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Q02080

- MEF2B_HUMAN

UniProt

Q02080 - MEF2B_HUMAN

Protein

Myocyte-specific enhancer factor 2B

Gene

MEF2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi58 – 8629Mef2-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. histone deacetylase binding Source: BHF-UCL
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. muscle organ development Source: ProtInc
    2. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_21402. CDO in myogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myocyte-specific enhancer factor 2B
    Alternative name(s):
    RSRFR2
    Serum response factor-like protein 2
    Gene namesi
    Name:MEF2B
    Synonyms:XMEF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6995. MEF2B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. cytoplasm Source: HPA
    3. nucleus Source: HPA
    4. transcription factor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 365365Myocyte-specific enhancer factor 2BPRO_0000199431Add
    BLAST

    Proteomic databases

    MaxQBiQ02080.
    PaxDbiQ02080.
    PRIDEiQ02080.

    PTM databases

    PhosphoSiteiQ02080.

    Expressioni

    Tissue specificityi

    Expressed in skeletal and cardiac muscle and brain.

    Gene expression databases

    BgeeiQ02080.
    CleanExiHS_MEF2B.
    GenevestigatoriQ02080.

    Organism-specific databases

    HPAiHPA004734.

    Interactioni

    Subunit structurei

    Interacts with HDAC7 By similarity. Heterodimer. Interacts with HDAC9.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi110371. 5 interactions.
    IntActiQ02080. 1 interaction.
    STRINGi9606.ENSP00000393159.

    Structurei

    Secondary structure

    1
    365
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi14 – 3926
    Beta strandi42 – 487
    Beta strandi54 – 607
    Helixi62 – 709
    Beta strandi76 – 805
    Helixi81 – 9313

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1N6JX-ray2.20A/B2-94[»]
    1TQEX-ray2.70P/Q/R/S1-93[»]
    ProteinModelPortaliQ02080.
    SMRiQ02080. Positions 2-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ02080.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 5755MADS-boxPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 3128Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the MEF2 family.Curated
    Contains 1 MADS-box domain.PROSITE-ProRule annotation
    Contains 1 Mef2-type DNA-binding domain.Curated

    Phylogenomic databases

    eggNOGiCOG5068.
    HOGENOMiHOG000230620.
    HOVERGENiHBG053944.
    KOiK09261.
    PhylomeDBiQ02080.
    TreeFamiTF314067.

    Family and domain databases

    InterProiIPR002100. TF_MADSbox.
    [Graphical view]
    PfamiPF00319. SRF-TF. 1 hit.
    [Graphical view]
    PRINTSiPR00404. MADSDOMAIN.
    SMARTiSM00432. MADS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55455. SSF55455. 1 hit.
    PROSITEiPS00350. MADS_BOX_1. 1 hit.
    PS50066. MADS_BOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02080-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS    50
    ANRLFQYAST DMDRVLLKYT EYSEPHESRT NTDILETLKR RGIGLDGPEL 100
    EPDEGPEEPG EKFRRLAGEG GDPALPRPRL YPAAPAMPSP DVVYGALPPP 150
    GCDPSGLGEA LPAQSRPSPF RPAAPKAGPP GLVHPLFSPS HLTSKTPPPL 200
    YLPTEGRRSD LPGGLAGPRG GLNTSRSLYS GLQNPCSTAT PGPPLGSFPF 250
    LPGGPPVGAE AWARRVPQPA APPRRPPQSA SSLSASLRPP GAPATFLRPS 300
    PIPCSSPGPW QSLCGLGPPC AGCPWPTAGP GRRSPGGTSP ERSPGTARAR 350
    GDPTSLQASS EKTQQ 365
    Length:365
    Mass (Da):38,639
    Last modified:February 1, 1996 - v2
    Checksum:iB12A19B1F659C7C7
    GO
    Isoform 2 (identifier: Q02080-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         257-365: VGAEAWARRV...LQASSEKTQQ → EYGLGDPPPP...RLPLADGWPR

    Show »
    Length:368
    Mass (Da):39,144
    Checksum:i239CC949587FB544
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951K → R in BAG62689. (PubMed:14702039)Curated
    Sequence conflicti195 – 1951K → R in BAH14699. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei257 – 365109VGAEA…EKTQQ → EYGLGDPPPPPGLLQPPTLA PWQPSRGDGPPAVSSQPSGG RSLGEEGPPTRGASPPTPPV SIKSERLSPAPGGPGDFPKT FPYPLLLARSLAEPLRPGPA LRRLPLADGWPR in isoform 2. 1 PublicationVSP_042322Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68502 mRNA. Translation: CAA48515.1.
    X63380 mRNA. Translation: CAA44978.1.
    AK301086 mRNA. Translation: BAG62689.1.
    AK316328 mRNA. Translation: BAH14699.1.
    AC002126 Genomic DNA. Translation: AAB86982.1.
    CH471106 Genomic DNA. Translation: EAW84788.1.
    BC126245 mRNA. Translation: AAI26246.1.
    BC136457 mRNA. Translation: AAI36458.1.
    BC171767 mRNA. Translation: AAI71767.1.
    CCDSiCCDS46024.1. [Q02080-2]
    PIRiA39481.
    RefSeqiNP_001139257.1. NM_001145785.1. [Q02080-2]
    NP_005910.1. NM_005919.3. [Q02080-1]
    UniGeneiHs.153629.

