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Q021Y7 (SYC_SOLUE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine--tRNA ligase

EC=6.1.1.16
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name=CysRS
Gene names
Name:cysS
Ordered Locus Names:Acid_3249
OrganismSolibacter usitatus (strain Ellin6076) [Complete proteome] [HAMAP]
Taxonomic identifier234267 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP-Rule MF_00041

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00041

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00041

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00041.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcysteinyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cysteine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Cysteine--tRNA ligase HAMAP-Rule MF_00041
PRO_1000006613

Regions

Motif31 – 4111"HIGH" region HAMAP-Rule MF_00041
Motif267 – 2715"KMSKS" region HAMAP-Rule MF_00041

Sites

Metal binding291Zinc By similarity
Metal binding2101Zinc By similarity
Metal binding2351Zinc By similarity
Metal binding2391Zinc By similarity
Binding site2701ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q021Y7 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: DC092EE902A34D49

FASTA46652,429
        10         20         30         40         50         60 
MALRFYNTLS QQVEEFTPAS DNTVRMYTCG PTVYDFAHIG NFRTFTFVDL LRKVLRANGF 

        70         80         90        100        110        120 
QLNHVMNITD VDDKIIRNAV AQHQSLEQYT KIYTEAFLED CKMLRLERPE RIAPATEHIH 

       130        140        150        160        170        180 
DMVSAIERLG DSQHTYASDG SVYFKIASFP GYGKLSHNDF SGNLAGARVD VDEYEKADAR 

       190        200        210        220        230        240 
DFALWKTPKE GEPFWDTTIG PGRPGWHIEC SVMAIKYLGE TLDIHAGGID LVFPHHENEI 

       250        260        270        280        290        300 
AQSESLTGKL FSRFWLHAEF LMVEGQKMSK SLGNYYTLRD LVAKGYEPES IRYLLASVPY 

       310        320        330        340        350        360 
RKSLNFTLDG LKAARIAIER LRNFKRRLET EPFAEGLSAI LAERTAQASQ AFIGGLNEDL 

       370        380        390        400        410        420 
NTAEALASVF EYVRDLNSAM DSGEFRAGNT TAALEFLARF DSIFDVLKPT AKAGELSDAE 

       430        440        450        460 
IDAQIAARAA AKKSRDFALA DQIRDQLLAQ GIILEDTKSG VRWKRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000473 Genomic DNA. Translation: ABJ84226.1.
RefSeqYP_824511.1. NC_008536.1.

3D structure databases

ProteinModelPortalQ021Y7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING234267.Acid_3249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ84226; ABJ84226; Acid_3249.
GeneID4429019.
KEGGsus:Acid_3249.
PATRIC32008854. VBICanSol30224_3397.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0215.
HOGENOMHOG000245250.
KOK01883.
OMAQIDIHAG.
OrthoDBEOG6RVFXC.
ProtClustDBPRK00260.

Enzyme and pathway databases

BioCycSUSI234267:GHSK-3278-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00041. Cys_tRNA_synth.
InterProIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR10890. PTHR10890. 1 hit.
PfamPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
SMARTSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00435. cysS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYC_SOLUE
AccessionPrimary (citable) accession number: Q021Y7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries