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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

COX6A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:HS08157-MONOMER.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Cytochrome c oxidase subunit VIA-muscle
Short name:
COX VIa-M
Gene namesi
Name:COX6A2
Synonyms:COX6A, COX6AH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2279. COX6A2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1339.
OpenTargetsiENSG00000156885.
PharmGKBiPA26796.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX6A2.
DMDMi116241323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12MitochondrionBy similarityAdd BLAST12
ChainiPRO_000000611613 – 97Cytochrome c oxidase subunit 6A2, mitochondrialAdd BLAST85

Proteomic databases

PaxDbiQ02221.
PeptideAtlasiQ02221.
PRIDEiQ02221.

PTM databases

PhosphoSitePlusiQ02221.

Expressioni

Tissue specificityi

Expressed specifically in heart and muscle.1 Publication

Gene expression databases

BgeeiENSG00000156885.
CleanExiHS_COX6A2.
GenevisibleiQ02221. HS.

Interactioni

Protein-protein interaction databases

BioGridi107732. 5 interactors.
IntActiQ02221. 10 interactors.
STRINGi9606.ENSP00000287490.

Structurei

3D structure databases

ProteinModelPortaliQ02221.
SMRiQ02221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiQ02221.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG091G0C5F.
PhylomeDBiQ02221.
TreeFamiTF105064.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLRPLTR GLASAAKGGH GGAGARTWRL LTFVLALPSV ALCTFNSYLH
60 70 80 90
SGHRPRPEFR PYQHLRIRTK PYPWGDGNHT LFHNSHVNPL PTGYEHP
Length:97
Mass (Da):10,815
Last modified:October 17, 2006 - v2
Checksum:i843AD80319891F1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55P → E in AAA52062 (PubMed:1327966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83308 mRNA. Translation: AAA52062.1.
U66875 Genomic DNA. Translation: AAC51328.1.
BC029818 mRNA. Translation: AAH29818.1.
CCDSiCCDS10712.1.
PIRiJC1304. OGHU6A.
RefSeqiNP_005196.1. NM_005205.3.
UniGeneiHs.250760.

Genome annotation databases

EnsembliENST00000287490; ENSP00000287490; ENSG00000156885.
GeneIDi1339.
KEGGihsa:1339.
UCSCiuc002ebx.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83308 mRNA. Translation: AAA52062.1.
U66875 Genomic DNA. Translation: AAC51328.1.
BC029818 mRNA. Translation: AAH29818.1.
CCDSiCCDS10712.1.
PIRiJC1304. OGHU6A.
RefSeqiNP_005196.1. NM_005205.3.
UniGeneiHs.250760.

3D structure databases

ProteinModelPortaliQ02221.
SMRiQ02221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107732. 5 interactors.
IntActiQ02221. 10 interactors.
STRINGi9606.ENSP00000287490.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSitePlusiQ02221.

Polymorphism and mutation databases

BioMutaiCOX6A2.
DMDMi116241323.

Proteomic databases

PaxDbiQ02221.
PeptideAtlasiQ02221.
PRIDEiQ02221.

Protocols and materials databases

DNASUi1339.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287490; ENSP00000287490; ENSG00000156885.
GeneIDi1339.
KEGGihsa:1339.
UCSCiuc002ebx.2. human.

Organism-specific databases

CTDi1339.
DisGeNETi1339.
GeneCardsiCOX6A2.
HGNCiHGNC:2279. COX6A2.
MIMi602009. gene.
neXtProtiNX_Q02221.
OpenTargetsiENSG00000156885.
PharmGKBiPA26796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiQ02221.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG091G0C5F.
PhylomeDBiQ02221.
TreeFamiTF105064.

Enzyme and pathway databases

BioCyciZFISH:HS08157-MONOMER.

Miscellaneous databases

ChiTaRSiCOX6A2. human.
GenomeRNAii1339.
PROiQ02221.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156885.
CleanExiHS_COX6A2.
GenevisibleiQ02221. HS.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCX6A2_HUMAN
AccessioniPrimary (citable) accession number: Q02221
Secondary accession number(s): O00761, Q6GTW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.