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Q02256

- PVH1_YEAST

UniProt

Q02256 - PVH1_YEAST

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Protein

Tyrosine-protein phosphatase YVH1

Gene

YVH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: SGD
  2. protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  1. ascospore wall assembly Source: SGD
  2. cAMP-mediated signaling Source: SGD
  3. meiotic nuclear division Source: SGD
  4. peptidyl-tyrosine dephosphorylation Source: GOC
  5. protein dephosphorylation Source: SGD
  6. response to stress Source: UniProtKB-KW
  7. ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-31445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase YVH1 (EC:3.1.3.48)
Short name:
PTPase YVH1
Gene namesi
Name:YVH1
Ordered Locus Names:YIR026C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIR026c.
SGDiS000001465. YVH1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Tyrosine-protein phosphatase YVH1PRO_0000094854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02256.
PaxDbiQ02256.
PeptideAtlasiQ02256.

Expressioni

Inductioni

By nitrogen starvation.

Gene expression databases

GenevestigatoriQ02256.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSG1P531453EBI-14322,EBI-23885

Protein-protein interaction databases

BioGridi35017. 64 interactions.
DIPiDIP-5192N.
IntActiQ02256. 23 interactions.
MINTiMINT-532728.
STRINGi4932.YIR026C.

Structurei

3D structure databases

ProteinModelPortaliQ02256.
SMRiQ02256. Positions 14-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 172172Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00740000115610.
HOGENOMiHOG000243638.
InParanoidiQ02256.
KOiK14819.
OMAiLSLRCKK.
OrthoDBiEOG71GB56.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02256-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGNANSVDE EVTRILGGIY LGGIRPIIDH RPLGAEFNIT HILSVIKFQV
60 70 80 90 100
IPEYLIRKGY TLKNIPIDDD DVTDVLQYFD ETNRFIDQCL FPNEVEYSPR
110 120 130 140 150
LVDFKKKPQR GAVFAHCQAG LSRSVTFIVA YLMYRYGLSL SMAMHAVKRK
160 170 180 190 200
KPSVEPNENF MEQLHLFEKM GGDFVDFDNP AYKQWKLKQS IKLDPSGSEL
210 220 230 240 250
VSNSGMFKDS ESSQDLDKLT EAEKSKVTAV RCKKCRTKLA LSTSFIAHDP
260 270 280 290 300
PSKESSEGHF IKRAANSHRI IDIQESQANC SHFFIEPLKW MQPELQGKQE
310 320 330 340 350
LEGKFSCPGC SSKVGGYNWK GSRCSCGKWV IPAIHLQTSK VDQFPLQSTA
360
LPNMVNFESE KVNR
Length:364
Mass (Da):41,185
Last modified:October 1, 1993 - v1
Checksum:i9E75C7CC14353B43
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711Missing in M69294. (PubMed:1803816)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04673 Genomic DNA. Translation: AAA34874.1.
Z38061 Genomic DNA. Translation: CAA86186.1.
M69294 Genomic DNA. No translation available.
BK006942 Genomic DNA. Translation: DAA08573.1.
PIRiS31304.
RefSeqiNP_012292.3. NM_001179548.3.

Genome annotation databases

EnsemblFungiiYIR026C; YIR026C; YIR026C.
GeneIDi854844.
KEGGisce:YIR026C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04673 Genomic DNA. Translation: AAA34874.1 .
Z38061 Genomic DNA. Translation: CAA86186.1 .
M69294 Genomic DNA. No translation available.
BK006942 Genomic DNA. Translation: DAA08573.1 .
PIRi S31304.
RefSeqi NP_012292.3. NM_001179548.3.

3D structure databases

ProteinModelPortali Q02256.
SMRi Q02256. Positions 14-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35017. 64 interactions.
DIPi DIP-5192N.
IntActi Q02256. 23 interactions.
MINTi MINT-532728.
STRINGi 4932.YIR026C.

Proteomic databases

MaxQBi Q02256.
PaxDbi Q02256.
PeptideAtlasi Q02256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIR026C ; YIR026C ; YIR026C .
GeneIDi 854844.
KEGGi sce:YIR026C.

Organism-specific databases

CYGDi YIR026c.
SGDi S000001465. YVH1.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00740000115610.
HOGENOMi HOG000243638.
InParanoidi Q02256.
KOi K14819.
OMAi LSLRCKK.
OrthoDBi EOG71GB56.

Enzyme and pathway databases

BioCyci YEAST:G3O-31445-MONOMER.

Miscellaneous databases

NextBioi 977731.
PROi Q02256.

Gene expression databases

Genevestigatori Q02256.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PIRSFi PIRSF000941. DUSP12. 1 hit.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation."
    Guan K., Hakes D.J., Wang Y., Park H.-D., Cooper T.G., Dixon J.E.
    Proc. Natl. Acad. Sci. U.S.A. 89:12175-12179(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The allantoinase (DAL1) gene of Saccharomyces cerevisiae."
    Buckholz R.G., Cooper T.G.
    Yeast 7:913-923(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-197.
  5. Erratum
    Buckholz R.G., Cooper T.G.
    Yeast 8:239-239(1992)
  6. "The yeast open reading frame encoding a dual specificity phosphatase."
    Guan K., Hakes D.J., Dixon J.E., Park H.D., Cooper T.G.
    Trends Biochem. Sci. 18:6-6(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO VH1.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPVH1_YEAST
AccessioniPrimary (citable) accession number: Q02256
Secondary accession number(s): D6VVV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7570 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3