    Genome annotation databases

    EnsembliENST00000424583; ENSP00000402154; ENSG00000213999. [Q02080-2]
    GeneIDi100271849.
    4207.
    KEGGihsa:100271849.
    hsa:4207.
    UCSCiuc002nll.2. human. [Q02080-2]
    uc002nlo.2. human. [Q02080-1]

    Polymorphism databases

    DMDMi1346514.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68502 mRNA. Translation: CAA48515.1 .
    X63380 mRNA. Translation: CAA44978.1 .
    AK301086 mRNA. Translation: BAG62689.1 .
    AK316328 mRNA. Translation: BAH14699.1 .
    AC002126 Genomic DNA. Translation: AAB86982.1 .
    CH471106 Genomic DNA. Translation: EAW84788.1 .
    BC126245 mRNA. Translation: AAI26246.1 .
    BC136457 mRNA. Translation: AAI36458.1 .
    BC171767 mRNA. Translation: AAI71767.1 .
    CCDSi CCDS46024.1. [Q02080-2 ]
    PIRi A39481.
    RefSeqi NP_001139257.1. NM_001145785.1. [Q02080-2 ]
    NP_005910.1. NM_005919.3. [Q02080-1 ]
    UniGenei Hs.153629.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1N6J X-ray 2.20 A/B 2-94 [» ]
    1TQE X-ray 2.70 P/Q/R/S 1-93 [» ]
    ProteinModelPortali Q02080.
    SMRi Q02080. Positions 2-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110371. 5 interactions.
    IntActi Q02080. 1 interaction.
    STRINGi 9606.ENSP00000393159.

    PTM databases

    PhosphoSitei Q02080.

    Polymorphism databases

    DMDMi 1346514.

    Proteomic databases

    MaxQBi Q02080.
    PaxDbi Q02080.
    PRIDEi Q02080.

    Protocols and materials databases

    DNASUi 4207.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000424583 ; ENSP00000402154 ; ENSG00000213999 . [Q02080-2 ]
    GeneIDi 100271849.
    4207.
    KEGGi hsa:100271849.
    hsa:4207.
    UCSCi uc002nll.2. human. [Q02080-2 ]
    uc002nlo.2. human. [Q02080-1 ]

    Organism-specific databases

    CTDi 100271849.
    4207.
    GeneCardsi GC19M019256.
    GC19M019258.
    HGNCi HGNC:6995. MEF2B.
    HPAi HPA004734.
    MIMi 600661. gene.
    neXtProti NX_Q02080.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5068.
    HOGENOMi HOG000230620.
    HOVERGENi HBG053944.
    KOi K09261.
    PhylomeDBi Q02080.
    TreeFami TF314067.

    Enzyme and pathway databases

    Reactomei REACT_21402. CDO in myogenesis.

    Miscellaneous databases

    EvolutionaryTracei Q02080.
    GeneWikii MEF2B.
    NextBioi 16574.
    PROi Q02080.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02080.
    CleanExi HS_MEF2B.
    Genevestigatori Q02080.

    Family and domain databases

    InterProi IPR002100. TF_MADSbox.
    [Graphical view ]
    Pfami PF00319. SRF-TF. 1 hit.
    [Graphical view ]
    PRINTSi PR00404. MADSDOMAIN.
    SMARTi SM00432. MADS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55455. SSF55455. 1 hit.
    PROSITEi PS00350. MADS_BOX_1. 1 hit.
    PS50066. MADS_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors."
      Yu Y.-T., Breitbart R.E., Smoot L.B., Lee Y., Mahdavi V., Nadal-Ginard B.
      Genes Dev. 6:1783-1798(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart and Skeletal muscle.
    2. "Human SRF-related proteins: DNA-binding properties and potential regulatory targets."
      Pollock R., Treisman R.
      Genes Dev. 5:2327-2341(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Testis.
    7. "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2."
      Han A., Pan F., Stroud J.C., Youn H.-D., Liu J.O., Chen L.
      Nature 422:730-734(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 2-94.
    8. "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2."
      Han A., He J., Wu Y., Liu J.O., Chen L.
      J. Mol. Biol. 345:91-102(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1-93 IN COMPLEX WITH HDAC9 AND DNA.

    Entry informationi

    Entry nameiMEF2B_HUMAN
    AccessioniPrimary (citable) accession number: Q02080
    Secondary accession number(s): A0AV80
    , B4DVH7, B7ZVY1, G5E9M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3