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Q02242 (PDCD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Programmed cell death protein 1

Short name=Protein PD-1
Short name=mPD-1
Alternative name(s):
CD_antigen=CD279
Gene names
Name:Pdcd1
Synonyms:Pd1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors By similarity.

Subunit structure

Monomer. Ref.2

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Thymus.

Developmental stage

Induced at programmed cell death.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 288268Programmed cell death protein 1
PRO_0000014893

Regions

Topological domain21 – 169149Extracellular Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 28898Cytoplasmic Potential
Domain31 – 139109Ig-like V-type

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Disulfide bond54 ↔ 123 Ref.2 Ref.3 Ref.4

Secondary structure

........................... 288
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q02242 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 4AD3C5F0F9D4200A

FASTA28831,842
        10         20         30         40         50         60 
MWVRQVPWSF TWAVLQLSWQ SGWLLEVPNG PWRSLTFYPA WLTVSEGANA TFTCSLSNWS 

        70         80         90        100        110        120 
EDLMLNWNRL SPSNQTEKQA AFCNGLSQPV QDARFQIIQL PNRHDFHMNI LDTRRNDSGI 

       130        140        150        160        170        180 
YLCGAISLHP KAKIEESPGA ELVVTERILE TSTRYPSPSP KPEGRFQGMV IGIMSALVGI 

       190        200        210        220        230        240 
PVLLLLAWAL AVFCSTSMSE ARGAGSKDDT LKEEPSAAPV PSVAYEELDF QGREKTPELP 

       250        260        270        280 
TACVHTEYAT IVFTEGLGAS AMGRRGSADG LQGPRPPRHE DGHCSWPL 

« Hide

References

[1]"Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death."
Ishida Y., Agata Y., Shibahara K., Honjo T.
EMBO J. 11:3887-3895(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structural and functional analysis of the costimulatory receptor programmed death-1."
Zhang X., Schwartz J.C., Guo X., Bhatia S., Cao E., Lorenz M., Cammer M., Chen L., Zhang Z.-Y., Edidin M.A., Nathenson S.G., Almo S.C.
Immunity 20:337-347(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 34-150, SUBUNIT, DISULFIDE BOND.
[3]"The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors."
Lin D.Y., Tanaka Y., Iwasaki M., Gittis A.G., Su H.P., Mikami B., Okazaki T., Honjo T., Minato N., Garboczi D.N.
Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 25-157 IN COMPLEX WITH CD274, DISULFIDE BOND.
[4]"Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2."
Lazar-Molnar E., Yan Q., Cao E., Ramagopal U., Nathenson S.G., Almo S.C.
Proc. Natl. Acad. Sci. U.S.A. 105:10483-10488(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 34-150 IN COMPLEX WITH PDCD1LG2, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67914 mRNA. Translation: CAA48113.1.
CCDSCCDS15200.1.
PIRS28029.
RefSeqNP_032824.1. NM_008798.2.
UniGeneMm.5024.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NPUX-ray2.00A34-150[»]
3BIKX-ray2.65B/C25-157[»]
3BP5X-ray1.80A34-150[»]
3BP6X-ray1.60A34-150[»]
3RNKX-ray1.74A34-150[»]
3RNQX-ray1.60A34-150[»]
3SBWX-ray2.28A/B34-150[»]
ProteinModelPortalQ02242.
SMRQ02242. Positions 34-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-29730N.
IntActQ02242. 1 interaction.
STRING10090.ENSMUSP00000027507.

PTM databases

PhosphoSiteQ02242.

Proteomic databases

PRIDEQ02242.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027507; ENSMUSP00000027507; ENSMUSG00000026285.
GeneID18566.
KEGGmmu:18566.
UCSCuc007cev.1. mouse.

Organism-specific databases

CTD5133.
MGIMGI:104879. Pdcd1.

Phylogenomic databases

eggNOGNOG46047.
HOGENOMHOG000253959.
HOVERGENHBG053534.
InParanoidQ02242.
KOK06744.
OMADFQWREK.
OrthoDBEOG7966J2.
PhylomeDBQ02242.
TreeFamTF336181.

Gene expression databases

ArrayExpressQ02242.
BgeeQ02242.
CleanExMM_PDCD1.
GenevestigatorQ02242.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ02242.
NextBio294392.
PROQ02242.
SOURCESearch...

Entry information

Entry namePDCD1_MOUSE
AccessionPrimary (citable) accession number: Q02242
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot