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Q02161

- RHD_HUMAN

UniProt

Q02161 - RHD_HUMAN

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Protein

Blood group Rh(D) polypeptide

Gene

RHD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

GO - Molecular functioni

  1. ammonium transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Protein family/group databases

TCDBi1.A.11.4.3. the ammonia transporter channel (amt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Blood group Rh(D) polypeptide
Alternative name(s):
RHXIII
Rh polypeptide 2
Short name:
RhPII
Rhesus D antigen
CD_antigen: CD240D
Gene namesi
Name:RHD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10009. RHD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence AnalysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence AnalysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti71275. Rh deficiency syndrome.
PharmGKBiPA34387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 417416Blood group Rh(D) polypeptidePRO_0000168190Add
BLAST

Proteomic databases

PaxDbiQ02161.
PRIDEiQ02161.

PTM databases

PhosphoSiteiQ02161.

Expressioni

Tissue specificityi

Restricted to tissues or cell lines expressing erythroid characters.

Gene expression databases

BgeeiQ02161.
ExpressionAtlasiQ02161. baseline and differential.
GenevestigatoriQ02161.

Interactioni

Protein-protein interaction databases

BioGridi111939. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ02161.
SMRiQ02161. Positions 40-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG314742.
GeneTreeiENSGT00390000005787.
HOVERGENiHBG004374.
InParanoidiQ02161.
KOiK06579.
OMAiTCGVHYT.
OrthoDBiEOG73NG3C.
PhylomeDBiQ02161.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02161-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV
60 70 80 90 100
GQDLTVMAAI GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ
110 120 130 140 150
FPSGKVVITL FSIRLATMSA LSVLISVDAV LGKVNLAQLV VMVLVEVTAL
160 170 180 190 200
GNLRMVISNI FNTDYHMNMM HIYVFAAYFG LSVAWCLPKP LPEGTEDKDQ
210 220 230 240 250
TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN TYYAVAVSVV
260 270 280 290 300
TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
310 320 330 340 350
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD
360 370 380 390 400
TVGAGNGMIG FQVLLSIGEL SLAIVIALMS GLLTGLLLNL KIWKAPHEAK
410
YFDDQVFWKF PHLAVGF
Length:417
Mass (Da):45,211
Last modified:May 18, 2010 - v3
Checksum:i38721BFA664AE199
GO
Isoform 2 (identifier: Q02161-2) [UniParc]FASTAAdd to Basket

Also known as: Short 1

The sequence of this isoform differs from the canonical sequence as follows:
     314-409: Missing.

Show »
Length:321
Mass (Da):34,837
Checksum:i79E9FB671F8F84E8
GO
Isoform 3 (identifier: Q02161-3) [UniParc]FASTAAdd to Basket

Also known as: Short 2

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: C → S
     317-417: Missing.

Show »
Length:316
Mass (Da):34,215
Checksum:i4BCD39AC4813587F
GO
Isoform 4 (identifier: Q02161-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-417: IGFQVLLSIG...WKFPHLAVGF → SLGWNLAVKM...PFIMHCRIQQ

Show »
Length:493
Mass (Da):53,641
Checksum:iA1122BAAF7764F2F
GO
Isoform 5 (identifier: Q02161-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-417: MIGFQVLLSI...WKFPHLAVGF → IFLIWLLDFK...LPAFVREKRS

Show »
Length:396
Mass (Da):43,290
Checksum:i39E89394C36B903F
GO
Isoform 6 (identifier: Q02161-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-378: GCCNRVLGIP...ELSLAIVIAL → DWLPGPPQHW...LPAFVREKRS
     379-417: Missing.

Show »
Length:378
Mass (Da):41,694
Checksum:i21ACB09A3D7A5DD2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391E → G in AAB26081. (PubMed:7916743)Curated
Sequence conflicti103 – 1031S → P in AAB26081. (PubMed:7916743)Curated
Sequence conflicti127 – 1271V → A in AAB26081. (PubMed:7916743)Curated
Sequence conflicti174 – 1741V → M in AAB34852. (PubMed:7606008)Curated
Sequence conflicti182 – 1821S → T in AAB26081. (PubMed:7916743)Curated
Sequence conflicti314 – 3141G → V in AAB26081. (PubMed:7916743)Curated
Sequence conflicti314 – 3141G → V in AAB31911. (PubMed:8080999)Curated
Sequence conflicti323 – 3231P → H in AAB26081. (PubMed:7916743)Curated
Sequence conflicti379 – 3791M → T in CAA44811. (PubMed:1438298)Curated
Sequence conflicti379 – 3791M → T in CAA44808. (PubMed:1438298)Curated
Sequence conflicti379 – 3791M → T in AAA02679. (PubMed:8329718)Curated
Sequence conflicti379 – 3791M → T in AAB26081. (PubMed:7916743)Curated
Sequence conflicti379 – 3791M → T in AAB34852. (PubMed:7606008)Curated
Sequence conflicti379 – 3791M → T in BAA81899. (PubMed:16510313)Curated
Sequence conflicti379 – 3791M → T in BAA81900. (PubMed:16510313)Curated
Sequence conflicti379 – 3791M → T in BAA81901. (PubMed:16510313)Curated
Sequence conflicti379 – 3791M → T in BAA82159. (PubMed:16510313)Curated
Sequence conflicti398 – 3981E → V in AAB34852. (PubMed:7606008)Curated

Polymorphismi

RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40 blood group antigen is a polymorphism in position 110.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161W → C.1 Publication
Corresponds to variant rs586178 [ dbSNP | Ensembl ].
VAR_034455
Natural varianti103 – 1031S → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_035615
Natural varianti110 – 1101L → P in Tar antigen. 1 Publication
VAR_006919
Natural varianti193 – 1931E → K.
Corresponds to variant rs17418091 [ dbSNP | Ensembl ].
VAR_034456
Natural varianti201 – 2011T → R.
Corresponds to variant rs17418098 [ dbSNP | Ensembl ].
VAR_034457
Natural varianti218 – 2181M → I.1 Publication
Corresponds to variant rs141540728 [ dbSNP | Ensembl ].
VAR_006920
Natural varianti223 – 2231F → V in RhDVa(FK) and RhDVa(TT). 1 Publication
Corresponds to variant rs1053356 [ dbSNP | Ensembl ].
VAR_013304
Natural varianti233 – 2331E → Q in RhDVa(FK), RhDVa(TO), RhDVa(TT) and RhDYo. 1 Publication
Corresponds to variant rs1053359 [ dbSNP | Ensembl ].
VAR_013305
Natural varianti238 – 2381V → M in RhDVa(TO) and RhDVa(TT). 1 Publication
Corresponds to variant rs1053360 [ dbSNP | Ensembl ].
VAR_013306
Natural varianti245 – 2451V → L in RhDVa(TT). 1 Publication
Corresponds to variant rs150073306 [ dbSNP | Ensembl ].
VAR_013307
Natural varianti263 – 2631G → R.
Corresponds to variant rs3118454 [ dbSNP | Ensembl ].
VAR_047996
Natural varianti306 – 3061V → I.
Corresponds to variant rs590813 [ dbSNP | Ensembl ].
VAR_047997
Natural varianti311 – 3111Y → C.
Corresponds to variant rs590787 [ dbSNP | Ensembl ].
VAR_047998

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei314 – 40996Missing in isoform 2. 1 PublicationVSP_005706Add
BLAST
Alternative sequencei314 – 37865GCCNR…IVIAL → DWLPGPPQHWGTQLGHRDSS HVWSPDSFLIWLLDFKQKHP RKTRPVQKQDNFLSLLPAFV REKRS in isoform 6. 1 PublicationVSP_047795Add
BLAST
Alternative sequencei316 – 3161C → S in isoform 3. 1 PublicationVSP_005707
Alternative sequencei317 – 417101Missing in isoform 3. 1 PublicationVSP_005708Add
BLAST
Alternative sequencei358 – 41760MIGFQ…LAVGF → IFLIWLLDFKQKHPRKTRPV QKQDNFLSLLPAFVREKRS in isoform 5. 1 PublicationVSP_047796Add
BLAST
Alternative sequencei359 – 41759IGFQV…LAVGF → SLGWNLAVKMAEAGDEELMR LDVSQRNHGGAAVPTGSWMP STETTIAPNYRDHISVVSSF GCWILSKSIQEKQGLFKNKT TSSHCCLHLYVRNAHDSKVS NVRAGTGVRENGVESFLCHS LRRISPFIMHCRIQQ in isoform 4. 1 PublicationVSP_047797Add
BLAST
Alternative sequencei379 – 41739Missing in isoform 6. 1 PublicationVSP_047798Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63097 mRNA. Translation: CAA44811.1.
X63094 mRNA. Translation: CAA44808.1.
L08429 mRNA. Translation: AAA02679.1.
S57971 mRNA. Translation: AAB26081.1.
S70174 mRNA. Translation: AAB30756.1.
S78509 mRNA. Translation: AAB34852.1.
S73913 mRNA. Translation: AAB31911.1.
AY751492 mRNA. Translation: AAU93636.1.
AY751493 mRNA. Translation: AAU93637.1.
AY751495 mRNA. Translation: AAU93639.1.
AB018966 mRNA. Translation: BAA81899.1.
AB018967 mRNA. Translation: BAA81900.1.
AB018968 mRNA. Translation: BAA81901.1.
AB018969 mRNA. Translation: BAA82159.1.
AL928711 Genomic DNA. Translation: CAH72602.1.
CCDSiCCDS262.1. [Q02161-1]
CCDS53285.1. [Q02161-2]
CCDS60028.1. [Q02161-4]
CCDS60030.1. [Q02161-5]
CCDS60031.1. [Q02161-6]
PIRiA46368.
I52615.
RefSeqiNP_001121163.1. NM_001127691.2. [Q02161-2]
NP_001269797.1. NM_001282868.1. [Q02161-6]
NP_001269798.1. NM_001282869.1. [Q02161-5]
NP_001269800.1. NM_001282871.1. [Q02161-4]
NP_057208.2. NM_016124.4.
UniGeneiHs.449968.

