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Protein

Histidinol-phosphatase

Gene

hisK

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-histidinol phosphate + H2O = L-histidinol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1304-MONOMER.
UniPathwayiUPA00031; UER00013.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphatase (EC:3.1.3.15)
Short name:
HolPase
Gene namesi
Name:hisK
Ordered Locus Names:LL1216
ORF Names:L37351
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Histidinol-phosphatasePRO_0000122319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L37351.

Structurei

Secondary structure

1
269
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 2910Combined sources
Beta strandi33 – 4210Combined sources
Helixi54 – 6714Combined sources
Turni68 – 714Combined sources
Beta strandi73 – 819Combined sources
Helixi84 – 863Combined sources
Helixi87 – 948Combined sources
Beta strandi100 – 1056Combined sources
Helixi119 – 1213Combined sources
Helixi126 – 14318Combined sources
Beta strandi148 – 1503Combined sources
Helixi155 – 1584Combined sources
Beta strandi159 – 1613Combined sources
Helixi170 – 1723Combined sources
Helixi173 – 18513Combined sources
Beta strandi189 – 1935Combined sources
Turni195 – 1984Combined sources
Helixi200 – 21516Combined sources
Beta strandi220 – 2245Combined sources
Beta strandi228 – 2303Combined sources
Helixi234 – 24613Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GC3X-ray1.32A2-269[»]
4GK8X-ray1.93A2-269[»]
4GYFX-ray1.65A2-269[»]
ProteinModelPortaliQ02150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PHP hydrolase family. HisK subfamily.Curated

Phylogenomic databases

eggNOGiCOG1387.
HOGENOMiHOG000244025.
KOiK04486.
OMAiDYWIVEM.
OrthoDBiEOG6JMMRV.

Family and domain databases

InterProiIPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PANTHERiPTHR21039. PTHR21039. 1 hit.
PfamiPF02811. PHP. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR01856. hisJ_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLDYHFHS HFSADSEELP RKHVTEAIAH GLEEICFTEH RDFYFPGMDF
60 70 80 90 100
SLNLPEYFQE INRLQAEFKD KIKIKIGLEM GIDLRFKSEI NQFIDSAPFD
110 120 130 140 150
FVIASVHEIG DIEVYDGTEF YLQKIKEEAQ REYLLACLDV VQNFENYNSF
160 170 180 190 200
GHLDYVARYG PYTDKSIKFA ENREILFEIL RALASKEKAL EINTRLFDDP
210 220 230 240 250
KTEQFYSDLL INFKKLGGKF ITLGTDSHIA KRDWLSIHKA RTLIKKAGFH
260
ELATFSGMKI DKNKKSIKE
Length:269
Mass (Da):31,473
Last modified:September 26, 2001 - v2
Checksum:iCF51601DEDD5B8C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251T → I in AAB81911 (PubMed:1400209).Curated
Sequence conflicti30 – 301H → Y in AAB81911 (PubMed:1400209).Curated
Sequence conflicti71 – 733KIK → EIN in AAB81911 (PubMed:1400209).Curated
Sequence conflicti125 – 1251I → T in AAB81911 (PubMed:1400209).Curated
Sequence conflicti146 – 1461N → T in AAB81911 (PubMed:1400209).Curated
Sequence conflicti168 – 1681K → T in AAB81911 (PubMed:1400209).Curated
Sequence conflicti187 – 1871E → G in AAB81911 (PubMed:1400209).Curated
Sequence conflicti203 – 2031E → G in AAB81911 (PubMed:1400209).Curated
Sequence conflicti215 – 2151K → R in AAB81911 (PubMed:1400209).Curated
Sequence conflicti250 – 2501H → R in AAB81911 (PubMed:1400209).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92974 Genomic DNA. Translation: AAB81911.1.
AE005176 Genomic DNA. Translation: AAK05314.1.
PIRiD47754.
H86776.
RefSeqiNP_267372.1. NC_002662.1.
WP_003131121.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05314; AAK05314; L37351.
GeneIDi1114864.
KEGGilla:L37351.
PATRICi22294810. VBILacLac136773_1313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92974 Genomic DNA. Translation: AAB81911.1.
AE005176 Genomic DNA. Translation: AAK05314.1.
PIRiD47754.
H86776.
RefSeqiNP_267372.1. NC_002662.1.
WP_003131121.1. NC_002662.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GC3X-ray1.32A2-269[»]
4GK8X-ray1.93A2-269[»]
4GYFX-ray1.65A2-269[»]
ProteinModelPortaliQ02150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L37351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05314; AAK05314; L37351.
GeneIDi1114864.
KEGGilla:L37351.
PATRICi22294810. VBILacLac136773_1313.

Phylogenomic databases

eggNOGiCOG1387.
HOGENOMiHOG000244025.
KOiK04486.
OMAiDYWIVEM.
OrthoDBiEOG6JMMRV.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00013.
BioCyciLLAC272623:GHSH-1304-MONOMER.

Family and domain databases

InterProiIPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PANTHERiPTHR21039. PTHR21039. 1 hit.
PfamiPF02811. PHP. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR01856. hisJ_fam. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Histidine biosynthesis genes in Lactococcus lactis subsp. lactis."
    Delorme C., Ehrlich S.D., Renault P.
    J. Bacteriol. 174:6571-6579(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCDO 2118.
  2. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiHIS9_LACLA
AccessioniPrimary (citable) accession number: Q02150
Secondary accession number(s): Q9CG89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 26, 2001
Last modified: May 27, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.