 4
	Repeat	383 – 420	38	ARM 5
	Repeat	423 – 464	42	ARM 6
	Repeat	470 – 510	41	ARM 7
	Repeat	512 – 551	40	ARM 8
	Repeat	574 – 613	40	ARM 9
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity
	Modified residue	20	1	Phosphotyrosine By similarity
	Modified residue	182	1	Phosphoserine By similarity
	Modified residue	660	1	Phosphotyrosine By similarity
	Modified residue	665	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02257-1 [UniParc]. Last modified December 6, 2005. Version 3. Checksum: 9609619D94052FC5	FASTA	745	81,801
	10 20 30 40 50 60 MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GIMDEDDACG RQYTLKKTTT 70 80 90 100 110 120 YTQGVPQNQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQT TNLQRLAEPS 130 140 150 160 170 180 QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM 190 200 210 220 230 240 GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE 250 260 270 280 290 300 SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 310 320 330 340 350 360 ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH 370 380 390 400 410 420 LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC 430 440 450 460 470 480 NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY 490 500 510 520 530 540 GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR 550 560 570 580 590 600 HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 610 620 630 640 650 660 QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY 670 680 690 700 710 720 RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT YRPMYSSDVP LDPLDMHMDL 730 740 DGDYPMDTYS DGLRPPYPTA DHMLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NOD.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon and Mammary tumor.
[3]	"Plakoglobin and beta-catenin: distinct but closely related." Butz S., Stappert J., Weissig H., Kemler R. Science 257:1142-1144(1992) [PubMed: 1509266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-745.
[4]	Butz S. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 418 AND 420.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK170934 mRNA. Translation: BAE42126.1. BC040757 mRNA. Translation: AAH40757.1. BC094461 mRNA. Translation: AAH94461.1. M90365 mRNA. Translation: AAB02885.1.
IPI	IPI00229475.
PIR	S35092.
RefSeq	NP_034723.1.
UniGene	Mm.299774
3D structure databases
HSSP	HSSP built from PDB template 2BCT based on UniProtKB Q02248.
SMR	Q02257. Positions 142-653.
ModBase	Search...
PTM databases
PhosphoSite	Q02257.
Proteomic databases
PRIDE	Q02257.
Genome annotation databases
Ensembl	ENSMUSG00000001552. Mus musculus. [Contig view]
GeneID	16480.
KEGG	mmu:16480.
Organism-specific databases
MGI	MGI:96650. Jup.
Phylogenomic databases
HOGENOM	Q02257.
HOVERGEN	Q02257.
OMA	Q02257. DDMDATY.
Gene expression databases
ArrayExpress	Q02257.
Bgee	Q02257.
CleanEx	MM_JUP.
GermOnline	ENSMUSG00000001552. Mus musculus.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR000225. Armadillo. IPR013284. Beta-catenin. IPR000357. HEAT. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
Pfam	PF00514. Arm. 6 hits. PF02985. HEAT. 1 hit. [Graphical view]
PRINTS	PR01869. BCATNINFAMLY.
SMART	SM00185. ARM. 12 hits. [Graphical view]
PROSITE	PS50176. ARM_REPEAT. 9 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	289775.
SOURCE	Search...

Entry information

Entry name

PLAK_MOUSE

Accession

Primary (citable) accession number: Q02257
Secondary accession number(s): Q8CGD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	December 6, 2005
Last modified:	June 16, 2009
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)