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Q02216

- MASY_CANTR

UniProt

Q02216 - MASY_CANTR

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Protein

Malate synthase, glyoxysomal

Gene

PMS1

more
Organism
Candida tropicalis (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741Proton acceptorBy similarity
Active sitei458 – 4581Proton donorBy similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase, glyoxysomal (EC:2.3.3.9)
Gene namesi
Name:PMS1
AND
Name:PMS2
OrganismiCandida tropicalis (Yeast)
Taxonomic identifieri5482 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Malate synthase, glyoxysomalPRO_0000166860Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ02216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.Curated

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02216-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPFPKTAD KVKGVQILGP IPDEAKHIFN QETLAFVATL HRGFEARRQE
60 70 80 90 100
LLNNRKEQQK LRDQGFLPDF LPETEYIRND STWTGPALAP GLIDRRCEIT
110 120 130 140 150
GPTDRKMVIN ALNSNVATYM ADFEDSLTPA WKNLVEGQVN LYDAVRRNLS
160 170 180 190 200
ATINGKQYNL NLEKGRHIPT LIVRPRGWHL TEKHVLVDGT PVSGGIFDFA
210 220 230 240 250
VYFYNSAKEA IAQGFGPYFY LPKMEHHLEA KLWNDIFNYS QDYIGLKRGT
260 270 280 290 300
IRASVLIETI PAVFQMDEII YQLREHSAGL NCGRWDYIFS YIKCLRNHPD
310 320 330 340 350
FILPDRSQVT MAAPFMSSYV KLLVHTTHKR KVHALGGMAA QIPIKDDEAR
360 370 380 390 400
NRAALENVTK DKLREVTLGC DSCWVAHPAL VPVVLKVFNE HMKGPNQISL
410 420 430 440 450
PPKEPFKPIT QRDLLSPFVP GAKITEQGIR ANIVIGISYI EAWLRNVGCV
460 470 480 490 500
PINYLMEDAA TAEVSRTQIW QWVTHGAKTD TGKVITKEYV KQLLDEEYAK
510 520 530 540 550
LTKNAKPGNK FKRAFEYFAP EALGEKYSDF VTTLIYDDVT TIGRALPGER

L
Length:551
Mass (Da):62,449
Last modified:July 1, 1993 - v1
Checksum:iA74A587A9F22C8EC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591N → S in PMS2.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13415 Genomic DNA. Translation: BAA02680.1.
D13416 Genomic DNA. Translation: BAA02681.1.
PIRiJX0195.
JX0196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13415 Genomic DNA. Translation: BAA02680.1 .
D13416 Genomic DNA. Translation: BAA02681.1 .
PIRi JX0195.
JX0196.

3D structure databases

ProteinModelPortali Q02216.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Presence of two transcribed malate synthase genes in an n-alkane-utilizing yeast, Candida tropicalis."
    Hikada M., Atomi H., Fukuda Y., Aoki A., Hishida T., Teranishi Y., Ueda M., Tanaka A.
    J. Biochem. 110:909-914(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMASY_CANTR
AccessioniPrimary (citable) accession number: Q02216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two genes for malate synthase in C.tropicalis. The sequence shown is that of PMS1, PMS2 differs at a single position.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3