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Q02136

- HISX_LACLA

UniProt

Q02136 - HISX_LACLA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei129 – 1291NADBy similarity
    Binding sitei191 – 1911NADBy similarity
    Binding sitei214 – 2141NADBy similarity
    Binding sitei237 – 2371SubstrateBy similarity
    Metal bindingi259 – 2591ZincBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Metal bindingi262 – 2621ZincBy similarity
    Binding sitei262 – 2621SubstrateBy similarity
    Active sitei327 – 3271Proton acceptorBy similarity
    Active sitei328 – 3281Proton acceptorBy similarity
    Binding sitei328 – 3281SubstrateBy similarity
    Metal bindingi361 – 3611ZincBy similarity
    Binding sitei361 – 3611SubstrateBy similarity
    Binding sitei415 – 4151SubstrateBy similarity
    Metal bindingi420 – 4201ZincBy similarity
    Binding sitei420 – 4201SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-1296-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:LL1209
    ORF Names:L0067
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Histidinol dehydrogenasePRO_0000135783Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272623.L0067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02136-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKQIDYQGK LEEIAEKFQG RKTEVSKEVN KTVQQIVADI QKNGDTALFN    50
    YAKKFDGYDV NTSNLLVTRM EREAGLEQID EDYFRILRRT KSQIEEFHKH 100
    QLGNSWNIFK ENGVIMGQIA RPLERVALYV PGGTAAYPST VIMNAVPALL 150
    AGVKEIIMIT PVKADGKVNP NILAAAEVCG IETIYKVGGA QGVAAVAYGT 200
    ESIPKVDKIV GPGNIFVATA KKICYGVVDI DMIAGPSEVL VIADKTAKPK 250
    YIAADLMAQA EHDKLASAIL VTTSEKLVQQ VDEELNRQVQ NLERREIIES 300
    SIRNYGGAIV VKNIDDAFDV SNQLAPEHLE VLTSEPLTQL PKIKNAGSIF 350
    IGEYTPEPLG DYMSGSNHVL PTGGTAKFYS GLGVYNFIKY LTYSYYPKEV 400
    LADFKEDVET FAKSEGLTAH ANSISVRFDE M 431
    Length:431
    Mass (Da):47,411
    Last modified:January 4, 2005 - v3
    Checksum:i3FFD2B5C75F9D1B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251V → L in AAK05307. (PubMed:11337471)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti38 – 381A → E in strain: IL1403.
    Natural varianti43 – 431N → S in strain: IL1403.
    Natural varianti69 – 691R → P in strain: IL1403.
    Natural varianti74 – 741A → T in strain: IL1403.
    Natural varianti164 – 1641A → T in strain: IL1403.
    Natural varianti245 – 2451K → E in strain: IL1403.
    Natural varianti248 – 2481K → N in strain: IL1403.
    Natural varianti295 – 2951R → S in strain: IL1403.
    Natural varianti301 – 3033SIR → YIS in strain: IL1403.
    Natural varianti316 – 3161D → E in strain: IL1403.
    Natural varianti403 – 4031D → A in strain: IL1403.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92974 Genomic DNA. No translation available.
    AE005176 Genomic DNA. Translation: AAK05307.1.
    PIRiA86776.
    E45734.
    RefSeqiNP_267365.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK05307; AAK05307; L0067.
    GeneIDi1114856.
    KEGGilla:L0067.
    PATRICi22294792. VBILacLac136773_1304.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92974 Genomic DNA. No translation available.
    AE005176 Genomic DNA. Translation: AAK05307.1 .
    PIRi A86776.
    E45734.
    RefSeqi NP_267365.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q02136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L0067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK05307 ; AAK05307 ; L0067 .
    GeneIDi 1114856.
    KEGGi lla:L0067.
    PATRICi 22294792. VBILacLac136773_1304.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci LLAC272623:GHSH-1296-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Histidine biosynthesis genes in Lactococcus lactis subsp. lactis."
      Delorme C., Ehrlich S.D., Renault P.
      J. Bacteriol. 174:6571-6579(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NCDO 2118.
    2. "Gene inactivation in Lactococcus lactis: histidine biosynthesis."
      Delorme C., Godon J.-J., Ehrlich S.D., Renault P.
      J. Bacteriol. 175:4391-4399(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IL1403.
    3. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiHISX_LACLA
    AccessioniPrimary (citable) accession number: Q02136
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    This protein is inactive in the dairy strain IL1403. The histidine biosynthesis pathway is not functional in the dairy strain IL1403.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3