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Q02081

- LAC4_THACU

UniProt

Q02081 - LAC4_THACU

Protein

Laccase-4

Gene

LCC4

Organism
Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.Curated

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    pH dependencei

    Optimum pH is 7.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Copper 1; type 2By similarity
    Metal bindingi85 – 851Copper 2; type 3By similarity
    Metal bindingi128 – 1281Copper 2; type 3By similarity
    Metal bindingi130 – 1301Copper 3; type 3By similarity
    Metal bindingi427 – 4271Copper 4; type 1By similarity
    Metal bindingi430 – 4301Copper 1; type 2By similarity
    Metal bindingi432 – 4321Copper 3; type 3By similarity
    Metal bindingi479 – 4791Copper 3; type 3By similarity
    Metal bindingi480 – 4801Copper 4; type 1By similarity
    Metal bindingi481 – 4811Copper 2; type 3By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-4 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 4
    Diphenol oxidase 4
    Urishiol oxidase 4
    Gene namesi
    Name:LCC4
    OrganismiThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
    Taxonomic identifieri107832 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCantharellalesCeratobasidiaceaeThanatephorus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 531512Laccase-4PRO_0000002938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    In mycelia, at a higher level than LCC1, LCC2 and LCC3.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02081.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 146124Plastocyanin-like 1Add
    BLAST
    Domaini158 – 315158Plastocyanin-like 2Add
    BLAST
    Domaini384 – 507124Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02081-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSSITLLPL LAAVSTPAFA AVRNYKFDIK NVNVAPDGFQ RPIVSVNGLV    50
    PGTLITANKG DTLRINVTNQ LTDPSMRRAT TIHWHGLFQA TTADEDGPAF 100
    VTQCPIAQNL SYTYEIPLHG QTGTMWYHAH LASQYVDGLR GPLVIYDPND 150
    PHKSRYDVDD ASTVVMLEDW YHTPAPVLEK QMFSTNNTAL LSPVPDSGLI 200
    NGKGRYVGGP AVPRSVINVK RGKRYRLRVI NASAIGSFTF SIEGHRLTVI 250
    EADGIPHQPL PVDSFQIYAG QRYSVIVEAN QTAANYWIRA PMTVAGAGTN 300
    ANLDPTNVFA VLHYEGAPNA EPTTEQGSAI GTALVEENLH ALINPGAPGG 350
    SAPADVSLNL AIGRSTVDGI LRFTFNNIKY EAPSLPTLLK ILANNASNDA 400
    DFTPNEHTIV LPHNKVIGAQ HHRGADHPIH LHGHVFDIVK SLGGTPNYVN 450
    PPRRDVVRVG GTGVVLRFKA DNPGPWFVHC HIDCTWRLGS HLSLPRPPAR 500
    FARVSSRSSP TMPGTSSAPS TRLFLPICSK W 531
    Length:531
    Mass (Da):57,545
    Last modified:November 1, 1996 - v1
    Checksum:i737339803F75AB19
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421P → S.
    Natural varianti119 – 1191H → R.
    Natural varianti246 – 2461R → S.
    Natural varianti256 – 2561P → L.
    Natural varianti261 – 2611P → A.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54277 Genomic DNA. Translation: CAA91042.1.
    PIRiS68120.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54277 Genomic DNA. Translation: CAA91042.1 .
    PIRi S68120.

    3D structure databases

    ProteinModelPortali Q02081.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
      Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
      Curr. Genet. 29:395-403(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: R22 / IMI 358730 / AG-6.

    Entry informationi

    Entry nameiLAC4_THACU
    AccessioniPrimary (citable) accession number: Q02081
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3