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Q02150

- HIS9_LACLA

UniProt

Q02150 - HIS9_LACLA

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Protein
Histidinol-phosphatase
Gene
hisK, LL1216, L37351
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-histidinol phosphate + H2O = L-histidinol + phosphate.

Pathwayi

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed DNA polymerase activity Source: InterPro
  3. histidinol-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1304-MONOMER.
UniPathwayiUPA00031; UER00013.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphatase (EC:3.1.3.15)
Short name:
HolPase
Gene namesi
Name:hisK
Ordered Locus Names:LL1216
ORF Names:L37351
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Histidinol-phosphatase
PRO_0000122319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L37351.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 2910
Beta strandi33 – 4210
Helixi54 – 6714
Turni68 – 714
Beta strandi73 – 819
Helixi84 – 863
Helixi87 – 948
Beta strandi100 – 1056
Helixi119 – 1213
Helixi126 – 14318
Beta strandi148 – 1503
Helixi155 – 1584
Beta strandi159 – 1613
Helixi170 – 1723
Helixi173 – 18513
Beta strandi189 – 1935
Turni195 – 1984
Helixi200 – 21516
Beta strandi220 – 2245
Beta strandi228 – 2303
Helixi234 – 24613

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GC3X-ray1.32A2-269[»]
4GK8X-ray1.93A2-269[»]
4GYFX-ray1.65A2-269[»]
ProteinModelPortaliQ02150.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1387.
HOGENOMiHOG000244025.
KOiK04486.
OMAiLDYPARY.
OrthoDBiEOG6JMMRV.

Family and domain databases

InterProiIPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PANTHERiPTHR21039. PTHR21039. 1 hit.
PfamiPF02811. PHP. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR01856. hisJ_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02150-1 [UniParc]FASTAAdd to Basket

« Hide

MKKLDYHFHS HFSADSEELP RKHVTEAIAH GLEEICFTEH RDFYFPGMDF    50
SLNLPEYFQE INRLQAEFKD KIKIKIGLEM GIDLRFKSEI NQFIDSAPFD 100
FVIASVHEIG DIEVYDGTEF YLQKIKEEAQ REYLLACLDV VQNFENYNSF 150
GHLDYVARYG PYTDKSIKFA ENREILFEIL RALASKEKAL EINTRLFDDP 200
KTEQFYSDLL INFKKLGGKF ITLGTDSHIA KRDWLSIHKA RTLIKKAGFH 250
ELATFSGMKI DKNKKSIKE 269
Length:269
Mass (Da):31,473
Last modified:September 26, 2001 - v2
Checksum:iCF51601DEDD5B8C2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251T → I in AAB81911. 1 Publication
Sequence conflicti30 – 301H → Y in AAB81911. 1 Publication
Sequence conflicti71 – 733KIK → EIN in AAB81911. 1 Publication
Sequence conflicti125 – 1251I → T in AAB81911. 1 Publication
Sequence conflicti146 – 1461N → T in AAB81911. 1 Publication
Sequence conflicti168 – 1681K → T in AAB81911. 1 Publication
Sequence conflicti187 – 1871E → G in AAB81911. 1 Publication
Sequence conflicti203 – 2031E → G in AAB81911. 1 Publication
Sequence conflicti215 – 2151K → R in AAB81911. 1 Publication
Sequence conflicti250 – 2501H → R in AAB81911. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92974 Genomic DNA. Translation: AAB81911.1.
AE005176 Genomic DNA. Translation: AAK05314.1.
PIRiD47754.
H86776.
RefSeqiNP_267372.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05314; AAK05314; L37351.
GeneIDi1114864.
KEGGilla:L37351.
PATRICi22294810. VBILacLac136773_1313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92974 Genomic DNA. Translation: AAB81911.1 .
AE005176 Genomic DNA. Translation: AAK05314.1 .
PIRi D47754.
H86776.
RefSeqi NP_267372.1. NC_002662.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GC3 X-ray 1.32 A 2-269 [» ]
4GK8 X-ray 1.93 A 2-269 [» ]
4GYF X-ray 1.65 A 2-269 [» ]
ProteinModelPortali Q02150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L37351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05314 ; AAK05314 ; L37351 .
GeneIDi 1114864.
KEGGi lla:L37351.
PATRICi 22294810. VBILacLac136773_1313.

Phylogenomic databases

eggNOGi COG1387.
HOGENOMi HOG000244025.
KOi K04486.
OMAi LDYPARY.
OrthoDBi EOG6JMMRV.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00013 .
BioCyci LLAC272623:GHSH-1304-MONOMER.

Family and domain databases

InterProi IPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view ]
PANTHERi PTHR21039. PTHR21039. 1 hit.
Pfami PF02811. PHP. 1 hit.
[Graphical view ]
SMARTi SM00481. POLIIIAc. 1 hit.
[Graphical view ]
SUPFAMi SSF89550. SSF89550. 1 hit.
TIGRFAMsi TIGR01856. hisJ_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Histidine biosynthesis genes in Lactococcus lactis subsp. lactis."
    Delorme C., Ehrlich S.D., Renault P.
    J. Bacteriol. 174:6571-6579(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCDO 2118.
  2. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiHIS9_LACLA
AccessioniPrimary (citable) accession number: Q02150
Secondary accession number(s): Q9CG89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 26, 2001
Last modified: May 14, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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