Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Programmed cell death protein 1

Gene

Pdcd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • immune system process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of tolerance induction Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of T cell apoptotic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 1
Short name:
Protein PD-1
Short name:
mPD-1
Alternative name(s):
CD_antigen: CD279
Gene namesi
Name:Pdcd1
Synonyms:Pd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104879. Pdcd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 169ExtracellularSequence analysisAdd BLAST149
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 288CytoplasmicSequence analysisAdd BLAST98

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001489321 – 288Programmed cell death protein 1Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi54 ↔ 123PROSITE-ProRule annotation3 Publications
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02242.
PRIDEiQ02242.

PTM databases

iPTMnetiQ02242.
PhosphoSitePlusiQ02242.
SwissPalmiQ02242.

Expressioni

Tissue specificityi

Thymus.

Developmental stagei

Induced at programmed cell death.

Gene expression databases

BgeeiENSMUSG00000026285.
CleanExiMM_PDCD1.
ExpressionAtlasiQ02242. baseline and differential.
GenevisibleiQ02242. MM.

Interactioni

Subunit structurei

Monomer.3 Publications

Protein-protein interaction databases

DIPiDIP-29730N.
IntActiQ02242. 1 interactor.
STRINGi10090.ENSMUSP00000027507.

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 38Combined sources4
Beta strandi40 – 45Combined sources6
Beta strandi50 – 58Combined sources9
Beta strandi64 – 70Combined sources7
Beta strandi76 – 83Combined sources8
Beta strandi86 – 91Combined sources6
Beta strandi95 – 99Combined sources5
Beta strandi103 – 112Combined sources10
Helixi115 – 117Combined sources3
Beta strandi119 – 127Combined sources9
Beta strandi129 – 131Combined sources3
Beta strandi133 – 136Combined sources4
Beta strandi140 – 145Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NPUX-ray2.00A34-150[»]
3BIKX-ray2.65B/C25-157[»]
3BP5X-ray1.80A34-150[»]
3BP6X-ray1.60A34-150[»]
3RNKX-ray1.74A34-150[»]
3RNQX-ray1.60A34-150[»]
3SBWX-ray2.28A/B34-150[»]
ProteinModelPortaliQ02242.
SMRiQ02242.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 139Ig-like V-typeAdd BLAST109

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J26W. Eukaryota.
ENOG41116U6. LUCA.
GeneTreeiENSGT00390000013662.
HOGENOMiHOG000253959.
HOVERGENiHBG053534.
InParanoidiQ02242.
KOiK06744.
OMAiDFQWREK.
OrthoDBiEOG091G0EE8.
PhylomeDBiQ02242.
TreeFamiTF336181.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVRQVPWSF TWAVLQLSWQ SGWLLEVPNG PWRSLTFYPA WLTVSEGANA
60 70 80 90 100
TFTCSLSNWS EDLMLNWNRL SPSNQTEKQA AFCNGLSQPV QDARFQIIQL
110 120 130 140 150
PNRHDFHMNI LDTRRNDSGI YLCGAISLHP KAKIEESPGA ELVVTERILE
160 170 180 190 200
TSTRYPSPSP KPEGRFQGMV IGIMSALVGI PVLLLLAWAL AVFCSTSMSE
210 220 230 240 250
ARGAGSKDDT LKEEPSAAPV PSVAYEELDF QGREKTPELP TACVHTEYAT
260 270 280
IVFTEGLGAS AMGRRGSADG LQGPRPPRHE DGHCSWPL
Length:288
Mass (Da):31,842
Last modified:July 1, 1993 - v1
Checksum:i4AD3C5F0F9D4200A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67914 mRNA. Translation: CAA48113.1.
CCDSiCCDS15200.1.
PIRiS28029.
RefSeqiNP_032824.1. NM_008798.2.
UniGeneiMm.5024.

Genome annotation databases

EnsembliENSMUST00000027507; ENSMUSP00000027507; ENSMUSG00000026285.
GeneIDi18566.
KEGGimmu:18566.
UCSCiuc007cev.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67914 mRNA. Translation: CAA48113.1.
CCDSiCCDS15200.1.
PIRiS28029.
RefSeqiNP_032824.1. NM_008798.2.
UniGeneiMm.5024.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NPUX-ray2.00A34-150[»]
3BIKX-ray2.65B/C25-157[»]
3BP5X-ray1.80A34-150[»]
3BP6X-ray1.60A34-150[»]
3RNKX-ray1.74A34-150[»]
3RNQX-ray1.60A34-150[»]
3SBWX-ray2.28A/B34-150[»]
ProteinModelPortaliQ02242.
SMRiQ02242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29730N.
IntActiQ02242. 1 interactor.
STRINGi10090.ENSMUSP00000027507.

PTM databases

iPTMnetiQ02242.
PhosphoSitePlusiQ02242.
SwissPalmiQ02242.

Proteomic databases

PaxDbiQ02242.
PRIDEiQ02242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027507; ENSMUSP00000027507; ENSMUSG00000026285.
GeneIDi18566.
KEGGimmu:18566.
UCSCiuc007cev.1. mouse.

Organism-specific databases

CTDi5133.
MGIiMGI:104879. Pdcd1.

Phylogenomic databases

eggNOGiENOG410J26W. Eukaryota.
ENOG41116U6. LUCA.
GeneTreeiENSGT00390000013662.
HOGENOMiHOG000253959.
HOVERGENiHBG053534.
InParanoidiQ02242.
KOiK06744.
OMAiDFQWREK.
OrthoDBiEOG091G0EE8.
PhylomeDBiQ02242.
TreeFamiTF336181.

Enzyme and pathway databases

ReactomeiR-MMU-389948. PD-1 signaling.

Miscellaneous databases

EvolutionaryTraceiQ02242.
PROiQ02242.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026285.
CleanExiMM_PDCD1.
ExpressionAtlasiQ02242. baseline and differential.
GenevisibleiQ02242. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD1_MOUSE
AccessioniPrimary (citable) accession number: Q02242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.