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Q02212

- COX2_PHYME

UniProt

Q02212 - COX2_PHYME

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Phytophthora megasperma (Potato pink rot fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi186 – 1861Copper ACurated
    Metal bindingi221 – 2211Copper ACurated
    Metal bindingi225 – 2251Copper ACurated
    Metal bindingi229 – 2291Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Encoded oniMitochondrion
    OrganismiPhytophthora megasperma (Potato pink rot fungus)
    Taxonomic identifieri4788 [NCBI]
    Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Cytochrome c oxidase subunit 2PRO_0000183661Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ02212.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini65 – 8218Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini104 – 266163Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02212-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTITNYINNQ FTFLDMAEPW QLGFQDPATP VMEGIINFHH DLMFFLISIV    50
    VFVCWMLFRV ITLFDEKKNK IPATVVHGAT IEIIWTSIPA LILLTVAVPS 100
    FALLYSMDEV IDPIITLKVI GSQWYWSYEY SDNLEFSDEP LIFDSYMIQE 150
    DDLAIGQFRI LEVDNRVVVP TNSHIRVLIT ASDVLHSWAI PSLGIKLDAC 200
    PGRLNQTSMF IKREGVFYGQ CSEICGVNHG FMPIVVEAVS LEDYLTWLKN 250
    KINFDFNVXL IKFYGI 266
    Length:266
    Mass (Da):30,491
    Last modified:October 1, 1996 - v1
    Checksum:i86E0DE02C801CB8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04457 Genomic DNA. Translation: AAA32022.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04457 Genomic DNA. Translation: AAA32022.2 .

    3D structure databases

    ProteinModelPortali Q02212.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genic rearrangements in Phytophthora mitochondrial DNA."
      Shumard-Hudspeth D.S., Hudspeth M.E.
      Curr. Genet. 17:413-415(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 695T.
      Tissue: Mycelium.
    2. "Oomycete mtDNA: Phytophthora genes for cytochrome c oxidase use an unmodified genetic code and encode proteins most similar to plants."
      Sachay D.J., Hudspeth D.S., Nadler S.A., Hudspeth M.E.
      Exp. Mycol. 17:7-23(1993)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 695T.
      Tissue: Mycelium.

    Entry informationi

    Entry nameiCOX2_PHYME
    AccessioniPrimary (citable) accession number: Q02212
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3