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Protein

Transcription factor Sp2

Gene

SP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri525 – 54925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. histone deacetylase binding Source: BHF-UCL
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. cardiovascular system development Source: Ensembl
  2. embryonic organ development Source: Ensembl
  3. fibroblast proliferation Source: Ensembl
  4. immune response Source: ProtInc
  5. in utero embryonic development Source: Ensembl
  6. multicellular organism growth Source: Ensembl
  7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  8. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ02086.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp2
Gene namesi
Name:SP2
Synonyms:KIAA0048
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11207. SP2.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36044.

Polymorphism and mutation databases

BioMutaiSP2.
DMDMi119370531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Transcription factor Sp2PRO_0000047140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02086.
PaxDbiQ02086.
PRIDEiQ02086.

PTM databases

PhosphoSiteiQ02086.

Expressioni

Gene expression databases

BgeeiQ02086.
CleanExiHS_SP2.
ExpressionAtlasiQ02086. baseline and differential.
GenevestigatoriQ02086.

Organism-specific databases

HPAiCAB010245.
HPA003357.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N54EBI-8651703,EBI-744695
FHL2Q141923EBI-8651703,EBI-701903
MCM7P339933EBI-8651703,EBI-355924

Protein-protein interaction databases

BioGridi112551. 13 interactions.
IntActiQ02086. 4 interactions.
STRINGi9606.ENSP00000365931.

Structurei

3D structure databases

ProteinModelPortaliQ02086.
SMRiQ02086. Positions 494-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri525 – 54925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
InParanoidiQ02086.
KOiK09192.
OMAiDKRSGEQ.
OrthoDBiEOG7JQBMX.
PhylomeDBiQ02086.
TreeFamiTF350150.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030451. SP2_TF.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF1. PTHR23235:SF1. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02086-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV
60 70 80 90 100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ
110 120 130 140 150
LSASYPGGQL VFAIQNPTMI NKGTRSNANI QYQAVPQIQA SNSQTIQVQP
160 170 180 190 200
NLTNQIQIIP GTNQAIITPS PSSHKPVPIK PAPIQKSSTT TTPVQSGANV
210 220 230 240 250
VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL SKTNKKARKK
260 270 280 290 300
SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ
310 320 330 340 350
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT
360 370 380 390 400
PTQVYIRTPS GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK
410 420 430 440 450
HSAAILRKER PLPKIAPAGS IISLNAAQLA AAAQAMQTIN INGVQVQGVP
460 470 480 490 500
VTITNTGGQQ QLTVQNVSGN NLTISGLSPT QIQLQMEQAL AGETQPGEKR
510 520 530 540 550
RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS LLRAHVRLHT
560 570 580 590 600
GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL
610
TKHYKTHLVT KNL
Length:613
Mass (Da):64,900
Last modified:December 12, 2006 - v3
Checksum:iDEE6BFCAE3405793
GO
Isoform 2 (identifier: Q02086-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:606
Mass (Da):64,153
Checksum:iA27C6D460D36E186
GO

Sequence cautioni

The sequence AAH16680.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH33814.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA05923.2 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77Missing in isoform 2. 1 PublicationVSP_022021

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28588 mRNA. Translation: BAA05923.2. Different initiation.
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94785.1.
BC016680 mRNA. Translation: AAH16680.1. Different initiation.
BC033814 mRNA. Translation: AAH33814.1. Different initiation.
M97190 mRNA. Translation: AAA36629.1.
CCDSiCCDS11521.2. [Q02086-1]
PIRiA44489.
RefSeqiNP_003101.3. NM_003110.5. [Q02086-1]
UniGeneiHs.514276.

Genome annotation databases

EnsembliENST00000376741; ENSP00000365931; ENSG00000167182. [Q02086-1]
GeneIDi6668.
KEGGihsa:6668.
UCSCiuc002imk.3. human. [Q02086-1]

Polymorphism and mutation databases

BioMutaiSP2.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28588 mRNA. Translation: BAA05923.2. Different initiation.
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94785.1.
BC016680 mRNA. Translation: AAH16680.1. Different initiation.
BC033814 mRNA. Translation: AAH33814.1. Different initiation.
M97190 mRNA. Translation: AAA36629.1.
CCDSiCCDS11521.2. [Q02086-1]
PIRiA44489.
RefSeqiNP_003101.3. NM_003110.5. [Q02086-1]
UniGeneiHs.514276.

3D structure databases

ProteinModelPortaliQ02086.
SMRiQ02086. Positions 494-608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112551. 13 interactions.
IntActiQ02086. 4 interactions.
STRINGi9606.ENSP00000365931.

PTM databases

PhosphoSiteiQ02086.

Polymorphism and mutation databases

BioMutaiSP2.
DMDMi119370531.

Proteomic databases

MaxQBiQ02086.
PaxDbiQ02086.
PRIDEiQ02086.

Protocols and materials databases

DNASUi6668.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376741; ENSP00000365931; ENSG00000167182. [Q02086-1]
GeneIDi6668.
KEGGihsa:6668.
UCSCiuc002imk.3. human. [Q02086-1]

Organism-specific databases

CTDi6668.
GeneCardsiGC17P045973.
HGNCiHGNC:11207. SP2.
HPAiCAB010245.
HPA003357.
MIMi601801. gene.
neXtProtiNX_Q02086.
PharmGKBiPA36044.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
InParanoidiQ02086.
KOiK09192.
OMAiDKRSGEQ.
OrthoDBiEOG7JQBMX.
PhylomeDBiQ02086.
TreeFamiTF350150.

Enzyme and pathway databases

SignaLinkiQ02086.

Miscellaneous databases

ChiTaRSiSP2. human.
GeneWikiiSp2_transcription_factor.
GenomeRNAii6668.
NextBioi25999.
PROiQ02086.
SOURCEiSearch...

Gene expression databases

BgeeiQ02086.
CleanExiHS_SP2.
ExpressionAtlasiQ02086. baseline and differential.
GenevestigatoriQ02086.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030451. SP2_TF.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF1. PTHR23235:SF1. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung, Lymph and Spleen.
  5. "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression."
    Kingsley C., Winoto A.
    Mol. Cell. Biol. 12:4251-4261(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-613.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSP2_HUMAN
AccessioniPrimary (citable) accession number: Q02086
Secondary accession number(s): A6NK74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 12, 2006
Last modified: April 29, 2015
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.