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Q02115 (LYAT_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulator LytR
Alternative name(s):
Membrane-bound protein LytR
Gene names
Name:lytR
Ordered Locus Names:BSU35650
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an attenuator role for both its own and lytABC operon expression, and thus regulates the expression of the major autolytic amidase of B.subtilis. Ref.1

Subcellular location

Cell membrane; Single-pass type II membrane protein Potential HAMAP-Rule MF_01140.

Disruption phenotype

Cells lacking this gene display a considerably increased transcription frequency of lytR and lytABC operon expression. Ref.1

Sequence similarities

Belongs to the LytR/CpsA/Psr regulatory protein family.

Caution

This protein is unrelated to LytR from S.aureus, which is part of a two-component regulatory system that, together with LytS, is involved in autolysis and cell wall metabolism. The B.subtilis ortholog of S.aureus LytR is LytT (AC P94514).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Transcriptional regulator LytR HAMAP-Rule MF_01140
PRO_0000218498

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain33 – 306274Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
Q02115 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: E79BE5DDFFA3B089

FASTA30634,586
        10         20         30         40         50         60 
MRNERRKKKK TLLLTILTII GLLVLGTGGY AYYLWHKAAS TVASIHESID KSKKRDKEVS 

        70         80         90        100        110        120 
INKKDPFSVL IMGVDERDGD KGRADTLIYM TVNPKTNTTD MVSIPRDTYT KIIGKGTMDK 

       130        140        150        160        170        180 
INHSYAFGGT QMTVDTVENF LDVPVDYFVK VNMESFRDVV DTLGGITVNS TFAFSYDGYS 

       190        200        210        220        230        240 
FGKGEITLNG KEALAYTRMR KEDPRGDFGR QDRQRQVIQG IINKGANISS ITKFGDMFKV 

       250        260        270        280        290        300 
VENNVKTNLT FDNMWDIQSD YKGARKHIKQ HELKGTGTKI NGIYYYQADE SALSDITKEL 


KESLEK

« Hide

References

« Hide 'large scale' references
[1]"Sequencing and analysis of the Bacillus subtilis lytRABC divergon: a regulatory unit encompassing the structural genes of the N-acetylmuramoyl-L-alanine amidase and its modifier."
Lazarevic V., Margot P., Soldo B., Karamata D.
J. Gen. Microbiol. 138:1949-1961(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS A TRANSCRIPTIONAL REGULATOR, DISRUPTION PHENOTYPE.
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Sequencing and analysis of the divergon comprising gtaB, the structural gene of UDP-glucose pyrophosphorylase of Bacillus subtilis 168."
Soldo B., Lazarevic V., Margot P., Karamata D.
J. Gen. Microbiol. 139:3185-3195(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 257-306.
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M87645 Genomic DNA. Translation: AAA22578.1.
AL009126 Genomic DNA. Translation: CAB15582.1.
Z22516 Genomic DNA. Translation: CAA80239.1.
PIRA47679.
RefSeqNP_391445.1. NC_000964.3.

3D structure databases

ProteinModelPortalQ02115.
SMRQ02115. Positions 63-305.
ModBaseSearch...

Protein-protein interaction databases

STRING224308.BSU35650.

Proteomic databases

PaxDbQ02115.

Protocols and materials databases

DNASU936787.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15582; CAB15582; BSU35650.
GeneID936787.
KEGGbsu:BSU35650.
PATRIC18979140. VBIBacSub10457_3732.

Organism-specific databases

GenoListBSU35650. [Micado]

Phylogenomic databases

eggNOGCOG1316.
HOGENOMHOG000236372.
OMARINNIYY.
ProtClustDBPRK09379.

Enzyme and pathway databases

BioCycBSUB:BSU35650-MONOMER.

Family and domain databases

HAMAPMF_01140. LytR.
InterProIPR004474. LytR_CpsA_psr.
IPR023734. Tscrpt_reg_LytR.
[Graphical view]
PfamPF03816. LytR_cpsA_psr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00350. lytR_cpsA_psr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYAT_BACSU
AccessionPrimary (citable) accession number: Q02115
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents