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Protein

Actinorhodin polyketide putative beta-ketoacyl synthase 2

Gene

SCO5088

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Actinorhodin polyketide putative beta-ketoacyl synthase 2 (EC:2.3.1.-)
Alternative name(s):
actI ORF2
Gene namesi
Ordered Locus Names:SCO5088
ORF Names:SCBAC28G1.14
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803491 – 407Actinorhodin polyketide putative beta-ketoacyl synthase 2Add BLAST407

Proteomic databases

PRIDEiQ02062.

Interactioni

Protein-protein interaction databases

IntActiQ02062. 1 interactor.
STRINGi100226.SCO5088.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 12Combined sources10
Beta strandi15 – 17Combined sources3
Helixi18 – 26Combined sources9
Beta strandi32 – 34Combined sources3
Turni36 – 39Combined sources4
Helixi40 – 42Combined sources3
Beta strandi47 – 49Combined sources3
Helixi56 – 59Combined sources4
Turni62 – 64Combined sources3
Helixi65 – 67Combined sources3
Helixi70 – 85Combined sources16
Helixi90 – 92Combined sources3
Helixi95 – 97Combined sources3
Beta strandi98 – 103Combined sources6
Helixi109 – 121Combined sources13
Helixi124 – 126Combined sources3
Helixi131 – 134Combined sources4
Helixi139 – 148Combined sources10
Beta strandi155 – 158Combined sources4
Helixi160 – 162Combined sources3
Helixi163 – 176Combined sources14
Beta strandi180 – 188Combined sources9
Helixi193 – 200Combined sources8
Helixi211 – 213Combined sources3
Beta strandi230 – 238Combined sources9
Helixi239 – 245Combined sources7
Beta strandi251 – 261Combined sources11
Helixi273 – 284Combined sources12
Helixi288 – 290Combined sources3
Beta strandi293 – 295Combined sources3
Helixi302 – 316Combined sources15
Beta strandi321 – 324Combined sources4
Helixi326 – 329Combined sources4
Helixi334 – 336Combined sources3
Helixi337 – 351Combined sources15
Helixi365 – 367Combined sources3
Beta strandi373 – 375Combined sources3
Beta strandi382 – 390Combined sources9
Turni391 – 393Combined sources3
Beta strandi394 – 402Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-B1-404[»]
1TQYX-ray2.00B/D/F/H2-407[»]
ProteinModelPortaliQ02062.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02062.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiENOG4105CZS. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02062.
KOiK05552.
OMAiAWFYAVN.
OrthoDBiPOG091H0C9J.
PhylomeDBiQ02062.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

Q02062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLITGVGV VAPNGLGLAP YWSAVLDGRH GLGPVTRFDV SRYPATLAGQ
60 70 80 90 100
IDDFHAPDHI PGRLLPQTDP STRLALTAAD WALQDAKADP ESLTDYDMGV
110 120 130 140 150
VTANACGGFD FTHREFRKLW SEGPKSVSVY ESFAWFYAVN TGQISIRHGM
160 170 180 190 200
RGPSSALVAE QAGGLDALGH ARRTIRRGTP LVVSGGVDSA LDPWGWVSQI
210 220 230 240 250
ASGRISTATD PDRAYLPFDE RAAGYVPGEG GAILVLEDSA AAEARGRHDA
260 270 280 290 300
YGELAGCAST FDPAPGSGRP AGLERAIRLA LNDAGTGPED VDVVFADGAG
310 320 330 340 350
VPELDAAEAR AIGRVFGREG VPVTVPKTTT GRLYSGGGPL DVVTALMSLR
360 370 380 390 400
EGVIAPTAGV TSVPREYGID LVLGEPRSTA PRTALVLARG RWGFNSAAVL

RRFAPTP
Length:407
Mass (Da):42,550
Last modified:February 1, 1995 - v1
Checksum:i59FC75A5A0D94632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63449 Genomic DNA. Translation: CAA45044.1.
AL939122 Genomic DNA. Translation: CAC44201.1.
PIRiS25841.
RefSeqiNP_629238.1. NC_003888.3.
WP_011030048.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC44201; CAC44201; CAC44201.
GeneIDi1100529.
KEGGisco:SCO5088.
PATRICi23740016. VBIStrCoe124346_5168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63449 Genomic DNA. Translation: CAA45044.1.
AL939122 Genomic DNA. Translation: CAC44201.1.
PIRiS25841.
RefSeqiNP_629238.1. NC_003888.3.
WP_011030048.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-B1-404[»]
1TQYX-ray2.00B/D/F/H2-407[»]
ProteinModelPortaliQ02062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02062. 1 interactor.
STRINGi100226.SCO5088.

Proteomic databases

PRIDEiQ02062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC44201; CAC44201; CAC44201.
GeneIDi1100529.
KEGGisco:SCO5088.
PATRICi23740016. VBIStrCoe124346_5168.

Phylogenomic databases

eggNOGiENOG4105CZS. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02062.
KOiK05552.
OMAiAWFYAVN.
OrthoDBiPOG091H0C9J.
PhylomeDBiQ02062.

Miscellaneous databases

EvolutionaryTraceiQ02062.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKASB_STRCO
AccessioniPrimary (citable) accession number: Q02062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 5, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This putative ketoacyl synthase lacks the active site cysteine.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.