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Q02086

- SP2_HUMAN

UniProt

Q02086 - SP2_HUMAN

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Protein

Transcription factor Sp2

Gene
SP2, KIAA0048
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri525 – 54925C2H2-type 1Add
BLAST
Zinc fingeri555 – 57925C2H2-type 2Add
BLAST
Zinc fingeri585 – 60723C2H2-type 3Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. histone deacetylase binding Source: BHF-UCL
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cardiovascular system development Source: Ensembl
  2. embryonic organ development Source: Ensembl
  3. fibroblast proliferation Source: Ensembl
  4. immune response Source: ProtInc
  5. in utero embryonic development Source: Ensembl
  6. multicellular organism growth Source: Ensembl
  7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ02086.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp2
Gene namesi
Name:SP2
Synonyms:KIAA0048
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11207. SP2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Transcription factor Sp2PRO_0000047140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02086.
PaxDbiQ02086.
PRIDEiQ02086.

PTM databases

PhosphoSiteiQ02086.

Expressioni

Gene expression databases

BgeeiQ02086.
CleanExiHS_SP2.
GenevestigatoriQ02086.

Organism-specific databases

HPAiCAB010245.
HPA003357.

Interactioni

Protein-protein interaction databases

BioGridi112551. 9 interactions.
IntActiQ02086. 2 interactions.
STRINGi9606.ENSP00000365931.

Structurei

3D structure databases

ProteinModelPortaliQ02086.
SMRiQ02086. Positions 522-608.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri525 – 54925C2H2-type 1Add
BLAST
Zinc fingeri555 – 57925C2H2-type 2Add
BLAST
Zinc fingeri585 – 60723C2H2-type 3Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
InParanoidiQ02086.
KOiK09192.
OMAiDKRSGEQ.
OrthoDBiEOG7JQBMX.
PhylomeDBiQ02086.
TreeFamiTF350150.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02086-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV    50
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ 100
LSASYPGGQL VFAIQNPTMI NKGTRSNANI QYQAVPQIQA SNSQTIQVQP 150
NLTNQIQIIP GTNQAIITPS PSSHKPVPIK PAPIQKSSTT TTPVQSGANV 200
VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL SKTNKKARKK 250
SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ 300
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT 350
PTQVYIRTPS GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK 400
HSAAILRKER PLPKIAPAGS IISLNAAQLA AAAQAMQTIN INGVQVQGVP 450
VTITNTGGQQ QLTVQNVSGN NLTISGLSPT QIQLQMEQAL AGETQPGEKR 500
RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS LLRAHVRLHT 550
GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL 600
TKHYKTHLVT KNL 613
Length:613
Mass (Da):64,900
Last modified:December 12, 2006 - v3
Checksum:iDEE6BFCAE3405793
GO
Isoform 2 (identifier: Q02086-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:606
Mass (Da):64,153
Checksum:iA27C6D460D36E186
GO

Sequence cautioni

The sequence AAH16680.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH33814.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA05923.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77Missing in isoform 2. VSP_022021

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28588 mRNA. Translation: BAA05923.2. Different initiation.
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94785.1.
BC016680 mRNA. Translation: AAH16680.1. Different initiation.
BC033814 mRNA. Translation: AAH33814.1. Different initiation.
M97190 mRNA. Translation: AAA36629.1.
CCDSiCCDS11521.2. [Q02086-1]
PIRiA44489.
RefSeqiNP_003101.3. NM_003110.5. [Q02086-1]
UniGeneiHs.514276.

Genome annotation databases

EnsembliENST00000376741; ENSP00000365931; ENSG00000167182. [Q02086-1]
GeneIDi6668.
KEGGihsa:6668.
UCSCiuc002imk.3. human. [Q02086-1]

Polymorphism databases

DMDMi119370531.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28588 mRNA. Translation: BAA05923.2 . Different initiation.
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94785.1 .
BC016680 mRNA. Translation: AAH16680.1 . Different initiation.
BC033814 mRNA. Translation: AAH33814.1 . Different initiation.
M97190 mRNA. Translation: AAA36629.1 .
CCDSi CCDS11521.2. [Q02086-1 ]
PIRi A44489.
RefSeqi NP_003101.3. NM_003110.5. [Q02086-1 ]
UniGenei Hs.514276.

3D structure databases

ProteinModelPortali Q02086.
SMRi Q02086. Positions 522-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112551. 9 interactions.
IntActi Q02086. 2 interactions.
STRINGi 9606.ENSP00000365931.

PTM databases

PhosphoSitei Q02086.

Polymorphism databases

DMDMi 119370531.

Proteomic databases

MaxQBi Q02086.
PaxDbi Q02086.
PRIDEi Q02086.

Protocols and materials databases

DNASUi 6668.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376741 ; ENSP00000365931 ; ENSG00000167182 . [Q02086-1 ]
GeneIDi 6668.
KEGGi hsa:6668.
UCSCi uc002imk.3. human. [Q02086-1 ]

Organism-specific databases

CTDi 6668.
GeneCardsi GC17P045973.
HGNCi HGNC:11207. SP2.
HPAi CAB010245.
HPA003357.
MIMi 601801. gene.
neXtProti NX_Q02086.
PharmGKBi PA36044.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234295.
HOVERGENi HBG008933.
InParanoidi Q02086.
KOi K09192.
OMAi DKRSGEQ.
OrthoDBi EOG7JQBMX.
PhylomeDBi Q02086.
TreeFami TF350150.

Enzyme and pathway databases

SignaLinki Q02086.

Miscellaneous databases

GeneWikii Sp2_transcription_factor.
GenomeRNAii 6668.
NextBioi 25999.
PROi Q02086.
SOURCEi Search...

Gene expression databases

Bgeei Q02086.
CleanExi HS_SP2.
Genevestigatori Q02086.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung, Lymph and Spleen.
  5. "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression."
    Kingsley C., Winoto A.
    Mol. Cell. Biol. 12:4251-4261(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-613.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSP2_HUMAN
AccessioniPrimary (citable) accession number: Q02086
Secondary accession number(s): A6NK74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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