SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q02241

- KIF23_HUMAN

UniProt

Q02241 - KIF23_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Kinesin-like protein KIF23
Gene
KIF23, KNSL5, MKLP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi112 – 1198ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule binding Source: UniProtKB
  3. microtubule motor activity Source: ProtInc
  4. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. blood coagulation Source: Reactome
  3. cytokinesis Source: UniProtKB
  4. metabolic process Source: GOC
  5. microtubule-based movement Source: Reactome
  6. mitotic cell cycle Source: Reactome
  7. mitotic spindle elongation Source: ProtInc
  8. positive regulation of cytokinesis Source: UniProtKB
  9. spindle midzone assembly involved in mitosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_1932. Mitotic Telophase/Cytokinesis.
REACT_25201. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF23
Alternative name(s):
Kinesin-like protein 5
Mitotic kinesin-like protein 1
Gene namesi
Name:KIF23
Synonyms:KNSL5, MKLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:6392. KIF23.

Subcellular locationi

Nucleus. Cytoplasmcytoskeletonspindle. Midbody
Note: Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.3 Publications

GO - Cellular componenti

  1. centralspindlin complex Source: UniProtKB
  2. centrosome Source: MGI
  3. cytosol Source: Reactome
  4. intercellular bridge Source: Ensembl
  5. kinesin complex Source: ProtInc
  6. microtubule Source: UniProtKB-KW
  7. midbody Source: UniProtKB
  8. mitotic spindle Source: UniProtKB
  9. nucleoplasm Source: Reactome
  10. nucleus Source: UniProtKB
  11. spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti98870. Congenital dyserythropoietic anemia type III.
PharmGKBiPA30181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Kinesin-like protein KIF23
PRO_0000125434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551Phosphoserine1 Publication
Modified residuei160 – 1601Phosphoserine1 Publication
Modified residuei605 – 6051Phosphoserine1 Publication
Modified residuei738 – 7381Phosphothreonine1 Publication
Modified residuei814 – 8141Phosphoserine1 Publication
Modified residuei867 – 8671Phosphoserine3 Publications
Modified residuei902 – 9021Phosphoserine2 Publications

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP8/UBPY.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ02241.
PaxDbiQ02241.
PRIDEiQ02241.

PTM databases

PhosphoSiteiQ02241.

Expressioni

Gene expression databases

ArrayExpressiQ02241.
BgeeiQ02241.
CleanExiHS_KIF23.
GenevestigatoriQ02241.

Organism-specific databases

HPAiCAB010414.
HPA045208.

Interactioni

Subunit structurei

Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARF6P6233023EBI-306852,EBI-638181
Arf6P6233110EBI-306852,EBI-988682From a different organism.
BIRC6Q9NR094EBI-306852,EBI-1765160
RACGAP1Q9H0H54EBI-306852,EBI-717233
YWHAZP631045EBI-306852,EBI-347088

Protein-protein interaction databases

BioGridi114873. 27 interactions.
DIPiDIP-40359N.
IntActiQ02241. 19 interactions.
MINTiMINT-1631617.
STRINGi9606.ENSP00000260363.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi814 – 8163
Beta strandi819 – 8224
Beta strandi833 – 8364
Beta strandi841 – 8466
Helixi849 – 8546
Beta strandi856 – 86510
Beta strandi871 – 88212
Beta strandi888 – 90114

