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Q02211

- COX1_PHYME

UniProt

Q02211 - COX1_PHYME

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Protein

Cytochrome c oxidase subunit 1

Gene
COX1
Organism
Phytophthora megasperma (Potato pink rot fungus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Iron (heme A axial ligand) Inferred
Metal bindingi249 – 2491Copper B Inferred
Metal bindingi253 – 2531Copper B Inferred
Metal bindingi298 – 2981Copper B Inferred
Metal bindingi299 – 2991Copper B Inferred
Metal bindingi384 – 3841Iron (heme A3 axial ligand) Inferred
Metal bindingi386 – 3861Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiPhytophthora megasperma (Potato pink rot fungus)
Taxonomic identifieri4788 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei154 – 17421Helical; Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Transmembranei275 – 29521Helical; Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Reviewed predictionAdd
BLAST
Transmembranei346 – 36621Helical; Reviewed predictionAdd
BLAST
Transmembranei385 – 40521Helical; Reviewed predictionAdd
BLAST
Transmembranei422 – 44221Helical; Reviewed predictionAdd
BLAST
Transmembranei467 – 48721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Cytochrome c oxidase subunit 1PRO_0000183389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki249 ↔ 2531'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ02211.
SMRiQ02211. Positions 13-481.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02211-1 [UniParc]FASTAAdd to Basket

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MNFKNINKCQ LDWLFSTNHK DIGTLYLIFS AFAGIVGTTL SLLIRMELAQ    50
PGNQIFMGNH QLYNVVVTAH AFIMVFFLVM PALIGGFGNW FVPLMIGAPD 100
MAFPRMNNIS FWLLPPALLL LVSSAIVESG AGTGWTVYPP LSSVQAHSGP 150
SVDLAIFSLH LTGISSLLGA INFISTIYNM RAPGLSFHRL PLFVWSVLIT 200
AFLLLLTLPV LAGAITMLLT DRNLNTSFYD PSGGGDPVLY QHLFWFFGHP 250
EVYILILPAF GIISQVAAAF AKKNVFGYLG MVYAMLSIGL LGCIVWAHHM 300
FTVGLDVDTR AYFSAATMII AVPTGIKIFS WLATLWGGSL KFETPLLFVL 350
GFILLFVVGG VTGVAMSNSG LDIAIHDTYY IVGHFHYVLS MGAVFGIFTG 400
FYFWIGKISG RKYPEILGQI HFWLFFIGVN ITFFPMHFLG LAGMPRRIPD 450
FPDAMSGWNA VSSFGSYISF FSALFFFYIV YVTLVYGKKT EN 492
Length:492
Mass (Da):54,325
Last modified:February 1, 1996 - v1
Checksum:i9214D85A2EE32021
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04457 Genomic DNA. Translation: AAA32023.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04457 Genomic DNA. Translation: AAA32023.2 .

3D structure databases

ProteinModelPortali Q02211.
SMRi Q02211. Positions 13-481.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genic rearrangements in Phytophthora mitochondrial DNA."
    Shumard-Hudspeth D.S., Hudspeth M.E.
    Curr. Genet. 17:413-415(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 695T.
  2. "Oomycete mtDNA: Phytophthora genes for cytochrome c oxidase use an unmodified genetic code and encode proteins most similar to plants."
    Sachay D.J., Hudspeth D.S., Nadler S.A., Hudspeth M.E.
    Exp. Mycol. 17:7-23(1993)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 695T.

Entry informationi

Entry nameiCOX1_PHYME
AccessioniPrimary (citable) accession number: Q02211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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