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Q02216

- MASY_CANTR

UniProt

Q02216 - MASY_CANTR

Protein

Malate synthase, glyoxysomal

Gene

PMS1

more
Organism
Candida tropicalis (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei174 – 1741Proton acceptorBy similarity
    Active sitei458 – 4581Proton donorBy similarity

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase, glyoxysomal (EC:2.3.3.9)
    Gene namesi
    Name:PMS1
    AND
    Name:PMS2
    OrganismiCandida tropicalis (Yeast)
    Taxonomic identifieri5482 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    GO - Cellular componenti

    1. glyoxysome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glyoxysome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Malate synthase, glyoxysomalPRO_0000166860Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ02216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the malate synthase family.Curated

    Family and domain databases

    InterProiIPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001363. Malate_synth. 1 hit.
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
    PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTPFPKTAD KVKGVQILGP IPDEAKHIFN QETLAFVATL HRGFEARRQE    50
    LLNNRKEQQK LRDQGFLPDF LPETEYIRND STWTGPALAP GLIDRRCEIT 100
    GPTDRKMVIN ALNSNVATYM ADFEDSLTPA WKNLVEGQVN LYDAVRRNLS 150
    ATINGKQYNL NLEKGRHIPT LIVRPRGWHL TEKHVLVDGT PVSGGIFDFA 200
    VYFYNSAKEA IAQGFGPYFY LPKMEHHLEA KLWNDIFNYS QDYIGLKRGT 250
    IRASVLIETI PAVFQMDEII YQLREHSAGL NCGRWDYIFS YIKCLRNHPD 300
    FILPDRSQVT MAAPFMSSYV KLLVHTTHKR KVHALGGMAA QIPIKDDEAR 350
    NRAALENVTK DKLREVTLGC DSCWVAHPAL VPVVLKVFNE HMKGPNQISL 400
    PPKEPFKPIT QRDLLSPFVP GAKITEQGIR ANIVIGISYI EAWLRNVGCV 450
    PINYLMEDAA TAEVSRTQIW QWVTHGAKTD TGKVITKEYV KQLLDEEYAK 500
    LTKNAKPGNK FKRAFEYFAP EALGEKYSDF VTTLIYDDVT TIGRALPGER 550
    L 551
    Length:551
    Mass (Da):62,449
    Last modified:July 1, 1993 - v1
    Checksum:iA74A587A9F22C8EC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti159 – 1591N → S in PMS2.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13415 Genomic DNA. Translation: BAA02680.1.
    D13416 Genomic DNA. Translation: BAA02681.1.
    PIRiJX0195.
    JX0196.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13415 Genomic DNA. Translation: BAA02680.1 .
    D13416 Genomic DNA. Translation: BAA02681.1 .
    PIRi JX0195.
    JX0196.

    3D structure databases

    ProteinModelPortali Q02216.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .

    Family and domain databases

    InterProi IPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001363. Malate_synth. 1 hit.
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
    PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Presence of two transcribed malate synthase genes in an n-alkane-utilizing yeast, Candida tropicalis."
      Hikada M., Atomi H., Fukuda Y., Aoki A., Hishida T., Teranishi Y., Ueda M., Tanaka A.
      J. Biochem. 110:909-914(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMASY_CANTR
    AccessioniPrimary (citable) accession number: Q02216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two genes for malate synthase in C.tropicalis. The sequence shown is that of PMS1, PMS2 differs at a single position.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3