Genome annotation databases

EnsembliENST00000328664; ENSP00000331871; ENSG00000187010. [Q02161-1]
ENST00000342055; ENSP00000339577; ENSG00000187010. [Q02161-4]
ENST00000357542; ENSP00000350150; ENSG00000187010. [Q02161-5]
ENST00000417538; ENSP00000396420; ENSG00000187010. [Q02161-6]
ENST00000454452; ENSP00000413849; ENSG00000187010. [Q02161-2]
GeneIDi6007.
KEGGihsa:6007.
UCSCiuc009vrm.3. human. [Q02161-1]
uc009vrn.3. human.
uc009vro.3. human.
uc009vrp.3. human.

Polymorphism databases

DMDMi296452980.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63097 mRNA. Translation: CAA44811.1 .
X63094 mRNA. Translation: CAA44808.1 .
L08429 mRNA. Translation: AAA02679.1 .
S57971 mRNA. Translation: AAB26081.1 .
S70174 mRNA. Translation: AAB30756.1 .
S78509 mRNA. Translation: AAB34852.1 .
S73913 mRNA. Translation: AAB31911.1 .
AY751492 mRNA. Translation: AAU93636.1 .
AY751493 mRNA. Translation: AAU93637.1 .
AY751495 mRNA. Translation: AAU93639.1 .
AB018966 mRNA. Translation: BAA81899.1 .
AB018967 mRNA. Translation: BAA81900.1 .
AB018968 mRNA. Translation: BAA81901.1 .
AB018969 mRNA. Translation: BAA82159.1 .
AL928711 Genomic DNA. Translation: CAH72602.1 .
CCDSi CCDS262.1. [Q02161-1 ]
CCDS53285.1. [Q02161-2 ]
CCDS60028.1. [Q02161-4 ]
CCDS60030.1. [Q02161-5 ]
CCDS60031.1. [Q02161-6 ]
PIRi A46368.
I52615.
RefSeqi NP_001121163.1. NM_001127691.2. [Q02161-2 ]
NP_001269797.1. NM_001282868.1. [Q02161-6 ]
NP_001269798.1. NM_001282869.1. [Q02161-5 ]
NP_001269800.1. NM_001282871.1. [Q02161-4 ]
NP_057208.2. NM_016124.4.
UniGenei Hs.449968.

3D structure databases

ProteinModelPortali Q02161.
SMRi Q02161. Positions 40-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111939. 2 interactions.

Protein family/group databases

TCDBi 1.A.11.4.3. the ammonia transporter channel (amt) family.

PTM databases

PhosphoSitei Q02161.

Polymorphism databases

DMDMi 296452980.

Proteomic databases

PaxDbi Q02161.
PRIDEi Q02161.

Protocols and materials databases

DNASUi 6007.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328664 ; ENSP00000331871 ; ENSG00000187010 . [Q02161-1 ]
ENST00000342055 ; ENSP00000339577 ; ENSG00000187010 . [Q02161-4 ]
ENST00000357542 ; ENSP00000350150 ; ENSG00000187010 . [Q02161-5 ]
ENST00000417538 ; ENSP00000396420 ; ENSG00000187010 . [Q02161-6 ]
ENST00000454452 ; ENSP00000413849 ; ENSG00000187010 . [Q02161-2 ]
GeneIDi 6007.
KEGGi hsa:6007.
UCSCi uc009vrm.3. human. [Q02161-1 ]
uc009vrn.3. human.
uc009vro.3. human.
uc009vrp.3. human.

