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Q02045

- MYL5_HUMAN

UniProt

Q02045 - MYL5_HUMAN

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Protein

Myosin light chain 5

Gene

MYL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi43 – 5412PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. structural constituent of muscle Source: ProtInc

GO - Biological processi

  1. regulation of muscle contraction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 5
Alternative name(s):
Myosin regulatory light chain 5
Superfast myosin regulatory light chain 2
Short name:
MYLC2
Short name:
MyLC-2
Gene namesi
Name:MYL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7586. MYL5.

Subcellular locationi

GO - Cellular componenti

  1. muscle myosin complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Myosin light chain 5PRO_0000198745Add
BLAST

Proteomic databases

PaxDbiQ02045.
PRIDEiQ02045.

Expressioni

Tissue specificityi

Expressed in fetal skeletal muscle and retina.

Gene expression databases

BgeeiQ02045.
CleanExiHS_MYL5.
ExpressionAtlasiQ02045. baseline and differential.
GenevestigatoriQ02045.

Organism-specific databases

HPAiHPA037381.
HPA039262.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi110720. 2 interactions.
IntActiQ02045. 1 interaction.
STRINGi9606.ENSP00000383023.

Structurei

3D structure databases

ProteinModelPortaliQ02045.
SMRiQ02045. Positions 22-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 6536EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini100 – 13536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 17136EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ02045.
KOiK12753.
OMAiILNAFKM.
OrthoDBiEOG7992RX.
PhylomeDBiQ02045.
TreeFamiTF314218.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02045-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRKTKKKE GGALRAQRAS SNVFSNFEQT QIQEFKEAFT LMDQNRDGFI
60 70 80 90 100
DKEDLKDTYA SLGKTNVKDD ELDAMLKEAS GPINFTMFLN LFGEKLSGTD
110 120 130 140 150
AEETILNAFK MLDPDGKGKI NKEYIKRLLM SQADKMTAEE VDQMFQFASI
160 170
DVAGNLDYKA LSYVITHGEE KEE
Length:173
Mass (Da):19,534
Last modified:July 1, 1993 - v1
Checksum:i79615F658A68157F
GO
Isoform 2 (identifier: Q02045-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:132
Mass (Da):14,888
Checksum:iEFC8C88365F42F41
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti88 – 881F → S.
Corresponds to variant rs2228354 [ dbSNP | Ensembl ].
VAR_050459

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform 2. 1 PublicationVSP_026448Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03785 mRNA. Translation: AAA59890.1.
BC040050 mRNA. Translation: AAH40050.1.
CCDSiCCDS43197.1. [Q02045-1]
PIRiI54328.
RefSeqiNP_002468.1. NM_002477.1. [Q02045-1]
XP_006713950.1. XM_006713887.1. [Q02045-2]
UniGeneiHs.410970.

Genome annotation databases

EnsembliENST00000400159; ENSP00000383023; ENSG00000215375. [Q02045-1]
ENST00000505477; ENSP00000423118; ENSG00000215375. [Q02045-2]
ENST00000506838; ENSP00000427153; ENSG00000215375. [Q02045-2]
ENST00000511290; ENSP00000425162; ENSG00000215375. [Q02045-2]
GeneIDi4636.
KEGGihsa:4636.
UCSCiuc003gav.3. human. [Q02045-1]

Polymorphism databases

DMDMi400266.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03785 mRNA. Translation: AAA59890.1 .
BC040050 mRNA. Translation: AAH40050.1 .
CCDSi CCDS43197.1. [Q02045-1 ]
PIRi I54328.
RefSeqi NP_002468.1. NM_002477.1. [Q02045-1 ]
XP_006713950.1. XM_006713887.1. [Q02045-2 ]
UniGenei Hs.410970.

3D structure databases

ProteinModelPortali Q02045.
SMRi Q02045. Positions 22-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110720. 2 interactions.
IntActi Q02045. 1 interaction.
STRINGi 9606.ENSP00000383023.

Polymorphism databases

DMDMi 400266.

Proteomic databases

PaxDbi Q02045.
PRIDEi Q02045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400159 ; ENSP00000383023 ; ENSG00000215375 . [Q02045-1 ]
ENST00000505477 ; ENSP00000423118 ; ENSG00000215375 . [Q02045-2 ]
ENST00000506838 ; ENSP00000427153 ; ENSG00000215375 . [Q02045-2 ]
ENST00000511290 ; ENSP00000425162 ; ENSG00000215375 . [Q02045-2 ]
GeneIDi 4636.
KEGGi hsa:4636.
UCSCi uc003gav.3. human. [Q02045-1 ]

Organism-specific databases

CTDi 4636.
GeneCardsi GC04P000661.
HGNCi HGNC:7586. MYL5.
HPAi HPA037381.
HPA039262.
MIMi 160782. gene.
neXtProti NX_Q02045.
PharmGKBi PA31383.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00760000119196.
HOGENOMi HOG000233018.
HOVERGENi HBG012180.
InParanoidi Q02045.
KOi K12753.
OMAi ILNAFKM.
OrthoDBi EOG7992RX.
PhylomeDBi Q02045.
TreeFami TF314218.

Miscellaneous databases

GenomeRNAii 4636.
NextBioi 17850.
PROi Q02045.
SOURCEi Search...

Gene expression databases

Bgeei Q02045.
CleanExi HS_MYL5.
ExpressionAtlasi Q02045. baseline and differential.
Genevestigatori Q02045.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates."
    Collins C.C., Schappert K.T., Hayden M.R.
    Hum. Mol. Genet. 1:727-733(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiMYL5_HUMAN
AccessioniPrimary (citable) accession number: Q02045
Secondary accession number(s): Q8IXL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This chain binds calcium.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3