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Protein

Fibroblast growth factor 7

Gene

Fgf7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

GO - Molecular functioni

  • growth factor activity Source: RGD
  • heparin binding Source: RGD
  • type 2 fibroblast growth factor receptor binding Source: RGD

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • lung development Source: RGD
  • ovarian follicle development Source: RGD
  • phosphatidylcholine biosynthetic process Source: RGD
  • phospholipid biosynthetic process Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of epithelial cell proliferation Source: RGD
  • surfactant homeostasis Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Gene namesi
Name:Fgf7
Synonyms:Fgf-7, Kgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61805. Fgf7.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131By similarityAdd
BLAST
Chaini32 – 194163Fibroblast growth factor 7PRO_0000008968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ02195.

PTM databases

iPTMnetiQ02195.
PhosphoSiteiQ02195.

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2 (By similarity). Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • type 2 fibroblast growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012700.

Structurei

Secondary structure

1
194
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi64 – 674Combined sources
Turni72 – 743Combined sources
Beta strandi75 – 795Combined sources
Beta strandi85 – 895Combined sources
Beta strandi98 – 1047Combined sources
Beta strandi107 – 1126Combined sources
Turni113 – 1153Combined sources
Turni145 – 1473Combined sources
Beta strandi152 – 1543Combined sources
Helixi176 – 1783Combined sources
Beta strandi188 – 1914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QQKX-ray3.10A/B55-194[»]
1QQLX-ray2.30A55-130[»]
ProteinModelPortaliQ02195.
SMRiQ02195. Positions 63-194.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02195.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ02195.
KOiK04358.
PhylomeDBiQ02195.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWILTRIL PTPLYRPCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MRNSYNIMEI
110 120 130 140 150
MTVAVGIVAI KGVESEYYLA MNKQGELYAK KECNEDCNFK ELILENHYNT
160 170 180 190
SASAKWTHSG GEMFVALNQK GLPVKGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,268
Last modified:July 1, 1993 - v1
Checksum:i5242CDAC305CC8C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56551 mRNA. Translation: CAA39892.1.
PIRiS26049.
RefSeqiNP_071518.1. NM_022182.1.
UniGeneiRn.98842.

Genome annotation databases

GeneIDi29348.
KEGGirno:29348.
UCSCiRGD:61805. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56551 mRNA. Translation: CAA39892.1.
PIRiS26049.
RefSeqiNP_071518.1. NM_022182.1.
UniGeneiRn.98842.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QQKX-ray3.10A/B55-194[»]
1QQLX-ray2.30A55-130[»]
ProteinModelPortaliQ02195.
SMRiQ02195. Positions 63-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012700.

PTM databases

iPTMnetiQ02195.
PhosphoSiteiQ02195.

Proteomic databases

PaxDbiQ02195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29348.
KEGGirno:29348.
UCSCiRGD:61805. rat.

Organism-specific databases

CTDi2252.
RGDi61805. Fgf7.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ02195.
KOiK04358.
PhylomeDBiQ02195.

Miscellaneous databases

EvolutionaryTraceiQ02195.
PROiQ02195.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of rat keratinocyte growth factor (heparin-binding growth factor type 7)."
    Yan G., Nikolaropoulos S., Wang F., McKeehan W.L.
    In Vitro Cell. Dev. Biol. 27A:437-438(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs."
    Ye S., Luo Y., Lu W., Jones R.B., Linhardt R.J., Capila I., Toida T., Kan M., Pelletier H., McKeehan W.L.
    Biochemistry 40:14429-14439(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 55-150, HEPARIN BINDING.

Entry informationi

Entry nameiFGF7_RAT
AccessioniPrimary (citable) accession number: Q02195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.