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Q02045

- MYL5_HUMAN

UniProt

Q02045 - MYL5_HUMAN

Protein

Myosin light chain 5

Gene

MYL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi43 – 5412PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. structural constituent of muscle Source: ProtInc

    GO - Biological processi

    1. regulation of muscle contraction Source: ProtInc

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin light chain 5
    Alternative name(s):
    Myosin regulatory light chain 5
    Superfast myosin regulatory light chain 2
    Short name:
    MYLC2
    Short name:
    MyLC-2
    Gene namesi
    Name:MYL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7586. MYL5.

    Subcellular locationi

    GO - Cellular componenti

    1. muscle myosin complex Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31383.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Myosin light chain 5PRO_0000198745Add
    BLAST

    Proteomic databases

    PaxDbiQ02045.
    PRIDEiQ02045.

    Expressioni

    Tissue specificityi

    Expressed in fetal skeletal muscle and retina.

    Gene expression databases

    ArrayExpressiQ02045.
    BgeeiQ02045.
    CleanExiHS_MYL5.
    GenevestigatoriQ02045.

    Organism-specific databases

    HPAiHPA037381.
    HPA039262.

    Interactioni

    Subunit structurei

    Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Protein-protein interaction databases

    BioGridi110720. 2 interactions.
    IntActiQ02045. 1 interaction.
    STRINGi9606.ENSP00000383023.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02045.
    SMRiQ02045. Positions 22-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 6536EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini100 – 13536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini136 – 17136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiQ02045.
    KOiK12753.
    OMAiILNAFKM.
    OrthoDBiEOG7992RX.
    PhylomeDBiQ02045.
    TreeFamiTF314218.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13405. EF-hand_6. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02045-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASRKTKKKE GGALRAQRAS SNVFSNFEQT QIQEFKEAFT LMDQNRDGFI    50
    DKEDLKDTYA SLGKTNVKDD ELDAMLKEAS GPINFTMFLN LFGEKLSGTD 100
    AEETILNAFK MLDPDGKGKI NKEYIKRLLM SQADKMTAEE VDQMFQFASI 150
    DVAGNLDYKA LSYVITHGEE KEE 173
    Length:173
    Mass (Da):19,534
    Last modified:July 1, 1993 - v1
    Checksum:i79615F658A68157F
    GO
    Isoform 2 (identifier: Q02045-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: Missing.

    Show »
    Length:132
    Mass (Da):14,888
    Checksum:iEFC8C88365F42F41
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti88 – 881F → S.
    Corresponds to variant rs2228354 [ dbSNP | Ensembl ].
    VAR_050459

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4141Missing in isoform 2. 1 PublicationVSP_026448Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03785 mRNA. Translation: AAA59890.1.
    BC040050 mRNA. Translation: AAH40050.1.
    CCDSiCCDS43197.1. [Q02045-1]
    PIRiI54328.
    RefSeqiNP_002468.1. NM_002477.1. [Q02045-1]
    XP_006713950.1. XM_006713887.1. [Q02045-2]
    UniGeneiHs.410970.

    Genome annotation databases

    EnsembliENST00000400159; ENSP00000383023; ENSG00000215375. [Q02045-1]
    ENST00000505477; ENSP00000423118; ENSG00000215375. [Q02045-2]
    ENST00000506838; ENSP00000427153; ENSG00000215375. [Q02045-2]
    ENST00000511290; ENSP00000425162; ENSG00000215375. [Q02045-2]
    GeneIDi4636.
    KEGGihsa:4636.
    UCSCiuc003gav.3. human. [Q02045-1]

    Polymorphism databases

    DMDMi400266.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03785 mRNA. Translation: AAA59890.1 .
    BC040050 mRNA. Translation: AAH40050.1 .
    CCDSi CCDS43197.1. [Q02045-1 ]
    PIRi I54328.
    RefSeqi NP_002468.1. NM_002477.1. [Q02045-1 ]
    XP_006713950.1. XM_006713887.1. [Q02045-2 ]
    UniGenei Hs.410970.

    3D structure databases

    ProteinModelPortali Q02045.
    SMRi Q02045. Positions 22-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110720. 2 interactions.
    IntActi Q02045. 1 interaction.
    STRINGi 9606.ENSP00000383023.

    Polymorphism databases

    DMDMi 400266.

    Proteomic databases

    PaxDbi Q02045.
    PRIDEi Q02045.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000400159 ; ENSP00000383023 ; ENSG00000215375 . [Q02045-1 ]
    ENST00000505477 ; ENSP00000423118 ; ENSG00000215375 . [Q02045-2 ]
    ENST00000506838 ; ENSP00000427153 ; ENSG00000215375 . [Q02045-2 ]
    ENST00000511290 ; ENSP00000425162 ; ENSG00000215375 . [Q02045-2 ]
    GeneIDi 4636.
    KEGGi hsa:4636.
    UCSCi uc003gav.3. human. [Q02045-1 ]

    Organism-specific databases

    CTDi 4636.
    GeneCardsi GC04P000661.
    HGNCi HGNC:7586. MYL5.
    HPAi HPA037381.
    HPA039262.
    MIMi 160782. gene.
    neXtProti NX_Q02045.
    PharmGKBi PA31383.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi Q02045.
    KOi K12753.
    OMAi ILNAFKM.
    OrthoDBi EOG7992RX.
    PhylomeDBi Q02045.
    TreeFami TF314218.

    Miscellaneous databases

    GenomeRNAii 4636.
    NextBioi 17850.
    PROi Q02045.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02045.
    Bgeei Q02045.
    CleanExi HS_MYL5.
    Genevestigatori Q02045.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13405. EF-hand_6. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates."
      Collins C.C., Schappert K.T., Hayden M.R.
      Hum. Mol. Genet. 1:727-733(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.

    Entry informationi

    Entry nameiMYL5_HUMAN
    AccessioniPrimary (citable) accession number: Q02045
    Secondary accession number(s): Q8IXL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This chain binds calcium.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3