C protein alpha-antigen precursor - Streptococcus agalactiae serotype Ia

Preferred order of sections

Names and origin

Protein names

Recommended name:
C protein alpha-antigen

Gene names

Name:	bca
Ordered Locus Names:	SAK_0517

Organism

Streptococcus agalactiae serotype Ia [Complete proteome] [HAMAP]

Taxonomic identifier

355315 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	1020 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in both virulence and immunity.
Subcellular location	Secreted › cell wall; Peptidoglycan-anchor Potential.
Miscellaneous	Identical repeating units define protective epitopes and may play a role in generating phenotypic and genotypic diversity.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cell wall Secreted
Domain	Repeat Signal
PTM	Peptidoglycan-anchor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell surface Inferred from electronic annotation. Source: InterPro cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 41

41

Chain

42 – 990

949

C protein alpha-antigen

PRO_0000005597

Propeptide

991 – 1020

30

Removed by sortase Potential

PRO_0000005598

Regions

Region

227 – 964

738

9 X 82 AA tandem repeats

Motif

987 – 991

5

LPXTG sorting signal Potential

Amino acid modifications

Modified residue

990

1

Pentaglycyl murein peptidoglycan amidated threonine Potential

Secondary structure

1

.

1020

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q02192 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 78035594FA190D5B
Show »

FASTA

1,020

108,705

        10         20         30         40         50         60 
MFRRSKNNSY DTSQTKQRFS IKKFKFGAAS VLIGLSFLGG VTQGNLNIFE ESIVAASTIP 

        70         80         90        100        110        120 
GSAATLNTSI TKNIQNGNAY IDLYDVKLGK IDPLQLIVLE QGFTAKYVFR QGTKYYGDVS 

       130        140        150        160        170        180 
QLQSTGRASL TYNIFGEDGL PHVKTDGQID IVSVALTIYD STTLRDKIEE VRTNANDPKW 

       190        200        210        220        230        240 
TEESRTEVLT GLDTIKTDID NNPKTQTDID SKIVEVNELE KLLVLSVPDK DKYDPTGGET 

       250        260        270        280        290        300 
TVPQGTPVSD KEITDLVKIP DGSKGVPTVV GDRPDTNVPG DHKVTVEVTY PDGTKDTVEV 

       310        320        330        340        350        360 
TVHVTPKPVP DKDKYDPTGG ETTVPQGTPV SDKEITDLVK IPDGSKGVPT VVGDRPDTNV 

       370        380        390        400        410        420 
PGDHKVTVEV TYPDGTKDTV EVTVHVTPKP VPDKDKYDPT GGETTVPQGT PVSDKEITDL 

       430        440        450        460        470        480 
VKIPDGSKGV PTVVGDRPDT NVPGDHKVTV EVTYPDGTKD TVEVTVHVTP KPVPDKDKYD 

       490        500        510        520        530        540 
PTGGETTVPQ GTPVSDKEIT DLVKIPDGSK GVPTVVGDRP DTNVPGDHKV TVEVTYPDGT 

       550        560        570        580        590        600 
KDTVEVTVHV TPKPVPDKDK YDPTGGETTV PQGTPVSDKE ITDLVKIPDG SKGVPTVVGD 

       610        620        630        640        650        660 
RPDTNVPGDH KVTVEVTYPD GTKDTVEVTV HVTPKPVPDK DKYDPTGGET TVPQGTPVSD 

       670        680        690        700        710        720 
KEITDLVKIP DGSKGVPTVV GDRPDTNVPG DHKVTVEVTY PDGTKDTVEV TVHVTPKPVP 

       730        740        750        760        770        780 
DKDKYDPTGG ETTVPQGTPV SDKEITDLVK IPDGSKGVPT VVGDRPDTNV PGDHKVTVEV 

       790        800        810        820        830        840 
TYPDGTKDTV EVTVHVTPKP VPDKDKYDPT GGETTVPQGT PVSDKEITDL VKIPDGSKGV 

       850        860        870        880        890        900 
PTVVGDRPDT NVPGDHKVTV EVTYPDGTKD TVEVTVHVTP KPVPDKDKYD PTGGETTVPQ 

       910        920        930        940        950        960 
GTPVSDKEIT DLVKIPDGSK GVPTVVGDRP DTNVPGDHKV TVEVTYPDGT KDTVEVTVHV 

       970        980        990       1000       1010       1020 
TPKPVPDKDK YDPTGKAQQV NGKGNKLPAT GENATPFFNV AALTIISSVG LLSVSKKKED

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci." Michel J.L., Madoff L.C., Olson K., Kling D.E., Kasper D.L., Ausubel F.M. Proc. Natl. Acad. Sci. U.S.A. 89:10060-10064(1992) [PubMed: 1438195] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27591 / A909 / CDC SS700 / Serotype Ia.
[2]	"Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial 'pan-genome'." Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D., Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T., Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D., Hauser C.R., Sundaram J.P. Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005) [PubMed: 16172379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27591 / A909 / CDC SS700 / Serotype Ia.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M97256 Genomic DNA. Translation: AAA26848.1.
CP000114 Genomic DNA. Translation: ABA45154.1.

RefSeq

YP_329152.1. NC_007432.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YWM	X-ray	1.86	A	52-225	[»]
2O0I	X-ray	3.10	1	57-225	[»]

ProteinModelPortal

Q02192.

SMR

Q02192. Positions 57-217.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBSTRT00000005659; EBSTRP00000005432; EBSTRG00000005659.

GeneID

3685804.

GenomeReviews

Gene locus SAK_0517 in contig CP000114_GR.

KEGG

sak:SAK_0517.

PATRIC

19632255. VBIStrAga82541_0439.

TIGR

SAK_0517.

Phylogenomic databases

GeneTree

EBGT00050000026640.

HOGENOM

HBG219698.

OMA

TPDSSTE.

ProtClustDB

CLSK452417.

Enzyme and pathway databases

BioCyc

SAGA205921:SAK_0517-MONOMER.

Family and domain databases

InterPro

IPR014933. AlphaC_N.
IPR005877. Gpos_YSIRK.
IPR019948. Gram-positive_anchor.
IPR019950. Gram_pos_anchor.
IPR019931. LPXTG-motif_cell_wall_anchor.
IPR012706. Rib_alpha_Esp.
IPR001899. Surface_protein_Gram_pos_cocci.
[Graphical view]

Pfam

PF08829. AlphaC_N. 1 hit.
PF00746. Gram_pos_anchor. 1 hit.
PF08428. Rib. 9 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]

PRINTS

PR00015. GPOSANCHOR.

TIGRFAMs

TIGR01167. LPXTG_anchor. 1 hit.
TIGR02331. Rib_alpha. 9 hits.
TIGR01168. YSIRK_signal. 1 hit.

PROSITE

PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

BCA_STRA1

Accession

Primary (citable) accession number: Q02192
Secondary accession number(s): Q3K2V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references