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Protein

Junction plakoglobin

Gene

Jup

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-5218920. VEGFR2 mediated vascular permeability.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Alternative name(s):
Desmoplakin III
Desmoplakin-3
Gene namesi
Name:Jup
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96650. Jup.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: Ensembl
  • apicolateral plasma membrane Source: Ensembl
  • catenin complex Source: MGI
  • cell-cell adherens junction Source: MGI
  • cell-cell junction Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic side of plasma membrane Source: Ensembl
  • cytosol Source: MGI
  • desmosome Source: CACAO
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • fascia adherens Source: Ensembl
  • focal adhesion Source: MGI
  • gamma-catenin-TCF7L2 complex Source: MGI
  • intercalated disc Source: MGI
  • intermediate filament Source: BHF-UCL
  • lateral plasma membrane Source: Ensembl
  • membrane Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • protein-DNA complex Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642791 – 745Junction plakoglobinAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi14O-linked (GlcNAc)By similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei182PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei730PhosphoserineBy similarity1

Post-translational modificationi

May be phosphorylated by FER.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ02257.
PaxDbiQ02257.
PeptideAtlasiQ02257.
PRIDEiQ02257.

PTM databases

iPTMnetiQ02257.
PhosphoSitePlusiQ02257.
SwissPalmiQ02257.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001552.
CleanExiMM_JUP.
GenevisibleiQ02257. MM.

Interactioni

Subunit structurei

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200874. 51 interactors.
IntActiQ02257. 49 interactors.
MINTiMINT-4115765.
STRINGi10090.ENSMUSP00000001592.

Structurei

3D structure databases

ProteinModelPortaliQ02257.
SMRiQ02257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati132 – 171ARM 1Add BLAST40
Repeati172 – 215ARM 2Add BLAST44
Repeati216 – 255ARM 3Add BLAST40
Repeati258 – 297ARM 4Add BLAST40
Repeati298 – 341ARM 5Add BLAST44
Repeati342 – 381ARM 6Add BLAST40
Repeati383 – 420ARM 7Add BLAST38
Repeati423 – 464ARM 8Add BLAST42
Repeati470 – 510ARM 9Add BLAST41
Repeati512 – 551ARM 10Add BLAST40
Repeati574 – 613ARM 11Add BLAST40
Repeati615 – 661ARM 12Add BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – 297Interaction with DSC1 and DSG1By similarityAdd BLAST166
Regioni574 – 661Interaction with DSC1By similarityAdd BLAST88

Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region (By similarity).By similarity

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 12 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ02257.
KOiK10056.
OMAiDPLDMHM.
OrthoDBiEOG091G03A5.
PhylomeDBiQ02257.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR030461. Plakoglobin/HMP-2.
[Graphical view]
PANTHERiPTHR23315:SF12. PTHR23315:SF12. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GIMDEDDACG
60 70 80 90 100
RQYTLKKTTT YTQGVPQNQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL
110 120 130 140 150
LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL
160 170 180 190 200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD
210 220 230 240 250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL
260 270 280 290 300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
310 320 330 340 350
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE
360 370 380 390 400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL
410 420 430 440 450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD
460 470 480 490 500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA
510 520 530 540 550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY
560 570 580 590 600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
610 620 630 640 650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF
660 670 680 690 700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT
710 720 730 740
YRPMYSSDVP LDPLDMHMDL DGDYPMDTYS DGLRPPYPTA DHMLA
Length:745
Mass (Da):81,801
Last modified:December 6, 2005 - v3
Checksum:i9609619D94052FC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170934 mRNA. Translation: BAE42126.1.
BC040757 mRNA. Translation: AAH40757.1.
BC094461 mRNA. Translation: AAH94461.1.
M90365 mRNA. Translation: AAB02885.1.
CCDSiCCDS25420.1.
PIRiS35092.
RefSeqiNP_034723.1. NM_010593.2.
XP_006532378.1. XM_006532315.3.
XP_006532379.1. XM_006532316.1.
UniGeneiMm.299774.

Genome annotation databases

EnsembliENSMUST00000001592; ENSMUSP00000001592; ENSMUSG00000001552.
ENSMUST00000107403; ENSMUSP00000103026; ENSMUSG00000001552.
GeneIDi16480.
KEGGimmu:16480.
UCSCiuc007lkz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170934 mRNA. Translation: BAE42126.1.
BC040757 mRNA. Translation: AAH40757.1.
BC094461 mRNA. Translation: AAH94461.1.
M90365 mRNA. Translation: AAB02885.1.
CCDSiCCDS25420.1.
PIRiS35092.
RefSeqiNP_034723.1. NM_010593.2.
XP_006532378.1. XM_006532315.3.
XP_006532379.1. XM_006532316.1.
UniGeneiMm.299774.

3D structure databases

ProteinModelPortaliQ02257.
SMRiQ02257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200874. 51 interactors.
IntActiQ02257. 49 interactors.
MINTiMINT-4115765.
STRINGi10090.ENSMUSP00000001592.

PTM databases

iPTMnetiQ02257.
PhosphoSitePlusiQ02257.
SwissPalmiQ02257.

Proteomic databases

MaxQBiQ02257.
PaxDbiQ02257.
PeptideAtlasiQ02257.
PRIDEiQ02257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001592; ENSMUSP00000001592; ENSMUSG00000001552.
ENSMUST00000107403; ENSMUSP00000103026; ENSMUSG00000001552.
GeneIDi16480.
KEGGimmu:16480.
UCSCiuc007lkz.2. mouse.

Organism-specific databases

CTDi3728.
MGIiMGI:96650. Jup.

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ02257.
KOiK10056.
OMAiDPLDMHM.
OrthoDBiEOG091G03A5.
PhylomeDBiQ02257.
TreeFamiTF317997.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-5218920. VEGFR2 mediated vascular permeability.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiJup. mouse.
PROiQ02257.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001552.
CleanExiMM_JUP.
GenevisibleiQ02257. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR030461. Plakoglobin/HMP-2.
[Graphical view]
PANTHERiPTHR23315:SF12. PTHR23315:SF12. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLAK_MOUSE
AccessioniPrimary (citable) accession number: Q02257
Secondary accession number(s): Q8CGD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.