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Q02257

- PLAK_MOUSE

UniProt

Q02257 - PLAK_MOUSE

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Protein

Junction plakoglobin

Gene

Jup

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.1 Publication

GO - Molecular functioni

  1. alpha-catenin binding Source: MGI
  2. cadherin binding Source: RefGenome
  3. protein kinase binding Source: RefGenome
  4. structural molecule activity Source: RefGenome
  5. transcription coactivator activity Source: RefGenome

GO - Biological processi

  1. atrioventricular valve morphogenesis Source: RefGenome
  2. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  3. cell adhesion Source: MGI
  4. cell migration Source: Ensembl
  5. cell morphogenesis Source: RefGenome
  6. cellular response to indole-3-methanol Source: Ensembl
  7. cytoskeletal anchoring at plasma membrane Source: RefGenome
  8. desmosome assembly Source: MGI
  9. detection of mechanical stimulus Source: Ensembl
  10. ectoderm development Source: RefGenome
  11. establishment of protein localization to plasma membrane Source: Ensembl
  12. gastrulation Source: RefGenome
  13. morphogenesis of embryonic epithelium Source: RefGenome
  14. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
  15. negative regulation of Wnt signaling pathway involved in heart development Source: RefGenome
  16. nervous system development Source: RefGenome
  17. oocyte development Source: RefGenome
  18. positive regulation of protein import into nucleus Source: Ensembl
  19. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  20. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  21. protein heterooligomerization Source: Ensembl
  22. regulation of cell proliferation Source: Ensembl
  23. regulation of heart rate by cardiac conduction Source: Ensembl
  24. single organismal cell-cell adhesion Source: MGI
  25. skin development Source: MGI
  26. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Alternative name(s):
Desmoplakin III
Desmoplakin-3
Gene namesi
Name:Jup
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96650. Jup.

Subcellular locationi

Cell junctionadherens junction. Cell junctiondesmosome. Cytoplasmcytoskeleton. Membrane; Peripheral membrane protein
Note: Cytoplasmic in a soluble and membrane-associated form.

GO - Cellular componenti

  1. actin cytoskeleton Source: RefGenome
  2. apicolateral plasma membrane Source: Ensembl
  3. basolateral plasma membrane Source: RefGenome
  4. beta-catenin destruction complex Source: RefGenome
  5. catenin complex Source: RefGenome
  6. cell-cell adherens junction Source: MGI
  7. cell-cell junction Source: MGI
  8. cytoplasmic side of plasma membrane Source: RefGenome
  9. cytosol Source: MGI
  10. desmosome Source: MGI
  11. extracellular vesicular exosome Source: Ensembl
  12. fascia adherens Source: RefGenome
  13. gamma-catenin-TCF7L2 complex Source: Ensembl
  14. intermediate filament Source: BHF-UCL
  15. lateral plasma membrane Source: Ensembl
  16. membrane Source: MGI
  17. protein-DNA complex Source: Ensembl
  18. Z disc Source: MGI
  19. zonula adherens Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Junction plakoglobinPRO_0000064279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi14 – 141O-linked (GlcNAc)By similarity
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei665 – 6651PhosphoserineBy similarity

Post-translational modificationi

May be phosphorylated by FER.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ02257.
PaxDbiQ02257.
PRIDEiQ02257.

PTM databases

PhosphoSiteiQ02257.

Expressioni

Gene expression databases

BgeeiQ02257.
CleanExiMM_JUP.
GenevestigatoriQ02257.

Interactioni

Subunit structurei

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200874. 11 interactions.
IntActiQ02257. 10 interactions.
MINTiMINT-4115765.

Structurei

3D structure databases

ProteinModelPortaliQ02257.
SMRiQ02257. Positions 68-673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati132 – 17140ARM 1Add
BLAST
Repeati172 – 21544ARM 2Add
BLAST
Repeati216 – 25540ARM 3Add
BLAST
Repeati258 – 29740ARM 4Add
BLAST
Repeati298 – 34144ARM 5Add
BLAST
Repeati342 – 38140ARM 6Add
BLAST
Repeati383 – 42038ARM 7Add
BLAST
Repeati423 – 46442ARM 8Add
BLAST
Repeati470 – 51041ARM 9Add
BLAST
Repeati512 – 55140ARM 10Add
BLAST
Repeati574 – 61340ARM 11Add
BLAST
Repeati615 – 66147ARM 12Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 297166Interaction with DSC1 and DSG1By similarityAdd
BLAST
Regioni574 – 66188Interaction with DSC1By similarityAdd
BLAST

Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region (By similarity).By similarity

