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Q02136

- HISX_LACLA

UniProt

Q02136 - HISX_LACLA

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Protein
Histidinol dehydrogenase
Gene
hisD, LL1209, L0067
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei327 – 3271Proton acceptor By similarity
Active sitei328 – 3281Proton acceptor By similarity
Binding sitei328 – 3281Substrate By similarity
Metal bindingi361 – 3611Zinc By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei415 – 4151Substrate By similarity
Metal bindingi420 – 4201Zinc By similarity
Binding sitei420 – 4201Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1296-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:LL1209
ORF Names:L0067
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenaseUniRule annotation
PRO_0000135783Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L0067.

Structurei

3D structure databases

ProteinModelPortaliQ02136.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02136-1 [UniParc]FASTAAdd to Basket

« Hide

MLKQIDYQGK LEEIAEKFQG RKTEVSKEVN KTVQQIVADI QKNGDTALFN    50
YAKKFDGYDV NTSNLLVTRM EREAGLEQID EDYFRILRRT KSQIEEFHKH 100
QLGNSWNIFK ENGVIMGQIA RPLERVALYV PGGTAAYPST VIMNAVPALL 150
AGVKEIIMIT PVKADGKVNP NILAAAEVCG IETIYKVGGA QGVAAVAYGT 200
ESIPKVDKIV GPGNIFVATA KKICYGVVDI DMIAGPSEVL VIADKTAKPK 250
YIAADLMAQA EHDKLASAIL VTTSEKLVQQ VDEELNRQVQ NLERREIIES 300
SIRNYGGAIV VKNIDDAFDV SNQLAPEHLE VLTSEPLTQL PKIKNAGSIF 350
IGEYTPEPLG DYMSGSNHVL PTGGTAKFYS GLGVYNFIKY LTYSYYPKEV 400
LADFKEDVET FAKSEGLTAH ANSISVRFDE M 431
Length:431
Mass (Da):47,411
Last modified:January 4, 2005 - v3
Checksum:i3FFD2B5C75F9D1B0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381A → E in strain: IL1403.
Natural varianti43 – 431N → S in strain: IL1403.
Natural varianti69 – 691R → P in strain: IL1403.
Natural varianti74 – 741A → T in strain: IL1403.
Natural varianti164 – 1641A → T in strain: IL1403.
Natural varianti245 – 2451K → E in strain: IL1403.
Natural varianti248 – 2481K → N in strain: IL1403.
Natural varianti295 – 2951R → S in strain: IL1403.
Natural varianti301 – 3033SIR → YIS in strain: IL1403.
Natural varianti316 – 3161D → E in strain: IL1403.
Natural varianti403 – 4031D → A in strain: IL1403.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251V → L in AAK05307. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92974 Genomic DNA. No translation available.
AE005176 Genomic DNA. Translation: AAK05307.1.
PIRiA86776.
E45734.
RefSeqiNP_267365.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05307; AAK05307; L0067.
GeneIDi1114856.
KEGGilla:L0067.
PATRICi22294792. VBILacLac136773_1304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92974 Genomic DNA. No translation available.
AE005176 Genomic DNA. Translation: AAK05307.1 .
PIRi A86776.
E45734.
RefSeqi NP_267365.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q02136.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L0067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05307 ; AAK05307 ; L0067 .
GeneIDi 1114856.
KEGGi lla:L0067.
PATRICi 22294792. VBILacLac136773_1304.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci LLAC272623:GHSH-1296-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Histidine biosynthesis genes in Lactococcus lactis subsp. lactis."
    Delorme C., Ehrlich S.D., Renault P.
    J. Bacteriol. 174:6571-6579(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCDO 2118.
  2. "Gene inactivation in Lactococcus lactis: histidine biosynthesis."
    Delorme C., Godon J.-J., Ehrlich S.D., Renault P.
    J. Bacteriol. 175:4391-4399(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IL1403.
  3. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiHISX_LACLA
AccessioniPrimary (citable) accession number: Q02136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This protein is inactive in the dairy strain IL1403. The histidine biosynthesis pathway is not functional in the dairy strain IL1403.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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