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Q021Y7

- SYC_SOLUE

UniProt

Q021Y7 - SYC_SOLUE

Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi29 – 291ZincUniRule annotation
    Metal bindingi210 – 2101ZincUniRule annotation
    Metal bindingi235 – 2351ZincUniRule annotation
    Metal bindingi239 – 2391ZincUniRule annotation
    Binding sitei270 – 2701ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSUSI234267:GHSK-3278-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
    Alternative name(s):
    Cysteinyl-tRNA synthetaseUniRule annotation
    Short name:
    CysRSUniRule annotation
    Gene namesi
    Name:cysSUniRule annotation
    Ordered Locus Names:Acid_3249
    OrganismiSolibacter usitatus (strain Ellin6076)
    Taxonomic identifieri234267 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
    ProteomesiUP000000671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Cysteine--tRNA ligasePRO_1000006613Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi234267.Acid_3249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ021Y7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi31 – 4111"HIGH" regionAdd
    BLAST
    Motifi267 – 2715"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0215.
    HOGENOMiHOG000245250.
    KOiK01883.
    OMAiMHADFDA.
    OrthoDBiEOG6RVFXC.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00041. Cys_tRNA_synth.
    InterProiIPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR10890. PTHR10890. 1 hit.
    PfamiPF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view]
    PRINTSiPR00983. TRNASYNTHCYS.
    SMARTiSM00840. DALR_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00435. cysS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q021Y7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRFYNTLS QQVEEFTPAS DNTVRMYTCG PTVYDFAHIG NFRTFTFVDL    50
    LRKVLRANGF QLNHVMNITD VDDKIIRNAV AQHQSLEQYT KIYTEAFLED 100
    CKMLRLERPE RIAPATEHIH DMVSAIERLG DSQHTYASDG SVYFKIASFP 150
    GYGKLSHNDF SGNLAGARVD VDEYEKADAR DFALWKTPKE GEPFWDTTIG 200
    PGRPGWHIEC SVMAIKYLGE TLDIHAGGID LVFPHHENEI AQSESLTGKL 250
    FSRFWLHAEF LMVEGQKMSK SLGNYYTLRD LVAKGYEPES IRYLLASVPY 300
    RKSLNFTLDG LKAARIAIER LRNFKRRLET EPFAEGLSAI LAERTAQASQ 350
    AFIGGLNEDL NTAEALASVF EYVRDLNSAM DSGEFRAGNT TAALEFLARF 400
    DSIFDVLKPT AKAGELSDAE IDAQIAARAA AKKSRDFALA DQIRDQLLAQ 450
    GIILEDTKSG VRWKRK 466
    Length:466
    Mass (Da):52,429
    Last modified:November 14, 2006 - v1
    Checksum:iDC092EE902A34D49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000473 Genomic DNA. Translation: ABJ84226.1.
    RefSeqiYP_824511.1. NC_008536.1.

    Genome annotation databases

    EnsemblBacteriaiABJ84226; ABJ84226; Acid_3249.
    GeneIDi4429019.
    KEGGisus:Acid_3249.
    PATRICi32008854. VBICanSol30224_3397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000473 Genomic DNA. Translation: ABJ84226.1 .
    RefSeqi YP_824511.1. NC_008536.1.

    3D structure databases

    ProteinModelPortali Q021Y7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 234267.Acid_3249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ84226 ; ABJ84226 ; Acid_3249 .
    GeneIDi 4429019.
    KEGGi sus:Acid_3249.
    PATRICi 32008854. VBICanSol30224_3397.

    Phylogenomic databases

    eggNOGi COG0215.
    HOGENOMi HOG000245250.
    KOi K01883.
    OMAi MHADFDA.
    OrthoDBi EOG6RVFXC.

    Enzyme and pathway databases

    BioCyci SUSI234267:GHSK-3278-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00041. Cys_tRNA_synth.
    InterProi IPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR10890. PTHR10890. 1 hit.
    Pfami PF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view ]
    PRINTSi PR00983. TRNASYNTHCYS.
    SMARTi SM00840. DALR_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00435. cysS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ellin6076.

    Entry informationi

    Entry nameiSYC_SOLUE
    AccessioniPrimary (citable) accession number: Q021Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3