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Q02075

- LAC2_THACU

UniProt

Q02075 - LAC2_THACU

Protein

Laccase-2

Gene

LCC2

Organism
Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.Curated

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi82 – 821Copper 1; type 2By similarity
    Metal bindingi84 – 841Copper 2; type 3By similarity
    Metal bindingi127 – 1271Copper 2; type 3By similarity
    Metal bindingi129 – 1291Copper 3; type 3By similarity
    Metal bindingi497 – 4971Copper 4; type 1By similarity
    Metal bindingi500 – 5001Copper 1; type 2By similarity
    Metal bindingi502 – 5021Copper 3; type 3By similarity
    Metal bindingi549 – 5491Copper 3; type 3By similarity
    Metal bindingi550 – 5501Copper 4; type 1By similarity
    Metal bindingi551 – 5511Copper 2; type 3By similarity
    Metal bindingi555 – 5551Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-2 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 2
    Diphenol oxidase 2
    Urishiol oxidase 2
    Gene namesi
    Name:LCC2
    OrganismiThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
    Taxonomic identifieri107832 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCantharellalesCeratobasidiaceaeThanatephorus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 599580Laccase-2PRO_0000002936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    In mycelia, at a lower level than LCC4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ02075.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 145125Plastocyanin-like 1Add
    BLAST
    Domaini157 – 307151Plastocyanin-like 2Add
    BLAST
    Domaini450 – 567118Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSTTSLFA LSLVASAFAR VVDYGFDVAN GAVAPDGVTR NAVLVNGRFP    50
    GPLITANKGD TLKITVRNKL SDPTMRRSTT IHWHGLLQHR TAEEDGPAFV 100
    TQCPIPPQES YTYTMPLGEQ TGTYWYHSHL SSQYVDGLRG PIVIYDPHDP 150
    YRNYYDVDDE RTVFTLADWY HTPSEAIIAT HDVLKTIPDS GTINGKGKYD 200
    PASANTNNTT LENLYTLKVK RGKRYRLRII NASAIASFRF GVQGHKCTII 250
    EADGVLTKPI EVDAFDILAG QRYSCILKAD QDPDSYWINA PITNVLNTNV 300
    QALLVYEDDK RPTHYPWKPF LTWKISNEII QYWQHKHGSH GHKGKGHHHK 350
    VRAIGGVSGL SSRVKSRASD LSKKAVELAA ALVAGEAELD KRQNEDNSTI 400
    VLDETKLIAL VQPGAPGGSR PADVVVPLDF GLNFANGLWT INNVSYSPPD 450
    VPTLLKILTD KDKVDASDFT ADEHTYILPK NQVVELHIKG QALGIVHPLH 500
    LHGHAFDVVQ FGDNAPNYVN PPRRDVVGVT DAGVRIQFRT DNPGPWFLHC 550
    HIDWHLEEGF AMVFAEAPED IKKGSQSVKP DGQWKKLCEK YEKLPEALQ 599
    Length:599
    Mass (Da):66,540
    Last modified:November 1, 1996 - v1
    Checksum:iF01DD5C52D0CBB91
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54276 Genomic DNA. Translation: CAA91041.1.
    PIRiS68118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54276 Genomic DNA. Translation: CAA91041.1 .
    PIRi S68118.

    3D structure databases

    ProteinModelPortali Q02075.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
      Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
      Curr. Genet. 29:395-403(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: R22 / IMI 358730 / AG-6.

    Entry informationi

    Entry nameiLAC2_THACU
    AccessioniPrimary (citable) accession number: Q02075
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3