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Protein

Protein MEH1

Gene

MEH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Component of the EGO complex, a complex involved in the regulation of microautophagy.2 Publications

Miscellaneous

Present with 2740 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cellular response to amino acid stimulus Source: InterPro
  • cholesterol homeostasis Source: InterPro
  • endosome localization Source: InterPro
  • lysosomal microautophagy Source: SGD
  • lysosome organization Source: InterPro
  • positive regulation of MAPK cascade Source: InterPro
  • positive regulation of TOR signaling Source: InterPro
  • protein localization to vacuole Source: SGD
  • protein transport Source: UniProtKB-KW
  • regulation of receptor recycling Source: InterPro
  • vacuolar acidification Source: SGD

Keywordsi

Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31985-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MEH1
Alternative name(s):
EGO complex subunit 1
GSE complex subunit 2
Gene namesi
Name:MEH1
Synonyms:EGO1, GSE2
Ordered Locus Names:YKR007W
ORF Names:YK106
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR007W.
SGDiS000001715. MEH1.

Subcellular locationi

GO - Cellular componenti

  • EGO complex Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • late endosome membrane Source: SGD
  • Ragulator complex Source: InterPro

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00002031932 – 184Protein MEH1Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi7S-palmitoyl cysteine1 Publication1
Lipidationi8S-palmitoyl cysteine1 Publication1
Modified residuei146PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ02205.
PRIDEiQ02205.

PTM databases

iPTMnetiQ02205.
SwissPalmiQ02205.

Interactioni

Subunit structurei

Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Component of the EGO complex, at least composed of GTR2, SLM4 and MEH1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34139. 325 interactors.
DIPiDIP-1922N.
IntActiQ02205. 13 interactors.
MINTiMINT-400825.

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi150 – 152Combined sources3
Helixi154 – 171Combined sources18
Beta strandi180 – 182Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XPMX-ray2.40A146-184[»]
ProteinModelPortaliQ02205.
SMRiQ02205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 71Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000113555.
InParanoidiQ02205.
OrthoDBiEOG092C5W6L.

Family and domain databases

InterProiView protein in InterPro
IPR028209. LAMTOR1/MEH1.
PfamiView protein in Pfam
PF15454. LAMTOR. 1 hit.
SMARTiView protein in SMART
SM01262. LAMTOR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVLSCCRN HSGEENEALL REQQAGYGSQ GNANDEYDAE QMRLKEHEHE
60 70 80 90 100
QKLLAREQEL RDIVANTNDK LIDISMINNS GIVIQGTDLQ EALDKRQQEE
110 120 130 140 150
GGDSREDERS AGDDNLSGHS VPSSGSAQAT THQTAPRTNT FTLLTSPDSA
160 170 180
KISKEQLKKL HSNILNEIFS QSQVNKPGPL TVPF
Length:184
Mass (Da):20,242
Last modified:July 1, 1993 - v1
Checksum:i995DD1E68331D050
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65124 Genomic DNA. Translation: CAA46245.1.
Z28232 Genomic DNA. Translation: CAA82077.1.
BK006944 Genomic DNA. Translation: DAA09163.1.
PIRiS25815.
RefSeqiNP_012932.1. NM_001179797.1.

Genome annotation databases

EnsemblFungiiYKR007W; YKR007W; YKR007W.
GeneIDi853876.
KEGGisce:YKR007W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65124 Genomic DNA. Translation: CAA46245.1.
Z28232 Genomic DNA. Translation: CAA82077.1.
BK006944 Genomic DNA. Translation: DAA09163.1.
PIRiS25815.
RefSeqiNP_012932.1. NM_001179797.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XPMX-ray2.40A146-184[»]
ProteinModelPortaliQ02205.
SMRiQ02205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34139. 325 interactors.
DIPiDIP-1922N.
IntActiQ02205. 13 interactors.
MINTiMINT-400825.

PTM databases

iPTMnetiQ02205.
SwissPalmiQ02205.

Proteomic databases

MaxQBiQ02205.
PRIDEiQ02205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR007W; YKR007W; YKR007W.
GeneIDi853876.
KEGGisce:YKR007W.

Organism-specific databases

EuPathDBiFungiDB:YKR007W.
SGDiS000001715. MEH1.

Phylogenomic databases

HOGENOMiHOG000113555.
InParanoidiQ02205.
OrthoDBiEOG092C5W6L.

Enzyme and pathway databases

BioCyciYEAST:G3O-31985-MONOMER.

Miscellaneous databases

PROiPR:Q02205.

Family and domain databases

InterProiView protein in InterPro
IPR028209. LAMTOR1/MEH1.
PfamiView protein in Pfam
PF15454. LAMTOR. 1 hit.
SMARTiView protein in SMART
SM01262. LAMTOR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMEH1_YEAST
AccessioniPrimary (citable) accession number: Q02205
Secondary accession number(s): D6VX73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 12, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.