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Protein

Complement C1q subcomponent subunit C

Gene

C1qc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166663. Initial triggering of complement.
R-MMU-173623. Classical antibody-mediated complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q subcomponent subunit C
Gene namesi
Name:C1qc
Synonyms:C1qg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88225. C1qc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Chaini30 – 246217Complement C1q subcomponent subunit CPRO_0000003525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 – 33InterchainBy similarity
Modified residuei37 – 3714-hydroxyprolineBy similarity
Modified residuei40 – 4014-hydroxyprolineBy similarity
Modified residuei43 – 4314-hydroxyprolineBy similarity
Modified residuei46 – 4614-hydroxyprolineBy similarity
Modified residuei64 – 6414-hydroxyprolineBy similarity
Modified residuei76 – 7615-hydroxylysineBy similarity
Modified residuei82 – 8214-hydroxyprolineBy similarity
Modified residuei97 – 9714-hydroxyprolineBy similarity
Modified residuei100 – 10014-hydroxyprolineBy similarity
Modified residuei106 – 10614-hydroxyprolineBy similarity

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

EPDiQ02105.
PaxDbiQ02105.
PRIDEiQ02105.

PTM databases

iPTMnetiQ02105.

Expressioni

Gene expression databases

CleanExiMM_C1QC.
GenevisibleiQ02105. MM.

Interactioni

Subunit structurei

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036747.

Structurei

3D structure databases

ProteinModelPortaliQ02105.
SMRiQ02105. Positions 82-110, 118-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 11382Collagen-likeAdd
BLAST
Domaini116 – 246131C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ02105.
KOiK03988.
OMAiKQKHQSV.
OrthoDBiEOG70ZZPW.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGPSCQPP CGLCLLLLFL LALPLRSQAS AGCYGIPGMP GMPGAPGKDG
60 70 80 90 100
HDGLQGPKGE PGIPAVPGTR GPKGQKGEPG MPGHRGKNGP RGTSGLPGDP
110 120 130 140 150
GPRGPPGEPG VEGRYKQKHQ SVFTVTRQTT QYPEANALVR FNSVVTNPQG
160 170 180 190 200
HYNPSTGKFT CEVPGLYYFV YYTSHTANLC VHLNLNLARV ASFCDHMFNS
210 220 230 240
KQVSSGGVLL RLQRGDEVWL SVNDYNGMVG IEGSNSVFSG FLLFPD
Length:246
Mass (Da):25,992
Last modified:October 3, 2012 - v2
Checksum:iD3D2EB5851359791
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101P → Q in CAA46993 (PubMed:1396691).Curated
Sequence conflicti10 – 101P → Q in CAA63535 (PubMed:8606057).Curated
Sequence conflicti10 – 101P → Q in AAH43945 (PubMed:15489334).Curated
Sequence conflicti10 – 101P → Q in AAH54443 (PubMed:15489334).Curated
Sequence conflicti70 – 701R → Q in CAA46993 (PubMed:1396691).Curated
Sequence conflicti70 – 701R → Q in AAH43945 (PubMed:15489334).Curated
Sequence conflicti70 – 701R → Q in AAH54443 (PubMed:15489334).Curated
Sequence conflicti208 – 2081V → A in CAA46993 (PubMed:1396691).Curated
Sequence conflicti208 – 2081V → A in AAH43945 (PubMed:15489334).Curated
Sequence conflicti208 – 2081V → A in AAH54443 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66295 mRNA. Translation: CAA46993.1.
X92960 Genomic DNA. Translation: CAA63535.1.
AL627214 Genomic DNA. Translation: CAM46145.1.
BC043945 mRNA. Translation: AAH43945.1.
BC054443 mRNA. Translation: AAH54443.1.
BC075724 mRNA. Translation: AAH75724.1.
CCDSiCCDS18811.1.
PIRiS29328.
RefSeqiNP_031600.2. NM_007574.2.
UniGeneiMm.439732.

Genome annotation databases

EnsembliENSMUST00000046332; ENSMUSP00000036747; ENSMUSG00000036896.
GeneIDi12262.
KEGGimmu:12262.
UCSCiuc008viq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66295 mRNA. Translation: CAA46993.1.
X92960 Genomic DNA. Translation: CAA63535.1.
AL627214 Genomic DNA. Translation: CAM46145.1.
BC043945 mRNA. Translation: AAH43945.1.
BC054443 mRNA. Translation: AAH54443.1.
BC075724 mRNA. Translation: AAH75724.1.
CCDSiCCDS18811.1.
PIRiS29328.
RefSeqiNP_031600.2. NM_007574.2.
UniGeneiMm.439732.

3D structure databases

ProteinModelPortaliQ02105.
SMRiQ02105. Positions 82-110, 118-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036747.

PTM databases

iPTMnetiQ02105.

Proteomic databases

EPDiQ02105.
PaxDbiQ02105.
PRIDEiQ02105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046332; ENSMUSP00000036747; ENSMUSG00000036896.
GeneIDi12262.
KEGGimmu:12262.
UCSCiuc008viq.1. mouse.

Organism-specific databases

CTDi714.
MGIiMGI:88225. C1qc.

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ02105.
KOiK03988.
OMAiKQKHQSV.
OrthoDBiEOG70ZZPW.
TreeFamiTF329591.

Enzyme and pathway databases

ReactomeiR-MMU-166663. Initial triggering of complement.
R-MMU-173623. Classical antibody-mediated complement activation.

Miscellaneous databases

NextBioi280702.
PROiQ02105.
SOURCEiSearch...

Gene expression databases

CleanExiMM_C1QC.
GenevisibleiQ02105. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q. Sequence similarity of complement subcomponent C1q, collagen type VIII and type X and precerebellin."
    Petry F., Reid K.B.M., Loos M.
    Eur. J. Biochem. 209:129-134(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Macrophage.
  2. "The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization."
    Petry F., McClive P.J., Botto M., Morley B.J., Morahan G., Loos M.
    Immunogenetics 43:370-376(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Colon, Kidney and Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiC1QC_MOUSE
AccessioniPrimary (citable) accession number: Q02105
Secondary accession number(s): Q6DI63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 3, 2012
Last modified: March 16, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.