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Protein

Morphine 6-dehydrogenase

Gene

morA

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Oxidizes only the C-6 hydroxy group of morphine and codeine.

Catalytic activityi

Morphine + NAD(P)+ = morphinone + NAD(P)H.

Pathwayi: codeine degradation

This protein is involved in the pathway codeine degradation, which is part of Alkaloid degradation.
View all proteins of this organism that are known to be involved in the pathway codeine degradation and in Alkaloid degradation.

Pathwayi: morphine degradation

This protein is involved in the pathway morphine degradation, which is part of Alkaloid degradation.
View all proteins of this organism that are known to be involved in the pathway morphine degradation and in Alkaloid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52Proton donorBy similarity1
Binding sitei110SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 22NADPSequence analysis10

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Alkaloid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00317.
UPA00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Morphine 6-dehydrogenase (EC:1.1.1.218)
Alternative name(s):
Naloxone reductase
Gene namesi
Name:morA
Encoded oniPlasmid pMDH7.20 Publication
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001246752 – 296Morphine 6-dehydrogenaseAdd BLAST295

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ02198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

KOiK03378.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKSPLINL NNGVKMPALG LGVFAASAEE TASAIASAIS SGYRLIDTAR
60 70 80 90 100
SYNNEAQVGE GIRNSGVDRA EMFVTTKLFN CDYGYERALR AFDESLGRLG
110 120 130 140 150
LDYVDLYLLH WPTKDWNATI QSWKAAEKIL GDGRARAIGV CNFLEDQLDE
160 170 180 190 200
LIAASDVVPA VNQIELHPYF AQKPLLAKNR ALGIVTEAWS PIGGAINDGD
210 220 230 240 250
GDNHGGRKHP LTDPVITTIA EAHGRSAAQV ILRWHFQNDV VAIPKSVNPE
260 270 280 290
RIAKNIDVFD FALSDAEMAQ LDELDTGVRI GPDPRDVDTS SFAEFV
Length:296
Mass (Da):32,124
Last modified:January 23, 2007 - v3
Checksum:iCC16A1DEAE804AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94775 Genomic DNA. Translation: AAB17356.1.

Genome annotation databases

KEGGiag:AAB17356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94775 Genomic DNA. Translation: AAB17356.1.

3D structure databases

ProteinModelPortaliQ02198.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAB17356.

Phylogenomic databases

KOiK03378.

Enzyme and pathway databases

UniPathwayiUPA00317.
UPA00318.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMORA_PSEPU
AccessioniPrimary (citable) accession number: Q02198
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.