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Q02161

- RHD_HUMAN

UniProt

Q02161 - RHD_HUMAN

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Protein
Blood group Rh(D) polypeptide
Gene
RHD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

GO - Molecular functioni

  1. ammonium transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Blood group antigen

    Protein family/group databases

    TCDBi1.A.11.4.3. the ammonia transporter channel (amt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Blood group Rh(D) polypeptide
    Alternative name(s):
    RHXIII
    Rh polypeptide 2
    Short name:
    RhPII
    Rhesus D antigen
    CD_antigen: CD240D
    Gene namesi
    Name:RHD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10009. RHD.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei44 – 6421Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei77 – 9721Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei107 – 12721Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei130 – 15021Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei167 – 18721Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei203 – 22321Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei238 – 25821Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei287 – 30721Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei334 – 35421Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei358 – 37821Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti71275. Rh deficiency syndrome.
    PharmGKBiPA34387.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 417416Blood group Rh(D) polypeptide
    PRO_0000168190Add
    BLAST

    Proteomic databases

    PaxDbiQ02161.
    PRIDEiQ02161.

    PTM databases

    PhosphoSiteiQ02161.

    Expressioni

    Tissue specificityi

    Restricted to tissues or cell lines expressing erythroid characters.

    Gene expression databases

    ArrayExpressiQ02161.
    BgeeiQ02161.
    GenevestigatoriQ02161.

    Interactioni

    Protein-protein interaction databases

    BioGridi111939. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02161.
    SMRiQ02161. Positions 40-308.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG314742.
    HOVERGENiHBG004374.
    KOiK06579.
    OMAiTCGVHYT.
    OrthoDBiEOG73NG3C.
    PhylomeDBiQ02161.
    TreeFamiTF314450.

    Family and domain databases

    Gene3Di1.10.3430.10. 1 hit.
    InterProiIPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view]
    PfamiPF00909. Ammonium_transp. 1 hit.
    [Graphical view]
    PRINTSiPR00342. RHESUSRHD.
    SUPFAMiSSF111352. SSF111352. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02161-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV    50
    GQDLTVMAAI GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ 100
    FPSGKVVITL FSIRLATMSA LSVLISVDAV LGKVNLAQLV VMVLVEVTAL 150
    GNLRMVISNI FNTDYHMNMM HIYVFAAYFG LSVAWCLPKP LPEGTEDKDQ 200
    TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN TYYAVAVSVV 250
    TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 300
    AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD 350
    TVGAGNGMIG FQVLLSIGEL SLAIVIALMS GLLTGLLLNL KIWKAPHEAK 400
    YFDDQVFWKF PHLAVGF 417
    Length:417
    Mass (Da):45,211
    Last modified:May 18, 2010 - v3
    Checksum:i38721BFA664AE199
    GO
    Isoform 2 (identifier: Q02161-2) [UniParc]FASTAAdd to Basket

    Also known as: Short 1

    The sequence of this isoform differs from the canonical sequence as follows:
         314-409: Missing.

    Show »
    Length:321
    Mass (Da):34,837
    Checksum:i79E9FB671F8F84E8
    GO
    Isoform 3 (identifier: Q02161-3) [UniParc]FASTAAdd to Basket

    Also known as: Short 2

    The sequence of this isoform differs from the canonical sequence as follows:
         316-316: C → S
         317-417: Missing.

    Show »
    Length:316
    Mass (Da):34,215
    Checksum:i4BCD39AC4813587F
    GO
    Isoform 4 (identifier: Q02161-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         359-417: IGFQVLLSIG...WKFPHLAVGF → SLGWNLAVKM...PFIMHCRIQQ

    Show »
    Length:493
    Mass (Da):53,641
    Checksum:iA1122BAAF7764F2F
    GO
    Isoform 5 (identifier: Q02161-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         358-417: MIGFQVLLSI...WKFPHLAVGF → IFLIWLLDFK...LPAFVREKRS

    Show »
    Length:396
    Mass (Da):43,290
    Checksum:i39E89394C36B903F
    GO
    Isoform 6 (identifier: Q02161-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         314-378: GCCNRVLGIP...ELSLAIVIAL → DWLPGPPQHW...LPAFVREKRS
         379-417: Missing.

    Show »
    Length:378
    Mass (Da):41,694
    Checksum:i21ACB09A3D7A5DD2
    GO

    Polymorphismi

    RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40 blood group antigen is a polymorphism in position 110.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161W → C.1 Publication
    Corresponds to variant rs586178 [ dbSNP | Ensembl ].
    VAR_034455
    Natural varianti103 – 1031S → C in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035615
    Natural varianti110 – 1101L → P in Tar antigen. 1 Publication
    VAR_006919
    Natural varianti193 – 1931E → K.
    Corresponds to variant rs17418091 [ dbSNP | Ensembl ].
    VAR_034456
    Natural varianti201 – 2011T → R.
    Corresponds to variant rs17418098 [ dbSNP | Ensembl ].
    VAR_034457
    Natural varianti218 – 2181M → I.1 Publication
    Corresponds to variant rs141540728 [ dbSNP | Ensembl ].
    VAR_006920
    Natural varianti223 – 2231F → V in RhDVa(FK) and RhDVa(TT). 1 Publication
    Corresponds to variant rs1053356 [ dbSNP | Ensembl ].
    VAR_013304
    Natural varianti233 – 2331E → Q in RhDVa(FK), RhDVa(TO), RhDVa(TT) and RhDYo. 1 Publication
    Corresponds to variant rs1053359 [ dbSNP | Ensembl ].
    VAR_013305
    Natural varianti238 – 2381V → M in RhDVa(TO) and RhDVa(TT). 1 Publication
    Corresponds to variant rs1053360 [ dbSNP | Ensembl ].
    VAR_013306
    Natural varianti245 – 2451V → L in RhDVa(TT). 1 Publication
    Corresponds to variant rs150073306 [ dbSNP | Ensembl ].
    VAR_013307
    Natural varianti263 – 2631G → R.
    Corresponds to variant rs3118454 [ dbSNP | Ensembl ].
    VAR_047996
    Natural varianti306 – 3061V → I.
    Corresponds to variant rs590813 [ dbSNP | Ensembl ].
    VAR_047997
    Natural varianti311 – 3111Y → C.
    Corresponds to variant rs590787 [ dbSNP | Ensembl ].
    VAR_047998

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei314 – 40996Missing in isoform 2.
    VSP_005706Add
    BLAST
    Alternative sequencei314 – 37865GCCNR…IVIAL → DWLPGPPQHWGTQLGHRDSS HVWSPDSFLIWLLDFKQKHP RKTRPVQKQDNFLSLLPAFV REKRS in isoform 6.
    VSP_047795Add
    BLAST
    Alternative sequencei316 – 3161C → S in isoform 3.
    VSP_005707
    Alternative sequencei317 – 417101Missing in isoform 3.
    VSP_005708Add
    BLAST
    Alternative sequencei358 – 41760MIGFQ…LAVGF → IFLIWLLDFKQKHPRKTRPV QKQDNFLSLLPAFVREKRS in isoform 5.
    VSP_047796Add
    BLAST
    Alternative sequencei359 – 41759IGFQV…LAVGF → SLGWNLAVKMAEAGDEELMR LDVSQRNHGGAAVPTGSWMP STETTIAPNYRDHISVVSSF GCWILSKSIQEKQGLFKNKT TSSHCCLHLYVRNAHDSKVS NVRAGTGVRENGVESFLCHS LRRISPFIMHCRIQQ in isoform 4.
    VSP_047797Add
    BLAST
    Alternative sequencei379 – 41739Missing in isoform 6.
    VSP_047798Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391E → G in AAB26081. 1 Publication
    Sequence conflicti103 – 1031S → P in AAB26081. 1 Publication
    Sequence conflicti127 – 1271V → A in AAB26081. 1 Publication
    Sequence conflicti174 – 1741V → M in AAB34852. 1 Publication
    Sequence conflicti182 – 1821S → T in AAB26081. 1 Publication
    Sequence conflicti314 – 3141G → V in AAB26081. 1 Publication
    Sequence conflicti314 – 3141G → V in AAB31911. 1 Publication
    Sequence conflicti323 – 3231P → H in AAB26081. 1 Publication
    Sequence conflicti379 – 3791M → T in CAA44811. 1 Publication
    Sequence conflicti379 – 3791M → T in CAA44808. 1 Publication
    Sequence conflicti379 – 3791M → T in AAA02679. 1 Publication
    Sequence conflicti379 – 3791M → T in AAB26081. 1 Publication
    Sequence conflicti379 – 3791M → T in AAB34852. 1 Publication
    Sequence conflicti379 – 3791M → T in BAA81899. 1 Publication
    Sequence conflicti379 – 3791M → T in BAA81900. 1 Publication
    Sequence conflicti379 – 3791M → T in BAA81901. 1 Publication
    Sequence conflicti379 – 3791M → T in BAA82159. 1 Publication
    Sequence conflicti398 – 3981E → V in AAB34852. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63097 mRNA. Translation: CAA44811.1.
    X63094 mRNA. Translation: CAA44808.1.
    L08429 mRNA. Translation: AAA02679.1.
    S57971 mRNA. Translation: AAB26081.1.
    S70174 mRNA. Translation: AAB30756.1.
    S78509 mRNA. Translation: AAB34852.1.
    S73913 mRNA. Translation: AAB31911.1.
    AY751492 mRNA. Translation: AAU93636.1.
    AY751493 mRNA. Translation: AAU93637.1.
    AY751495 mRNA. Translation: AAU93639.1.
    AB018966 mRNA. Translation: BAA81899.1.
    AB018967 mRNA. Translation: BAA81900.1.
    AB018968 mRNA. Translation: BAA81901.1.
    AB018969 mRNA. Translation: BAA82159.1.
    AL928711 Genomic DNA. Translation: CAH72602.1.
    CCDSiCCDS262.1. [Q02161-1]
    CCDS53285.1. [Q02161-2]
    CCDS60028.1. [Q02161-4]
    CCDS60030.1. [Q02161-5]
    CCDS60031.1. [Q02161-6]
    PIRiA46368.
    I52615.
    RefSeqiNP_001121163.1. NM_001127691.2. [Q02161-2]
    NP_001269797.1. NM_001282868.1. [Q02161-6]
    NP_001269798.1. NM_001282869.1. [Q02161-5]
    NP_001269800.1. NM_001282871.1. [Q02161-4]
    NP_057208.2. NM_016124.4.
    UniGeneiHs.449968.

