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Q02216 (MASY_CANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate synthase, glyoxysomal

EC=2.3.3.9
Gene names
Name:PMS1
AND
Name:PMS2
OrganismCandida tropicalis (Yeast)
Taxonomic identifier5482 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.

Subcellular location

Glyoxysome.

Miscellaneous

There are two genes for malate synthase in C.tropicalis. The sequence shown is that of PMS1, PMS2 differs at a single position.

Sequence similarities

Belongs to the malate synthase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmalate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Malate synthase, glyoxysomal
PRO_0000166860

Sites

Active site1741Proton acceptor By similarity
Active site4581Proton donor By similarity

Natural variations

Natural variant1591N → S in PMS2.

Sequences

Sequence LengthMass (Da)Tools
Q02216 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: A74A587A9F22C8EC

FASTA55162,449
        10         20         30         40         50         60 
MSTPFPKTAD KVKGVQILGP IPDEAKHIFN QETLAFVATL HRGFEARRQE LLNNRKEQQK 

        70         80         90        100        110        120 
LRDQGFLPDF LPETEYIRND STWTGPALAP GLIDRRCEIT GPTDRKMVIN ALNSNVATYM 

       130        140        150        160        170        180 
ADFEDSLTPA WKNLVEGQVN LYDAVRRNLS ATINGKQYNL NLEKGRHIPT LIVRPRGWHL 

       190        200        210        220        230        240 
TEKHVLVDGT PVSGGIFDFA VYFYNSAKEA IAQGFGPYFY LPKMEHHLEA KLWNDIFNYS 

       250        260        270        280        290        300 
QDYIGLKRGT IRASVLIETI PAVFQMDEII YQLREHSAGL NCGRWDYIFS YIKCLRNHPD 

       310        320        330        340        350        360 
FILPDRSQVT MAAPFMSSYV KLLVHTTHKR KVHALGGMAA QIPIKDDEAR NRAALENVTK 

       370        380        390        400        410        420 
DKLREVTLGC DSCWVAHPAL VPVVLKVFNE HMKGPNQISL PPKEPFKPIT QRDLLSPFVP 

       430        440        450        460        470        480 
GAKITEQGIR ANIVIGISYI EAWLRNVGCV PINYLMEDAA TAEVSRTQIW QWVTHGAKTD 

       490        500        510        520        530        540 
TGKVITKEYV KQLLDEEYAK LTKNAKPGNK FKRAFEYFAP EALGEKYSDF VTTLIYDDVT 

       550 
TIGRALPGER L 

« Hide

References

[1]"Presence of two transcribed malate synthase genes in an n-alkane-utilizing yeast, Candida tropicalis."
Hikada M., Atomi H., Fukuda Y., Aoki A., Hishida T., Teranishi Y., Ueda M., Tanaka A.
J. Biochem. 110:909-914(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13415 Genomic DNA. Translation: BAA02680.1.
D13416 Genomic DNA. Translation: BAA02681.1.
PIRJX0195.
JX0196.

3D structure databases

ProteinModelPortalQ02216.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00720.

Family and domain databases

InterProIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF001363. Malate_synth. 1 hit.
SUPFAMSSF51645. SSF51645. 1 hit.
TIGRFAMsTIGR01344. malate_syn_A. 1 hit.
PROSITEPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMASY_CANTR
AccessionPrimary (citable) accession number: Q02216
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways