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Q02212 (COX2_PHYME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismPhytophthora megasperma (Potato pink rot fungus)
Taxonomic identifier4788 [NCBI]
Taxonomic lineageEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Cytochrome c oxidase subunit 2
PRO_0000183661

Regions

Topological domain1 – 4343Mitochondrial intermembrane Potential
Transmembrane44 – 6421Helical; Potential
Topological domain65 – 8218Mitochondrial matrix Potential
Transmembrane83 – 10321Helical; Potential
Topological domain104 – 266163Mitochondrial intermembrane Potential

Sites

Metal binding1861Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable
Metal binding2291Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
Q02212 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 86E0DE02C801CB8D

FASTA26630,491
        10         20         30         40         50         60 
MTITNYINNQ FTFLDMAEPW QLGFQDPATP VMEGIINFHH DLMFFLISIV VFVCWMLFRV 

        70         80         90        100        110        120 
ITLFDEKKNK IPATVVHGAT IEIIWTSIPA LILLTVAVPS FALLYSMDEV IDPIITLKVI 

       130        140        150        160        170        180 
GSQWYWSYEY SDNLEFSDEP LIFDSYMIQE DDLAIGQFRI LEVDNRVVVP TNSHIRVLIT 

       190        200        210        220        230        240 
ASDVLHSWAI PSLGIKLDAC PGRLNQTSMF IKREGVFYGQ CSEICGVNHG FMPIVVEAVS 

       250        260 
LEDYLTWLKN KINFDFNVXL IKFYGI 

« Hide

References

[1]"Genic rearrangements in Phytophthora mitochondrial DNA."
Shumard-Hudspeth D.S., Hudspeth M.E.
Curr. Genet. 17:413-415(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 695T.
Tissue: Mycelium.
[2]"Oomycete mtDNA: Phytophthora genes for cytochrome c oxidase use an unmodified genetic code and encode proteins most similar to plants."
Sachay D.J., Hudspeth D.S., Nadler S.A., Hudspeth M.E.
Exp. Mycol. 17:7-23(1993)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 695T.
Tissue: Mycelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04457 Genomic DNA. Translation: AAA32022.2.

3D structure databases

ProteinModelPortalQ02212.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_PHYME
AccessionPrimary (citable) accession number: Q02212
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families