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Q02080

- MEF2B_HUMAN

UniProt

Q02080 - MEF2B_HUMAN

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Protein

Myocyte-specific enhancer factor 2B

Gene

MEF2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi58 – 8629Mef2-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. histone deacetylase binding Source: BHF-UCL
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. muscle organ development Source: ProtInc
  2. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Myocyte-specific enhancer factor 2B
Alternative name(s):
RSRFR2
Serum response factor-like protein 2
Gene namesi
Name:MEF2B
Synonyms:XMEF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6995. MEF2B.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: HPA
  2. cytoplasm Source: HPA
  3. nucleus Source: HPA
  4. transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Myocyte-specific enhancer factor 2BPRO_0000199431Add
BLAST

Proteomic databases

MaxQBiQ02080.
PaxDbiQ02080.
PRIDEiQ02080.

PTM databases

PhosphoSiteiQ02080.

Expressioni

Tissue specificityi

Expressed in skeletal and cardiac muscle and brain.

Gene expression databases

BgeeiQ02080.
CleanExiHS_MEF2B.
ExpressionAtlasiQ02080. baseline.
GenevestigatoriQ02080.

Organism-specific databases

HPAiHPA004734.

Interactioni

Subunit structurei

Interacts with HDAC7 (By similarity). Heterodimer. Interacts with HDAC9.By similarity1 Publication

Protein-protein interaction databases

BioGridi110371. 5 interactions.
IntActiQ02080. 1 interaction.
STRINGi9606.ENSP00000393159.

Structurei

Secondary structure

1
365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 3926Combined sources
Beta strandi42 – 487Combined sources
Beta strandi54 – 607Combined sources
Helixi62 – 709Combined sources
Beta strandi76 – 805Combined sources
Helixi81 – 9313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N6JX-ray2.20A/B2-94[»]
1TQEX-ray2.70P/Q/R/S1-93[»]
ProteinModelPortaliQ02080.
SMRiQ02080. Positions 2-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02080.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5755MADS-boxPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 3128Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the MEF2 family.Curated
Contains 1 MADS-box domain.PROSITE-ProRule annotation
Contains 1 Mef2-type DNA-binding domain.Curated

Phylogenomic databases

eggNOGiCOG5068.
GeneTreeiENSGT00390000011828.
HOGENOMiHOG000230620.
HOVERGENiHBG053944.
InParanoidiQ02080.
KOiK09261.
PhylomeDBiQ02080.
TreeFamiTF314067.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02080-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
ANRLFQYAST DMDRVLLKYT EYSEPHESRT NTDILETLKR RGIGLDGPEL
110 120 130 140 150
EPDEGPEEPG EKFRRLAGEG GDPALPRPRL YPAAPAMPSP DVVYGALPPP
160 170 180 190 200
GCDPSGLGEA LPAQSRPSPF RPAAPKAGPP GLVHPLFSPS HLTSKTPPPL
210 220 230 240 250
YLPTEGRRSD LPGGLAGPRG GLNTSRSLYS GLQNPCSTAT PGPPLGSFPF
260 270 280 290 300
LPGGPPVGAE AWARRVPQPA APPRRPPQSA SSLSASLRPP GAPATFLRPS
310 320 330 340 350
PIPCSSPGPW QSLCGLGPPC AGCPWPTAGP GRRSPGGTSP ERSPGTARAR
360
GDPTSLQASS EKTQQ
Length:365
Mass (Da):38,639
Last modified:February 1, 1996 - v2
Checksum:iB12A19B1F659C7C7
GO
Isoform 2 (identifier: Q02080-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-365: VGAEAWARRV...LQASSEKTQQ → EYGLGDPPPP...RLPLADGWPR

Show »
Length:368
Mass (Da):39,144
Checksum:i239CC949587FB544
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951K → R in BAG62689. (PubMed:14702039)Curated
Sequence conflicti195 – 1951K → R in BAH14699. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei257 – 365109VGAEA…EKTQQ → EYGLGDPPPPPGLLQPPTLA PWQPSRGDGPPAVSSQPSGG RSLGEEGPPTRGASPPTPPV SIKSERLSPAPGGPGDFPKT FPYPLLLARSLAEPLRPGPA LRRLPLADGWPR in isoform 2. 1 PublicationVSP_042322Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68502 mRNA. Translation: CAA48515.1.
X63380 mRNA. Translation: CAA44978.1.
AK301086 mRNA. Translation: BAG62689.1.
AK316328 mRNA. Translation: BAH14699.1.
AC002126 Genomic DNA. Translation: AAB86982.1.
CH471106 Genomic DNA. Translation: EAW84788.1.
BC126245 mRNA. Translation: AAI26246.1.
BC136457 mRNA. Translation: AAI36458.1.
BC171767 mRNA. Translation: AAI71767.1.
CCDSiCCDS46024.1. [Q02080-2]
PIRiA39481.
RefSeqiNP_001139257.1. NM_001145785.1. [Q02080-2]
NP_005910.1. NM_005919.3. [Q02080-1]
UniGeneiHs.153629.

Genome annotation databases

EnsembliENST00000424583; ENSP00000402154; ENSG00000213999. [Q02080-2]
GeneIDi100271849.
4207.
KEGGihsa:100271849.
hsa:4207.
UCSCiuc002nll.2. human. [Q02080-2]
uc002nlo.2. human. [Q02080-1]

Polymorphism databases

DMDMi1346514.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68502 mRNA. Translation: CAA48515.1 .
X63380 mRNA. Translation: CAA44978.1 .
AK301086 mRNA. Translation: BAG62689.1 .
AK316328 mRNA. Translation: BAH14699.1 .
AC002126 Genomic DNA. Translation: AAB86982.1 .
CH471106 Genomic DNA. Translation: EAW84788.1 .
BC126245 mRNA. Translation: AAI26246.1 .
BC136457 mRNA. Translation: AAI36458.1 .
BC171767 mRNA. Translation: AAI71767.1 .
CCDSi CCDS46024.1. [Q02080-2 ]
PIRi A39481.
RefSeqi NP_001139257.1. NM_001145785.1. [Q02080-2 ]
NP_005910.1. NM_005919.3. [Q02080-1 ]
UniGenei Hs.153629.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1N6J X-ray 2.20 A/B 2-94 [» ]
1TQE X-ray 2.70 P/Q/R/S 1-93 [» ]
ProteinModelPortali Q02080.
SMRi Q02080. Positions 2-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110371. 5 interactions.
IntActi Q02080. 1 interaction.
STRINGi 9606.ENSP00000393159.

PTM databases

PhosphoSitei Q02080.

Polymorphism databases

DMDMi 1346514.

Proteomic databases

MaxQBi Q02080.
PaxDbi Q02080.
PRIDEi Q02080.

Protocols and materials databases

DNASUi 4207.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000424583 ; ENSP00000402154 ; ENSG00000213999 . [Q02080-2 ]
GeneIDi 100271849.
4207.
KEGGi hsa:100271849.
hsa:4207.
UCSCi uc002nll.2. human. [Q02080-2 ]
uc002nlo.2. human. [Q02080-1 ]

Organism-specific databases

CTDi 100271849.
4207.
GeneCardsi GC19M019256.
HGNCi HGNC:6995. MEF2B.
HPAi HPA004734.
MIMi 600661. gene.
neXtProti NX_Q02080.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5068.
GeneTreei ENSGT00390000011828.
HOGENOMi HOG000230620.
HOVERGENi HBG053944.
InParanoidi Q02080.
KOi K09261.
PhylomeDBi Q02080.
TreeFami TF314067.

Enzyme and pathway databases

Reactomei REACT_21402. CDO in myogenesis.

Miscellaneous databases

EvolutionaryTracei Q02080.
GeneWikii MEF2B.
NextBioi 16574.
PROi Q02080.
SOURCEi Search...

Gene expression databases

Bgeei Q02080.
CleanExi HS_MEF2B.
ExpressionAtlasi Q02080. baseline.
Genevestigatori Q02080.

Family and domain databases

InterProi IPR002100. TF_MADSbox.
[Graphical view ]
Pfami PF00319. SRF-TF. 1 hit.
[Graphical view ]
PRINTSi PR00404. MADSDOMAIN.
SMARTi SM00432. MADS. 1 hit.
[Graphical view ]
SUPFAMi SSF55455. SSF55455. 1 hit.
PROSITEi PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors."
    Yu Y.-T., Breitbart R.E., Smoot L.B., Lee Y., Mahdavi V., Nadal-Ginard B.
    Genes Dev. 6:1783-1798(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart and Skeletal muscle.
  2. "Human SRF-related proteins: DNA-binding properties and potential regulatory targets."
    Pollock R., Treisman R.
    Genes Dev. 5:2327-2341(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  7. "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2."
    Han A., Pan F., Stroud J.C., Youn H.-D., Liu J.O., Chen L.
    Nature 422:730-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 2-94.
  8. "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2."
    Han A., He J., Wu Y., Liu J.O., Chen L.
    J. Mol. Biol. 345:91-102(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1-93 IN COMPLEX WITH HDAC9 AND DNA.

Entry informationi

Entry nameiMEF2B_HUMAN
AccessioniPrimary (citable) accession number: Q02080
Secondary accession number(s): A0AV80
, B4DVH7, B7ZVY1, G5E9M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3