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Q02086

- SP2_HUMAN

UniProt

Q02086 - SP2_HUMAN

Protein

Transcription factor Sp2

Gene

SP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri525 – 54925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri585 – 60723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. histone deacetylase binding Source: BHF-UCL
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cardiovascular system development Source: Ensembl
    2. embryonic organ development Source: Ensembl
    3. fibroblast proliferation Source: Ensembl
    4. immune response Source: ProtInc
    5. in utero embryonic development Source: Ensembl
    6. multicellular organism growth Source: Ensembl
    7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ02086.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor Sp2
    Gene namesi
    Name:SP2
    Synonyms:KIAA0048
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11207. SP2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36044.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613Transcription factor Sp2PRO_0000047140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei78 – 781Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ02086.
    PaxDbiQ02086.
    PRIDEiQ02086.

    PTM databases

    PhosphoSiteiQ02086.

    Expressioni

    Gene expression databases

    BgeeiQ02086.
    CleanExiHS_SP2.
    GenevestigatoriQ02086.

    Organism-specific databases

    HPAiCAB010245.
    HPA003357.

    Interactioni

    Protein-protein interaction databases

    BioGridi112551. 9 interactions.
    IntActiQ02086. 2 interactions.
    STRINGi9606.ENSP00000365931.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02086.
    SMRiQ02086. Positions 522-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri525 – 54925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri585 – 60723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234295.
    HOVERGENiHBG008933.
    InParanoidiQ02086.
    KOiK09192.
    OMAiDKRSGEQ.
    OrthoDBiEOG7JQBMX.
    PhylomeDBiQ02086.
    TreeFamiTF350150.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02086-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV    50
    EAAVTPPAPP QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ 100
    LSASYPGGQL VFAIQNPTMI NKGTRSNANI QYQAVPQIQA SNSQTIQVQP 150
    NLTNQIQIIP GTNQAIITPS PSSHKPVPIK PAPIQKSSTT TTPVQSGANV 200
    VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL SKTNKKARKK 250
    SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ 300
    VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT 350
    PTQVYIRTPS GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK 400
    HSAAILRKER PLPKIAPAGS IISLNAAQLA AAAQAMQTIN INGVQVQGVP 450
    VTITNTGGQQ QLTVQNVSGN NLTISGLSPT QIQLQMEQAL AGETQPGEKR 500
    RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS LLRAHVRLHT 550
    GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL 600
    TKHYKTHLVT KNL 613
    Length:613
    Mass (Da):64,900
    Last modified:December 12, 2006 - v3
    Checksum:iDEE6BFCAE3405793
    GO
    Isoform 2 (identifier: Q02086-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: Missing.

    Show »
    Length:606
    Mass (Da):64,153
    Checksum:iA27C6D460D36E186
    GO

    Sequence cautioni

    The sequence AAH16680.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH33814.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA05923.2 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77Missing in isoform 2. 1 PublicationVSP_022021

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28588 mRNA. Translation: BAA05923.2. Different initiation.
    AC018521 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94785.1.
    BC016680 mRNA. Translation: AAH16680.1. Different initiation.
    BC033814 mRNA. Translation: AAH33814.1. Different initiation.
    M97190 mRNA. Translation: AAA36629.1.
    CCDSiCCDS11521.2. [Q02086-1]
    PIRiA44489.
    RefSeqiNP_003101.3. NM_003110.5. [Q02086-1]
    UniGeneiHs.514276.

    Genome annotation databases

    EnsembliENST00000376741; ENSP00000365931; ENSG00000167182. [Q02086-1]
    GeneIDi6668.
    KEGGihsa:6668.
    UCSCiuc002imk.3. human. [Q02086-1]

    Polymorphism databases

    DMDMi119370531.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28588 mRNA. Translation: BAA05923.2 . Different initiation.
    AC018521 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94785.1 .
    BC016680 mRNA. Translation: AAH16680.1 . Different initiation.
    BC033814 mRNA. Translation: AAH33814.1 . Different initiation.
    M97190 mRNA. Translation: AAA36629.1 .
    CCDSi CCDS11521.2. [Q02086-1 ]
    PIRi A44489.
    RefSeqi NP_003101.3. NM_003110.5. [Q02086-1 ]
    UniGenei Hs.514276.

    3D structure databases

    ProteinModelPortali Q02086.
    SMRi Q02086. Positions 522-608.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112551. 9 interactions.
    IntActi Q02086. 2 interactions.
    STRINGi 9606.ENSP00000365931.

    PTM databases

    PhosphoSitei Q02086.

    Polymorphism databases

    DMDMi 119370531.

    Proteomic databases

    MaxQBi Q02086.
    PaxDbi Q02086.
    PRIDEi Q02086.

    Protocols and materials databases

    DNASUi 6668.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376741 ; ENSP00000365931 ; ENSG00000167182 . [Q02086-1 ]
    GeneIDi 6668.
    KEGGi hsa:6668.
    UCSCi uc002imk.3. human. [Q02086-1 ]

    Organism-specific databases

    CTDi 6668.
    GeneCardsi GC17P045973.
    HGNCi HGNC:11207. SP2.
    HPAi CAB010245.
    HPA003357.
    MIMi 601801. gene.
    neXtProti NX_Q02086.
    PharmGKBi PA36044.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234295.
    HOVERGENi HBG008933.
    InParanoidi Q02086.
    KOi K09192.
    OMAi DKRSGEQ.
    OrthoDBi EOG7JQBMX.
    PhylomeDBi Q02086.
    TreeFami TF350150.

    Enzyme and pathway databases

    SignaLinki Q02086.

    Miscellaneous databases

    GeneWikii Sp2_transcription_factor.
    GenomeRNAii 6668.
    NextBioi 25999.
    PROi Q02086.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02086.
    CleanExi HS_SP2.
    Genevestigatori Q02086.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
      Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
      DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone marrow.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung, Lymph and Spleen.
    5. "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression."
      Kingsley C., Winoto A.
      Mol. Cell. Biol. 12:4251-4261(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-613.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiSP2_HUMAN
    AccessioniPrimary (citable) accession number: Q02086
    Secondary accession number(s): A6NK74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3