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Protein

Actinorhodin polyketide synthase acyl carrier protein

Gene

SCO5089

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acyl carrier protein.

Pathwayi: actinorhodin biosynthesis

This protein is involved in the pathway actinorhodin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway actinorhodin biosynthesis and in Antibiotic biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00173.

Names & Taxonomyi

Protein namesi
Recommended name:
Actinorhodin polyketide synthase acyl carrier protein
Short name:
ACP
Alternative name(s):
actI ORF3
Gene namesi
Ordered Locus Names:SCO5089
ORF Names:SCBAC28G1.15
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001802551 – 86Actinorhodin polyketide synthase acyl carrier proteinAdd BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation2 Publications1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of the apo-ACP-like protein.Curated

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiQ02054.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5089.

Structurei

Secondary structure

186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 15Combined sources9
Beta strandi18 – 22Combined sources5
Turni26 – 28Combined sources3
Helixi30 – 32Combined sources3
Turni35 – 39Combined sources5
Turni42 – 44Combined sources3
Helixi45 – 52Combined sources8
Turni53 – 56Combined sources4
Turni62 – 67Combined sources6
Helixi71 – 85Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AF8NMR-A1-86[»]
1NNZmodel-B1-86[»]
2AF8NMR-A1-86[»]
2K0XNMR-A1-86[»]
2K0YNMR-A1-86[»]
2KG6NMR-A1-86[»]
2KG8NMR-A1-86[»]
2KG9NMR-A1-86[»]
2KGANMR-A1-86[»]
2KGCNMR-A1-86[»]
2KGDNMR-A1-86[»]
2KGENMR-A1-86[»]
2MVUNMR-A1-86[»]
2MVVNMR-A1-86[»]
ProteinModelPortaliQ02054.
SMRiQ02054.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02054.

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4106ARF. Bacteria.
ENOG410XZMS. LUCA.
HOGENOMiHOG000178184.
InParanoidiQ02054.
KOiK05553.
OMAiRECAGED.
OrthoDBiPOG091H0E1M.
PhylomeDBiQ02054.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLLTTDDL RRALVECAGE TDGTDLSGDF LDLRFEDIGY DSLALMETAA
60 70 80
RLESRYGVSI PDDVAGRVDT PRELLDLING ALAEAA
Length:86
Mass (Da):9,248
Last modified:February 1, 1995 - v1
Checksum:iFF9D516AC14E212D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63449 Genomic DNA. Translation: CAA45045.1.
AL939122 Genomic DNA. Translation: CAC44202.1.
PIRiS25842.
RefSeqiNP_629239.1. NC_003888.3.
WP_003973889.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC44202; CAC44202; CAC44202.
GeneIDi1100530.
KEGGisco:SCO5089.
PATRICi23740018. VBIStrCoe124346_5169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63449 Genomic DNA. Translation: CAA45045.1.
AL939122 Genomic DNA. Translation: CAC44202.1.
PIRiS25842.
RefSeqiNP_629239.1. NC_003888.3.
WP_003973889.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AF8NMR-A1-86[»]
1NNZmodel-B1-86[»]
2AF8NMR-A1-86[»]
2K0XNMR-A1-86[»]
2K0YNMR-A1-86[»]
2KG6NMR-A1-86[»]
2KG8NMR-A1-86[»]
2KG9NMR-A1-86[»]
2KGANMR-A1-86[»]
2KGCNMR-A1-86[»]
2KGDNMR-A1-86[»]
2KGENMR-A1-86[»]
2MVUNMR-A1-86[»]
2MVVNMR-A1-86[»]
ProteinModelPortaliQ02054.
SMRiQ02054.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5089.

Proteomic databases

PRIDEiQ02054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC44202; CAC44202; CAC44202.
GeneIDi1100530.
KEGGisco:SCO5089.
PATRICi23740018. VBIStrCoe124346_5169.

Phylogenomic databases

eggNOGiENOG4106ARF. Bacteria.
ENOG410XZMS. LUCA.
HOGENOMiHOG000178184.
InParanoidiQ02054.
KOiK05553.
OMAiRECAGED.
OrthoDBiPOG091H0E1M.
PhylomeDBiQ02054.

Enzyme and pathway databases

UniPathwayiUPA00173.

Miscellaneous databases

EvolutionaryTraceiQ02054.
PROiQ02054.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACPX_STRCO
AccessioniPrimary (citable) accession number: Q02054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.