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VHXX-ray2.81B/D/F/H794-911[»]
ProteinModelPortaliQ02241.
SMRiQ02241. Positions 21-455, 799-904.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 436412Kinesin motor
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni794 – 911118Interaction with ARF6
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili535 – 62086 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi7 – 115Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000273893.
HOVERGENiHBG052253.
InParanoidiQ02241.
KOiK17387.
OMAiQTSLKDP.
OrthoDBiEOG7PCJG5.
PhylomeDBiQ02241.
TreeFamiTF105232.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02241-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSARAKTPR KPTVKKGSQT NLKDPVGVYC RVRPLGFPDQ ECCIEVINNT    50
TVQLHTPEGY RLNRNGDYKE TQYSFKQVFG THTTQKELFD VVANPLVNDL 100
IHGKNGLLFT YGVTGSGKTH TMTGSPGEGG LLPRCLDMIF NSIGSFQAKR 150
YVFKSNDRNS MDIQCEVDAL LERQKREAMP NPKTSSSKRQ VDPEFADMIT 200
VQEFCKAEEV DEDSVYGVFV SYIEIYNNYI YDLLEEVPFD PIKPKPPQSK 250
LLREDKNHNM YVAGCTEVEV KSTEEAFEVF WRGQKKRRIA NTHLNRESSR 300
SHSVFNIKLV QAPLDADGDN VLQEKEQITI SQLSLVDLAG SERTNRTRAE 350
GNRLREAGNI NQSLMTLRTC MDVLRENQMY GTNKMVPYRD SKLTHLFKNY 400
FDGEGKVRMI VCVNPKAEDY EENLQVMRFA EVTQEVEVAR PVDKAICGLT 450
PGRRYRNQPR GPVGNEPLVT DVVLQSFPPL PSCEILDIND EQTLPRLIEA 500
LEKRHNLRQM MIDEFNKQSN AFKALLQEFD NAVLSKENHM QGKLNEKEKM 550
ISGQKLEIER LEKKNKTLEY KIEILEKTTT IYEEDKRNLQ QELETQNQKL 600
QRQFSDKRRL EARLQGMVTE TTMKWEKECE RRVAAKQLEM QNKLWVKDEK 650
LKQLKAIVTE PKTEKPERPS RERDREKVTQ RSVSPSPVPL SSNYIAQISN 700
GQQLMSQPQL HRRSNSCSSI SVASCISEWE QKIPTYNTPL KVTSIARRRQ 750
QEPGQSKTCI VSDRRRGMYW TEGREVVPTF RNEIEIEEDH CGRLLFQPDQ 800
NAPPIRLRHR RSRSAGDRWV DHKPASNMQT ETVMQPHVPH AITVSVANEK 850
ALAKCEKYML THQELASDGE IETKLIKGDI YKTRGGGQSV QFTDIETLKQ 900
ESPNGSRKRR SSTVAPAQPD GAESEWTDVE TRCSVAVEMR AGSQLGPGYQ 950
HHAQPKRKKP 960
Length:960
Mass (Da):110,059
Last modified:November 28, 2006 - v3
Checksum:iB2AA784D2D236A90
GO
Isoform 2 (identifier: Q02241-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-793: Missing.

Show »
Length:856
Mass (Da):98,105
Checksum:iDDE7CEB480ABE58A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti515 – 5151F → L.
Corresponds to variant rs17310879 [ dbSNP | Ensembl ].
VAR_049686

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei690 – 793104Missing in isoform 2.
VSP_021801Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67155 mRNA. Translation: CAA47628.2.
BC017705 mRNA. Translation: AAH17705.2.
BC051826 mRNA. Translation: AAH51826.1.
CCDSiCCDS32278.1. [Q02241-1]
CCDS32279.1. [Q02241-2]
PIRiS28262.
RefSeqiNP_004847.2. NM_004856.6. [Q02241-2]
NP_612565.1. NM_138555.3. [Q02241-1]
UniGeneiHs.270845.

Genome annotation databases

EnsembliENST00000260363; ENSP00000260363; ENSG00000137807. [Q02241-1]
ENST00000352331; ENSP00000304978; ENSG00000137807. [Q02241-2]
ENST00000559279; ENSP00000453386; ENSG00000137807. [Q02241-2]
GeneIDi9493.
KEGGihsa:9493.
UCSCiuc002asb.3. human. [Q02241-1]
uc002asc.3. human. [Q02241-2]

Polymorphism databases

DMDMi118572664.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67155 mRNA. Translation: CAA47628.2 .
BC017705 mRNA. Translation: AAH17705.2 .
BC051826 mRNA. Translation: AAH51826.1 .
CCDSi CCDS32278.1. [Q02241-1 ]
CCDS32279.1. [Q02241-2 ]
PIRi S28262.
RefSeqi NP_004847.2. NM_004856.6. [Q02241-2 ]
NP_612565.1. NM_138555.3. [Q02241-1 ]
UniGenei Hs.270845.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VHX X-ray 2.81 B/D/F/H 794-911 [» ]
ProteinModelPortali Q02241.
SMRi Q02241. Positions 21-455, 799-904.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114873. 27 interactions.
DIPi DIP-40359N.
IntActi Q02241. 19 interactions.
MINTi MINT-1631617.
STRINGi 9606.ENSP00000260363.

