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Q02211

- COX1_PHYME

UniProt

Q02211 - COX1_PHYME

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Phytophthora megasperma (Potato pink rot fungus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi70 – 701Iron (heme A axial ligand)Curated
    Metal bindingi249 – 2491Copper BCurated
    Metal bindingi253 – 2531Copper BCurated
    Metal bindingi298 – 2981Copper BCurated
    Metal bindingi299 – 2991Copper BCurated
    Metal bindingi384 – 3841Iron (heme A3 axial ligand)Curated
    Metal bindingi386 – 3861Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Encoded oniMitochondrion
    OrganismiPhytophthora megasperma (Potato pink rot fungus)
    Taxonomic identifieri4788 [NCBI]
    Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Cytochrome c oxidase subunit 1PRO_0000183389Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki249 ↔ 2531'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ02211.
    SMRiQ02211. Positions 13-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02211-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFKNINKCQ LDWLFSTNHK DIGTLYLIFS AFAGIVGTTL SLLIRMELAQ    50
    PGNQIFMGNH QLYNVVVTAH AFIMVFFLVM PALIGGFGNW FVPLMIGAPD 100
    MAFPRMNNIS FWLLPPALLL LVSSAIVESG AGTGWTVYPP LSSVQAHSGP 150
    SVDLAIFSLH LTGISSLLGA INFISTIYNM RAPGLSFHRL PLFVWSVLIT 200
    AFLLLLTLPV LAGAITMLLT DRNLNTSFYD PSGGGDPVLY QHLFWFFGHP 250
    EVYILILPAF GIISQVAAAF AKKNVFGYLG MVYAMLSIGL LGCIVWAHHM 300
    FTVGLDVDTR AYFSAATMII AVPTGIKIFS WLATLWGGSL KFETPLLFVL 350
    GFILLFVVGG VTGVAMSNSG LDIAIHDTYY IVGHFHYVLS MGAVFGIFTG 400
    FYFWIGKISG RKYPEILGQI HFWLFFIGVN ITFFPMHFLG LAGMPRRIPD 450
    FPDAMSGWNA VSSFGSYISF FSALFFFYIV YVTLVYGKKT EN 492
    Length:492
    Mass (Da):54,325
    Last modified:February 1, 1996 - v1
    Checksum:i9214D85A2EE32021
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04457 Genomic DNA. Translation: AAA32023.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04457 Genomic DNA. Translation: AAA32023.2 .

    3D structure databases

    ProteinModelPortali Q02211.
    SMRi Q02211. Positions 13-481.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genic rearrangements in Phytophthora mitochondrial DNA."
      Shumard-Hudspeth D.S., Hudspeth M.E.
      Curr. Genet. 17:413-415(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 695T.
    2. "Oomycete mtDNA: Phytophthora genes for cytochrome c oxidase use an unmodified genetic code and encode proteins most similar to plants."
      Sachay D.J., Hudspeth D.S., Nadler S.A., Hudspeth M.E.
      Exp. Mycol. 17:7-23(1993)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 695T.

    Entry informationi

    Entry nameiCOX1_PHYME
    AccessioniPrimary (citable) accession number: Q02211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3