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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

COX6A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

  • generation of precursor metabolites and energy Source: ProtInc
Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Cytochrome c oxidase subunit VIA-muscle
Short name:
COX VIa-M
Gene namesi
Name:COX6A2
Synonyms:COX6A, COX6AH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2279. COX6A2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26796.

Chemistry

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX6A2.
DMDMi116241323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212MitochondrionBy similarityAdd
BLAST
Chaini13 – 9785Cytochrome c oxidase subunit 6A2, mitochondrialPRO_0000006116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki70 – 70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ02221.
PRIDEiQ02221.

PTM databases

PhosphoSiteiQ02221.

Expressioni

Tissue specificityi

Expressed specifically in heart and muscle.1 Publication

Gene expression databases

BgeeiQ02221.
CleanExiHS_COX6A2.
GenevisibleiQ02221. HS.

Interactioni

Protein-protein interaction databases

BioGridi107732. 5 interactions.
IntActiQ02221. 10 interactions.
STRINGi9606.ENSP00000287490.

Structurei

3D structure databases

ProteinModelPortaliQ02221.
SMRiQ02221. Positions 13-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiQ02221.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG757D0Z.
PhylomeDBiQ02221.
TreeFamiTF105064.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLRPLTR GLASAAKGGH GGAGARTWRL LTFVLALPSV ALCTFNSYLH
60 70 80 90
SGHRPRPEFR PYQHLRIRTK PYPWGDGNHT LFHNSHVNPL PTGYEHP
Length:97
Mass (Da):10,815
Last modified:October 17, 2006 - v2
Checksum:i843AD80319891F1B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551P → E in AAA52062 (PubMed:1327966).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83308 mRNA. Translation: AAA52062.1.
U66875 Genomic DNA. Translation: AAC51328.1.
BC029818 mRNA. Translation: AAH29818.1.
CCDSiCCDS10712.1.
PIRiJC1304. OGHU6A.
RefSeqiNP_005196.1. NM_005205.3.
UniGeneiHs.250760.

Genome annotation databases

EnsembliENST00000287490; ENSP00000287490; ENSG00000156885.
GeneIDi1339.
KEGGihsa:1339.
UCSCiuc002ebx.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83308 mRNA. Translation: AAA52062.1.
U66875 Genomic DNA. Translation: AAC51328.1.
BC029818 mRNA. Translation: AAH29818.1.
CCDSiCCDS10712.1.
PIRiJC1304. OGHU6A.
RefSeqiNP_005196.1. NM_005205.3.
UniGeneiHs.250760.

3D structure databases

ProteinModelPortaliQ02221.
SMRiQ02221. Positions 13-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107732. 5 interactions.
IntActiQ02221. 10 interactions.
STRINGi9606.ENSP00000287490.

Chemistry

DrugBankiDB02659. Cholic Acid.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteiQ02221.

Polymorphism and mutation databases

BioMutaiCOX6A2.
DMDMi116241323.

Proteomic databases

PaxDbiQ02221.
PRIDEiQ02221.

Protocols and materials databases

DNASUi1339.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287490; ENSP00000287490; ENSG00000156885.
GeneIDi1339.
KEGGihsa:1339.
UCSCiuc002ebx.2. human.

Organism-specific databases

CTDi1339.
GeneCardsiCOX6A2.
HGNCiHGNC:2279. COX6A2.
MIMi602009. gene.
neXtProtiNX_Q02221.
PharmGKBiPA26796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiQ02221.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG757D0Z.
PhylomeDBiQ02221.
TreeFamiTF105064.

Miscellaneous databases

ChiTaRSiCOX6A2. human.
GenomeRNAii1339.
NextBioi5437.
PROiQ02221.
SOURCEiSearch...

Gene expression databases

BgeeiQ02221.
CleanExiHS_COX6A2.
GenevisibleiQ02221. HS.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase."
    Fabrizi G.M., Sadlock J., Hirano M., Mita S., Koga Y., Rizzuto R., Zeviani M., Schon E.A.
    Gene 119:307-312(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle."
    Bachman N.J., Riggs P.K., Siddiqui N.Y., Makris G.J., Womack J.E., Lomax M.I.
    Genomics 42:146-151(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCX6A2_HUMAN
AccessioniPrimary (citable) accession number: Q02221
Secondary accession number(s): O00761, Q6GTW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 17, 2006
Last modified: November 11, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.