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Q02080 (MEF2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myocyte-specific enhancer factor 2B
Alternative name(s):
RSRFR2
Serum response factor-like protein 2
Gene names
Name:MEF2B
Synonyms:XMEF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

Subunit structure

Interacts with HDAC7 By similarity. Heterodimer. Interacts with HDAC9.

Subcellular location

Nucleus.

Tissue specificity

Expressed in skeletal and cardiac muscle and brain.

Sequence similarities

Belongs to the MEF2 family.

Contains 1 MADS-box domain.

Contains 1 Mef2-type DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q02080-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q02080-2)

The sequence of this isoform differs from the canonical sequence as follows:
     257-365: VGAEAWARRV...LQASSEKTQQ → EYGLGDPPPP...RLPLADGWPR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Myocyte-specific enhancer factor 2B
PRO_0000199431

Regions

Domain3 – 5755MADS-box
DNA binding58 – 8629Mef2-type Potential
Compositional bias4 – 3128Lys-rich (basic)

Natural variations

Alternative sequence257 – 365109VGAEA…EKTQQ → EYGLGDPPPPPGLLQPPTLA PWQPSRGDGPPAVSSQPSGG RSLGEEGPPTRGASPPTPPV SIKSERLSPAPGGPGDFPKT FPYPLLLARSLAEPLRPGPA LRRLPLADGWPR in isoform 2.
VSP_042322

Experimental info

Sequence conflict1951K → R in BAG62689. Ref.3
Sequence conflict1951K → R in BAH14699. Ref.3

Secondary structure

............ 365
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: B12A19B1F659C7C7

FASTA36538,639
        10         20         30         40         50         60 
MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS ANRLFQYAST 

        70         80         90        100        110        120 
DMDRVLLKYT EYSEPHESRT NTDILETLKR RGIGLDGPEL EPDEGPEEPG EKFRRLAGEG 

       130        140        150        160        170        180 
GDPALPRPRL YPAAPAMPSP DVVYGALPPP GCDPSGLGEA LPAQSRPSPF RPAAPKAGPP 

       190        200        210        220        230        240 
GLVHPLFSPS HLTSKTPPPL YLPTEGRRSD LPGGLAGPRG GLNTSRSLYS GLQNPCSTAT 

       250        260        270        280        290        300 
PGPPLGSFPF LPGGPPVGAE AWARRVPQPA APPRRPPQSA SSLSASLRPP GAPATFLRPS 

       310        320        330        340        350        360 
PIPCSSPGPW QSLCGLGPPC AGCPWPTAGP GRRSPGGTSP ERSPGTARAR GDPTSLQASS 


EKTQQ 

« Hide

Isoform 2 [UniParc].

Checksum: 239CC949587FB544
Show »

FASTA36839,144

References

« Hide 'large scale' references
[1]"Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors."
Yu Y.-T., Breitbart R.E., Smoot L.B., Lee Y., Mahdavi V., Nadal-Ginard B.
Genes Dev. 6:1783-1798(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Heart and Skeletal muscle.
[2]"Human SRF-related proteins: DNA-binding properties and potential regulatory targets."
Pollock R., Treisman R.
Genes Dev. 5:2327-2341(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Spleen.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Testis.
[7]"Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2."
Han A., Pan F., Stroud J.C., Youn H.-D., Liu J.O., Chen L.
Nature 422:730-734(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 2-94.
[8]"Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2."
Han A., He J., Wu Y., Liu J.O., Chen L.
J. Mol. Biol. 345:91-102(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1-93 IN COMPLEX WITH HDAC9 AND DNA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68502 mRNA. Translation: CAA48515.1.
X63380 mRNA. Translation: CAA44978.1.
AK301086 mRNA. Translation: BAG62689.1.
AK316328 mRNA. Translation: BAH14699.1.
AC002126 Genomic DNA. Translation: AAB86982.1.
CH471106 Genomic DNA. Translation: EAW84788.1.
BC126245 mRNA. Translation: AAI26246.1.
BC136457 mRNA. Translation: AAI36458.1.
BC171767 mRNA. Translation: AAI71767.1.
CCDSCCDS46024.1. [Q02080-2]
PIRA39481.
RefSeqNP_001139257.1. NM_001145785.1. [Q02080-2]
NP_005910.1. NM_005919.3. [Q02080-1]
UniGeneHs.153629.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1N6JX-ray2.20A/B2-94[»]
1TQEX-ray2.70P/Q/R/S1-93[»]
ProteinModelPortalQ02080.
SMRQ02080. Positions 2-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110371. 5 interactions.
IntActQ02080. 1 interaction.
STRING9606.ENSP00000393159.

PTM databases

PhosphoSiteQ02080.

Polymorphism databases

DMDM1346514.

Proteomic databases

MaxQBQ02080.
PaxDbQ02080.
PRIDEQ02080.

Protocols and materials databases

DNASU4207.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000162023; ENSP00000162023; ENSG00000213999. [Q02080-2]
ENST00000424583; ENSP00000402154; ENSG00000213999. [Q02080-2]
ENST00000602424; ENSP00000473308; ENSG00000213999. [Q02080-1]
GeneID100271849.
4207.
KEGGhsa:100271849.
hsa:4207.
UCSCuc002nll.2. human. [Q02080-2]
uc002nlo.2. human. [Q02080-1]

Organism-specific databases

CTD100271849.
4207.
GeneCardsGC19M019256.
GC19M019258.
HGNCHGNC:6995. MEF2B.
HPAHPA004734.
MIM600661. gene.
neXtProtNX_Q02080.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5068.
HOGENOMHOG000230620.
HOVERGENHBG053944.
KOK09261.
PhylomeDBQ02080.
TreeFamTF314067.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

BgeeQ02080.
CleanExHS_MEF2B.
GenevestigatorQ02080.

Family and domain databases

InterProIPR002100. TF_MADSbox.
[Graphical view]
PfamPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSPR00404. MADSDOMAIN.
SMARTSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMSSF55455. SSF55455. 1 hit.
PROSITEPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ02080.
GeneWikiMEF2B.
NextBio16574.
PROQ02080.
SOURCESearch...

Entry information

Entry nameMEF2B_HUMAN
AccessionPrimary (citable) accession number: Q02080
Secondary accession number(s): A0AV80 expand/collapse secondary AC list , B4DVH7, B7ZVY1, G5E9M1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM