Tyrosine-protein phosphatase YVH1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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Q02256 (PVH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase YVH1
Short name=PTPase YVH1
EC=3.1.3.48

Gene names

Name:	YVH1
Ordered Locus Names:	YIR026C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Induction	By nitrogen starvation.
Miscellaneous	Present with 7570 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Biological process	Stress response
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ascospore wall assembly Inferred from mutant phenotype PubMed 10464190. Source: SGD cAMP-mediated signaling Inferred from mutant phenotype PubMed 10852885. Source: SGD meiosis Inferred from mutant phenotype PubMed 8896280. Source: SGD response to stress Inferred from electronic annotation. Source: UniProtKB-KW ribosomal large subunit assembly Inferred from mutant phenotype PubMed 19114459 PubMed 19797078 PubMed 19797079. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 14562095 PubMed 19797078 PubMed 19797079. Source: SGD nucleus Inferred from direct assay PubMed 19797078 PubMed 19797079. Source: SGD
Molecular_function	protein tyrosine phosphatase activity Inferred from direct assay Ref.1. Source: SGD protein tyrosine/serine/threonine phosphatase activity Inferred from sequence alignment Ref.1. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSG1	P53145	3	EBI-14322,EBI-23885

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 364

364

Tyrosine-protein phosphatase YVH1

PRO_0000094854

Regions

Domain

1 – 172

172

Tyrosine-protein phosphatase

Sites

Active site

117

Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue

196

Phosphoserine Ref.8

Modified residue

202

Phosphoserine Ref.8

Modified residue

204

Phosphoserine Ref.8

Modified residue

212

Phosphoserine Ref.8

Experimental info

Sequence conflict

Missing in M69294. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q02256 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 9E75C7CC14353B43
Show »

FASTA

364

41,185

        10         20         30         40         50         60 
MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV IPEYLIRKGY 

        70         80         90        100        110        120 
TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR LVDFKKKPQR GAVFAHCQAG 

       130        140        150        160        170        180 
LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK KPSVEPNENF MEQLHLFEKM GGDFVDFDNP 

       190        200        210        220        230        240 
AYKQWKLKQS IKLDPSGSEL VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA 

       250        260        270        280        290        300 
LSTSFIAHDP PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE 

       310        320        330        340        350        360 
LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA LPNMVNFESE 


KVNR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation." Guan K., Hakes D.J., Wang Y., Park H.-D., Cooper T.G., Dixon J.E. Proc. Natl. Acad. Sci. U.S.A. 89:12175-12179(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"The allantoinase (DAL1) gene of Saccharomyces cerevisiae." Buckholz R.G., Cooper T.G. Yeast 7:913-923(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-197.
[5]	Erratum Buckholz R.G., Cooper T.G. Yeast 8:239-239(1992)
[6]	"The yeast open reading frame encoding a dual specificity phosphatase." Guan K., Hakes D.J., Dixon J.E., Park H.D., Cooper T.G. Trends Biochem. Sci. 18:6-6(1993) [PubMed] [Europe PMC] [Abstract] Cited for: SIMILARITY TO VH1.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-202; SER-204 AND SER-212, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L04673 Genomic DNA. Translation: AAA34874.1. Z38061 Genomic DNA. Translation: CAA86186.1. M69294 Genomic DNA. No translation available. BK006942 Genomic DNA. Translation: DAA08573.1.
PIR	S31304.
RefSeq	NP_012292.3. NM_001179548.3.
3D structure databases
ProteinModelPortal	Q02256.
SMR	Q02256. Positions 14-169.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5192N.
IntAct	Q02256. 23 interactions.
MINT	MINT-532728.
STRING	4932.YIR026C.
Proteomic databases
PaxDb	Q02256.
PeptideAtlas	Q02256.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIR026C; YIR026C; YIR026C.
GeneID	854844.
KEGG	sce:YIR026C. sce:YIR034C.
Organism-specific databases
CYGD	YIR026c.
SGD	S000001465. YVH1.
Phylogenomic databases
eggNOG	COG2453.
GeneTree	ENSGT00680000099678.
HOGENOM	HOG000243638.
KO	K00290. K14819.
OMA	AYLMYRY.
OrthoDB	EOG4RR9T2.
Gene expression databases
Genevestigator	Q02256.
GermOnline	YIR026C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR016278. DUSP12. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PIRSF	PIRSF000941. DUSP12. 1 hit.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	977731.

Entry information

Entry name

PVH1_YEAST

Accession

Primary (citable) accession number: Q02256
Secondary accession number(s): D6VVV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents