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Protein

Actinorhodin polyketide putative beta-ketoacyl synthase 1

Gene

SCO5087

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pathwayi: actinorhodin biosynthesis

This protein is involved in the pathway actinorhodin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway actinorhodin biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei212PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00173.

Names & Taxonomyi

Protein namesi
Recommended name:
Actinorhodin polyketide putative beta-ketoacyl synthase 1 (EC:2.3.1.-)
Alternative name(s):
actI ORF1
Gene namesi
Ordered Locus Names:SCO5087
ORF Names:SCBAC28G1.13
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803421 – 467Actinorhodin polyketide putative beta-ketoacyl synthase 1Add BLAST467

Proteomic databases

PRIDEiQ02059.

Interactioni

Protein-protein interaction databases

IntActiQ02059. 1 interactor.
STRINGi100226.SCO5087.

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 57Combined sources10
Beta strandi60 – 62Combined sources3
Helixi63 – 72Combined sources10
Beta strandi77 – 79Combined sources3
Beta strandi92 – 94Combined sources3
Helixi100 – 103Combined sources4
Helixi107 – 112Combined sources6
Helixi115 – 131Combined sources17
Turni135 – 137Combined sources3
Helixi140 – 142Combined sources3
Beta strandi143 – 148Combined sources6
Helixi154 – 165Combined sources12
Turni166 – 169Combined sources4
Helixi175 – 177Combined sources3
Turni180 – 182Combined sources3
Helixi183 – 186Combined sources4
Helixi190 – 199Combined sources10
Beta strandi205 – 208Combined sources4
Helixi211 – 213Combined sources3
Helixi214 – 227Combined sources14
Beta strandi232 – 240Combined sources9
Helixi245 – 253Combined sources9
Helixi264 – 266Combined sources3
Beta strandi283 – 291Combined sources9
Helixi292 – 297Combined sources6
Beta strandi304 – 313Combined sources10
Helixi326 – 339Combined sources14
Helixi343 – 345Combined sources3
Beta strandi348 – 350Combined sources3
Helixi357 – 370Combined sources14
Helixi372 – 377Combined sources6
Helixi384 – 387Combined sources4
Turni391 – 393Combined sources3
Helixi394 – 408Combined sources15
Beta strandi419 – 421Combined sources3
Beta strandi430 – 432Combined sources3
Beta strandi439 – 447Combined sources9
Turni448 – 450Combined sources3
Beta strandi451 – 458Combined sources8
Helixi460 – 465Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-A45-461[»]
1TQYX-ray2.00A/C/E/G45-467[»]
ProteinModelPortaliQ02059.
SMRiQ02059.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02059.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiENOG4105C0Q. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02059.
KOiK05551.
OMAiMGPNNTI.
OrthoDBiPOG091H018O.
PhylomeDBiQ02059.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLDAAPVDP ASRGPVSAFE PPSSHGADDD DDHRTNASKE LFGLKRRVVI
60 70 80 90 100
TGVGVRAPGG NGTRQFWELL TSGRTATRRI SFFDPSPYRS QVAAEADFDP
110 120 130 140 150
VAEGFGPREL DRMDRASQFA VACAREAFAA SGLDPDTLDP ARVGVSLGSA
160 170 180 190 200
VAAATSLERE YLLLSDSGRD WEVDAAWLSR HMFDYLVPSV MPAEVAWAVG
210 220 230 240 250
AEGPVTMVST GCTSGLDSVG NAVRAIEEGS ADVMFAGAAD TPITPIVVAC
260 270 280 290 300
FDAIRATTAR NDDPEHASRP FDGTRDGFVL AEGAAMFVLE DYDSALARGA
310 320 330 340 350
RIHAEISGYA TRCNAYHMTG LKADGREMAE TIRVALDESR TDATDIDYIN
360 370 380 390 400
AHGSGTRQND RHETAAYKRA LGEHARRTPV SSIKSMVGHS LGAIGSLEIA
410 420 430 440 450
ACVLALEHGV VPPTANLRTS DPECDLDYVP LEARERKLRS VLTVGSGFGG
460
FQSAMVLRDA ETAGAAA
Length:467
Mass (Da):49,504
Last modified:January 17, 2003 - v2
Checksum:i6B5BEE32B5241C60
GO

Sequence cautioni

The sequence CAA45043 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA. Translation: CAC44200.1.
X63449 Genomic DNA. Translation: CAA45043.1. Different initiation.
PIRiS25840.
RefSeqiNP_629237.1. NC_003888.3.
WP_003973891.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC44200; CAC44200; CAC44200.
GeneIDi1100528.
KEGGisco:SCO5087.
PATRICi23740014. VBIStrCoe124346_5167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA. Translation: CAC44200.1.
X63449 Genomic DNA. Translation: CAA45043.1. Different initiation.
PIRiS25840.
RefSeqiNP_629237.1. NC_003888.3.
WP_003973891.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-A45-461[»]
1TQYX-ray2.00A/C/E/G45-467[»]
ProteinModelPortaliQ02059.
SMRiQ02059.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02059. 1 interactor.
STRINGi100226.SCO5087.

Proteomic databases

PRIDEiQ02059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC44200; CAC44200; CAC44200.
GeneIDi1100528.
KEGGisco:SCO5087.
PATRICi23740014. VBIStrCoe124346_5167.

Phylogenomic databases

eggNOGiENOG4105C0Q. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02059.
KOiK05551.
OMAiMGPNNTI.
OrthoDBiPOG091H018O.
PhylomeDBiQ02059.

Enzyme and pathway databases

UniPathwayiUPA00173.

Miscellaneous databases

EvolutionaryTraceiQ02059.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKASA_STRCO
AccessioniPrimary (citable) accession number: Q02059
Secondary accession number(s): Q93IZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 17, 2003
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.