Organism-specific databases

CTDi 6007.
GeneCardsi GC01P025599.
HGNCi HGNC:10009. RHD.
MIMi 111680. gene.
neXtProti NX_Q02161.
Orphaneti 71275. Rh deficiency syndrome.
PharmGKBi PA34387.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314742.
GeneTreei ENSGT00390000005787.
HOVERGENi HBG004374.
InParanoidi Q02161.
KOi K06579.
OMAi TCGVHYT.
OrthoDBi EOG73NG3C.
PhylomeDBi Q02161.
TreeFami TF314450.

Miscellaneous databases

GeneWikii RHD_(gene).
GenomeRNAii 6007.
NextBioi 23439.
PROi Q02161.
SOURCEi Search...

Gene expression databases

Bgeei Q02161.
ExpressionAtlasi Q02161. baseline and differential.
Genevestigatori Q02161.

Family and domain databases

Gene3Di 1.10.3430.10. 1 hit.
InterProi IPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view ]
Pfami PF00909. Ammonium_transp. 1 hit.
[Graphical view ]
PRINTSi PR00342. RHESUSRHD.
SUPFAMi SSF111352. SSF111352. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and primary structure of the human blood group RhD polypeptide."
    le van Kim C., Mouro I., Cherif-Zahar B., Raynal V., Cherrier C., Cartron J.-P., Colin Y.
    Proc. Natl. Acad. Sci. U.S.A. 89:10925-10929(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-218.
    Tissue: Bone marrow.
  2. "Multiple Rh messenger RNA isoforms are produced by alternative splicing."
    le van Kim C., Cherif-Zahar B., Raynal V., Mouro I., Lopez M., Cartron J.-P., Colin Y.
    Blood 80:1074-1078(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. "Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals."
    Arce M.A., Thompson E.S., Wagner S., Coyne K.E., Ferdman B.A., Lublin D.M.
    Blood 82:651-655(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system."
    Kajii E., Umenishi F., Iwamoto S., Ikemoto S.
    Hum. Genet. 91:157-162(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Identification of a new RhD-specific mRNA from K562 cells."
    Westhoff C.M., Wylie D.E.
    Blood 83:3098-3100(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  6. "Identification of a partial internal deletion in the RH locus causing the human erythrocyte D-phenotype."
    Huang C.-H., Reid M.E., Chen Y.
    Blood 86:784-790(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-16.
  7. "Rh(D) antigen expression and isolation of a new Rh(D) cDNA isoform in human erythroleukemic K562 cells."
    Suyama K., Lunn R., Haller S., Goldstein J.
    Blood 84:1975-1981(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  8. "Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele."
    Shao C.P., Xiong W., Zhou Y.Y.
    Transfus. Apher. Sci. 34:145-152(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5 AND 6), ALTERNATIVE SPLICING.
  9. "Polymorphisms of RhDVa in Japanese."
    Hyodo H., Ishikawa Y., Kashiwase K., Ogawa A., Watanabe Y., Tsuneyama H., Toyoda C., Uchikawa M., Akaza T., Fujii T.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-223; GLN-233; MET-238 AND LEU-245.
  10. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane."
    Avent N.D., Ridgwell K., Mawby W.J., Tanner M.J.A., Anstee D.J., Kumpel B.
    Biochem. J. 256:1043-1046(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-33.
  12. "Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes."
    Saboori A.M., Smith B.L., Agre P.
    Proc. Natl. Acad. Sci. U.S.A. 85:4042-4045(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
  13. "Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains."
    Bloy C., Blanchard D., Dahr W., Beyreuther K., Salmon C., Cartron J.-P.
    Blood 72:661-666(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-17.
  14. "Regarding the size of Rh proteins."
    Suyama K., Goldstein J., Aebersold R., Kent S.
    Blood 77:411-411(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 401-407.
  15. "Leu110Pro substitution in the RhD polypeptide is responsible for the DVII category blood group phenotype."
    Rouillac C., le van Kim C., Beolet M., Cartron J.-P., Colin Y.
    Am. J. Hematol. 49:87-88(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TAR ANTIGEN PRO-110.
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-103.

Entry informationi

Entry nameiRHD_HUMAN
AccessioniPrimary (citable) accession number: Q02161
Secondary accession number(s): Q02162
, Q07618, Q16147, Q16235, Q16355, Q5VSK0, Q5XLS9, Q5XLT1, Q5XLT2, Q9NPK0, Q9UQ20, Q9UQ21, Q9UQ22, Q9UQ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3