Laccase-3 precursor - Thanatephorus cucumeris (Black scurf of potato)

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Reviewed, UniProtKB/Swiss-Prot Q02079 (LAC3_THACU)

Last modified November 25, 2008. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Laccase-3
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 3
    Urishiol oxidase 3
    Diphenol oxidase 3

Gene names

Name:

LCC3

Organism

Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Cantharellales › Ceratobasidiaceae › Thanatephorus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Lignin degradation and detoxification of lignin-derived products Probable.
Catalytic activity	4 benzenediol + O(2) = 4 benzosemiquinone + 2 H(2)O.
Cofactor	Binds 4 copper ions per monomer By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted.
Tissue specificity	In mycelia, at a lower level than LCC4.
Sequence similarities	Belongs to the multicopper oxidase family. Contains 3 plastocyanin-like domains.

Ontologies

Keywords
Biological process	Lignin degradation
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lignin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: InterPro laccase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

18

Potential

Chain

554

Laccase-3

PRO_0000002937

Regions

Domain

125

Plastocyanin-like 1

Domain

148

Plastocyanin-like 2

Domain

119

Plastocyanin-like 3

Sites

Metal binding

1

Copper 1; type 2 By similarity

Metal binding

1

Copper 2; type 3 By similarity

Metal binding

1

Copper 2; type 3 By similarity

Metal binding

1

Copper 3; type 3 By similarity

Metal binding

1

Copper 4; type 1 By similarity

Metal binding

1

Copper 1; type 2 By similarity

Metal binding

1

Copper 3; type 3 By similarity

Metal binding

1

Copper 3; type 3 By similarity

Metal binding

1

Copper 4; type 1 By similarity

Metal binding

1

Copper 2; type 3 By similarity

Metal binding

1

Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

1

D → N

Natural variant

1

R → H

Natural variant

1

H → Y

Natural variant

1

I → V

Sequences

Sequence

Length

Mass (Da)

Tools

Q02079-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: DF1E2AF9FF108CE4
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572

63,747

        10         20         30         40         50         60 
MARTTFLVSV SLFVSAVLAR TVEYNLKISN GKIAPDGVER DATLVNGGYP GPLIFANKGD 

        70         80         90        100        110        120 
TLKVKVQNKL TNPDMYRTTS IHWHGLLQHR NADDDGPAFV TQCPIVPQAS YTYTMPLGDQ 

       130        140        150        160        170        180 
TGTYWYHSHL SSQYVDGLRG PLVIYDPKDP HRRLYDIDDE KTVLIIGDWY HTSSKAILAT 

       190        200        210        220        230        240 
GNITLQQPDS ATINGKGRFD PDNTPANPNT LYTLKVKRGK RYRLRVINSS AIASFRMSIQ 

       250        260        270        280        290        300 
GHKMTVIAAD GVSTKPYQVD SFDILAGQRI DAVVEANQEP DTYWINAPLT NVANKTAQAL 

       310        320        330        340        350        360 
LIYEDDRRPY HPPKGPYRKW SVSEAIIKYW KHKHGRGLLS GHGGLKARMM EGSLHLHGRR 

       370        380        390        400        410        420 
DIVKRQNETT TVVMDETKLV PLEHPGAACG SKPADLVIDL TFGVNFTTGH WMINGIPHKS 

       430        440        450        460        470        480 
PDMPTLLKIL TDTDGVTESD FTQPEHTIIL PKNKCVEFNI KGNSGLGIVH PIHLHGHTFD 

       490        500        510        520        530        540 
VVQFGNNPPN YVNPPRRDVV GATDEGVRFQ FKTDNPGPWF LHCHIDWHLE EGFAMVFAEA 

       550        560        570 
PEAIKGGPKS VPVDRQWKDL CRKYGSLPAG FL

References

[1]

"The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
Curr. Genet. 29:395-403(1996) [PubMed: 8598061] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: RS22.

Cross-references

Sequence databases
	Z54215 Genomic DNA. Translation: CAA90942.1.
PIR	S68119.
3D structure databases
HSSP	HSSP built from PDB template 1HFU based on UniProtKB Q9Y780.
ModBase	Search...
Family and domain databases
InterPro	IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. [Graphical view]
Gene3D	G3DSA:2.60.40.420. Cupredoxin. 3 hits.
Pfam	PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit. [Graphical view]
PROSITE	PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LAC3_THACU

Accession

Primary (citable) accession number: Q02079

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents