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Protein

C protein alpha-antigen

Gene

bca

Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in both virulence and immunity.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
C protein alpha-antigen
Gene namesi
Name:bca
Ordered Locus Names:SAK_0517
OrganismiStreptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Taxonomic identifieri205921 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Add BLAST41
ChainiPRO_000000559742 – 990C protein alpha-antigenAdd BLAST949
PropeptideiPRO_0000005598991 – 1020Removed by sortasePROSITE-ProRule annotationAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei990Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Structurei

Secondary structure

11020
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi63 – 66Combined sources4
Turni71 – 73Combined sources3
Beta strandi78 – 82Combined sources5
Helixi83 – 87Combined sources5
Helixi93 – 96Combined sources4
Beta strandi97 – 99Combined sources3
Beta strandi104 – 111Combined sources8
Beta strandi114 – 118Combined sources5
Helixi119 – 121Combined sources3
Beta strandi126 – 135Combined sources10
Beta strandi139 – 141Combined sources3
Beta strandi147 – 149Combined sources3
Beta strandi151 – 159Combined sources9
Helixi162 – 175Combined sources14
Helixi182 – 201Combined sources20
Helixi206 – 220Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWMX-ray1.86A52-225[»]
2O0IX-ray3.10157-225[»]
ProteinModelPortaliQ02192.
SMRiQ02192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02192.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 9649 X 82 AA tandem repeatsAdd BLAST738

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi987 – 991LPXTG sorting signalPROSITE-ProRule annotation5

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000095184.
OMAiVVTYPDK.

Family and domain databases

InterProiIPR014933. AlphaC_N.
IPR019948. Gram-positive_anchor.
IPR019950. M_anchor.
IPR012706. Rib_alpha_Esp.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF08829. AlphaC_N. 1 hit.
PF00746. Gram_pos_anchor. 1 hit.
PF08428. Rib. 9 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
PRINTSiPR00015. GPOSANCHOR.
TIGRFAMsiTIGR02331. rib_alpha. 9 hits.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRRSKNNSY DTSQTKQRFS IKKFKFGAAS VLIGLSFLGG VTQGNLNIFE
60 70 80 90 100
ESIVAASTIP GSAATLNTSI TKNIQNGNAY IDLYDVKLGK IDPLQLIVLE
110 120 130 140 150
QGFTAKYVFR QGTKYYGDVS QLQSTGRASL TYNIFGEDGL PHVKTDGQID
160 170 180 190 200
IVSVALTIYD STTLRDKIEE VRTNANDPKW TEESRTEVLT GLDTIKTDID
210 220 230 240 250
NNPKTQTDID SKIVEVNELE KLLVLSVPDK DKYDPTGGET TVPQGTPVSD
260 270 280 290 300
KEITDLVKIP DGSKGVPTVV GDRPDTNVPG DHKVTVEVTY PDGTKDTVEV
310 320 330 340 350
TVHVTPKPVP DKDKYDPTGG ETTVPQGTPV SDKEITDLVK IPDGSKGVPT
360 370 380 390 400
VVGDRPDTNV PGDHKVTVEV TYPDGTKDTV EVTVHVTPKP VPDKDKYDPT
410 420 430 440 450
GGETTVPQGT PVSDKEITDL VKIPDGSKGV PTVVGDRPDT NVPGDHKVTV
460 470 480 490 500
EVTYPDGTKD TVEVTVHVTP KPVPDKDKYD PTGGETTVPQ GTPVSDKEIT
510 520 530 540 550
DLVKIPDGSK GVPTVVGDRP DTNVPGDHKV TVEVTYPDGT KDTVEVTVHV
560 570 580 590 600
TPKPVPDKDK YDPTGGETTV PQGTPVSDKE ITDLVKIPDG SKGVPTVVGD
610 620 630 640 650
RPDTNVPGDH KVTVEVTYPD GTKDTVEVTV HVTPKPVPDK DKYDPTGGET
660 670 680 690 700
TVPQGTPVSD KEITDLVKIP DGSKGVPTVV GDRPDTNVPG DHKVTVEVTY
710 720 730 740 750
PDGTKDTVEV TVHVTPKPVP DKDKYDPTGG ETTVPQGTPV SDKEITDLVK
760 770 780 790 800
IPDGSKGVPT VVGDRPDTNV PGDHKVTVEV TYPDGTKDTV EVTVHVTPKP
810 820 830 840 850
VPDKDKYDPT GGETTVPQGT PVSDKEITDL VKIPDGSKGV PTVVGDRPDT
860 870 880 890 900
NVPGDHKVTV EVTYPDGTKD TVEVTVHVTP KPVPDKDKYD PTGGETTVPQ
910 920 930 940 950
GTPVSDKEIT DLVKIPDGSK GVPTVVGDRP DTNVPGDHKV TVEVTYPDGT
960 970 980 990 1000
KDTVEVTVHV TPKPVPDKDK YDPTGKAQQV NGKGNKLPAT GENATPFFNV
1010 1020
AALTIISSVG LLSVSKKKED
Length:1,020
Mass (Da):108,705
Last modified:June 1, 1994 - v1
Checksum:i78035594FA190D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97256 Genomic DNA. Translation: AAA26848.1.
CP000114 Genomic DNA. Translation: ABA45154.1.
RefSeqiWP_000489955.1. NC_007432.1.

Genome annotation databases

EnsemblBacteriaiABA45154; ABA45154; SAK_0517.
KEGGisak:SAK_0517.
PATRICi19632255. VBIStrAga82541_0439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97256 Genomic DNA. Translation: AAA26848.1.
CP000114 Genomic DNA. Translation: ABA45154.1.
RefSeqiWP_000489955.1. NC_007432.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWMX-ray1.86A52-225[»]
2O0IX-ray3.10157-225[»]
ProteinModelPortaliQ02192.
SMRiQ02192.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA45154; ABA45154; SAK_0517.
KEGGisak:SAK_0517.
PATRICi19632255. VBIStrAga82541_0439.

Phylogenomic databases

HOGENOMiHOG000095184.
OMAiVVTYPDK.

Miscellaneous databases

EvolutionaryTraceiQ02192.

Family and domain databases

InterProiIPR014933. AlphaC_N.
IPR019948. Gram-positive_anchor.
IPR019950. M_anchor.
IPR012706. Rib_alpha_Esp.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF08829. AlphaC_N. 1 hit.
PF00746. Gram_pos_anchor. 1 hit.
PF08428. Rib. 9 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
PRINTSiPR00015. GPOSANCHOR.
TIGRFAMsiTIGR02331. rib_alpha. 9 hits.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCA_STRA1
AccessioniPrimary (citable) accession number: Q02192
Secondary accession number(s): Q3K2V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Identical repeating units define protective epitopes and may play a role in generating phenotypic and genotypic diversity.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.