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Q02045 (MYL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin light chain 5
Alternative name(s):
Myosin regulatory light chain 5
Superfast myosin regulatory light chain 2
Short name=MYLC2
Short name=MyLC-2
Gene names
Name:MYL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Tissue specificity

Expressed in fetal skeletal muscle and retina.

Miscellaneous

This chain binds calcium By similarity.

Sequence similarities

Contains 3 EF-hand domains.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandCalcium
Metal-binding
   Molecular functionMotor protein
Muscle protein
Myosin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of muscle contraction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentmuscle myosin complex

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

structural constituent of muscle

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q02045-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q02045-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173Myosin light chain 5
PRO_0000198745

Regions

Domain30 – 6536EF-hand 1
Domain100 – 13536EF-hand 2
Domain136 – 17136EF-hand 3
Calcium binding43 – 5412 By similarity

Natural variations

Alternative sequence1 – 4141Missing in isoform 2.
VSP_026448
Natural variant881F → S.
Corresponds to variant rs2228354 [ dbSNP | Ensembl ].
VAR_050459

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 79615F658A68157F

FASTA17319,534
        10         20         30         40         50         60 
MASRKTKKKE GGALRAQRAS SNVFSNFEQT QIQEFKEAFT LMDQNRDGFI DKEDLKDTYA 

        70         80         90        100        110        120 
SLGKTNVKDD ELDAMLKEAS GPINFTMFLN LFGEKLSGTD AEETILNAFK MLDPDGKGKI 

       130        140        150        160        170 
NKEYIKRLLM SQADKMTAEE VDQMFQFASI DVAGNLDYKA LSYVITHGEE KEE 

« Hide

Isoform 2 [UniParc].

Checksum: EFC8C88365F42F41
Show »

FASTA13214,888

References

« Hide 'large scale' references
[1]"The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates."
Collins C.C., Schappert K.T., Hayden M.R.
Hum. Mol. Genet. 1:727-733(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L03785 mRNA. Translation: AAA59890.1.
BC040050 mRNA. Translation: AAH40050.1.
CCDSCCDS43197.1. [Q02045-1]
PIRI54328.
RefSeqNP_002468.1. NM_002477.1. [Q02045-1]
XP_006713950.1. XM_006713887.1. [Q02045-2]
UniGeneHs.410970.

3D structure databases

ProteinModelPortalQ02045.
SMRQ02045. Positions 22-171.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110720. 2 interactions.
IntActQ02045. 1 interaction.
STRING9606.ENSP00000383023.

Polymorphism databases

DMDM400266.

Proteomic databases

PaxDbQ02045.
PRIDEQ02045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000400159; ENSP00000383023; ENSG00000215375. [Q02045-1]
ENST00000505477; ENSP00000423118; ENSG00000215375. [Q02045-2]
ENST00000506838; ENSP00000427153; ENSG00000215375. [Q02045-2]
ENST00000511290; ENSP00000425162; ENSG00000215375. [Q02045-2]
GeneID4636.
KEGGhsa:4636.
UCSCuc003gav.3. human. [Q02045-1]

Organism-specific databases

CTD4636.
GeneCardsGC04P000661.
HGNCHGNC:7586. MYL5.
HPAHPA037381.
HPA039262.
MIM160782. gene.
neXtProtNX_Q02045.
PharmGKBPA31383.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidQ02045.
KOK12753.
OMAILNAFKM.
OrthoDBEOG7992RX.
PhylomeDBQ02045.
TreeFamTF314218.

Gene expression databases

ArrayExpressQ02045.
BgeeQ02045.
CleanExHS_MYL5.
GenevestigatorQ02045.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13405. EF-hand_6. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4636.
NextBio17850.
PROQ02045.
SOURCESearch...

Entry information

Entry nameMYL5_HUMAN
AccessionPrimary (citable) accession number: Q02045
Secondary accession number(s): Q8IXL8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM