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Protein

Actinorhodin polyketide putative beta-ketoacyl synthase 2

Gene

SCO5088

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Actinorhodin polyketide putative beta-ketoacyl synthase 2 (EC:2.3.1.-)
Alternative name(s):
actI ORF2
Gene namesi
Ordered Locus Names:SCO5088
ORF Names:SCBAC28G1.14
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Actinorhodin polyketide putative beta-ketoacyl synthase 2PRO_0000180349Add
BLAST

Proteomic databases

PRIDEiQ02062.

Interactioni

Protein-protein interaction databases

IntActiQ02062. 1 interaction.
STRINGi100226.SCO5088.

Structurei

Secondary structure

1
407
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1210Combined sources
Beta strandi15 – 173Combined sources
Helixi18 – 269Combined sources
Beta strandi32 – 343Combined sources
Turni36 – 394Combined sources
Helixi40 – 423Combined sources
Beta strandi47 – 493Combined sources
Helixi56 – 594Combined sources
Turni62 – 643Combined sources
Helixi65 – 673Combined sources
Helixi70 – 8516Combined sources
Helixi90 – 923Combined sources
Helixi95 – 973Combined sources
Beta strandi98 – 1036Combined sources
Helixi109 – 12113Combined sources
Helixi124 – 1263Combined sources
Helixi131 – 1344Combined sources
Helixi139 – 14810Combined sources
Beta strandi155 – 1584Combined sources
Helixi160 – 1623Combined sources
Helixi163 – 17614Combined sources
Beta strandi180 – 1889Combined sources
Helixi193 – 2008Combined sources
Helixi211 – 2133Combined sources
Beta strandi230 – 2389Combined sources
Helixi239 – 2457Combined sources
Beta strandi251 – 26111Combined sources
Helixi273 – 28412Combined sources
Helixi288 – 2903Combined sources
Beta strandi293 – 2953Combined sources
Helixi302 – 31615Combined sources
Beta strandi321 – 3244Combined sources
Helixi326 – 3294Combined sources
Helixi334 – 3363Combined sources
Helixi337 – 35115Combined sources
Helixi365 – 3673Combined sources
Beta strandi373 – 3753Combined sources
Beta strandi382 – 3909Combined sources
Turni391 – 3933Combined sources
Beta strandi394 – 4029Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-B1-404[»]
1TQYX-ray2.00B/D/F/H2-407[»]
ProteinModelPortaliQ02062.
SMRiQ02062. Positions 2-403.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02062.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiENOG4105CZS. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02062.
KOiK05552.
OMAiAWFYAVN.
OrthoDBiPOG091H0C9J.
PhylomeDBiQ02062.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

Q02062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLITGVGV VAPNGLGLAP YWSAVLDGRH GLGPVTRFDV SRYPATLAGQ
60 70 80 90 100
IDDFHAPDHI PGRLLPQTDP STRLALTAAD WALQDAKADP ESLTDYDMGV
110 120 130 140 150
VTANACGGFD FTHREFRKLW SEGPKSVSVY ESFAWFYAVN TGQISIRHGM
160 170 180 190 200
RGPSSALVAE QAGGLDALGH ARRTIRRGTP LVVSGGVDSA LDPWGWVSQI
210 220 230 240 250
ASGRISTATD PDRAYLPFDE RAAGYVPGEG GAILVLEDSA AAEARGRHDA
260 270 280 290 300
YGELAGCAST FDPAPGSGRP AGLERAIRLA LNDAGTGPED VDVVFADGAG
310 320 330 340 350
VPELDAAEAR AIGRVFGREG VPVTVPKTTT GRLYSGGGPL DVVTALMSLR
360 370 380 390 400
EGVIAPTAGV TSVPREYGID LVLGEPRSTA PRTALVLARG RWGFNSAAVL

RRFAPTP
Length:407
Mass (Da):42,550
Last modified:February 1, 1995 - v1
Checksum:i59FC75A5A0D94632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63449 Genomic DNA. Translation: CAA45044.1.
AL939122 Genomic DNA. Translation: CAC44201.1.
PIRiS25841.
RefSeqiNP_629238.1. NC_003888.3.
WP_011030048.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC44201; CAC44201; CAC44201.
GeneIDi1100529.
KEGGisco:SCO5088.
PATRICi23740016. VBIStrCoe124346_5168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63449 Genomic DNA. Translation: CAA45044.1.
AL939122 Genomic DNA. Translation: CAC44201.1.
PIRiS25841.
RefSeqiNP_629238.1. NC_003888.3.
WP_011030048.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-B1-404[»]
1TQYX-ray2.00B/D/F/H2-407[»]
ProteinModelPortaliQ02062.
SMRiQ02062. Positions 2-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02062. 1 interaction.
STRINGi100226.SCO5088.

Proteomic databases

PRIDEiQ02062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC44201; CAC44201; CAC44201.
GeneIDi1100529.
KEGGisco:SCO5088.
PATRICi23740016. VBIStrCoe124346_5168.

Phylogenomic databases

eggNOGiENOG4105CZS. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02062.
KOiK05552.
OMAiAWFYAVN.
OrthoDBiPOG091H0C9J.
PhylomeDBiQ02062.

Miscellaneous databases

EvolutionaryTraceiQ02062.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKASB_STRCO
AccessioniPrimary (citable) accession number: Q02062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This putative ketoacyl synthase lacks the active site cysteine.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.