Keratinocyte growth factor precursor - Rattus norvegicus (Rat)

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Reviewed, UniProtKB/Swiss-Prot Q02195 (FGF7_RAT)

Last modified June 16, 2009. Version 76. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Keratinocyte growth factor
      Short name=KGF
Alternative name(s):
    Fibroblast growth factor 7
      Short name=FGF-7
    Heparin-binding growth factor 7
      Short name=HBGF-7

Gene names

Name:	Fgf7
Synonyms:	Fgf-7, Kgf

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Subunit structure	Interacts with FGFBP1 By similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

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Ontologies

Keywords
Domain	Signal
Molecular function	Growth factor Mitogen
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell proliferation Inferred from electronic annotation. Source: UniProtKB-KW lung development Inferred from mutant phenotype. Source: RGD ovarian follicle development Inferred from mutant phenotype. Source: RGD phosphatidylcholine biosynthetic process Inferred from mutant phenotype. Source: RGD positive regulation of epithelial cell proliferation Inferred from direct assay. Source: RGD surfactant homeostasis Inferred from mutant phenotype. Source: RGD wound healing Inferred from direct assay. Source: RGD
Cellular component	extracellular space Inferred from direct assay. Source: RGD
Molecular function	growth factor activity Inferred from mutant phenotype. Source: RGD heparin binding Inferred from direct assay. Source: RGD type 2 fibroblast growth factor receptor binding Inferred from direct assay. Source: RGD
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 31

By similarity

Chain

32 – 194

163

Keratinocyte growth factor

PRO_0000008968

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

149

N-linked (GlcNAc...) Potential

Secondary structure

194

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q02195-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 5242CDAC305CC8C1
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FASTA

194

22,268

        10         20         30         40         50         60 
MRKWILTRIL PTPLYRPCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE RHTRSYDYME 

        70         80         90        100        110        120 
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MRNSYNIMEI MTVAVGIVAI KGVESEYYLA 

       130        140        150        160        170        180 
MNKQGELYAK KECNEDCNFK ELILENHYNT SASAKWTHSG GEMFVALNQK GLPVKGKKTK 

       190 
KEQKTAHFLP MAIT

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References

[1]	"Sequence of rat keratinocyte growth factor (heparin-binding growth factor type 7)." Yan G., Nikolaropoulos S., Wang F., McKeehan W.L. In Vitro Cell. Dev. Biol. 27A:437-438(1991) [PubMed: 1869483] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The crystal structures of rat fibroblast growth factor 7 and rat / human fibroblast growth factor 1 chimera." Ye S., Luo Y., Lu W., Jones R.B., Linhardt R.J., Kan M., McKeehan W.L., Pelletier H. Submitted (JUN-1999) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 55-294.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

X56551 mRNA. Translation: CAA39892.1.

IPI

IPI00204091.

PIR

S26049.

RefSeq

NP_071518.1.

UniGene

Rn.98842

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QQK	X-ray	3.10	A/B	55-194	[»]
1QQL	X-ray	2.30	A	55-150	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSRNOG00000009425. Rattus norvegicus. [Contig view]

GeneID

29348.

KEGG

rno:29348.

Organism-specific databases

RGD

61805. Fgf7.

Phylogenomic databases

HOVERGEN

Q02195.

Gene expression databases

ArrayExpress

Q02195.

GermOnline

ENSRNOG00000009425. Rattus norvegicus.

Family and domain databases

InterPro

IPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]

PANTHER

PTHR11486. IL1_HBGF. 1 hit.

Pfam

PF00167. FGF. 1 hit.
[Graphical view]

PRINTS

PR00263. HBGFFGF.
PR00262. IL1HBGF.

ProDom

PD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00442. FGF. 1 hit.
[Graphical view]

PROSITE

PS00247. HBGF_FGF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

608848.

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Entry information

Entry name

FGF7_RAT

Accession

Primary (citable) accession number: Q02195

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families