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Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291ZincUniRule annotation
Metal bindingi210 – 2101ZincUniRule annotation
Metal bindingi235 – 2351ZincUniRule annotation
Metal bindingi239 – 2391ZincUniRule annotation
Binding sitei270 – 2701ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-3278-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
Alternative name(s):
Cysteinyl-tRNA synthetaseUniRule annotation
Short name:
CysRSUniRule annotation
Gene namesi
Name:cysSUniRule annotation
Ordered Locus Names:Acid_3249
OrganismiSolibacter usitatus (strain Ellin6076)
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
ProteomesiUP000000671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Cysteine--tRNA ligasePRO_1000006613Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi234267.Acid_3249.

Structurei

3D structure databases

ProteinModelPortaliQ021Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi31 – 4111"HIGH" regionAdd
BLAST
Motifi267 – 2715"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0215.
HOGENOMiHOG000245250.
KOiK01883.
OMAiQIDIHAG.
OrthoDBiEOG6RVFXC.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q021Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRFYNTLS QQVEEFTPAS DNTVRMYTCG PTVYDFAHIG NFRTFTFVDL
60 70 80 90 100
LRKVLRANGF QLNHVMNITD VDDKIIRNAV AQHQSLEQYT KIYTEAFLED
110 120 130 140 150
CKMLRLERPE RIAPATEHIH DMVSAIERLG DSQHTYASDG SVYFKIASFP
160 170 180 190 200
GYGKLSHNDF SGNLAGARVD VDEYEKADAR DFALWKTPKE GEPFWDTTIG
210 220 230 240 250
PGRPGWHIEC SVMAIKYLGE TLDIHAGGID LVFPHHENEI AQSESLTGKL
260 270 280 290 300
FSRFWLHAEF LMVEGQKMSK SLGNYYTLRD LVAKGYEPES IRYLLASVPY
310 320 330 340 350
RKSLNFTLDG LKAARIAIER LRNFKRRLET EPFAEGLSAI LAERTAQASQ
360 370 380 390 400
AFIGGLNEDL NTAEALASVF EYVRDLNSAM DSGEFRAGNT TAALEFLARF
410 420 430 440 450
DSIFDVLKPT AKAGELSDAE IDAQIAARAA AKKSRDFALA DQIRDQLLAQ
460
GIILEDTKSG VRWKRK
Length:466
Mass (Da):52,429
Last modified:November 14, 2006 - v1
Checksum:iDC092EE902A34D49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000473 Genomic DNA. Translation: ABJ84226.1.
RefSeqiWP_011684988.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ84226; ABJ84226; Acid_3249.
KEGGisus:Acid_3249.
PATRICi32008854. VBICanSol30224_3397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000473 Genomic DNA. Translation: ABJ84226.1.
RefSeqiWP_011684988.1. NC_008536.1.

3D structure databases

ProteinModelPortaliQ021Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi234267.Acid_3249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ84226; ABJ84226; Acid_3249.
KEGGisus:Acid_3249.
PATRICi32008854. VBICanSol30224_3397.

Phylogenomic databases

eggNOGiCOG0215.
HOGENOMiHOG000245250.
KOiK01883.
OMAiQIDIHAG.
OrthoDBiEOG6RVFXC.

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-3278-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin6076.

Entry informationi

Entry nameiSYC_SOLUE
AccessioniPrimary (citable) accession number: Q021Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.