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Reviewed, UniProtKB/Swiss-Prot Q02195 (FGF7_RAT)

Last modified November 25, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Keratinocyte growth factor
      Short name=KGF
Alternative name(s):
    Fibroblast growth factor 7
      Short name=FGF-7
    Heparin-binding growth factor 7
      Short name=HBGF-7
Gene names
Name: Fgf7
Synonyms: Fgf-7, Kgf
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Subunit structure

Interacts with FGFBP1 By similarity.

Sequence similarities

Belongs to the heparin-binding growth factors family.

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Ontologies

Keywords

   DomainSignal
   Molecular functionGrowth factor
Mitogen
   PTMGlycoprotein
   Technical term3D-structure

Gene Ontology (GO)

   Molecular functiongrowth factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 By similarity
Chain32 – 194163Keratinocyte growth factor
PRO_0000008968

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential

Secondary structure

1 ......................... 194
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q02195-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 5242CDAC305CC8C1

FASTA19422,268
        10         20         30         40         50         60 
MRKWILTRIL PTPLYRPCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MRNSYNIMEI MTVAVGIVAI KGVESEYYLA 

       130        140        150        160        170        180 
MNKQGELYAK KECNEDCNFK ELILENHYNT SASAKWTHSG GEMFVALNQK GLPVKGKKTK 

       190 
KEQKTAHFLP MAIT

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References

[1]"Sequence of rat keratinocyte growth factor (heparin-binding growth factor type 7)."
Yan G., Nikolaropoulos S., Wang F., McKeehan W.L.
In Vitro Cell. Dev. Biol. 27A:437-438(1991) [PubMed: 1869483] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The crystal structures of rat fibroblast growth factor 7 and rat / human fibroblast growth factor 1 chimera."
Ye S., Luo Y., Lu W., Jones R.B., Linhardt R.J., Kan M., McKeehan W.L., Pelletier H.
Submitted (JUN-1999) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 55-294.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X56551 mRNA. Translation: CAA39892.1.
PIRS26049.
RefSeqNP_071518.1.
UniGeneRn.98842

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1QQKX-ray3.10A/B55-194[»]
1QQLX-ray2.30A55-171[»]
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000009425. Rattus norvegicus. [Contig view]
GeneID29348.
KEGGrno:29348.

Organism-specific databases

RGD61805. Fgf7.

Phylogenomic databases

HOVERGENQ02195.

Gene expression databases

ArrayExpressQ02195.
GermOnlineENSRNOG00000009425. Rattus norvegicus.

Family and domain databases

InterProIPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
ProDomPD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio608848.

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Entry information

Entry nameFGF7_RAT
AccessionPrimary (citable) accession number: Q02195
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 25, 2008
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents