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Protein

Tyrosine-protein phosphatase YVH1

Gene

YVH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei117Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • cAMP-mediated signaling Source: SGD
  • meiotic nuclear division Source: SGD
  • positive regulation of autophagosome assembly Source: SGD
  • protein dephosphorylation Source: SGD
  • ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-31445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase YVH1 (EC:3.1.3.48)
Short name:
PTPase YVH1
Gene namesi
Name:YVH1
Ordered Locus Names:YIR026C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR026C.
SGDiS000001465. YVH1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytoplasmic stress granule Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948541 – 364Tyrosine-protein phosphatase YVH1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02256.
PRIDEiQ02256.

PTM databases

iPTMnetiQ02256.

Expressioni

Inductioni

By nitrogen starvation.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSG1P531453EBI-14322,EBI-23885

Protein-protein interaction databases

BioGridi35017. 62 interactors.
DIPiDIP-5192N.
IntActiQ02256. 26 interactors.
MINTiMINT-532728.

Structurei

3D structure databases

ProteinModelPortaliQ02256.
SMRiQ02256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172Tyrosine-protein phosphataseAdd BLAST172

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00740000115610.
HOGENOMiHOG000243638.
InParanoidiQ02256.
KOiK14819.
OMAiFAWQGMQ.
OrthoDBiEOG092C4Z60.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 3 hits.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV
60 70 80 90 100
IPEYLIRKGY TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR
110 120 130 140 150
LVDFKKKPQR GAVFAHCQAG LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK
160 170 180 190 200
KPSVEPNENF MEQLHLFEKM GGDFVDFDNP AYKQWKLKQS IKLDPSGSEL
210 220 230 240 250
VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA LSTSFIAHDP
260 270 280 290 300
PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE
310 320 330 340 350
LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA
360
LPNMVNFESE KVNR
Length:364
Mass (Da):41,185
Last modified:October 1, 1993 - v1
Checksum:i9E75C7CC14353B43
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71Missing in M69294 (PubMed:1803816).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04673 Genomic DNA. Translation: AAA34874.1.
Z38061 Genomic DNA. Translation: CAA86186.1.
M69294 Genomic DNA. No translation available.
BK006942 Genomic DNA. Translation: DAA08573.1.
PIRiS31304.
RefSeqiNP_012292.3. NM_001179548.3.

Genome annotation databases

EnsemblFungiiYIR026C; YIR026C; YIR026C.
GeneIDi854844.
KEGGisce:YIR026C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04673 Genomic DNA. Translation: AAA34874.1.
Z38061 Genomic DNA. Translation: CAA86186.1.
M69294 Genomic DNA. No translation available.
BK006942 Genomic DNA. Translation: DAA08573.1.
PIRiS31304.
RefSeqiNP_012292.3. NM_001179548.3.

3D structure databases

ProteinModelPortaliQ02256.
SMRiQ02256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35017. 62 interactors.
DIPiDIP-5192N.
IntActiQ02256. 26 interactors.
MINTiMINT-532728.

PTM databases

iPTMnetiQ02256.

Proteomic databases

MaxQBiQ02256.
PRIDEiQ02256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR026C; YIR026C; YIR026C.
GeneIDi854844.
KEGGisce:YIR026C.

Organism-specific databases

EuPathDBiFungiDB:YIR026C.
SGDiS000001465. YVH1.

Phylogenomic databases

GeneTreeiENSGT00740000115610.
HOGENOMiHOG000243638.
InParanoidiQ02256.
KOiK14819.
OMAiFAWQGMQ.
OrthoDBiEOG092C4Z60.

Enzyme and pathway databases

BioCyciYEAST:G3O-31445-MONOMER.

Miscellaneous databases

PROiQ02256.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 3 hits.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPVH1_YEAST
AccessioniPrimary (citable) accession number: Q02256
Secondary accession number(s): D6VVV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7570 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.