Q02050 (VL1_HPV19) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major capsid protein L1

Gene names

Name:

L1

Organism

Human papillomavirus type 19 [Complete proteome]

Taxonomic identifier

10608 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Betapapillomavirus › Betapapillomavirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.
Subunit structure	Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the papillomaviridae L1 protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Cellular component	Virion
Developmental stage	Late protein
Molecular function	Capsid protein T=7 icosahedral capsid protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	T=7 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	Major capsid protein L1		PRO_0000133503

Sequences

	Sequence		Length	Mass (Da)
	Q02050 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: 6E0A86E6640A9CD3	FASTA	546	61,683
	10 20 30 40 50 60 MTPVVIFTYI PAFASDSNEN VNIYNFLLQM AVWQAASGKV YLPPSTPVAR VQSTDEYVQR 70 80 90 100 110 120 TNIYYHAYSD RLLTVGHPYF NVYNVAGSKL EIPKVSGNQH RVFRLKLPDP NRFALADMSV 130 140 150 160 170 180 YNPDKERLVW GCRGIEIGRG QPLGVGSVGH PLFNKVGDTE NPNSYKGTST DDRQNVSFDP 190 200 210 220 230 240 KQLQMFIIGC APCIGEHWDK ALPCAEQDIP QGSCPPIELI NSVIEDGDMA DIGYGNLNFK 250 260 270 280 290 300 ALQQNRSDVS LDIVNETCKY PDFLKMQNDV YGDSCFFYAR REQCYARHFF VRGGKTGDDI 310 320 330 340 350 360 PAGQIDEGSM KNTYYIPPNN SQQQYTNLGN AMYFPTVSGS LVSSDAQLFN RPFWLQRAQG 370 380 390 400 410 420 HNNGICWFNQ LFVTVVDNTR NTNFSISVNS DGTDVAKIAD YNSANFKEYL RHVEEYEISL 430 440 450 460 470 480 ILQLCKIPLK AEVLAQINAM NSNILEEWQL GFVPAPDNPI QDTYRYIDSL ATRCPDKNPP 490 500 510 520 530 540 KEKVDPYKNL HFWNVDLSER LSLDLDQYAL GRKFLFQAGL QQATVNGTKT ISSRVSSRGT KRKRKN

References

[1]	"Primer-directed sequencing of human papillomavirus types." Delius H., Hofmann B. Curr. Top. Microbiol. Immunol. 186:13-31(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Phylogenetic analysis of 48 papillomavirus types and 28 subtypes and variants: a showcase for the molecular evolution of DNA viruses." Chan S.-Y., Bernard H.U., Ong C.K., Chan S.P., Birgit H., Delius H. J. Virol. 66:5714-5725(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 344-387.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74470 Genomic DNA. Translation: CAA52523.1. M96288 Genomic DNA. Translation: AAA47027.1.
PIR	S36490.
3D structure databases
ProteinModelPortal	Q02050.
SMR	Q02050. Positions 50-520.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.175.20. 1 hit.
InterPro	IPR002210. Capsid_L1_Papillomavir. IPR011222. dsDNA_vir_gr_I_capsid. [Graphical view]
Pfam	PF00500. Late_protein_L1. 1 hit. [Graphical view]
PRINTS	PR00865. HPVCAPSIDL1.
SUPFAM	SSF88648. dsDNA_vir_gr_I_capsid. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VL1_HPV19

Accession

Primary (citable) accession number: Q02050

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program