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Protein

CRE-binding bZIP protein SKO1

Gene

SKO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the CRE motif 5'-TGACGTCA-3' and acts as a repressor of transcription of the SUC2 gene and most probably other genes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33183-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CRE-binding bZIP protein SKO1
Gene namesi
Name:SKO1
Synonyms:ACR1
Ordered Locus Names:YNL167C
ORF Names:N1702
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL167C.
SGDiS000005111. SKO1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647CRE-binding bZIP protein SKO1PRO_0000076517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941PhosphoserineCombined sources
Modified residuei113 – 1131PhosphothreonineCombined sources
Modified residuei399 – 3991PhosphoserineCombined sources
Modified residuei558 – 5581PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02100.

PTM databases

iPTMnetiQ02100.

Interactioni

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: SGD
  • RNA polymerase II repressing transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi35661. 50 interactions.
DIPiDIP-700N.
IntActiQ02100. 3 interactions.
MINTiMINT-2783288.

Structurei

3D structure databases

ProteinModelPortaliQ02100.
SMRiQ02100. Positions 437-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini429 – 49264bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni430 – 45122Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni454 – 4618Leucine-zipperPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ02100.
KOiK09051.
OMAiHNLHIPN.
OrthoDBiEOG092C1VHI.

Family and domain databases

InterProiIPR004827. bZIP.
IPR020956. TF_Aft1_OSM.
[Graphical view]
PfamiPF11785. Aft1_OSA. 1 hit.
PF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEERSRQP STVSTFDLEP NPFEQSFASS KKALSLPGTI SHPSLPKELS
60 70 80 90 100
RNNSTSTITQ HSQRSTHSLN SIPEENGNST VTDNSNHNDV KKDSPSFLPG
110 120 130 140 150
QQRPTIISPP ILTPGGSKRL PPLLLSPSIL YQANSTTNPS QNSHSVSVSN
160 170 180 190 200
SNPSAIGVSS TSGSLYPNSS SPSGTSLIRQ PRNSNVTTSN SGNGFPTNDS
210 220 230 240 250
QMPGFLLNLS KSGLTPNESN IRTGLTPGIL TQSYNYPVLP SINKNTITGS
260 270 280 290 300
KNVNKSVTVN GSIENHPHVN IMHPTVNGTP LTPGLSSLLN LPSTGVLANP
310 320 330 340 350
VFKSTPTTNT TDGTVNNSIS NSNFSPNTST KAAVKMDNPA EFNAIEHSAH
360 370 380 390 400
NHKENENLTT QIENNDQFNN KTRKRKRRMS STSSTSKASR KNSISRKNSA
410 420 430 440 450
VTTAPAQKDD VENNKISNNV TLDENEEQER KRKEFLERNR VAASKFRKRK
460 470 480 490 500
KEYIKKIEND LQFYESEYDD LTQVIGKLCG IIPSSSSNSQ FNVNVSTPSS
510 520 530 540 550
SSPPSTSLIA LLESSISRSD YSSAMSVLSN MKQLICETNF YRRGGKNPRD
560 570 580 590 600
DMDGQEDSFN KDTNVVKSEN AGYPSVNSRP IILDKKYSLN SGANISKSNT
610 620 630 640
TTNNVGNSAQ NIINSCYSVT NPLVINANSD THDTNKHDVL STLPHNN
Length:647
Mass (Da):70,192
Last modified:July 1, 1993 - v1
Checksum:i3E0B8C72A6CE14AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67875 Genomic DNA. Translation: CAA48074.1.
S49588 Genomic DNA. Translation: AAB24288.1.
X92517 Genomic DNA. Translation: CAA63272.1.
Z71443 Genomic DNA. Translation: CAA96054.1.
BK006947 Genomic DNA. Translation: DAA10381.1.
PIRiS26386.
RefSeqiNP_014232.1. NM_001183005.1.

Genome annotation databases

EnsemblFungiiYNL167C; YNL167C; YNL167C.
GeneIDi855554.
KEGGisce:YNL167C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67875 Genomic DNA. Translation: CAA48074.1.
S49588 Genomic DNA. Translation: AAB24288.1.
X92517 Genomic DNA. Translation: CAA63272.1.
Z71443 Genomic DNA. Translation: CAA96054.1.
BK006947 Genomic DNA. Translation: DAA10381.1.
PIRiS26386.
RefSeqiNP_014232.1. NM_001183005.1.

3D structure databases

ProteinModelPortaliQ02100.
SMRiQ02100. Positions 437-481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35661. 50 interactions.
DIPiDIP-700N.
IntActiQ02100. 3 interactions.
MINTiMINT-2783288.

PTM databases

iPTMnetiQ02100.

Proteomic databases

MaxQBiQ02100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL167C; YNL167C; YNL167C.
GeneIDi855554.
KEGGisce:YNL167C.

Organism-specific databases

EuPathDBiFungiDB:YNL167C.
SGDiS000005111. SKO1.

Phylogenomic databases

InParanoidiQ02100.
KOiK09051.
OMAiHNLHIPN.
OrthoDBiEOG092C1VHI.

Enzyme and pathway databases

BioCyciYEAST:G3O-33183-MONOMER.

Miscellaneous databases

PROiQ02100.

Family and domain databases

InterProiIPR004827. bZIP.
IPR020956. TF_Aft1_OSM.
[Graphical view]
PfamiPF11785. Aft1_OSA. 1 hit.
PF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSKO1_YEAST
AccessioniPrimary (citable) accession number: Q02100
Secondary accession number(s): D6W115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.