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Q02211

- COX1_PHYME

UniProt

Q02211 - COX1_PHYME

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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Phytophthora megasperma (Potato pink rot fungus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Iron (heme A axial ligand)Curated
Metal bindingi249 – 2491Copper BCurated
Metal bindingi253 – 2531Copper BCurated
Metal bindingi298 – 2981Copper BCurated
Metal bindingi299 – 2991Copper BCurated
Metal bindingi384 – 3841Iron (heme A3 axial ligand)Curated
Metal bindingi386 – 3861Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiPhytophthora megasperma (Potato pink rot fungus)
Taxonomic identifieri4788 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Transmembranei422 – 44221HelicalSequence AnalysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Cytochrome c oxidase subunit 1PRO_0000183389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki249 ↔ 2531'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ02211.
SMRiQ02211. Positions 13-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02211-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFKNINKCQ LDWLFSTNHK DIGTLYLIFS AFAGIVGTTL SLLIRMELAQ
60 70 80 90 100
PGNQIFMGNH QLYNVVVTAH AFIMVFFLVM PALIGGFGNW FVPLMIGAPD
110 120 130 140 150
MAFPRMNNIS FWLLPPALLL LVSSAIVESG AGTGWTVYPP LSSVQAHSGP
160 170 180 190 200
SVDLAIFSLH LTGISSLLGA INFISTIYNM RAPGLSFHRL PLFVWSVLIT
210 220 230 240 250
AFLLLLTLPV LAGAITMLLT DRNLNTSFYD PSGGGDPVLY QHLFWFFGHP
260 270 280 290 300
EVYILILPAF GIISQVAAAF AKKNVFGYLG MVYAMLSIGL LGCIVWAHHM
310 320 330 340 350
FTVGLDVDTR AYFSAATMII AVPTGIKIFS WLATLWGGSL KFETPLLFVL
360 370 380 390 400
GFILLFVVGG VTGVAMSNSG LDIAIHDTYY IVGHFHYVLS MGAVFGIFTG
410 420 430 440 450
FYFWIGKISG RKYPEILGQI HFWLFFIGVN ITFFPMHFLG LAGMPRRIPD
460 470 480 490
FPDAMSGWNA VSSFGSYISF FSALFFFYIV YVTLVYGKKT EN
Length:492
Mass (Da):54,325
Last modified:February 1, 1996 - v1
Checksum:i9214D85A2EE32021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04457 Genomic DNA. Translation: AAA32023.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04457 Genomic DNA. Translation: AAA32023.2 .

3D structure databases

ProteinModelPortali Q02211.
SMRi Q02211. Positions 13-481.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genic rearrangements in Phytophthora mitochondrial DNA."
    Shumard-Hudspeth D.S., Hudspeth M.E.
    Curr. Genet. 17:413-415(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 695T.
  2. "Oomycete mtDNA: Phytophthora genes for cytochrome c oxidase use an unmodified genetic code and encode proteins most similar to plants."
    Sachay D.J., Hudspeth D.S., Nadler S.A., Hudspeth M.E.
    Exp. Mycol. 17:7-23(1993)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 695T.

Entry informationi

Entry nameiCOX1_PHYME
AccessioniPrimary (citable) accession number: Q02211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3