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Q02111

- KPCT_MOUSE

UniProt

Q02111 - KPCT_MOUSE

Protein

Protein kinase C theta type

Gene

Prkcq

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1.6 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei409 – 4091ATPPROSITE-ProRule annotation
    Active sitei504 – 5041Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri159 – 20951Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 28151Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi386 – 3949ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. protein kinase C activity Source: MGI

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW
    2. inflammatory response Source: UniProtKB-KW
    3. intracellular signal transduction Source: MGI
    4. membrane protein ectodomain proteolysis Source: BHF-UCL
    5. negative regulation of insulin receptor signaling pathway Source: UniProtKB
    6. negative regulation of T cell apoptotic process Source: UniProtKB
    7. positive regulation of interleukin-17 production Source: UniProtKB
    8. positive regulation of interleukin-2 biosynthetic process Source: MGI
    9. positive regulation of interleukin-4 production Source: UniProtKB
    10. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    11. positive regulation of T cell activation Source: UniProtKB
    12. positive regulation of T cell proliferation Source: MGI
    13. positive regulation of T-helper 17 type immune response Source: UniProtKB
    14. positive regulation of T-helper 2 cell activation Source: UniProtKB
    15. protein phosphorylation Source: MGI
    16. regulation of platelet aggregation Source: UniProtKB
    17. regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Immunity, Inflammatory response

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_219232. Effects of PIP2 hydrolysis.
    REACT_224460. Apoptotic cleavage of cellular proteins.
    REACT_225145. Downstream TCR signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C theta type (EC:2.7.11.13)
    Alternative name(s):
    nPKC-theta
    Gene namesi
    Name:Prkcq
    Synonyms:Pkcq
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:97601. Prkcq.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein
    Note: In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. immunological synapse Source: MGI
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707Protein kinase C theta typePRO_0000055709Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei90 – 901Phosphotyrosine; by LCKBy similarity
    Modified residuei219 – 2191Phosphothreonine; by autocatalysisBy similarity
    Modified residuei348 – 3481PhosphoserineBy similarity
    Modified residuei538 – 5381Phosphothreonine; by PDPK1By similarity
    Modified residuei676 – 6761Phosphoserine; by autocatalysisSequence Analysis
    Modified residuei685 – 6851PhosphoserineBy similarity
    Modified residuei695 – 6951Phosphoserine; by autocatalysisSequence Analysis

    Post-translational modificationi

    Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ02111.
    PaxDbiQ02111.
    PRIDEiQ02111.

    PTM databases

    PhosphoSiteiQ02111.

    Expressioni

    Tissue specificityi

    T-lymphocytes and skeletal muscle.2 Publications

    Gene expression databases

    ArrayExpressiQ02111.
    BgeeiQ02111.
    CleanExiMM_PRKCQ.
    GenevestigatoriQ02111.

    Interactioni

    Subunit structurei

    Interacts with GLRX3 (via N-terminus). Interacts with ECT2. Part of a membrane raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAP4K3Q8IVH84EBI-2639157,EBI-1758170From a different organism.
    Map4k3Q99JP02EBI-2639157,EBI-5324222
    NfixP70257-23EBI-2639157,EBI-2639084

    Protein-protein interaction databases

    BioGridi202202. 3 interactions.
    DIPiDIP-55947N.
    IntActiQ02111. 4 interactions.
    STRINGi10090.ENSMUSP00000028118.

    Structurei

    Secondary structure

    1
    707
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi234 – 2374
    Turni246 – 2483
    Beta strandi254 – 2563
    Beta strandi259 – 2624
    Turni263 – 2653
    Helixi271 – 2766

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FKDX-ray1.63A232-281[»]
    ProteinModelPortaliQ02111.
    SMRiQ02111. Positions 3-126, 144-700.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 123116C2Add
    BLAST
    Domaini380 – 634255Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini635 – 70672AGC-kinase C-terminalAdd
    BLAST

    Domaini

    The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 C2 domain.Curated
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri159 – 20951Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 28151Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117339.
    HOGENOMiHOG000233022.
    HOVERGENiHBG108317.
    InParanoidiQ02111.
    KOiK18052.
    OMAiREPQGIS.
    PhylomeDBiQ02111.
    TreeFamiTF102004.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000961. AGC-kinase_C.
    IPR000008. C2_dom.
    IPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR027264. PKC_theta.
    IPR017892. Pkinase_C.
    IPR014376. Prot_kin_PKC_delta.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000551. PKC_delta. 1 hit.
    PIRSF501105. Protein_kin_C_theta. 1 hit.
    PRINTSiPR00008. DAGPEDOMAIN.
    SMARTiSM00109. C1. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPFLRIGLS NFDCGTCQAC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP    50
    TMYPPWDSTF DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN 100
    GRTEIWLELK PQGRMLMNAR YFLEMSDTKD MSEFENEGFF ALHQRRGAIK 150
    QAKVHHVKCH EFTATFFPQP TFCSVCHEFV WGLNKQGYQC RQCNAAIHKK 200
    CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK SPTFCEHCGT 250
    LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300
    ARSLRDSEHI FREGPVEIGL PCSTKNETRP PCVPTPGKRE PQGISWDSPL 350
    DGSNKSAGPP EPEVSMRRTS LQLKLKIDDF ILHKMLGKGS FGKVFLAEFK 400
    RTNQFFAIKA LKKDVVLMDD DVECTMVEKR VLSLAWEHPF LTHMFCTFQT 450
    KENLFFVMEY LNGGDLMYHI QSCHKFDLSR ATFYAAEVIL GLQFLHSKGI 500
    VYRDLKLDNI LLDRDGHIKI ADFGMCKENM LGDAKTNTFC GTPDYIAPEI 550
    LLGQKYNHSV DWWSFGVLVY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600
    WLEREAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP 650
    FRPKVKSPYD CSNFDKEFLS EKPRLSFADR ALINSMDQNM FSNFSFINPG 700
    METLICS 707
    Length:707
    Mass (Da):81,573
    Last modified:July 1, 1993 - v1
    Checksum:i7A16492116CD2880
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11091 mRNA. Translation: BAA01864.1.
    CCDSiCCDS15682.1.
    PIRiA44500.
    RefSeqiNP_032885.1. NM_008859.2.
    UniGeneiMm.329993.

    Genome annotation databases

    EnsembliENSMUST00000028118; ENSMUSP00000028118; ENSMUSG00000026778.
    GeneIDi18761.
    KEGGimmu:18761.
    UCSCiuc008iic.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D11091 mRNA. Translation: BAA01864.1 .
    CCDSi CCDS15682.1.
    PIRi A44500.
    RefSeqi NP_032885.1. NM_008859.2.
    UniGenei Mm.329993.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FKD X-ray 1.63 A 232-281 [» ]
    ProteinModelPortali Q02111.
    SMRi Q02111. Positions 3-126, 144-700.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202202. 3 interactions.
    DIPi DIP-55947N.
    IntActi Q02111. 4 interactions.
    STRINGi 10090.ENSMUSP00000028118.

    Chemistry

    ChEMBLi CHEMBL1075295.

    PTM databases

    PhosphoSitei Q02111.

    Proteomic databases

    MaxQBi Q02111.
    PaxDbi Q02111.
    PRIDEi Q02111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028118 ; ENSMUSP00000028118 ; ENSMUSG00000026778 .
    GeneIDi 18761.
    KEGGi mmu:18761.
    UCSCi uc008iic.1. mouse.

    Organism-specific databases

    CTDi 5588.
    MGIi MGI:97601. Prkcq.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117339.
    HOGENOMi HOG000233022.
    HOVERGENi HBG108317.
    InParanoidi Q02111.
    KOi K18052.
    OMAi REPQGIS.
    PhylomeDBi Q02111.
    TreeFami TF102004.

    Enzyme and pathway databases

    Reactomei REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_219232. Effects of PIP2 hydrolysis.
    REACT_224460. Apoptotic cleavage of cellular proteins.
    REACT_225145. Downstream TCR signaling.

    Miscellaneous databases

    NextBioi 294949.
    PROi Q02111.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02111.
    Bgeei Q02111.
    CleanExi MM_PRKCQ.
    Genevestigatori Q02111.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000961. AGC-kinase_C.
    IPR000008. C2_dom.
    IPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR027264. PKC_theta.
    IPR017892. Pkinase_C.
    IPR014376. Prot_kin_PKC_delta.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000551. PKC_delta. 1 hit.
    PIRSF501105. Protein_kin_C_theta. 1 hit.
    PRINTSi PR00008. DAGPEDOMAIN.
    SMARTi SM00109. C1. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle."
      Osada S., Mizuno K., Saido T.C., Suzuki K., Kuroki T., Ohno S.
      Mol. Cell. Biol. 12:3930-3938(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AUTOPHOSPHORYLATION, TISSUE SPECIFICITY.
    2. "PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes."
      Sun Z., Arendt C.W., Ellmeier W., Schaeffer E.M., Sunshine M.J., Gandhi L., Annes J., Petrzilka D., Kupfer A., Schwartzberg P.L., Littman D.R.
      Nature 404:402-407(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ACTIVATION OF NF-KAPPA-B, TISSUE SPECIFICITY.
    3. "Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells."
      Pfeifhofer C., Kofler K., Gruber T., Tabrizi N.G., Lutz C., Maly K., Leitges M., Baier G.
      J. Exp. Med. 197:1525-1535(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ACTIVATION OF NFATC1 AND NFATC2.
    4. "Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses."
      Marsland B.J., Soos T.J., Spaeth G., Littman D.R., Kopf M.
      J. Exp. Med. 200:181-189(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN T-HELPER 2 ACTIVATION.
    5. "Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice."
      Tan S.L., Zhao J., Bi C., Chen X.C., Hepburn D.L., Wang J., Sedgwick J.D., Chintalacharuvu S.R., Na S.
      J. Immunol. 176:2872-2879(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN T-HELPER 17 ACTIVATION.
    6. "Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance."
      Wang C., Liu M., Riojas R.A., Xin X., Gao Z., Zeng R., Wu J., Dong L.Q., Liu F.
      J. Biol. Chem. 284:2038-2044(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF PDPK1.

    Entry informationi

    Entry nameiKPCT_MOUSE
    AccessioniPrimary (citable) accession number: Q02111
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3