Q02103 (DCD_ACIAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:

dcd

Organism

Acidianus ambivalens (Desulfurolobus ambivalens)

Taxonomic identifier

2283 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Acidianus

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Probable deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146		PRO_0000156025

Sequences

	Sequence		Length	Mass (Da)
	Q02103 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: B4D922503CD4B25A	FASTA	173	19,858
	10 20 30 40 50 60 MILGDRDLKY YLEKGWIVIS PLTQDTIREN GVDLRVGGEI ARFKKTDEIY EDGKDPRSFY 70 80 90 100 110 120 EIEKGDEFII YPNEHVLLVT EEYVKLPNDV MAFVNLRSSF ARLGLFVPPT IVDAGFEGQL 130 140 150 160 170 TIEVLGSAFP VKIKRGTRFL HLIFARTLTP VENPYHGKYQ GQQGVTLPKF KFR

References

[1]	"Molecular characterisation of a DNA ligase gene of the extremely thermophilic archaeon Desulfurolobus ambivalens shows close phylogenetic relationship to eukaryotic ligases." Kletzin A. Nucleic Acids Res. 20:5389-5396(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Lei 10 / DSM 3772 / JCM 9191.
[2]	"Novel protein families in archaean genomes." Ouzounis C., Kyrpides N., Sander C. Nucleic Acids Res. 23:565-570(1995) [PubMed] [Europe PMC] [Abstract] Cited for: SIMILARITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63438 Genomic DNA. Translation: CAA45033.1.
PIR	S26382.
3D structure databases
ProteinModelPortal	Q02103.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00610; UER00665.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase.
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_ACIAM

Accession

Primary (citable) accession number: Q02103

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program