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Q02150 (HIS9_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol-phosphatase

Short name=HolPase
EC=3.1.3.15
Gene names
Name:hisK
Ordered Locus Names:LL1216
ORF Names:L37351
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-histidinol phosphate + H2O = L-histidinol + phosphate.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.

Sequence similarities

Belongs to the PHP hydrolase family. HisK subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Histidinol-phosphatase
PRO_0000122319

Experimental info

Sequence conflict251T → I in AAB81911. Ref.1
Sequence conflict301H → Y in AAB81911. Ref.1
Sequence conflict71 – 733KIK → EIN in AAB81911. Ref.1
Sequence conflict1251I → T in AAB81911. Ref.1
Sequence conflict1461N → T in AAB81911. Ref.1
Sequence conflict1681K → T in AAB81911. Ref.1
Sequence conflict1871E → G in AAB81911. Ref.1
Sequence conflict2031E → G in AAB81911. Ref.1
Sequence conflict2151K → R in AAB81911. Ref.1
Sequence conflict2501H → R in AAB81911. Ref.1

Secondary structure

....................................... 269
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q02150 [UniParc].

Last modified September 26, 2001. Version 2.
Checksum: CF51601DEDD5B8C2

FASTA26931,473
        10         20         30         40         50         60 
MKKLDYHFHS HFSADSEELP RKHVTEAIAH GLEEICFTEH RDFYFPGMDF SLNLPEYFQE 

        70         80         90        100        110        120 
INRLQAEFKD KIKIKIGLEM GIDLRFKSEI NQFIDSAPFD FVIASVHEIG DIEVYDGTEF 

       130        140        150        160        170        180 
YLQKIKEEAQ REYLLACLDV VQNFENYNSF GHLDYVARYG PYTDKSIKFA ENREILFEIL 

       190        200        210        220        230        240 
RALASKEKAL EINTRLFDDP KTEQFYSDLL INFKKLGGKF ITLGTDSHIA KRDWLSIHKA 

       250        260 
RTLIKKAGFH ELATFSGMKI DKNKKSIKE 

« Hide

References

« Hide 'large scale' references
[1]"Histidine biosynthesis genes in Lactococcus lactis subsp. lactis."
Delorme C., Ehrlich S.D., Renault P.
J. Bacteriol. 174:6571-6579(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NCDO 2118.
[2]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U92974 Genomic DNA. Translation: AAB81911.1.
AE005176 Genomic DNA. Translation: AAK05314.1.
PIRD47754.
H86776.
RefSeqNP_267372.1. NC_002662.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GC3X-ray1.32A2-269[»]
4GK8X-ray1.93A2-269[»]
4GYFX-ray1.65A2-269[»]
ProteinModelPortalQ02150.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L37351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05314; AAK05314; L37351.
GeneID1114864.
KEGGlla:L37351.
PATRIC22294810. VBILacLac136773_1313.

Phylogenomic databases

eggNOGCOG1387.
HOGENOMHOG000244025.
KOK04486.
OMALDYPARY.
OrthoDBEOG6JMMRV.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1304-MONOMER.
UniPathwayUPA00031; UER00013.

Family and domain databases

InterProIPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PANTHERPTHR21039. PTHR21039. 1 hit.
PfamPF02811. PHP. 1 hit.
[Graphical view]
SMARTSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMSSF89550. SSF89550. 1 hit.
TIGRFAMsTIGR01856. hisJ_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS9_LACLA
AccessionPrimary (citable) accession number: Q02150
Secondary accession number(s): Q9CG89
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 26, 2001
Last modified: May 14, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways