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Protein

Complement C1q subcomponent subunit C

Gene

C1qc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166663. Initial triggering of complement.
R-MMU-173623. Classical antibody-mediated complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q subcomponent subunit C
Gene namesi
Name:C1qc
Synonyms:C1qg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88225. C1qc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000000352530 – 246Complement C1q subcomponent subunit CAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33InterchainBy similarity
Modified residuei374-hydroxyprolineBy similarity1
Modified residuei404-hydroxyprolineBy similarity1
Modified residuei434-hydroxyprolineBy similarity1
Modified residuei464-hydroxyprolineBy similarity1
Modified residuei644-hydroxyprolineBy similarity1
Modified residuei765-hydroxylysineBy similarity1
Modified residuei824-hydroxyprolineBy similarity1
Modified residuei974-hydroxyprolineBy similarity1
Modified residuei1004-hydroxyprolineBy similarity1
Modified residuei1064-hydroxyprolineBy similarity1

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PaxDbiQ02105.
PeptideAtlasiQ02105.
PRIDEiQ02105.

PTM databases

iPTMnetiQ02105.
PhosphoSitePlusiQ02105.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036896.
CleanExiMM_C1QC.
GenevisibleiQ02105. MM.

Interactioni

Subunit structurei

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036747.

Structurei

3D structure databases

ProteinModelPortaliQ02105.
SMRiQ02105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 113Collagen-likeAdd BLAST82
Domaini116 – 246C1qPROSITE-ProRule annotationAdd BLAST131

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ02105.
KOiK03988.
OMAiTAFCDHM.
OrthoDBiEOG091G0L3Y.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGPSCQPP CGLCLLLLFL LALPLRSQAS AGCYGIPGMP GMPGAPGKDG
60 70 80 90 100
HDGLQGPKGE PGIPAVPGTR GPKGQKGEPG MPGHRGKNGP RGTSGLPGDP
110 120 130 140 150
GPRGPPGEPG VEGRYKQKHQ SVFTVTRQTT QYPEANALVR FNSVVTNPQG
160 170 180 190 200
HYNPSTGKFT CEVPGLYYFV YYTSHTANLC VHLNLNLARV ASFCDHMFNS
210 220 230 240
KQVSSGGVLL RLQRGDEVWL SVNDYNGMVG IEGSNSVFSG FLLFPD
Length:246
Mass (Da):25,992
Last modified:October 3, 2012 - v2
Checksum:iD3D2EB5851359791
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10P → Q in CAA46993 (PubMed:1396691).Curated1
Sequence conflicti10P → Q in CAA63535 (PubMed:8606057).Curated1
Sequence conflicti10P → Q in AAH43945 (PubMed:15489334).Curated1
Sequence conflicti10P → Q in AAH54443 (PubMed:15489334).Curated1
Sequence conflicti70R → Q in CAA46993 (PubMed:1396691).Curated1
Sequence conflicti70R → Q in AAH43945 (PubMed:15489334).Curated1
Sequence conflicti70R → Q in AAH54443 (PubMed:15489334).Curated1
Sequence conflicti208V → A in CAA46993 (PubMed:1396691).Curated1
Sequence conflicti208V → A in AAH43945 (PubMed:15489334).Curated1
Sequence conflicti208V → A in AAH54443 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66295 mRNA. Translation: CAA46993.1.
X92960 Genomic DNA. Translation: CAA63535.1.
AL627214 Genomic DNA. Translation: CAM46145.1.
BC043945 mRNA. Translation: AAH43945.1.
BC054443 mRNA. Translation: AAH54443.1.
BC075724 mRNA. Translation: AAH75724.1.
CCDSiCCDS18811.1.
PIRiS29328.
RefSeqiNP_031600.2. NM_007574.2.
XP_017175416.1. XM_017319927.1.
UniGeneiMm.439732.

Genome annotation databases

EnsembliENSMUST00000046332; ENSMUSP00000036747; ENSMUSG00000036896.
GeneIDi12262.
KEGGimmu:12262.
UCSCiuc008viq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66295 mRNA. Translation: CAA46993.1.
X92960 Genomic DNA. Translation: CAA63535.1.
AL627214 Genomic DNA. Translation: CAM46145.1.
BC043945 mRNA. Translation: AAH43945.1.
BC054443 mRNA. Translation: AAH54443.1.
BC075724 mRNA. Translation: AAH75724.1.
CCDSiCCDS18811.1.
PIRiS29328.
RefSeqiNP_031600.2. NM_007574.2.
XP_017175416.1. XM_017319927.1.
UniGeneiMm.439732.

3D structure databases

ProteinModelPortaliQ02105.
SMRiQ02105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036747.

PTM databases

iPTMnetiQ02105.
PhosphoSitePlusiQ02105.

Proteomic databases

PaxDbiQ02105.
PeptideAtlasiQ02105.
PRIDEiQ02105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046332; ENSMUSP00000036747; ENSMUSG00000036896.
GeneIDi12262.
KEGGimmu:12262.
UCSCiuc008viq.1. mouse.

Organism-specific databases

CTDi714.
MGIiMGI:88225. C1qc.

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ02105.
KOiK03988.
OMAiTAFCDHM.
OrthoDBiEOG091G0L3Y.
TreeFamiTF329591.

Enzyme and pathway databases

ReactomeiR-MMU-166663. Initial triggering of complement.
R-MMU-173623. Classical antibody-mediated complement activation.

Miscellaneous databases

PROiQ02105.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036896.
CleanExiMM_C1QC.
GenevisibleiQ02105. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QC_MOUSE
AccessioniPrimary (citable) accession number: Q02105
Secondary accession number(s): Q6DI63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.