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Q02256 (PVH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase YVH1

Short name=PTPase YVH1
EC=3.1.3.48
Gene names
Name:YVH1
Ordered Locus Names:YIR026C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Induction

By nitrogen starvation.

Miscellaneous

Present with 7570 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LSG1P531453EBI-14322,EBI-23885

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Tyrosine-protein phosphatase YVH1
PRO_0000094854

Regions

Domain1 – 172172Tyrosine-protein phosphatase

Sites

Active site1171Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue1961Phosphoserine Ref.8

Experimental info

Sequence conflict711Missing in M69294. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q02256 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 9E75C7CC14353B43

FASTA36441,185
        10         20         30         40         50         60 
MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV IPEYLIRKGY 

        70         80         90        100        110        120 
TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR LVDFKKKPQR GAVFAHCQAG 

       130        140        150        160        170        180 
LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK KPSVEPNENF MEQLHLFEKM GGDFVDFDNP 

       190        200        210        220        230        240 
AYKQWKLKQS IKLDPSGSEL VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA 

       250        260        270        280        290        300 
LSTSFIAHDP PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE 

       310        320        330        340        350        360 
LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA LPNMVNFESE 


KVNR 

« Hide

References

« Hide 'large scale' references
[1]"A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation."
Guan K., Hakes D.J., Wang Y., Park H.-D., Cooper T.G., Dixon J.E.
Proc. Natl. Acad. Sci. U.S.A. 89:12175-12179(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The allantoinase (DAL1) gene of Saccharomyces cerevisiae."
Buckholz R.G., Cooper T.G.
Yeast 7:913-923(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-197.
[5]Erratum
Buckholz R.G., Cooper T.G.
Yeast 8:239-239(1992)
[6]"The yeast open reading frame encoding a dual specificity phosphatase."
Guan K., Hakes D.J., Dixon J.E., Park H.D., Cooper T.G.
Trends Biochem. Sci. 18:6-6(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: SIMILARITY TO VH1.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04673 Genomic DNA. Translation: AAA34874.1.
Z38061 Genomic DNA. Translation: CAA86186.1.
M69294 Genomic DNA. No translation available.
BK006942 Genomic DNA. Translation: DAA08573.1.
PIRS31304.
RefSeqNP_012292.3. NM_001179548.3.

3D structure databases

ProteinModelPortalQ02256.
SMRQ02256. Positions 14-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35017. 63 interactions.
DIPDIP-5192N.
IntActQ02256. 23 interactions.
MINTMINT-532728.
STRING4932.YIR026C.

Proteomic databases

PaxDbQ02256.
PeptideAtlasQ02256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIR026C; YIR026C; YIR026C.
GeneID854844.
KEGGsce:YIR026C.

Organism-specific databases

CYGDYIR026c.
SGDS000001465. YVH1.

Phylogenomic databases

eggNOGCOG2453.
GeneTreeENSGT00740000115610.
HOGENOMHOG000243638.
KOK14819.
OMAHYFVEPL.
OrthoDBEOG71GB56.

Enzyme and pathway databases

BioCycYEAST:G3O-31445-MONOMER.

Gene expression databases

GenevestigatorQ02256.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFPIRSF000941. DUSP12. 1 hit.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977731.
PROQ02256.

Entry information

Entry namePVH1_YEAST
AccessionPrimary (citable) accession number: Q02256
Secondary accession number(s): D6VVV7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families