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Q021Y7

- SYC_SOLUE

UniProt

Q021Y7 - SYC_SOLUE

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Protein
Cysteine--tRNA ligase
Gene
cysS, Acid_3249
Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Zinc By similarity
Metal bindingi210 – 2101Zinc By similarity
Metal bindingi235 – 2351Zinc By similarity
Metal bindingi239 – 2391Zinc By similarity
Binding sitei270 – 2701ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-3278-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:Acid_3249
OrganismiSolibacter usitatus (strain Ellin6076)
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
ProteomesiUP000000671: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Cysteine--tRNA ligaseUniRule annotation
PRO_1000006613Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi234267.Acid_3249.

Structurei

3D structure databases

ProteinModelPortaliQ021Y7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi31 – 4111"HIGH" regionUniRule annotation
Add
BLAST
Motifi267 – 2715"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0215.
HOGENOMiHOG000245250.
KOiK01883.
OMAiMHADFDA.
OrthoDBiEOG6RVFXC.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q021Y7-1 [UniParc]FASTAAdd to Basket

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MALRFYNTLS QQVEEFTPAS DNTVRMYTCG PTVYDFAHIG NFRTFTFVDL    50
LRKVLRANGF QLNHVMNITD VDDKIIRNAV AQHQSLEQYT KIYTEAFLED 100
CKMLRLERPE RIAPATEHIH DMVSAIERLG DSQHTYASDG SVYFKIASFP 150
GYGKLSHNDF SGNLAGARVD VDEYEKADAR DFALWKTPKE GEPFWDTTIG 200
PGRPGWHIEC SVMAIKYLGE TLDIHAGGID LVFPHHENEI AQSESLTGKL 250
FSRFWLHAEF LMVEGQKMSK SLGNYYTLRD LVAKGYEPES IRYLLASVPY 300
RKSLNFTLDG LKAARIAIER LRNFKRRLET EPFAEGLSAI LAERTAQASQ 350
AFIGGLNEDL NTAEALASVF EYVRDLNSAM DSGEFRAGNT TAALEFLARF 400
DSIFDVLKPT AKAGELSDAE IDAQIAARAA AKKSRDFALA DQIRDQLLAQ 450
GIILEDTKSG VRWKRK 466
Length:466
Mass (Da):52,429
Last modified:November 14, 2006 - v1
Checksum:iDC092EE902A34D49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ84226.1.
RefSeqiYP_824511.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ84226; ABJ84226; Acid_3249.
GeneIDi4429019.
KEGGisus:Acid_3249.
PATRICi32008854. VBICanSol30224_3397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ84226.1 .
RefSeqi YP_824511.1. NC_008536.1.

3D structure databases

ProteinModelPortali Q021Y7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234267.Acid_3249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ84226 ; ABJ84226 ; Acid_3249 .
GeneIDi 4429019.
KEGGi sus:Acid_3249.
PATRICi 32008854. VBICanSol30224_3397.

Phylogenomic databases

eggNOGi COG0215.
HOGENOMi HOG000245250.
KOi K01883.
OMAi MHADFDA.
OrthoDBi EOG6RVFXC.

Enzyme and pathway databases

BioCyci SUSI234267:GHSK-3278-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00041. Cys_tRNA_synth.
InterProi IPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR10890. PTHR10890. 1 hit.
Pfami PF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00983. TRNASYNTHCYS.
SMARTi SM00840. DALR_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00435. cysS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin6076.

Entry informationi

Entry nameiSYC_SOLUE
AccessioniPrimary (citable) accession number: Q021Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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