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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Phytophthora megasperma (Potato pink rot fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi186Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1
Metal bindingi229Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiPhytophthora megasperma (Potato pink rot fungus)
Taxonomic identifieri4788 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43Mitochondrial intermembraneSequence analysisAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 82Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 266Mitochondrial intermembraneSequence analysisAdd BLAST163

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836611 – 266Cytochrome c oxidase subunit 2Add BLAST266

Proteomic databases

PRIDEiQ02212

Structurei

3D structure databases

ProteinModelPortaliQ02212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q02212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITNYINNQ FTFLDMAEPW QLGFQDPATP VMEGIINFHH DLMFFLISIV
60 70 80 90 100
VFVCWMLFRV ITLFDEKKNK IPATVVHGAT IEIIWTSIPA LILLTVAVPS
110 120 130 140 150
FALLYSMDEV IDPIITLKVI GSQWYWSYEY SDNLEFSDEP LIFDSYMIQE
160 170 180 190 200
DDLAIGQFRI LEVDNRVVVP TNSHIRVLIT ASDVLHSWAI PSLGIKLDAC
210 220 230 240 250
PGRLNQTSMF IKREGVFYGQ CSEICGVNHG FMPIVVEAVS LEDYLTWLKN
260
KINFDFNVXL IKFYGI
Length:266
Mass (Da):30,491
Last modified:October 1, 1996 - v1
Checksum:i86E0DE02C801CB8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04457 Genomic DNA Translation: AAA32022.2

Entry informationi

Entry nameiCOX2_PHYME
AccessioniPrimary (citable) accession number: Q02212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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