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Protein

Cytochrome c oxidase subunit 2, mitochondrial

Gene

COX2

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi327Copper ACurated1
Metal bindingi362Copper ACurated1
Metal bindingi366Copper ACurated1
Metal bindingi370Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini120 – 181Mitochondrial intermembraneSequence analysisAdd BLAST62
Transmembranei182 – 198HelicalSequence analysisAdd BLAST17
Topological domaini199 – 226Mitochondrial matrixSequence analysisAdd BLAST28
Transmembranei227 – 243HelicalSequence analysisAdd BLAST17
Topological domaini244 – 394Mitochondrial intermembraneSequence analysisAdd BLAST151

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei‹1 – ?119MitochondrionSequence analysisAdd BLAST›119
ChainiPRO_0000006043?120 – 394Cytochrome c oxidase subunit 2, mitochondrialAdd BLAST275

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA09G04480.1.

Structurei

3D structure databases

ProteinModelPortaliQ02226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
InParanoidiQ02226.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ILCPLEAFIV QHILTISVMG LLSCFRSTVL RKCSKGSSGM SRFLYTNNFQ
60 70 80 90 100
RNLISSGGNE SYYGYFNRRS YTSLYMGTGT VGGITSARIR VPNVGCEGFM
110 120 130 140 150
CSSHLSITQR NSRLIHSTSK IVPNSEIQNI TTEMVKTPEV SRWMDQVIPT
160 170 180 190 200
IAPCDAAEPW QLGFQDAATP IMQGIIDLHH DIFFFVIQIG VFVSWVLLRA
210 220 230 240 250
LWHFRSKMNP IPQRIVHGTT IEILWTIFPS VILMFIAIPS FALLYSMDDI
260 270 280 290 300
VVDPAITIKA IGHQWYWTYE YSDYNNSDEQ SLAFDSYMIP EDDLELGQLR
310 320 330 340 350
LLEVDNRVVV PAKTHLRVII TSADVLHSWA VPSLGVKCDA VPGRLNQIST
360 370 380 390
FIQREGVYYG QCSEICGTNH AFMPIVIEAV STKDYGSWVS SQVN
Length:394
Mass (Da):44,333
Last modified:October 1, 1993 - v1
Checksum:iCDE7AE60D38F3C0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11980 Genomic DNA. Translation: CAA78032.1.
PIRiS28027.
UniGeneiGma.32270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11980 Genomic DNA. Translation: CAA78032.1.
PIRiS28027.
UniGeneiGma.32270.

3D structure databases

ProteinModelPortaliQ02226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3847.GLYMA09G04480.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
InParanoidiQ02226.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOXT_SOYBN
AccessioniPrimary (citable) accession number: Q02226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.