Q02086 (SP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor Sp2

Gene names

Name:	SP2
Synonyms:	KIAA0048

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	613 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Sequence caution	The sequence AAH16680.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH33814.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA05923.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Traceable author statement Ref.5. Source: ProtInc regulation of transcription from RNA polymerase II promoter Traceable author statement Ref.5. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q02086-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q02086-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 613	613	Transcription factor Sp2		PRO_0000047140
Regions
	Zinc finger	525 – 549	25	C2H2-type 1
	Zinc finger	555 – 579	25	C2H2-type 2
	Zinc finger	585 – 607	23	C2H2-type 3
Amino acid modifications
	Modified residue	78	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 7	7	Missing in isoform 2.		VSP_022021

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 12, 2006. Version 3. Checksum: DEE6BFCAE3405793	FASTA	613	64,900
	10 20 30 40 50 60 MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV EAAVTPPAPP 70 80 90 100 110 120 QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ LSASYPGGQL VFAIQNPTMI 130 140 150 160 170 180 NKGTRSNANI QYQAVPQIQA SNSQTIQVQP NLTNQIQIIP GTNQAIITPS PSSHKPVPIK 190 200 210 220 230 240 PAPIQKSSTT TTPVQSGANV VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL 250 260 270 280 290 300 SKTNKKARKK SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ 310 320 330 340 350 360 VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT PTQVYIRTPS 370 380 390 400 410 420 GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK HSAAILRKER PLPKIAPAGS 430 440 450 460 470 480 IISLNAAQLA AAAQAMQTIN INGVQVQGVP VTITNTGGQQ QLTVQNVSGN NLTISGLSPT 490 500 510 520 530 540 QIQLQMEQAL AGETQPGEKR RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS 550 560 570 580 590 600 LLRAHVRLHT GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL 610 TKHYKTHLVT KNL
	Isoform 2 [UniParc]. Checksum: A27C6D460D36E186	FASTA	606	64,153
	10 20 30 40 50 60 MAATAAVSPS DYLQPAASTT QDSQPSPLAL LAATCSKIGP PAVEAAVTPP APPQPTPRKL 70 80 90 100 110 120 VPIKPAPLPL SPGKNSFGIL SSKGNILQIQ GSQLSASYPG GQLVFAIQNP TMINKGTRSN 130 140 150 160 170 180 ANIQYQAVPQ IQASNSQTIQ VQPNLTNQIQ IIPGTNQAII TPSPSSHKPV PIKPAPIQKS 190 200 210 220 230 240 STTTTPVQSG ANVVKLTGGG GNVTLTLPVN NLVNASDTGA PTQLLTESPP TPLSKTNKKA 250 260 270 280 290 300 RKKSLPASQP PVAVAEQVET VLIETTADNI IQAGNNLLIV QSPGGGQPAV VQQVQVVPPK 310 320 330 340 350 360 AEQQQVVQIP QQALRVVQAA SATLPTVPQK PSQNFQIQAA EPTPTQVYIR TPSGEVQTVL 370 380 390 400 410 420 VQDSPPATAA ATSNTTCSSP ASRAPHLSGT SKKHSAAILR KERPLPKIAP AGSIISLNAA 430 440 450 460 470 480 QLAAAAQAMQ TININGVQVQ GVPVTITNTG GQQQLTVQNV SGNNLTISGL SPTQIQLQME 490 500 510 520 530 540 QALAGETQPG EKRRRMACTC PNCKDGEKRS GEQGKKKHVC HIPDCGKTFR KTSLLRAHVR 550 560 570 580 590 600 LHTGERPFVC NWFFCGKRFT RSDELQRHAR THTGDKRFEC AQCQKRFMRS DHLTKHYKTH LVTKNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung, Lymph and Spleen.
[5]	"Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression." Kingsley C., Winoto A. Mol. Cell. Biol. 12:4251-4261(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-613.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D28588 mRNA. Translation: BAA05923.2. Different initiation. AC018521 Genomic DNA. No translation available. CH471109 Genomic DNA. Translation: EAW94785.1. BC016680 mRNA. Translation: AAH16680.1. Different initiation. BC033814 mRNA. Translation: AAH33814.1. Different initiation. M97190 mRNA. Translation: AAA36629.1.
IPI	IPI00333077. IPI00744064.
PIR	A44489.
RefSeq	NP_003101.3. NM_003110.5.
UniGene	Hs.514276.
3D structure databases
ProteinModelPortal	Q02086.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000365931.
PTM databases
PhosphoSite	Q02086.
Polymorphism databases
DMDM	119370531.
Proteomic databases
PaxDb	Q02086.
PRIDE	Q02086.
Protocols and materials databases
DNASU	6668.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376741; ENSP00000365931; ENSG00000167182.
GeneID	6668.
KEGG	hsa:6668.
UCSC	uc002imk.3. human.
Organism-specific databases
CTD	6668.
GeneCards	GC17P045973.
HGNC	HGNC:11207. SP2.
HPA	CAB010245. HPA003357.
MIM	601801. gene.
neXtProt	NX_Q02086.
PharmGKB	PA36044.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234295.
HOVERGEN	HBG008933.
InParanoid	Q02086.
KO	K09192.
OMA	NCKDGDK.
OrthoDB	EOG4K6G4F.
Enzyme and pathway databases
SignaLink	Q02086.
Gene expression databases
Bgee	Q02086.
CleanEx	HS_SP2.
Genevestigator	Q02086.
GermOnline	ENSG00000167182. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6668.
NextBio	25999.
SOURCE	Search...

Entry information

Entry name

SP2_HUMAN

Accession

Primary (citable) accession number: Q02086
Secondary accession number(s): A6NK74

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	December 12, 2006
Last modified:	May 29, 2013
This is version 120 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.