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Q02246

- CNTN2_HUMAN

UniProt

Q02246 - CNTN2_HUMAN

Protein

Contactin-2

Gene

CNTN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.1 Publication

    GO - Molecular functioni

    1. carbohydrate binding Source: Ensembl
    2. identical protein binding Source: BHF-UCL

    GO - Biological processi

    1. adult walking behavior Source: Ensembl
    2. axonal fasciculation Source: Ensembl
    3. axon guidance Source: Reactome
    4. cell adhesion Source: ProtInc
    5. cellular protein localization Source: BHF-UCL
    6. central nervous system myelination Source: Ensembl
    7. cerebral cortex GABAergic interneuron migration Source: Ensembl
    8. clustering of voltage-gated potassium channels Source: BHF-UCL
    9. establishment of protein localization to juxtaparanode region of axon Source: Ensembl
    10. learning Source: Ensembl
    11. microtubule cytoskeleton organization Source: Ensembl
    12. negative regulation of neuron differentiation Source: Ensembl
    13. positive regulation of adenosine receptor signaling pathway Source: Ensembl
    14. positive regulation of protein processing Source: Ensembl
    15. presynaptic membrane organization Source: UniProtKB
    16. receptor internalization Source: Ensembl
    17. regulation of astrocyte differentiation Source: Ensembl
    18. regulation of axon diameter Source: Ensembl
    19. regulation of neuronal synaptic plasticity Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_18312. NCAM1 interactions.
    REACT_22205. L1CAM interactions.
    REACT_22329. NrCAM interactions.

    Protein family/group databases

    TCDBi8.A.23.1.3. the basigin (basigin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Contactin-2
    Alternative name(s):
    Axonal glycoprotein TAG-1
    Axonin-1
    Transient axonal glycoprotein 1
    Short name:
    TAX-1
    Gene namesi
    Name:CNTN2
    Synonyms:AXT, TAG1, TAX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2172. CNTN2.

    Subcellular locationi

    Cell membrane; Lipid-anchorGPI-anchor
    Note: Attached to the neuronal membrane by a GPI-anchor and is also released from neurons.

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. juxtaparanode region of axon Source: BHF-UCL
    5. myelin sheath Source: BHF-UCL
    6. neuronal cell body Source: Ensembl
    7. node of Ranvier Source: BHF-UCL
    8. plasma membrane Source: BHF-UCL
    9. synapse Source: BHF-UCL
    10. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Epilepsy, familial adult myoclonic, 5 (FAME5) [MIM:615400]: A form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Epilepsy

    Organism-specific databases

    MIMi615400. phenotype.
    Orphaneti86814. Benign adult familial myoclonic epilepsy.
    PharmGKBiPA26686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 30301 PublicationAdd
    BLAST
    Chaini31 – 1012982Contactin-2PRO_0000014695Add
    BLAST
    Propeptidei1013 – 104028Removed in mature formSequence AnalysisPRO_0000014696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi61 ↔ 1111 PublicationPROSITE-ProRule annotation
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 2071 PublicationPROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi261 ↔ 3061 PublicationPROSITE-ProRule annotation
    Disulfide bondi348 ↔ 3951 PublicationPROSITE-ProRule annotation
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi830 – 8301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi904 – 9041N-linked (GlcNAc...)1 Publication
    Glycosylationi918 – 9181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi940 – 9401N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1012 – 10121GPI-anchor amidated asparagineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ02246.
    PRIDEiQ02246.

    PTM databases

    PhosphoSiteiQ02246.

    Expressioni

    Gene expression databases

    BgeeiQ02246.
    CleanExiHS_CNTN2.
    GenevestigatoriQ02246.

    Organism-specific databases

    HPAiHPA001397.
    HPA012497.

    Interactioni

    Protein-protein interaction databases

    BioGridi112763. 35 interactions.
    IntActiQ02246. 2 interactions.
    MINTiMINT-2805397.
    STRINGi9606.ENSP00000330633.

