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Protein

Anthranilate phosphoribosyltransferase, chloroplastic

Gene

PAT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase beta subunit 2, chloroplastic (ASB2), Anthranilate synthase beta subunit 1, chloroplastic (ASB1), Anthranilate synthase alpha subunit 1, chloroplastic (ASA1), Anthranilate synthase alpha subunit 2, chloroplastic (ASA2)
  2. Anthranilate phosphoribosyltransferase, chloroplastic (PAT1)
  3. N-(5'-phosphoribosyl)anthranilate isomerase 2, chloroplastic (PAI2), N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic (PAI3), N-(5'-phosphoribosyl)anthranilate isomerase 1, chloroplastic (PAI1)
  4. Indole-3-glycerol phosphate synthase, chloroplastic (IGPS)
  5. Tryptophan synthase alpha chain (TRPA1), Tryptophan synthase alpha chain, chloroplastic (TSA1), Tryptophan synthase (AXX17_At5g53930), Tryptophan synthase (At5g54810), Tryptophan synthase (At5g28237), Tryptophan synthase (AXX17_At5g28490), Tryptophan synthase (AXX17_At4g31220), Tryptophan synthase, Tryptophan synthase beta chain 1, chloroplastic (TSB1), Tryptophan synthase (At4g27070), Tryptophan synthase (At5g28237), Tryptophan synthase beta chain 2, chloroplastic (TSB2), Tryptophan synthase (AXX17_At4g31220)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • anthranilate phosphoribosyltransferase activity Source: TAIR

GO - Biological processi

  • tryptophan biosynthetic process Source: TAIR

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciARA:AT5G17990-MONOMER
UniPathwayiUPA00035; UER00041

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase, chloroplastic (EC:2.4.2.18)
Gene namesi
Name:PAT1
Ordered Locus Names:At5g17990
ORF Names:MCM23.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G17990
TAIRilocus:2161528 AT5G17990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000035788? – 444Anthranilate phosphoribosyltransferase, chloroplastic
Transit peptidei1 – ?ChloroplastSequence analysis

Proteomic databases

PaxDbiQ02166
PRIDEiQ02166

Expressioni

Gene expression databases

ExpressionAtlasiQ02166 baseline and differential
GenevisibleiQ02166 AT

Interactioni

Protein-protein interaction databases

BioGridi16942, 6 interactors
IntActiQ02166, 1 interactor
STRINGi3702.AT5G17990.1

Structurei

3D structure databases

ProteinModelPortaliQ02166
SMRiQ02166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 189Phosphoribosyl pyrophosphate binding siteSequence analysis9

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1438 Eukaryota
COG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiEOG09360D2K
PhylomeDBiQ02166

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIAVATTSS IVSGIKLSGI LTSFNAVDDA SSSCGRSNLT GVRIFPTLSR
60 70 80 90 100
RRFSSIGAVS PIRGDAQSSF SRSSFACSQN LGLSGGFSAA EALPPACANA
110 120 130 140 150
SPSSIKSFNQ LIETLIDRVD LSETEAESSL EFLLNEANEA LISAFLVLLR
160 170 180 190 200
AKGETYEEIV GLARAMMKHA RKVEGLVDAV DIVGTGGDGA NTVNISTGSS
210 220 230 240 250
ILAAACGAKV AKQGNRSSSS ACGSADVLEA LGVVLDLGPE GIKRCVEEGG
260 270 280 290 300
IGFMMSPMYH PAMKIVGPVR KKLKIKTVFN ILGPMLNPAR VSYAVVGVYH
310 320 330 340 350
KDLVVKMAKA LQRFGMKRAL VVHSCGLDEM SPLGGGLVYD VTPEKIEEFS
360 370 380 390 400
FDPLDFGIPR CTLEDLRGGG PDYNADVLRR VLSGESGAIA DSLILNAAAA
410 420 430 440
LLVSNRVQTL AEGVTVAREV QSSGKAIKTL DSWINISNLA QKSQ
Length:444
Mass (Da):46,520
Last modified:July 1, 1993 - v1
Checksum:i397DFD3141BED2C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39 – 41Missing in AAB02913 (Ref. 2) Curated3
Sequence conflicti65D → H in AAB02913 (Ref. 2) Curated1
Sequence conflicti76 – 78ACS → VCP in AAB02913 (Ref. 2) Curated3
Sequence conflicti89A → T in AAB02913 (Ref. 2) Curated1
Sequence conflicti98A → E in AAB02913 (Ref. 2) Curated1
Sequence conflicti124T → S in AAB02913 (Ref. 2) Curated1
Sequence conflicti234V → A in AAB02913 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96073 Genomic DNA Translation: AAA32835.1
U58942 Genomic DNA Translation: AAB02913.1
AB015473 Genomic DNA Translation: BAB08398.1
CP002688 Genomic DNA Translation: AED92493.1
AY054506 mRNA Translation: AAK96697.1
AY093298 mRNA Translation: AAM13297.1
RefSeqiNP_197300.1, NM_121804.5
UniGeneiAt.19968
At.71230
At.75028

Genome annotation databases

EnsemblPlantsiAT5G17990.1; AT5G17990.1; AT5G17990
GeneIDi831666
GrameneiAT5G17990.1; AT5G17990.1; AT5G17990
KEGGiath:AT5G17990

Similar proteinsi

Entry informationi

Entry nameiTRPD_ARATH
AccessioniPrimary (citable) accession number: Q02166
Secondary accession number(s): Q42557
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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