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Protein

Tyrosine-protein phosphatase YVH1

Gene

YVH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.

Miscellaneous

Present with 7570 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei117Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • cAMP-mediated signaling Source: SGD
  • meiotic cell cycle Source: SGD
  • positive regulation of autophagosome assembly Source: SGD
  • protein dephosphorylation Source: SGD
  • ribosomal large subunit assembly Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processStress response

Enzyme and pathway databases

BioCyciYEAST:G3O-31445-MONOMER
ReactomeiR-SCE-202670 ERKs are inactivated

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase YVH1 (EC:3.1.3.48)
Short name:
PTPase YVH1
Gene namesi
Name:YVH1
Ordered Locus Names:YIR026C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR026C
SGDiS000001465 YVH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948541 – 364Tyrosine-protein phosphatase YVH1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02256
PaxDbiQ02256
PRIDEiQ02256

PTM databases

iPTMnetiQ02256

Expressioni

Inductioni

By nitrogen starvation.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSG1P531453EBI-14322,EBI-23885

Protein-protein interaction databases

BioGridi35017, 119 interactors
DIPiDIP-5192N
IntActiQ02256, 27 interactors
MINTiQ02256
STRINGi4932.YIR026C

Structurei

3D structure databases

ProteinModelPortaliQ02256
SMRiQ02256
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172Tyrosine-protein phosphataseAdd BLAST172

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118853
HOGENOMiHOG000243638
InParanoidiQ02256
KOiK14819
OMAiQGRLYCP
OrthoDBiEOG092C4Z60

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR016278 DUSP12
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PIRSFiPIRSF000941 DUSP12, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q02256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV
60 70 80 90 100
IPEYLIRKGY TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR
110 120 130 140 150
LVDFKKKPQR GAVFAHCQAG LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK
160 170 180 190 200
KPSVEPNENF MEQLHLFEKM GGDFVDFDNP AYKQWKLKQS IKLDPSGSEL
210 220 230 240 250
VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA LSTSFIAHDP
260 270 280 290 300
PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE
310 320 330 340 350
LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA
360
LPNMVNFESE KVNR
Length:364
Mass (Da):41,185
Last modified:October 1, 1993 - v1
Checksum:i9E75C7CC14353B43
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71Missing in M69294 (PubMed:1803816).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04673 Genomic DNA Translation: AAA34874.1
Z38061 Genomic DNA Translation: CAA86186.1
M69294 Genomic DNA No translation available.
BK006942 Genomic DNA Translation: DAA08573.1
PIRiS31304
RefSeqiNP_012292.3, NM_001179548.3

Genome annotation databases

EnsemblFungiiYIR026C; YIR026C; YIR026C
GeneIDi854844
KEGGisce:YIR026C

Similar proteinsi

Entry informationi

Entry nameiPVH1_YEAST
AccessioniPrimary (citable) accession number: Q02256
Secondary accession number(s): D6VVV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health