    Structurei

    Secondary structure

    1
    1040
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 417
    Beta strandi46 – 516
    Beta strandi55 – 595
    Beta strandi62 – 676
    Beta strandi70 – 756
    Beta strandi87 – 915
    Beta strandi94 – 996
    Helixi102 – 1054
    Beta strandi107 – 1159
    Beta strandi118 – 1214
    Beta strandi125 – 1328
    Beta strandi151 – 1533
    Beta strandi160 – 1623
    Beta strandi165 – 1728
    Beta strandi180 – 1856
    Beta strandi187 – 1893
    Beta strandi192 – 1965
    Beta strandi203 – 21311
    Beta strandi216 – 2216
    Beta strandi225 – 2273
    Beta strandi229 – 2313
    Beta strandi237 – 2437
    Beta strandi247 – 2526
    Beta strandi257 – 2604
    Beta strandi262 – 2676
    Beta strandi270 – 2756
    Beta strandi289 – 2957
    Helixi298 – 3003
    Beta strandi302 – 3109
    Beta strandi313 – 32412
    Beta strandi329 – 3313
    Beta strandi336 – 3394
    Beta strandi344 – 3474
    Beta strandi352 – 3543
    Beta strandi357 – 36610
    Beta strandi373 – 3764
    Beta strandi379 – 3846
    Helixi387 – 3893
    Beta strandi391 – 3988
    Beta strandi403 – 41311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OM5X-ray3.07A34-414[»]
    ProteinModelPortaliQ02246.
    SMRiQ02246. Positions 34-997.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ02246.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 12886Ig-like C2-type 1Add
    BLAST
    Domaini133 – 22290Ig-like C2-type 2Add
    BLAST
    Domaini239 – 32284Ig-like C2-type 3Add
    BLAST
    Domaini327 – 41185Ig-like C2-type 4Add
    BLAST
    Domaini417 – 50488Ig-like C2-type 5Add
    BLAST
    Domaini509 – 60395Ig-like C2-type 6Add
    BLAST
    Domaini610 – 70899Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini713 – 81098Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini815 – 91096Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini915 – 100692Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi794 – 7963Cell attachment siteBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi606 – 6127Gly/Pro-rich

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG293951.
    HOGENOMiHOG000059617.
    HOVERGENiHBG051047.
    InParanoidiQ02246.
    KOiK06760.
    OMAiECFAFGN.
    OrthoDBiEOG7J17Z5.
    PhylomeDBiQ02246.
    TreeFamiTF351103.

    Family and domain databases

    Gene3Di2.60.40.10. 9 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF07679. I-set. 4 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 5 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02246-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTATRRKPH LLLVAAVALV SSSAWSSALG SQTTFGPVFE DQPLSVLFPE     50
    ESTEEQVLLA CRARASPPAT YRWKMNGTEM KLEPGSRHQL VGGNLVIMNP 100
    TKAQDAGVYQ CLASNPVGTV VSREAILRFG FLQEFSKEER DPVKAHEGWG 150
    VMLPCNPPAH YPGLSYRWLL NEFPNFIPTD GRHFVSQTTG NLYIARTNAS 200
    DLGNYSCLAT SHMDFSTKSV FSKFAQLNLA AEDTRLFAPS IKARFPAETY 250
    ALVGQQVTLE CFAFGNPVPR IKWRKVDGSL SPQWTTAEPT LQIPSVSFED 300
    EGTYECEAEN SKGRDTVQGR IIVQAQPEWL KVISDTEADI GSNLRWGCAA 350
    AGKPRPTVRW LRNGEPLASQ NRVEVLAGDL RFSKLSLEDS GMYQCVAENK 400
    HGTIYASAEL AVQALAPDFR LNPVRRLIPA ARGGEILIPC QPRAAPKAVV 450
    LWSKGTEILV NSSRVTVTPD GTLIIRNISR SDEGKYTCFA ENFMGKANST 500
    GILSVRDATK ITLAPSSADI NLGDNLTLQC HASHDPTMDL TFTWTLDDFP 550
    IDFDKPGGHY RRTNVKETIG DLTILNAQLR HGGKYTCMAQ TVVDSASKEA 600
    TVLVRGPPGP PGGVVVRDIG DTTIQLSWSR GFDNHSPIAK YTLQARTPPA 650
    GKWKQVRTNP ANIEGNAETA QVLGLTPWMD YEFRVIASNI LGTGEPSGPS 700
    SKIRTREAAP SVAPSGLSGG GGAPGELIVN WTPMSREYQN GDGFGYLLSF 750
    RRQGSTHWQT ARVPGADAQY FVYSNESVRP YTPFEVKIRS YNRRGDGPES 800
    LTALVYSAEE EPRVAPTKVW AKGVSSSEMN VTWEPVQQDM NGILLGYEIR 850
    YWKAGDKEAA ADRVRTAGLD TSARVSGLHP NTKYHVTVRA YNRAGTGPAS 900
    PSANATTMKP PPRRPPGNIS WTFSSSSLSI KWDPVVPFRN ESAVTGYKML 950
    YQNDLHLTPT LHLTGKNWIE IPVPEDIGHA LVQIRTTGPG GDGIPAEVHI 1000
    VRNGGTSMMV ENMAVRPAPH PGTVISHSVA MLILIGSLEL 1040
    Length:1,040
    Mass (Da):113,393
    Last modified:July 1, 1993 - v1
    Checksum:i254E78DD3C28EFB6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti145 – 1451A → T.
    Corresponds to variant rs2275697 [ dbSNP | Ensembl ].
    VAR_021918
    Natural varianti366 – 3661P → L.
    Corresponds to variant rs2229866 [ dbSNP | Ensembl ].
    VAR_029129
    Natural varianti657 – 6571R → W.
    Corresponds to variant rs2305276 [ dbSNP | Ensembl ].
    VAR_021919
    Natural varianti1024 – 10241V → I.
    Corresponds to variant rs17416074 [ dbSNP | Ensembl ].
    VAR_049867

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68274 mRNA. Translation: CAA48335.1.
    X67734 mRNA. Translation: CAA47963.1.
    X84420 Genomic DNA. Translation: CAA59137.1.
    AL583832 Genomic DNA. Translation: CAI15288.1.
    X92681 Genomic DNA. Translation: CAA63365.1.
    CCDSiCCDS1449.1.
    PIRiS35508. A49356.
    RefSeqiNP_005067.1. NM_005076.3.
    UniGeneiHs.519220.

