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Q02256

- PVH1_YEAST

UniProt

Q02256 - PVH1_YEAST

Protein

Tyrosine-protein phosphatase YVH1

Gene

YVH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei117 – 1171Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein tyrosine/serine/threonine phosphatase activity Source: SGD
    3. protein tyrosine phosphatase activity Source: SGD

    GO - Biological processi

    1. ascospore wall assembly Source: SGD
    2. cAMP-mediated signaling Source: SGD
    3. meiotic nuclear division Source: SGD
    4. peptidyl-tyrosine dephosphorylation Source: GOC
    5. protein dephosphorylation Source: SGD
    6. response to stress Source: UniProtKB-KW
    7. ribosomal large subunit assembly Source: SGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31445-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase YVH1 (EC:3.1.3.48)
    Short name:
    PTPase YVH1
    Gene namesi
    Name:YVH1
    Ordered Locus Names:YIR026C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIR026c.
    SGDiS000001465. YVH1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Tyrosine-protein phosphatase YVH1PRO_0000094854Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei196 – 1961Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ02256.
    PaxDbiQ02256.
    PeptideAtlasiQ02256.

    Expressioni

    Inductioni

    By nitrogen starvation.

    Gene expression databases

    GenevestigatoriQ02256.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSG1P531453EBI-14322,EBI-23885

    Protein-protein interaction databases

    BioGridi35017. 63 interactions.
    DIPiDIP-5192N.
    IntActiQ02256. 23 interactions.
    MINTiMINT-532728.
    STRINGi4932.YIR026C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02256.
    SMRiQ02256. Positions 14-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 172172Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00740000115610.
    HOGENOMiHOG000243638.
    KOiK14819.
    OMAiLSLRCKK.
    OrthoDBiEOG71GB56.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR016278. DUSP12.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000941. DUSP12. 1 hit.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02256-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV    50
    IPEYLIRKGY TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR 100
    LVDFKKKPQR GAVFAHCQAG LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK 150
    KPSVEPNENF MEQLHLFEKM GGDFVDFDNP AYKQWKLKQS IKLDPSGSEL 200
    VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA LSTSFIAHDP 250
    PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE 300
    LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA 350
    LPNMVNFESE KVNR 364
    Length:364
    Mass (Da):41,185
    Last modified:October 1, 1993 - v1
    Checksum:i9E75C7CC14353B43
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711Missing in M69294. (PubMed:1803816)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04673 Genomic DNA. Translation: AAA34874.1.
    Z38061 Genomic DNA. Translation: CAA86186.1.
    M69294 Genomic DNA. No translation available.
    BK006942 Genomic DNA. Translation: DAA08573.1.
    PIRiS31304.
    RefSeqiNP_012292.3. NM_001179548.3.

    Genome annotation databases

    EnsemblFungiiYIR026C; YIR026C; YIR026C.
    GeneIDi854844.
    KEGGisce:YIR026C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04673 Genomic DNA. Translation: AAA34874.1 .
    Z38061 Genomic DNA. Translation: CAA86186.1 .
    M69294 Genomic DNA. No translation available.
    BK006942 Genomic DNA. Translation: DAA08573.1 .
    PIRi S31304.
    RefSeqi NP_012292.3. NM_001179548.3.

    3D structure databases

    ProteinModelPortali Q02256.
    SMRi Q02256. Positions 14-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35017. 63 interactions.
    DIPi DIP-5192N.
    IntActi Q02256. 23 interactions.
    MINTi MINT-532728.
    STRINGi 4932.YIR026C.

    Proteomic databases

    MaxQBi Q02256.
    PaxDbi Q02256.
    PeptideAtlasi Q02256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIR026C ; YIR026C ; YIR026C .
    GeneIDi 854844.
    KEGGi sce:YIR026C.

    Organism-specific databases

    CYGDi YIR026c.
    SGDi S000001465. YVH1.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00740000115610.
    HOGENOMi HOG000243638.
    KOi K14819.
    OMAi LSLRCKK.
    OrthoDBi EOG71GB56.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31445-MONOMER.

    Miscellaneous databases

    NextBioi 977731.
    PROi Q02256.

    Gene expression databases

    Genevestigatori Q02256.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR016278. DUSP12.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000941. DUSP12. 1 hit.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation."
      Guan K., Hakes D.J., Wang Y., Park H.-D., Cooper T.G., Dixon J.E.
      Proc. Natl. Acad. Sci. U.S.A. 89:12175-12179(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The allantoinase (DAL1) gene of Saccharomyces cerevisiae."
      Buckholz R.G., Cooper T.G.
      Yeast 7:913-923(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-197.
    5. Erratum
      Buckholz R.G., Cooper T.G.
      Yeast 8:239-239(1992)
    6. "The yeast open reading frame encoding a dual specificity phosphatase."
      Guan K., Hakes D.J., Dixon J.E., Park H.D., Cooper T.G.
      Trends Biochem. Sci. 18:6-6(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SIMILARITY TO VH1.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPVH1_YEAST
    AccessioniPrimary (citable) accession number: Q02256
    Secondary accession number(s): D6VVV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 7570 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3