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Protein

Fibroblast growth factor 7

Gene

Fgf7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

GO - Molecular functioni

  • growth factor activity Source: RGD
  • heparin binding Source: RGD
  • type 2 fibroblast growth factor receptor binding Source: RGD

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • lung development Source: RGD
  • ovarian follicle development Source: RGD
  • phosphatidylcholine biosynthetic process Source: RGD
  • phospholipid biosynthetic process Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of epithelial cell proliferation Source: RGD
  • surfactant homeostasis Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Gene namesi
Name:Fgf7
Synonyms:Fgf-7, Kgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61805. Fgf7.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000000896832 – 194Fibroblast growth factor 7Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ02195.

PTM databases

iPTMnetiQ02195.
PhosphoSitePlusiQ02195.

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2 (By similarity). Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • type 2 fibroblast growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012700.

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi64 – 67Combined sources4
Turni72 – 74Combined sources3
Beta strandi75 – 79Combined sources5
Beta strandi85 – 89Combined sources5
Beta strandi98 – 104Combined sources7
Beta strandi107 – 112Combined sources6
Turni113 – 115Combined sources3
Turni145 – 147Combined sources3
Beta strandi152 – 154Combined sources3
Helixi176 – 178Combined sources3
Beta strandi188 – 191Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QQKX-ray3.10A/B55-194[»]
1QQLX-ray2.30A55-130[»]
ProteinModelPortaliQ02195.
SMRiQ02195.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02195.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ02195.
KOiK04358.
PhylomeDBiQ02195.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWILTRIL PTPLYRPCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MRNSYNIMEI
110 120 130 140 150
MTVAVGIVAI KGVESEYYLA MNKQGELYAK KECNEDCNFK ELILENHYNT
160 170 180 190
SASAKWTHSG GEMFVALNQK GLPVKGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,268
Last modified:July 1, 1993 - v1
Checksum:i5242CDAC305CC8C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56551 mRNA. Translation: CAA39892.1.
PIRiS26049.
RefSeqiNP_071518.1. NM_022182.1.
UniGeneiRn.98842.

Genome annotation databases

GeneIDi29348.
KEGGirno:29348.
UCSCiRGD:61805. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56551 mRNA. Translation: CAA39892.1.
PIRiS26049.
RefSeqiNP_071518.1. NM_022182.1.
UniGeneiRn.98842.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QQKX-ray3.10A/B55-194[»]
1QQLX-ray2.30A55-130[»]
ProteinModelPortaliQ02195.
SMRiQ02195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012700.

PTM databases

iPTMnetiQ02195.
PhosphoSitePlusiQ02195.

Proteomic databases

PaxDbiQ02195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29348.
KEGGirno:29348.
UCSCiRGD:61805. rat.

Organism-specific databases

CTDi2252.
RGDi61805. Fgf7.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ02195.
KOiK04358.
PhylomeDBiQ02195.

Miscellaneous databases

EvolutionaryTraceiQ02195.
PROiQ02195.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF7_RAT
AccessioniPrimary (citable) accession number: Q02195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.