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Protein

Myocyte-specific enhancer factor 2B

Gene

MEF2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi58 – 86Mef2-typeSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • muscle organ development Source: ProtInc
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-375170 CDO in myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Myocyte-specific enhancer factor 2B
Alternative name(s):
RSRFR2
Serum response factor-like protein 2
Gene namesi
Name:MEF2B
Synonyms:XMEF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213999.15
HGNCiHGNC:6995 MEF2B
MIMi600661 gene
neXtProtiNX_Q02080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100271849
4207
OpenTargetsiENSG00000064489
ENSG00000213999

Polymorphism and mutation databases

BioMutaiMEF2B
DMDMi1346514

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994311 – 365Myocyte-specific enhancer factor 2BAdd BLAST365

Proteomic databases

MaxQBiQ02080
PaxDbiQ02080
PeptideAtlasiQ02080
PRIDEiQ02080

PTM databases

iPTMnetiQ02080
PhosphoSitePlusiQ02080

Expressioni

Tissue specificityi

Expressed in skeletal and cardiac muscle and brain.

Gene expression databases

BgeeiENSG00000213999
CleanExiHS_MEF2B
ExpressionAtlasiQ02080 baseline and differential
GenevisibleiQ02080 HS

Organism-specific databases

HPAiHPA004734

Interactioni

Subunit structurei

Interacts with HDAC7 (By similarity). Heterodimer. Interacts with HDAC9.By similarity1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: BHF-UCL
  • protein dimerization activity Source: InterPro

Protein-protein interaction databases

BioGridi110371, 3 interactors
938509, 10 interactors
IntActiQ02080, 3 interactors
STRINGi9606.ENSP00000162023

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 39Combined sources26
Beta strandi42 – 48Combined sources7
Beta strandi54 – 60Combined sources7
Helixi62 – 70Combined sources9
Beta strandi76 – 80Combined sources5
Helixi81 – 93Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6JX-ray2.20A/B2-94[»]
1TQEX-ray2.70P/Q/R/S1-93[»]
6BYYX-ray2.30A/B/C/D63-91[»]
6BZ1X-ray2.97A/B/C/D65-91[»]
6C9LX-ray2.30A/B/C/D/E/F1-93[»]
ProteinModelPortaliQ02080
SMRiQ02080
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02080

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 57MADS-boxPROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 31Lys-rich (basic)Add BLAST28

Sequence similaritiesi

Belongs to the MEF2 family.Curated

Phylogenomic databases

eggNOGiKOG0014 Eukaryota
COG5068 LUCA
GeneTreeiENSGT00390000011828
HOGENOMiHOG000230620
HOVERGENiHBG053944
InParanoidiQ02080
KOiK09261
PhylomeDBiQ02080
TreeFamiTF314067

Family and domain databases

CDDicd00265 MADS_MEF2_like, 1 hit
Gene3Di3.40.1810.10, 1 hit
InterProiView protein in InterPro
IPR033896 MADS_MEF2-like
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf
PfamiView protein in Pfam
PF00319 SRF-TF, 1 hit
PRINTSiPR00404 MADSDOMAIN
SMARTiView protein in SMART
SM00432 MADS, 1 hit
SUPFAMiSSF55455 SSF55455, 1 hit
PROSITEiView protein in PROSITE
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02080-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
ANRLFQYAST DMDRVLLKYT EYSEPHESRT NTDILETLKR RGIGLDGPEL
110 120 130 140 150
EPDEGPEEPG EKFRRLAGEG GDPALPRPRL YPAAPAMPSP DVVYGALPPP
160 170 180 190 200
GCDPSGLGEA LPAQSRPSPF RPAAPKAGPP GLVHPLFSPS HLTSKTPPPL
210 220 230 240 250
YLPTEGRRSD LPGGLAGPRG GLNTSRSLYS GLQNPCSTAT PGPPLGSFPF
260 270 280 290 300
LPGGPPVGAE AWARRVPQPA APPRRPPQSA SSLSASLRPP GAPATFLRPS
310 320 330 340 350
PIPCSSPGPW QSLCGLGPPC AGCPWPTAGP GRRSPGGTSP ERSPGTARAR
360
GDPTSLQASS EKTQQ
Length:365
Mass (Da):38,639
Last modified:February 1, 1996 - v2
Checksum:iB12A19B1F659C7C7
GO
Isoform 2 (identifier: Q02080-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-365: VGAEAWARRV...LQASSEKTQQ → EYGLGDPPPP...RLPLADGWPR

Show »
Length:368
Mass (Da):39,144
Checksum:i239CC949587FB544
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195K → R in BAG62689 (PubMed:14702039).Curated1
Sequence conflicti195K → R in BAH14699 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042322257 – 365VGAEA…EKTQQ → EYGLGDPPPPPGLLQPPTLA PWQPSRGDGPPAVSSQPSGG RSLGEEGPPTRGASPPTPPV SIKSERLSPAPGGPGDFPKT FPYPLLLARSLAEPLRPGPA LRRLPLADGWPR in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68502 mRNA Translation: CAA48515.1
X63380 mRNA Translation: CAA44978.1
AK301086 mRNA Translation: BAG62689.1
AK316328 mRNA Translation: BAH14699.1
AC002126 Genomic DNA Translation: AAB86982.1
CH471106 Genomic DNA Translation: EAW84788.1
BC126245 mRNA Translation: AAI26246.1
BC136457 mRNA Translation: AAI36458.1
BC171767 mRNA Translation: AAI71767.1
CCDSiCCDS46024.1 [Q02080-2]
PIRiA39481
RefSeqiNP_001139257.1, NM_001145785.1 [Q02080-2]
NP_005910.1, NM_005919.3 [Q02080-1]
UniGeneiHs.153629

Genome annotation databases

EnsembliENST00000424583; ENSP00000402154; ENSG00000213999 [Q02080-2]
GeneIDi100271849
4207
KEGGihsa:100271849
hsa:4207
UCSCiuc002nll.3 human [Q02080-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMEF2B_HUMAN
AccessioniPrimary (citable) accession number: Q02080
Secondary accession number(s): A0AV80
, B4DVH7, B7ZVY1, G5E9M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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