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Q02242

- PDCD1_MOUSE

UniProt

Q02242 - PDCD1_MOUSE

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Protein

Programmed cell death protein 1

Gene
Pdcd1, Pd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 1
Short name:
Protein PD-1
Short name:
mPD-1
Alternative name(s):
CD_antigen: CD279
Gene namesi
Name:Pdcd1
Synonyms:Pd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:104879. Pdcd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 169149Extracellular Reviewed predictionAdd
BLAST
Transmembranei170 – 19021Helical; Reviewed predictionAdd
BLAST
Topological domaini191 – 28898Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 288268Programmed cell death protein 1PRO_0000014893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi54 ↔ 1233 Publications
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ02242.

PTM databases

PhosphoSiteiQ02242.

Expressioni

Tissue specificityi

Thymus.

Developmental stagei

Induced at programmed cell death.

Gene expression databases

ArrayExpressiQ02242.
BgeeiQ02242.
CleanExiMM_PDCD1.
GenevestigatoriQ02242.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

DIPiDIP-29730N.
IntActiQ02242. 1 interaction.
STRINGi10090.ENSMUSP00000027507.

Structurei

Secondary structure

1
288
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 384
Beta strandi40 – 456
Beta strandi50 – 589
Beta strandi64 – 707
Beta strandi76 – 838
Beta strandi86 – 916
Beta strandi95 – 995
Beta strandi103 – 11210
Helixi115 – 1173
Beta strandi119 – 1279
Beta strandi129 – 1313
Beta strandi133 – 1364
Beta strandi140 – 1456

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NPUX-ray2.00A34-150[»]
3BIKX-ray2.65B/C25-157[»]
3BP5X-ray1.80A34-150[»]
3BP6X-ray1.60A34-150[»]
3RNKX-ray1.74A34-150[»]
3RNQX-ray1.60A34-150[»]
3SBWX-ray2.28A/B34-150[»]
ProteinModelPortaliQ02242.
SMRiQ02242. Positions 34-149.

Miscellaneous databases

EvolutionaryTraceiQ02242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 139109Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46047.
HOGENOMiHOG000253959.
HOVERGENiHBG053534.
InParanoidiQ02242.
KOiK06744.
OMAiDFQWREK.
OrthoDBiEOG7966J2.
PhylomeDBiQ02242.
TreeFamiTF336181.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02242-1 [UniParc]FASTAAdd to Basket

« Hide

MWVRQVPWSF TWAVLQLSWQ SGWLLEVPNG PWRSLTFYPA WLTVSEGANA    50
TFTCSLSNWS EDLMLNWNRL SPSNQTEKQA AFCNGLSQPV QDARFQIIQL 100
PNRHDFHMNI LDTRRNDSGI YLCGAISLHP KAKIEESPGA ELVVTERILE 150
TSTRYPSPSP KPEGRFQGMV IGIMSALVGI PVLLLLAWAL AVFCSTSMSE 200
ARGAGSKDDT LKEEPSAAPV PSVAYEELDF QGREKTPELP TACVHTEYAT 250
IVFTEGLGAS AMGRRGSADG LQGPRPPRHE DGHCSWPL 288
Length:288
Mass (Da):31,842
Last modified:July 1, 1993 - v1
Checksum:i4AD3C5F0F9D4200A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67914 mRNA. Translation: CAA48113.1.
CCDSiCCDS15200.1.
PIRiS28029.
RefSeqiNP_032824.1. NM_008798.2.
UniGeneiMm.5024.

Genome annotation databases

EnsembliENSMUST00000027507; ENSMUSP00000027507; ENSMUSG00000026285.
GeneIDi18566.
KEGGimmu:18566.
UCSCiuc007cev.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67914 mRNA. Translation: CAA48113.1 .
CCDSi CCDS15200.1.
PIRi S28029.
RefSeqi NP_032824.1. NM_008798.2.
UniGenei Mm.5024.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NPU X-ray 2.00 A 34-150 [» ]
3BIK X-ray 2.65 B/C 25-157 [» ]
3BP5 X-ray 1.80 A 34-150 [» ]
3BP6 X-ray 1.60 A 34-150 [» ]
3RNK X-ray 1.74 A 34-150 [» ]
3RNQ X-ray 1.60 A 34-150 [» ]
3SBW X-ray 2.28 A/B 34-150 [» ]
ProteinModelPortali Q02242.
SMRi Q02242. Positions 34-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29730N.
IntActi Q02242. 1 interaction.
STRINGi 10090.ENSMUSP00000027507.

PTM databases

PhosphoSitei Q02242.

Proteomic databases

PRIDEi Q02242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027507 ; ENSMUSP00000027507 ; ENSMUSG00000026285 .
GeneIDi 18566.
KEGGi mmu:18566.
UCSCi uc007cev.1. mouse.

Organism-specific databases

CTDi 5133.
MGIi MGI:104879. Pdcd1.

Phylogenomic databases

eggNOGi NOG46047.
HOGENOMi HOG000253959.
HOVERGENi HBG053534.
InParanoidi Q02242.
KOi K06744.
OMAi DFQWREK.
OrthoDBi EOG7966J2.
PhylomeDBi Q02242.
TreeFami TF336181.

Miscellaneous databases

EvolutionaryTracei Q02242.
NextBioi 294392.
PROi Q02242.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q02242.
Bgeei Q02242.
CleanExi MM_PDCD1.
Genevestigatori Q02242.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death."
    Ishida Y., Agata Y., Shibahara K., Honjo T.
    EMBO J. 11:3887-3895(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural and functional analysis of the costimulatory receptor programmed death-1."
    Zhang X., Schwartz J.C., Guo X., Bhatia S., Cao E., Lorenz M., Cammer M., Chen L., Zhang Z.-Y., Edidin M.A., Nathenson S.G., Almo S.C.
    Immunity 20:337-347(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 34-150, SUBUNIT, DISULFIDE BOND.
  3. "The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors."
    Lin D.Y., Tanaka Y., Iwasaki M., Gittis A.G., Su H.P., Mikami B., Okazaki T., Honjo T., Minato N., Garboczi D.N.
    Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 25-157 IN COMPLEX WITH CD274, DISULFIDE BOND.
  4. "Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2."
    Lazar-Molnar E., Yan Q., Cao E., Ramagopal U., Nathenson S.G., Almo S.C.
    Proc. Natl. Acad. Sci. U.S.A. 105:10483-10488(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 34-150 IN COMPLEX WITH PDCD1LG2, DISULFIDE BOND.

Entry informationi

Entry nameiPDCD1_MOUSE
AccessioniPrimary (citable) accession number: Q02242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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