    Genome annotation databases

    EnsembliENST00000331830; ENSP00000330633; ENSG00000184144.
    GeneIDi6900.
    KEGGihsa:6900.
    UCSCiuc001hbq.1. human.

    Polymorphism databases

    DMDMi399092.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68274 mRNA. Translation: CAA48335.1 .
    X67734 mRNA. Translation: CAA47963.1 .
    X84420 Genomic DNA. Translation: CAA59137.1 .
    AL583832 Genomic DNA. Translation: CAI15288.1 .
    X92681 Genomic DNA. Translation: CAA63365.1 .
    CCDSi CCDS1449.1.
    PIRi S35508. A49356.
    RefSeqi NP_005067.1. NM_005076.3.
    UniGenei Hs.519220.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OM5 X-ray 3.07 A 34-414 [» ]
    ProteinModelPortali Q02246.
    SMRi Q02246. Positions 34-997.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112763. 35 interactions.
    IntActi Q02246. 2 interactions.
    MINTi MINT-2805397.
    STRINGi 9606.ENSP00000330633.

    Protein family/group databases

    TCDBi 8.A.23.1.3. the basigin (basigin) family.

    PTM databases

    PhosphoSitei Q02246.

    Polymorphism databases

    DMDMi 399092.

    Proteomic databases

    PaxDbi Q02246.
    PRIDEi Q02246.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331830 ; ENSP00000330633 ; ENSG00000184144 .
    GeneIDi 6900.
    KEGGi hsa:6900.
    UCSCi uc001hbq.1. human.

    Organism-specific databases

    CTDi 6900.
    GeneCardsi GC01P205012.
    HGNCi HGNC:2172. CNTN2.
    HPAi HPA001397.
    HPA012497.
    MIMi 190197. gene.
    615400. phenotype.
    neXtProti NX_Q02246.
    Orphaneti 86814. Benign adult familial myoclonic epilepsy.
    PharmGKBi PA26686.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293951.
    HOGENOMi HOG000059617.
    HOVERGENi HBG051047.
    InParanoidi Q02246.
    KOi K06760.
    OMAi ECFAFGN.
    OrthoDBi EOG7J17Z5.
    PhylomeDBi Q02246.
    TreeFami TF351103.

    Enzyme and pathway databases

    Reactomei REACT_18312. NCAM1 interactions.
    REACT_22205. L1CAM interactions.
    REACT_22329. NrCAM interactions.

    Miscellaneous databases

    ChiTaRSi CNTN2. human.
    EvolutionaryTracei Q02246.
    GeneWikii CNTN2.
    GenomeRNAii 6900.
    NextBioi 26975.
    PROi Q02246.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02246.
    CleanExi HS_CNTN2.
    Genevestigatori Q02246.

    Family and domain databases

    Gene3Di 2.60.40.10. 9 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF07679. I-set. 4 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1."
      Hasler T.H., Rader C., Stoeckli E.T., Zuellig R.A., Sonderegger P.
      Eur. J. Biochem. 211:329-339(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1."
      Tsiotra C.P., Karagogeos D., Theodorakis K., Michaelidis M.T., Modi W.S., Furley J.A., Jessel M.T., Papamatheakis J.
      Genomics 18:562-567(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter."
      Kozlov S.V., Giger R.J., Hasler T., Korvatska E., Schorderet D.F., Sonderegger P.
      Genomics 30:141-148(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Molecular structure and functional studies of the TAX-1 promoter."
      Tsiotra C.P., Theodorakis C., Michaelidis M.T., Mamalaki C., Karagogeus D., Papamatheakis J.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-136.
      Tissue: Placenta.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 31-45.
    7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-904.
      Tissue: Plasma.
    8. "Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2."
      Stogmann E., Reinthaler E., Eltawil S., El Etribi M.A., Hemeda M., El Nahhas N., Gaber A.M., Fouad A., Edris S., Benet-Pages A., Eck S.H., Pataraia E., Mei D., Brice A., Lesage S., Guerrini R., Zimprich F., Strom T.M., Zimprich A.
      Brain 136:1155-1160(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN FAME5, FUNCTION.
    9. "The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction."
      Mortl M., Sonderegger P., Diederichs K., Welte W.
      Protein Sci. 16:2174-2183(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.07 ANGSTROMS) OF 34-414, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCNTN2_HUMAN
    AccessioniPrimary (citable) accession number: Q02246
    Secondary accession number(s): P78432, Q5T054
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3