SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q02081

- LAC4_THACU

UniProt

Q02081 - LAC4_THACU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Laccase-4
Gene
LCC4
Organism
Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products Inferred.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

pH dependencei

Optimum pH is 7.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Copper 1; type 2 By similarity
Metal bindingi85 – 851Copper 2; type 3 By similarity
Metal bindingi128 – 1281Copper 2; type 3 By similarity
Metal bindingi130 – 1301Copper 3; type 3 By similarity
Metal bindingi427 – 4271Copper 4; type 1 By similarity
Metal bindingi430 – 4301Copper 1; type 2 By similarity
Metal bindingi432 – 4321Copper 3; type 3 By similarity
Metal bindingi479 – 4791Copper 3; type 3 By similarity
Metal bindingi480 – 4801Copper 4; type 1 By similarity
Metal bindingi481 – 4811Copper 2; type 3 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-4 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 4
Diphenol oxidase 4
Urishiol oxidase 4
Gene namesi
Name:LCC4
OrganismiThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Taxonomic identifieri107832 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCantharellalesCeratobasidiaceaeThanatephorus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 531512Laccase-4
PRO_0000002938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi280 – 2801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

In mycelia, at a higher level than LCC1, LCC2 and LCC3.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ02081.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 146124Plastocyanin-like 1
Add
BLAST
Domaini158 – 315158Plastocyanin-like 2
Add
BLAST
Domaini384 – 507124Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02081-1 [UniParc]FASTAAdd to Basket

« Hide

MLSSITLLPL LAAVSTPAFA AVRNYKFDIK NVNVAPDGFQ RPIVSVNGLV    50
PGTLITANKG DTLRINVTNQ LTDPSMRRAT TIHWHGLFQA TTADEDGPAF 100
VTQCPIAQNL SYTYEIPLHG QTGTMWYHAH LASQYVDGLR GPLVIYDPND 150
PHKSRYDVDD ASTVVMLEDW YHTPAPVLEK QMFSTNNTAL LSPVPDSGLI 200
NGKGRYVGGP AVPRSVINVK RGKRYRLRVI NASAIGSFTF SIEGHRLTVI 250
EADGIPHQPL PVDSFQIYAG QRYSVIVEAN QTAANYWIRA PMTVAGAGTN 300
ANLDPTNVFA VLHYEGAPNA EPTTEQGSAI GTALVEENLH ALINPGAPGG 350
SAPADVSLNL AIGRSTVDGI LRFTFNNIKY EAPSLPTLLK ILANNASNDA 400
DFTPNEHTIV LPHNKVIGAQ HHRGADHPIH LHGHVFDIVK SLGGTPNYVN 450
PPRRDVVRVG GTGVVLRFKA DNPGPWFVHC HIDCTWRLGS HLSLPRPPAR 500
FARVSSRSSP TMPGTSSAPS TRLFLPICSK W 531
Length:531
Mass (Da):57,545
Last modified:November 1, 1996 - v1
Checksum:i737339803F75AB19
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421P → S.
Natural varianti119 – 1191H → R.
Natural varianti246 – 2461R → S.
Natural varianti256 – 2561P → L.
Natural varianti261 – 2611P → A.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54277 Genomic DNA. Translation: CAA91042.1.
PIRiS68120.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54277 Genomic DNA. Translation: CAA91042.1 .
PIRi S68120.

3D structure databases

ProteinModelPortali Q02081.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
    Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
    Curr. Genet. 29:395-403(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: R22 / IMI 358730 / AG-6.

Entry informationi

Entry nameiLAC4_THACU
AccessioniPrimary (citable) accession number: Q02081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi