Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q02246

- CNTN2_HUMAN

UniProt

Q02246 - CNTN2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Contactin-2

Gene

CNTN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: Ensembl
  2. identical protein binding Source: BHF-UCL

GO - Biological processi

  1. adult walking behavior Source: Ensembl
  2. axonal fasciculation Source: Ensembl
  3. axon guidance Source: Reactome
  4. cell adhesion Source: ProtInc
  5. cellular protein localization Source: BHF-UCL
  6. central nervous system myelination Source: Ensembl
  7. cerebral cortex GABAergic interneuron migration Source: Ensembl
  8. clustering of voltage-gated potassium channels Source: BHF-UCL
  9. establishment of protein localization to juxtaparanode region of axon Source: Ensembl
  10. learning Source: Ensembl
  11. microtubule cytoskeleton organization Source: Ensembl
  12. negative regulation of neuron differentiation Source: Ensembl
  13. positive regulation of adenosine receptor signaling pathway Source: Ensembl
  14. positive regulation of protein processing Source: Ensembl
  15. presynaptic membrane organization Source: UniProtKB
  16. receptor internalization Source: Ensembl
  17. regulation of astrocyte differentiation Source: Ensembl
  18. regulation of axon diameter Source: Ensembl
  19. regulation of neuronal synaptic plasticity Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_18312. NCAM1 interactions.
REACT_22205. L1CAM interactions.
REACT_22329. NrCAM interactions.

Protein family/group databases

TCDBi8.A.23.1.3. the basigin (basigin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-2
Alternative name(s):
Axonal glycoprotein TAG-1
Axonin-1
Transient axonal glycoprotein 1
Short name:
TAX-1
Gene namesi
Name:CNTN2
Synonyms:AXT, TAG1, TAX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2172. CNTN2.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor
Note: Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. juxtaparanode region of axon Source: BHF-UCL
  5. myelin sheath Source: BHF-UCL
  6. neuronal cell body Source: Ensembl
  7. node of Ranvier Source: BHF-UCL
  8. plasma membrane Source: BHF-UCL
  9. synapse Source: BHF-UCL
  10. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Epilepsy, familial adult myoclonic, 5 (FAME5) [MIM:615400]: A form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Epilepsy

Organism-specific databases

MIMi615400. phenotype.
Orphaneti86814. Benign adult familial myoclonic epilepsy.
PharmGKBiPA26686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 1012982Contactin-2PRO_0000014695Add
BLAST
Propeptidei1013 – 104028Removed in mature formSequence AnalysisPRO_0000014696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 1111 PublicationPROSITE-ProRule annotation
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi155 ↔ 2071 PublicationPROSITE-ProRule annotation
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi261 ↔ 3061 PublicationPROSITE-ProRule annotation
Disulfide bondi348 ↔ 3951 PublicationPROSITE-ProRule annotation
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi830 – 8301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi904 – 9041N-linked (GlcNAc...)1 Publication
Glycosylationi918 – 9181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi940 – 9401N-linked (GlcNAc...)Sequence Analysis
Lipidationi1012 – 10121GPI-anchor amidated asparagineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ02246.
PRIDEiQ02246.

PTM databases

PhosphoSiteiQ02246.

Expressioni

Gene expression databases

BgeeiQ02246.
CleanExiHS_CNTN2.
GenevestigatoriQ02246.

Organism-specific databases

HPAiHPA001397.
HPA012497.

Interactioni

Protein-protein interaction databases

BioGridi112763. 34 interactions.
IntActiQ02246. 2 interactions.
MINTiMINT-2805397.
STRINGi9606.ENSP00000330633.

Structurei

Secondary structure

1
1040
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 417
Beta strandi46 – 516
Beta strandi55 – 595
Beta strandi62 – 676
Beta strandi70 – 756
Beta strandi87 – 915
Beta strandi94 – 996
Helixi102 – 1054
Beta strandi107 – 1159
Beta strandi118 – 1214
Beta strandi125 – 1328
Beta strandi151 – 1533
Beta strandi160 – 1623
Beta strandi165 – 1728
Beta strandi180 – 1856
Beta strandi187 – 1893
Beta strandi192 – 1965
Beta strandi203 – 21311
Beta strandi216 – 2216
Beta strandi225 – 2273
Beta strandi229 – 2313
Beta strandi237 – 2437
Beta strandi247 – 2526
Beta strandi257 – 2604
Beta strandi262 – 2676
Beta strandi270 – 2756
Beta strandi289 – 2957
Helixi298 – 3003
Beta strandi302 – 3109
Beta strandi313 – 32412
Beta strandi329 – 3313
Beta strandi336 – 3394
Beta strandi344 – 3474
Beta strandi352 – 3543
Beta strandi357 – 36610
Beta strandi373 – 3764
Beta strandi379 – 3846
Helixi387 – 3893
Beta strandi391 – 3988
Beta strandi403 – 41311

