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Protein

Actinorhodin polyketide putative beta-ketoacyl synthase 1

Gene

SCO5087

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pathwayi: actinorhodin biosynthesis

This protein is involved in the pathway actinorhodin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway actinorhodin biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei212 – 2121PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00173.

Names & Taxonomyi

Protein namesi
Recommended name:
Actinorhodin polyketide putative beta-ketoacyl synthase 1 (EC:2.3.1.-)
Alternative name(s):
actI ORF1
Gene namesi
Ordered Locus Names:SCO5087
ORF Names:SCBAC28G1.13
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Actinorhodin polyketide putative beta-ketoacyl synthase 1PRO_0000180342Add
BLAST

Proteomic databases

PRIDEiQ02059.

Interactioni

Protein-protein interaction databases

IntActiQ02059. 1 interaction.
STRINGi100226.SCO5087.

Structurei

Secondary structure

1
467
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 5710Combined sources
Beta strandi60 – 623Combined sources
Helixi63 – 7210Combined sources
Beta strandi77 – 793Combined sources
Beta strandi92 – 943Combined sources
Helixi100 – 1034Combined sources
Helixi107 – 1126Combined sources
Helixi115 – 13117Combined sources
Turni135 – 1373Combined sources
Helixi140 – 1423Combined sources
Beta strandi143 – 1486Combined sources
Helixi154 – 16512Combined sources
Turni166 – 1694Combined sources
Helixi175 – 1773Combined sources
Turni180 – 1823Combined sources
Helixi183 – 1864Combined sources
Helixi190 – 19910Combined sources
Beta strandi205 – 2084Combined sources
Helixi211 – 2133Combined sources
Helixi214 – 22714Combined sources
Beta strandi232 – 2409Combined sources
Helixi245 – 2539Combined sources
Helixi264 – 2663Combined sources
Beta strandi283 – 2919Combined sources
Helixi292 – 2976Combined sources
Beta strandi304 – 31310Combined sources
Helixi326 – 33914Combined sources
Helixi343 – 3453Combined sources
Beta strandi348 – 3503Combined sources
Helixi357 – 37014Combined sources
Helixi372 – 3776Combined sources
Helixi384 – 3874Combined sources
Turni391 – 3933Combined sources
Helixi394 – 40815Combined sources
Beta strandi419 – 4213Combined sources
Beta strandi430 – 4323Combined sources
Beta strandi439 – 4479Combined sources
Turni448 – 4503Combined sources
Beta strandi451 – 4588Combined sources
Helixi460 – 4656Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-A45-461[»]
1TQYX-ray2.00A/C/E/G45-467[»]
ProteinModelPortaliQ02059.
SMRiQ02059. Positions 46-466.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02059.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiENOG4105C0Q. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02059.
KOiK05551.
OMAiHLYGYMV.
OrthoDBiEOG6DG2SR.
PhylomeDBiQ02059.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLDAAPVDP ASRGPVSAFE PPSSHGADDD DDHRTNASKE LFGLKRRVVI
60 70 80 90 100
TGVGVRAPGG NGTRQFWELL TSGRTATRRI SFFDPSPYRS QVAAEADFDP
110 120 130 140 150
VAEGFGPREL DRMDRASQFA VACAREAFAA SGLDPDTLDP ARVGVSLGSA
160 170 180 190 200
VAAATSLERE YLLLSDSGRD WEVDAAWLSR HMFDYLVPSV MPAEVAWAVG
210 220 230 240 250
AEGPVTMVST GCTSGLDSVG NAVRAIEEGS ADVMFAGAAD TPITPIVVAC
260 270 280 290 300
FDAIRATTAR NDDPEHASRP FDGTRDGFVL AEGAAMFVLE DYDSALARGA
310 320 330 340 350
RIHAEISGYA TRCNAYHMTG LKADGREMAE TIRVALDESR TDATDIDYIN
360 370 380 390 400
AHGSGTRQND RHETAAYKRA LGEHARRTPV SSIKSMVGHS LGAIGSLEIA
410 420 430 440 450
ACVLALEHGV VPPTANLRTS DPECDLDYVP LEARERKLRS VLTVGSGFGG
460
FQSAMVLRDA ETAGAAA
Length:467
Mass (Da):49,504
Last modified:January 17, 2003 - v2
Checksum:i6B5BEE32B5241C60
GO

Sequence cautioni

The sequence CAA45043.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA. Translation: CAC44200.1.
X63449 Genomic DNA. Translation: CAA45043.1. Different initiation.
PIRiS25840.
RefSeqiNP_629237.1. NC_003888.3.
WP_003973891.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC44200; CAC44200; CAC44200.
GeneIDi1100528.
KEGGisco:SCO5087.
PATRICi23740014. VBIStrCoe124346_5167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA. Translation: CAC44200.1.
X63449 Genomic DNA. Translation: CAA45043.1. Different initiation.
PIRiS25840.
RefSeqiNP_629237.1. NC_003888.3.
WP_003973891.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QXGmodel-A45-461[»]
1TQYX-ray2.00A/C/E/G45-467[»]
ProteinModelPortaliQ02059.
SMRiQ02059. Positions 46-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02059. 1 interaction.
STRINGi100226.SCO5087.

Proteomic databases

PRIDEiQ02059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC44200; CAC44200; CAC44200.
GeneIDi1100528.
KEGGisco:SCO5087.
PATRICi23740014. VBIStrCoe124346_5167.

Phylogenomic databases

eggNOGiENOG4105C0Q. Bacteria.
COG0304. LUCA.
HOGENOMiHOG000060166.
InParanoidiQ02059.
KOiK05551.
OMAiHLYGYMV.
OrthoDBiEOG6DG2SR.
PhylomeDBiQ02059.

Enzyme and pathway databases

UniPathwayiUPA00173.

Miscellaneous databases

EvolutionaryTraceiQ02059.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SMARTiSM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.
  2. "Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin."
    Fernandez-Moreno M.A., Martinez E., Boto L., Hopwood D.A., Malpartida F.
    J. Biol. Chem. 267:19278-19290(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-467.
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiKASA_STRCO
AccessioniPrimary (citable) accession number: Q02059
Secondary accession number(s): Q93IZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 17, 2003
Last modified: May 11, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.