    Genome annotation databases

    EnsembliENST00000328664; ENSP00000331871; ENSG00000187010. [Q02161-1]
    ENST00000342055; ENSP00000339577; ENSG00000187010. [Q02161-4]
    ENST00000357542; ENSP00000350150; ENSG00000187010. [Q02161-5]
    ENST00000417538; ENSP00000396420; ENSG00000187010. [Q02161-6]
    ENST00000454452; ENSP00000413849; ENSG00000187010. [Q02161-2]
    GeneIDi6007.
    KEGGihsa:6007.
    UCSCiuc009vrm.3. human. [Q02161-1]

    Polymorphism databases

    DMDMi296452980.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63097 mRNA. Translation: CAA44811.1 .
    X63094 mRNA. Translation: CAA44808.1 .
    L08429 mRNA. Translation: AAA02679.1 .
    S57971 mRNA. Translation: AAB26081.1 .
    S70174 mRNA. Translation: AAB30756.1 .
    S78509 mRNA. Translation: AAB34852.1 .
    S73913 mRNA. Translation: AAB31911.1 .
    AY751492 mRNA. Translation: AAU93636.1 .
    AY751493 mRNA. Translation: AAU93637.1 .
    AY751495 mRNA. Translation: AAU93639.1 .
    AB018966 mRNA. Translation: BAA81899.1 .
    AB018967 mRNA. Translation: BAA81900.1 .
    AB018968 mRNA. Translation: BAA81901.1 .
    AB018969 mRNA. Translation: BAA82159.1 .
    AL928711 Genomic DNA. Translation: CAH72602.1 .
    CCDSi CCDS262.1. [Q02161-1 ]
    CCDS53285.1. [Q02161-2 ]
    CCDS60028.1. [Q02161-4 ]
    CCDS60030.1. [Q02161-5 ]
    CCDS60031.1. [Q02161-6 ]
    PIRi A46368.
    I52615.
    RefSeqi NP_001121163.1. NM_001127691.2. [Q02161-2 ]
    NP_001269797.1. NM_001282868.1. [Q02161-6 ]
    NP_001269798.1. NM_001282869.1. [Q02161-5 ]
    NP_001269800.1. NM_001282871.1. [Q02161-4 ]
    NP_057208.2. NM_016124.4.
    UniGenei Hs.449968.

    3D structure databases

    ProteinModelPortali Q02161.
    SMRi Q02161. Positions 40-308.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 111939. 2 interactions.

    Protein family/group databases

    TCDBi 1.A.11.4.3. the ammonia transporter channel (amt) family.

    PTM databases

    PhosphoSitei Q02161.

    Polymorphism databases

    DMDMi 296452980.

    Proteomic databases

    PaxDbi Q02161.
    PRIDEi Q02161.

    Protocols and materials databases

    DNASUi 6007.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328664 ; ENSP00000331871 ; ENSG00000187010 . [Q02161-1 ]
    ENST00000342055 ; ENSP00000339577 ; ENSG00000187010 . [Q02161-4 ]
    ENST00000357542 ; ENSP00000350150 ; ENSG00000187010 . [Q02161-5 ]
    ENST00000417538 ; ENSP00000396420 ; ENSG00000187010 . [Q02161-6 ]
    ENST00000454452 ; ENSP00000413849 ; ENSG00000187010 . [Q02161-2 ]
    GeneIDi 6007.
    KEGGi hsa:6007.
    UCSCi uc009vrm.3. human. [Q02161-1 ]

    Organism-specific databases

    CTDi 6007.
    GeneCardsi GC01P025599.
    HGNCi HGNC:10009. RHD.
    MIMi 111680. gene.
    neXtProti NX_Q02161.
    Orphaneti 71275. Rh deficiency syndrome.
    PharmGKBi PA34387.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314742.
    HOVERGENi HBG004374.
    KOi K06579.
    OMAi TCGVHYT.
    OrthoDBi EOG73NG3C.
    PhylomeDBi Q02161.
    TreeFami TF314450.

    Miscellaneous databases

    GeneWikii RHD_(gene).
    GenomeRNAii 6007.
    NextBioi 23439.
    PROi Q02161.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02161.
    Bgeei Q02161.
    Genevestigatori Q02161.

    Family and domain databases

    Gene3Di 1.10.3430.10. 1 hit.
    InterProi IPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view ]
    Pfami PF00909. Ammonium_transp. 1 hit.
    [Graphical view ]
    PRINTSi PR00342. RHESUSRHD.
    SUPFAMi SSF111352. SSF111352. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Molecular cloning and primary structure of the human blood group RhD polypeptide."
      le van Kim C., Mouro I., Cherif-Zahar B., Raynal V., Cherrier C., Cartron J.-P., Colin Y.
      Proc. Natl. Acad. Sci. U.S.A. 89:10925-10929(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-218.
      Tissue: Bone marrow.
    2. "Multiple Rh messenger RNA isoforms are produced by alternative splicing."
      le van Kim C., Cherif-Zahar B., Raynal V., Mouro I., Lopez M., Cartron J.-P., Colin Y.
      Blood 80:1074-1078(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. "Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals."
      Arce M.A., Thompson E.S., Wagner S., Coyne K.E., Ferdman B.A., Lublin D.M.
      Blood 82:651-655(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system."
      Kajii E., Umenishi F., Iwamoto S., Ikemoto S.
      Hum. Genet. 91:157-162(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Identification of a new RhD-specific mRNA from K562 cells."
      Westhoff C.M., Wylie D.E.
      Blood 83:3098-3100(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    6. "Identification of a partial internal deletion in the RH locus causing the human erythrocyte D-phenotype."
      Huang C.-H., Reid M.E., Chen Y.
      Blood 86:784-790(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-16.
    7. "Rh(D) antigen expression and isolation of a new Rh(D) cDNA isoform in human erythroleukemic K562 cells."
      Suyama K., Lunn R., Haller S., Goldstein J.
      Blood 84:1975-1981(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    8. "Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele."
      Shao C.P., Xiong W., Zhou Y.Y.
      Transfus. Apher. Sci. 34:145-152(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5 AND 6), ALTERNATIVE SPLICING.
    9. "Polymorphisms of RhDVa in Japanese."
      Hyodo H., Ishikawa Y., Kashiwase K., Ogawa A., Watanabe Y., Tsuneyama H., Toyoda C., Uchikawa M., Akaza T., Fujii T.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-223; GLN-233; MET-238 AND LEU-245.
    10. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane."
      Avent N.D., Ridgwell K., Mawby W.J., Tanner M.J.A., Anstee D.J., Kumpel B.
      Biochem. J. 256:1043-1046(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-33.
    12. "Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes."
      Saboori A.M., Smith B.L., Agre P.
      Proc. Natl. Acad. Sci. U.S.A. 85:4042-4045(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
    13. "Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains."
      Bloy C., Blanchard D., Dahr W., Beyreuther K., Salmon C., Cartron J.-P.
      Blood 72:661-666(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-17.
    14. "Regarding the size of Rh proteins."
      Suyama K., Goldstein J., Aebersold R., Kent S.
      Blood 77:411-411(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 401-407.
    15. "Leu110Pro substitution in the RhD polypeptide is responsible for the DVII category blood group phenotype."
      Rouillac C., le van Kim C., Beolet M., Cartron J.-P., Colin Y.
      Am. J. Hematol. 49:87-88(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TAR ANTIGEN PRO-110.
    16. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-103.

    Entry informationi

    Entry nameiRHD_HUMAN
    AccessioniPrimary (citable) accession number: Q02161
    Secondary accession number(s): Q02162
    , Q07618, Q16147, Q16235, Q16355, Q5VSK0, Q5XLS9, Q5XLT1, Q5XLT2, Q9NPK0, Q9UQ20, Q9UQ21, Q9UQ22, Q9UQ23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 18, 2010
    Last modified: July 9, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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