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OM5X-ray3.07A34-414[»]
ProteinModelPortaliQ02246.
SMRiQ02246. Positions 34-997.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02246.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 12886Ig-like C2-type 1Add
BLAST
Domaini133 – 22290Ig-like C2-type 2Add
BLAST
Domaini239 – 32284Ig-like C2-type 3Add
BLAST
Domaini327 – 41185Ig-like C2-type 4Add
BLAST
Domaini417 – 50488Ig-like C2-type 5Add
BLAST
Domaini509 – 60395Ig-like C2-type 6Add
BLAST
Domaini610 – 70899Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini713 – 81098Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini815 – 91096Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini915 – 100692Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi794 – 7963Cell attachment siteBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi606 – 6127Gly/Pro-rich

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG293951.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ02246.
KOiK06760.
OMAiECFAFGN.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ02246.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02246-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTATRRKPH LLLVAAVALV SSSAWSSALG SQTTFGPVFE DQPLSVLFPE
60 70 80 90 100
ESTEEQVLLA CRARASPPAT YRWKMNGTEM KLEPGSRHQL VGGNLVIMNP
110 120 130 140 150
TKAQDAGVYQ CLASNPVGTV VSREAILRFG FLQEFSKEER DPVKAHEGWG
160 170 180 190 200
VMLPCNPPAH YPGLSYRWLL NEFPNFIPTD GRHFVSQTTG NLYIARTNAS
210 220 230 240 250
DLGNYSCLAT SHMDFSTKSV FSKFAQLNLA AEDTRLFAPS IKARFPAETY
260 270 280 290 300
ALVGQQVTLE CFAFGNPVPR IKWRKVDGSL SPQWTTAEPT LQIPSVSFED
310 320 330 340 350
EGTYECEAEN SKGRDTVQGR IIVQAQPEWL KVISDTEADI GSNLRWGCAA
360 370 380 390 400
AGKPRPTVRW LRNGEPLASQ NRVEVLAGDL RFSKLSLEDS GMYQCVAENK
410 420 430 440 450
HGTIYASAEL AVQALAPDFR LNPVRRLIPA ARGGEILIPC QPRAAPKAVV
460 470 480 490 500
LWSKGTEILV NSSRVTVTPD GTLIIRNISR SDEGKYTCFA ENFMGKANST
510 520 530 540 550
GILSVRDATK ITLAPSSADI NLGDNLTLQC HASHDPTMDL TFTWTLDDFP
560 570 580 590 600
IDFDKPGGHY RRTNVKETIG DLTILNAQLR HGGKYTCMAQ TVVDSASKEA
610 620 630 640 650
TVLVRGPPGP PGGVVVRDIG DTTIQLSWSR GFDNHSPIAK YTLQARTPPA
660 670 680 690 700
GKWKQVRTNP ANIEGNAETA QVLGLTPWMD YEFRVIASNI LGTGEPSGPS
710 720 730 740 750
SKIRTREAAP SVAPSGLSGG GGAPGELIVN WTPMSREYQN GDGFGYLLSF
760 770 780 790 800
RRQGSTHWQT ARVPGADAQY FVYSNESVRP YTPFEVKIRS YNRRGDGPES
810 820 830 840 850
LTALVYSAEE EPRVAPTKVW AKGVSSSEMN VTWEPVQQDM NGILLGYEIR
860 870 880 890 900
YWKAGDKEAA ADRVRTAGLD TSARVSGLHP NTKYHVTVRA YNRAGTGPAS
910 920 930 940 950
PSANATTMKP PPRRPPGNIS WTFSSSSLSI KWDPVVPFRN ESAVTGYKML
960 970 980 990 1000
YQNDLHLTPT LHLTGKNWIE IPVPEDIGHA LVQIRTTGPG GDGIPAEVHI
1010 1020 1030 1040
VRNGGTSMMV ENMAVRPAPH PGTVISHSVA MLILIGSLEL
Length:1,040
Mass (Da):113,393
Last modified:July 1, 1993 - v1
Checksum:i254E78DD3C28EFB6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451A → T.
Corresponds to variant rs2275697 [ dbSNP | Ensembl ].
VAR_021918
Natural varianti366 – 3661P → L.
Corresponds to variant rs2229866 [ dbSNP | Ensembl ].
VAR_029129
Natural varianti657 – 6571R → W.
Corresponds to variant rs2305276 [ dbSNP | Ensembl ].
VAR_021919
Natural varianti1024 – 10241V → I.
Corresponds to variant rs17416074 [ dbSNP | Ensembl ].
VAR_049867

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68274 mRNA. Translation: CAA48335.1.
X67734 mRNA. Translation: CAA47963.1.
X84420 Genomic DNA. Translation: CAA59137.1.
AL583832 Genomic DNA. Translation: CAI15288.1.
X92681 Genomic DNA. Translation: CAA63365.1.
CCDSiCCDS1449.1.
PIRiS35508. A49356.
RefSeqiNP_005067.1. NM_005076.3.
UniGeneiHs.519220.

Genome annotation databases

EnsembliENST00000331830; ENSP00000330633; ENSG00000184144.
GeneIDi6900.
KEGGihsa:6900.
UCSCiuc001hbq.1. human.

Polymorphism databases

DMDMi399092.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68274 mRNA. Translation: CAA48335.1 .
X67734 mRNA. Translation: CAA47963.1 .
X84420 Genomic DNA. Translation: CAA59137.1 .
AL583832 Genomic DNA. Translation: CAI15288.1 .
X92681 Genomic DNA. Translation: CAA63365.1 .
CCDSi CCDS1449.1.
PIRi S35508. A49356.
RefSeqi NP_005067.1. NM_005076.3.
UniGenei Hs.519220.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OM5 X-ray 3.07 A 34-414 [» ]
ProteinModelPortali Q02246.
SMRi Q02246. Positions 34-997.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112763. 34 interactions.
IntActi Q02246. 2 interactions.
MINTi MINT-2805397.
STRINGi 9606.ENSP00000330633.

Protein family/group databases

TCDBi 8.A.23.1.3. the basigin (basigin) family.

PTM databases

PhosphoSitei Q02246.

Polymorphism databases

DMDMi 399092.

Proteomic databases

PaxDbi Q02246.
PRIDEi Q02246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331830 ; ENSP00000330633 ; ENSG00000184144 .
GeneIDi 6900.
KEGGi hsa:6900.
UCSCi uc001hbq.1. human.

Organism-specific databases

CTDi 6900.
GeneCardsi GC01P205012.
HGNCi HGNC:2172. CNTN2.
HPAi HPA001397.
HPA012497.
MIMi 190197. gene.
615400. phenotype.
neXtProti NX_Q02246.
Orphaneti 86814. Benign adult familial myoclonic epilepsy.
PharmGKBi PA26686.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293951.
GeneTreei ENSGT00760000118840.
HOGENOMi HOG000059617.
HOVERGENi HBG051047.
InParanoidi Q02246.
KOi K06760.
OMAi ECFAFGN.
OrthoDBi EOG7J17Z5.
PhylomeDBi Q02246.
TreeFami TF351103.

Enzyme and pathway databases

Reactomei REACT_18312. NCAM1 interactions.
REACT_22205. L1CAM interactions.
REACT_22329. NrCAM interactions.

Miscellaneous databases

ChiTaRSi CNTN2. human.
EvolutionaryTracei Q02246.
GeneWikii CNTN2.
GenomeRNAii 6900.
NextBioi 26975.
PROi Q02246.
SOURCEi Search...

Gene expression databases

Bgeei Q02246.
CleanExi HS_CNTN2.
Genevestigatori Q02246.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF07679. I-set. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1."
    Hasler T.H., Rader C., Stoeckli E.T., Zuellig R.A., Sonderegger P.
    Eur. J. Biochem. 211:329-339(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1."
    Tsiotra C.P., Karagogeos D., Theodorakis K., Michaelidis M.T., Modi W.S., Furley J.A., Jessel M.T., Papamatheakis J.
    Genomics 18:562-567(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter."
    Kozlov S.V., Giger R.J., Hasler T., Korvatska E., Schorderet D.F., Sonderegger P.
    Genomics 30:141-148(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Molecular structure and functional studies of the TAX-1 promoter."
    Tsiotra C.P., Theodorakis C., Michaelidis M.T., Mamalaki C., Karagogeus D., Papamatheakis J.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-136.
    Tissue: Placenta.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 31-45.
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-904.
    Tissue: Plasma.
  8. "Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2."
    Stogmann E., Reinthaler E., Eltawil S., El Etribi M.A., Hemeda M., El Nahhas N., Gaber A.M., Fouad A., Edris S., Benet-Pages A., Eck S.H., Pataraia E., Mei D., Brice A., Lesage S., Guerrini R., Zimprich F., Strom T.M., Zimprich A.
    Brain 136:1155-1160(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN FAME5, FUNCTION.
  9. "The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction."
    Mortl M., Sonderegger P., Diederichs K., Welte W.
    Protein Sci. 16:2174-2183(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.07 ANGSTROMS) OF 34-414, DISULFIDE BONDS.

Entry informationi

Entry nameiCNTN2_HUMAN
AccessioniPrimary (citable) accession number: Q02246
Secondary accession number(s): P78432, Q5T054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3