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 12 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ02257.
KOiK10056.
OMAiMNLIEQP.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ02257.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02257 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GIMDEDDACG
60 70 80 90 100
RQYTLKKTTT YTQGVPQNQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL
110 120 130 140 150
LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL
160 170 180 190 200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD
210 220 230 240 250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL
260 270 280 290 300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
310 320 330 340 350
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE
360 370 380 390 400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL
410 420 430 440 450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD
460 470 480 490 500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA
510 520 530 540 550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY
560 570 580 590 600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
610 620 630 640 650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF
660 670 680 690 700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT
710 720 730 740
YRPMYSSDVP LDPLDMHMDL DGDYPMDTYS DGLRPPYPTA DHMLA
Length:745
Mass (Da):81,801
Last modified:December 6, 2005 - v3
Checksum:i9609619D94052FC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK170934 mRNA. Translation: BAE42126.1.
BC040757 mRNA. Translation: AAH40757.1.
BC094461 mRNA. Translation: AAH94461.1.
M90365 mRNA. Translation: AAB02885.1.
CCDSiCCDS25420.1.
PIRiS35092.
RefSeqiNP_034723.1. NM_010593.2.
XP_006532378.1. XM_006532315.1.
XP_006532379.1. XM_006532316.1.
UniGeneiMm.299774.

Genome annotation databases

EnsembliENSMUST00000001592; ENSMUSP00000001592; ENSMUSG00000001552.
ENSMUST00000107403; ENSMUSP00000103026; ENSMUSG00000001552.
GeneIDi16480.
KEGGimmu:16480.
UCSCiuc007lkz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK170934 mRNA. Translation: BAE42126.1 .
BC040757 mRNA. Translation: AAH40757.1 .
BC094461 mRNA. Translation: AAH94461.1 .
M90365 mRNA. Translation: AAB02885.1 .
CCDSi CCDS25420.1.
PIRi S35092.
RefSeqi NP_034723.1. NM_010593.2.
XP_006532378.1. XM_006532315.1.
XP_006532379.1. XM_006532316.1.
UniGenei Mm.299774.

3D structure databases

ProteinModelPortali Q02257.
SMRi Q02257. Positions 68-673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200874. 11 interactions.
IntActi Q02257. 10 interactions.
MINTi MINT-4115765.

PTM databases

PhosphoSitei Q02257.

Proteomic databases

MaxQBi Q02257.
PaxDbi Q02257.
PRIDEi Q02257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001592 ; ENSMUSP00000001592 ; ENSMUSG00000001552 .
ENSMUST00000107403 ; ENSMUSP00000103026 ; ENSMUSG00000001552 .
GeneIDi 16480.
KEGGi mmu:16480.
UCSCi uc007lkz.2. mouse.

Organism-specific databases

CTDi 3728.
MGIi MGI:96650. Jup.

Phylogenomic databases

eggNOGi NOG297695.
GeneTreei ENSGT00730000110821.
HOGENOMi HOG000230958.
HOVERGENi HBG000919.
InParanoidi Q02257.
KOi K10056.
OMAi MNLIEQP.
OrthoDBi EOG7X9G6B.
PhylomeDBi Q02257.
TreeFami TF317997.

Miscellaneous databases

ChiTaRSi JUP. mouse.
NextBioi 289775.
PROi Q02257.
SOURCEi Search...

Gene expression databases

Bgeei Q02257.
CleanExi MM_JUP.
Genevestigatori Q02257.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  3. "Plakoglobin and beta-catenin: distinct but closely related."
    Butz S., Stappert J., Weissig H., Kemler R.
    Science 257:1142-1144(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-745.
  4. Butz S.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 418 AND 420.
  5. "Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion."
    Butz S., Kemler R.
    FEBS Lett. 355:195-200(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN AN E-CADHERIN/CATENIN ADHESION COMPLEX.
  6. "Deconstructing the cadherin-catenin-actin complex."
    Yamada S., Pokutta S., Drees F., Weis W.I., Nelson W.J.
    Cell 123:889-901(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECONSTITUTION OF THE E-CADHERIN/CATENIN ADHESION COMPLEX, LACK OF ACTIN-BINDING BY THE E-CADHERIN/CATENIN ADHESION COMPLEX.
  7. "VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF."
    Nottebaum A.F., Cagna G., Winderlich M., Gamp A.C., Linnepe R., Polaschegg C., Filippova K., Lyck R., Engelhardt B., Kamenyeva O., Bixel M.G., Butz S., Vestweber D.
    J. Exp. Med. 205:2929-2945(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPLAK_MOUSE
AccessioniPrimary (citable) accession number: Q02257
Secondary accession number(s): Q8CGD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3