Chemistry

BindingDBi Q02241.
ChEMBLi CHEMBL5899.

PTM databases

PhosphoSitei Q02241.

Polymorphism databases

DMDMi 118572664.

Proteomic databases

MaxQBi Q02241.
PaxDbi Q02241.
PRIDEi Q02241.

Protocols and materials databases

DNASUi 9493.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260363 ; ENSP00000260363 ; ENSG00000137807 . [Q02241-1 ]
ENST00000352331 ; ENSP00000304978 ; ENSG00000137807 . [Q02241-2 ]
ENST00000559279 ; ENSP00000453386 ; ENSG00000137807 . [Q02241-2 ]
GeneIDi 9493.
KEGGi hsa:9493.
UCSCi uc002asb.3. human. [Q02241-1 ]
uc002asc.3. human. [Q02241-2 ]

Organism-specific databases

CTDi 9493.
GeneCardsi GC15P069706.
HGNCi HGNC:6392. KIF23.
HPAi CAB010414.
HPA045208.
MIMi 605064. gene.
neXtProti NX_Q02241.
Orphaneti 98870. Congenital dyserythropoietic anemia type III.
PharmGKBi PA30181.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOGENOMi HOG000273893.
HOVERGENi HBG052253.
InParanoidi Q02241.
KOi K17387.
OMAi QTSLKDP.
OrthoDBi EOG7PCJG5.
PhylomeDBi Q02241.
TreeFami TF105232.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_1932. Mitotic Telophase/Cytokinesis.
REACT_25201. Kinesins.

Miscellaneous databases

GeneWikii KIF23.
GenomeRNAii 9493.
NextBioi 35566.
PROi Q02241.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q02241.
Bgeei Q02241.
CleanExi HS_KIF23.
Genevestigatori Q02241.

Family and domain databases

Gene3Di 3.40.850.10. 2 hits.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles."
    Nislow C., Lombillo V.A., Kuriyama R., McIntosh J.R.
    Nature 359:543-547(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Gryka M.A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-960 (ISOFORM 1).
    Tissue: Lymph and Uterus.
  4. "Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity."
    Mishima M., Kaitna S., Glotzer M.
    Dev. Cell 2:41-54(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CENTRALSPINDLIN COMPLEX, ASSOCIATION TO MICROTUBULES, INTERACTION WITH RACGAP1.
  5. "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation."
    Kurasawa Y., Earnshaw W.C., Mochizuki Y., Dohmae N., Todokoro K.
    EMBO J. 23:3237-3248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRC1.
  6. "Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis."
    Tomas A., Futter C., Moss S.E.
    J. Cell Biol. 165:813-822(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ANXA11, SUBCELLULAR LOCATION.
  7. "An ECT2-centralspindlin complex regulates the localization and function of RhoA."
    Yuce O., Piekny A., Glotzer M.
    J. Cell Biol. 170:571-582(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RACGAP1.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155; SER-814; SER-867 AND SER-902, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Dissecting the role of Rho-mediated signaling in contractile ring formation."
    Kamijo K., Ohara N., Abe M., Uchimura T., Hosoya H., Lee J.S., Miki T.
    Mol. Biol. Cell 17:43-55(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE CENTRALSPINDLIN COMPLEX, INTERACTION WITH ECT2 AND RACGAP1, SUBCELLULAR LOCATION.
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
    Pohl C., Jentsch S.
    Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, DEUBIQUITINATION, INTERACTION WITH BIRC6/BRUCE AND USP8/UBPY.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; THR-738; SER-867 AND SER-902, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation."
    Wolfe B.A., Takaki T., Petronczki M., Glotzer M.
    PLoS Biol. 7:E1000110-E1000110(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ECT2.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-867, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-605, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis."
    Makyio H., Ohgi M., Takei T., Takahashi S., Takatsu H., Katoh Y., Hanai A., Ueda T., Kanaho Y., Xie Y., Shin H.W., Kamikubo H., Kataoka M., Kawasaki M., Kato R., Wakatsuki S., Nakayama K.
    EMBO J. 31:2590-2603(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 794-911 IN COMPLEX WITH ARF6, INTERACTION WITH ARF6, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiKIF23_HUMAN
AccessioniPrimary (citable) accession number: Q02241
Secondary accession number(s): Q8WVP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 28, 2006
Last modified: September 3, 2014
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi