Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q02150

- HIS9_LACLA

UniProt

Q02150 - HIS9_LACLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histidinol-phosphatase

Gene

hisK

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-histidinol phosphate + H2O = L-histidinol + phosphate.

Pathwayi

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed DNA polymerase activity Source: InterPro
  3. histidinol-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1304-MONOMER.
UniPathwayiUPA00031; UER00013.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphatase (EC:3.1.3.15)
Short name:
HolPase
Gene namesi
Name:hisK
Ordered Locus Names:LL1216
ORF Names:L37351
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Histidinol-phosphatasePRO_0000122319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L37351.

Structurei

Secondary structure

1
269
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 2910Combined sources
Beta strandi33 – 4210Combined sources
Helixi54 – 6714Combined sources
Turni68 – 714Combined sources
Beta strandi73 – 819Combined sources
Helixi84 – 863Combined sources
Helixi87 – 948Combined sources
Beta strandi100 – 1056Combined sources
Helixi119 – 1213Combined sources
Helixi126 – 14318Combined sources
Beta strandi148 – 1503Combined sources
Helixi155 – 1584Combined sources
Beta strandi159 – 1613Combined sources
Helixi170 – 1723Combined sources
Helixi173 – 18513Combined sources
Beta strandi189 – 1935Combined sources
Turni195 – 1984Combined sources
Helixi200 – 21516Combined sources
Beta strandi220 – 2245Combined sources
Beta strandi228 – 2303Combined sources
Helixi234 – 24613Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GC3X-ray1.32A2-269[»]
4GK8X-ray1.93A2-269[»]
4GYFX-ray1.65A2-269[»]
ProteinModelPortaliQ02150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PHP hydrolase family. HisK subfamily.Curated

Phylogenomic databases

eggNOGiCOG1387.
HOGENOMiHOG000244025.
KOiK04486.
OMAiLDYPARY.
OrthoDBiEOG6JMMRV.

Family and domain databases

InterProiIPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PANTHERiPTHR21039. PTHR21039. 1 hit.
PfamiPF02811. PHP. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR01856. hisJ_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02150-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKLDYHFHS HFSADSEELP RKHVTEAIAH GLEEICFTEH RDFYFPGMDF
60 70 80 90 100
SLNLPEYFQE INRLQAEFKD KIKIKIGLEM GIDLRFKSEI NQFIDSAPFD
110 120 130 140 150
FVIASVHEIG DIEVYDGTEF YLQKIKEEAQ REYLLACLDV VQNFENYNSF
160 170 180 190 200
GHLDYVARYG PYTDKSIKFA ENREILFEIL RALASKEKAL EINTRLFDDP
210 220 230 240 250
KTEQFYSDLL INFKKLGGKF ITLGTDSHIA KRDWLSIHKA RTLIKKAGFH
260
ELATFSGMKI DKNKKSIKE
Length:269
Mass (Da):31,473
Last modified:September 26, 2001 - v2
Checksum:iCF51601DEDD5B8C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251T → I in AAB81911. (PubMed:1400209)Curated
Sequence conflicti30 – 301H → Y in AAB81911. (PubMed:1400209)Curated
Sequence conflicti71 – 733KIK → EIN in AAB81911. (PubMed:1400209)Curated
Sequence conflicti125 – 1251I → T in AAB81911. (PubMed:1400209)Curated
Sequence conflicti146 – 1461N → T in AAB81911. (PubMed:1400209)Curated
Sequence conflicti168 – 1681K → T in AAB81911. (PubMed:1400209)Curated
Sequence conflicti187 – 1871E → G in AAB81911. (PubMed:1400209)Curated
Sequence conflicti203 – 2031E → G in AAB81911. (PubMed:1400209)Curated
Sequence conflicti215 – 2151K → R in AAB81911. (PubMed:1400209)Curated
Sequence conflicti250 – 2501H → R in AAB81911. (PubMed:1400209)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92974 Genomic DNA. Translation: AAB81911.1.
AE005176 Genomic DNA. Translation: AAK05314.1.
PIRiD47754.
H86776.
RefSeqiNP_267372.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05314; AAK05314; L37351.
GeneIDi1114864.
KEGGilla:L37351.
PATRICi22294810. VBILacLac136773_1313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92974 Genomic DNA. Translation: AAB81911.1 .
AE005176 Genomic DNA. Translation: AAK05314.1 .
PIRi D47754.
H86776.
RefSeqi NP_267372.1. NC_002662.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GC3 X-ray 1.32 A 2-269 [» ]
4GK8 X-ray 1.93 A 2-269 [» ]
4GYF X-ray 1.65 A 2-269 [» ]
ProteinModelPortali Q02150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L37351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05314 ; AAK05314 ; L37351 .
GeneIDi 1114864.
KEGGi lla:L37351.
PATRICi 22294810. VBILacLac136773_1313.

Phylogenomic databases

eggNOGi COG1387.
HOGENOMi HOG000244025.
KOi K04486.
OMAi LDYPARY.
OrthoDBi EOG6JMMRV.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00013 .
BioCyci LLAC272623:GHSH-1304-MONOMER.

Family and domain databases

InterProi IPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view ]
PANTHERi PTHR21039. PTHR21039. 1 hit.
Pfami PF02811. PHP. 1 hit.
[Graphical view ]
SMARTi SM00481. POLIIIAc. 1 hit.
[Graphical view ]
SUPFAMi SSF89550. SSF89550. 1 hit.
TIGRFAMsi TIGR01856. hisJ_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Histidine biosynthesis genes in Lactococcus lactis subsp. lactis."
    Delorme C., Ehrlich S.D., Renault P.
    J. Bacteriol. 174:6571-6579(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCDO 2118.
  2. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiHIS9_LACLA
AccessioniPrimary (citable) accession number: Q02150
Secondary accession number(s): Q9CG89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 26, 2001
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3