Q02155 (HXK_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase
EC=2.7.1.1

Gene names

Name:

HK

Organism

Plasmodium falciparum

Taxonomic identifier

5833 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Pathway	Carbohydrate metabolism; hexose metabolism.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Hexokinase		PRO_0000197598
Regions
	Nucleotide binding	102 – 107	6	ATP Potential
	Region	177 – 203	27	Glucose-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q02155 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 6EE843FB0E1A3F3F	FASTA	493	55,346
	10 20 30 40 50 60 MSEYDIAKND VTYTKLDTIE CDIPINEELS WRINKFVNQL RISYSTLEEF VDNFVYELKK 70 80 90 100 110 120 GLEAHRKHPN LWIPHECSFK MLDSCIANIP TGQEKGTYYA IDFGGTNFRA VRASLDGKGK 130 140 150 160 170 180 IKRDQETYSL KFTGSYSHEK GLLDKHATAS QLFDHFAERI KYIMGEFNDL DNKEVKSVGF 190 200 210 220 230 240 TFSFPCTSPS INCSILIDWT KGFETGRATN DPVEGRDVCK LMNDAFVRAA IPAKVCCVLN 250 260 270 280 290 300 DAVGTLMSCA YQKGRGTPPC YIGIILGTGS NGCYYEPEWK KYKYAGKIIN IEFGNFDKDL 310 320 330 340 350 360 PTSPIDLVMD WYSANRSRQL FEKMISGAYL GEIVRRFMVN VLQSACSKKM WISDSFNSES 370 380 390 400 410 420 GSVVLNDTSK NFEDSRKVAK AAWDMDFTDE QIYVLRKICE AVYNRSAALA RGTIAAIAKR 430 440 450 460 470 480 IKIIEHSKFT CGVDGSLFVK NAWYCKRLQE HLKVILADKA ENLIIIPADD GSGKGAAITA 490 AVIALNADIP QLP

References

[1]	"Molecular analysis of Plasmodium falciparum hexokinase." Olafsson P., Matile H., Cesta U. Mol. Biochem. Parasitol. 56:89-102(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M92054 Genomic DNA. Translation: AAA29613.1.
PIR	A48457.
3D structure databases
ProteinModelPortal	Q02155.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG5026.
Enzyme and pathway databases
SABIO-RK	Q02155.
UniPathway	UPA00242.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK_PLAFA

Accession

Primary (citable) accession number: Q02155

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)