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Protein

Myosin light chain 5

Gene

MYL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi43 – 54PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • structural constituent of muscle Source: ProtInc

GO - Biological processi

  • muscle contraction Source: Reactome
  • regulation of muscle contraction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31688-MONOMER.
ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 5
Alternative name(s):
Myosin regulatory light chain 5
Superfast myosin regulatory light chain 2
Short name:
MYLC2
Short name:
MyLC-2
Gene namesi
Name:MYL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:7586. MYL5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • muscle myosin complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4636.
OpenTargetsiENSG00000215375.
PharmGKBiPA31383.

Polymorphism and mutation databases

BioMutaiMYL5.
DMDMi400266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987451 – 173Myosin light chain 5Add BLAST173

Proteomic databases

PaxDbiQ02045.
PeptideAtlasiQ02045.
PRIDEiQ02045.

PTM databases

iPTMnetiQ02045.
PhosphoSitePlusiQ02045.

Expressioni

Tissue specificityi

Expressed in fetal skeletal muscle and retina.

Gene expression databases

BgeeiENSG00000215375.
CleanExiHS_MYL5.
ExpressionAtlasiQ02045. baseline and differential.
GenevisibleiQ02045. HS.

Organism-specific databases

HPAiHPA037381.
HPA039262.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi110720. 3 interactors.
IntActiQ02045. 1 interactor.
STRINGi9606.ENSP00000383023.

Structurei

3D structure databases

ProteinModelPortaliQ02045.
SMRiQ02045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 65EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini100 – 135EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini136 – 171EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ02045.
KOiK12753.
OMAiSQADKMT.
OrthoDBiEOG091G0QF6.
PhylomeDBiQ02045.
TreeFamiTF314218.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRKTKKKE GGALRAQRAS SNVFSNFEQT QIQEFKEAFT LMDQNRDGFI
60 70 80 90 100
DKEDLKDTYA SLGKTNVKDD ELDAMLKEAS GPINFTMFLN LFGEKLSGTD
110 120 130 140 150
AEETILNAFK MLDPDGKGKI NKEYIKRLLM SQADKMTAEE VDQMFQFASI
160 170
DVAGNLDYKA LSYVITHGEE KEE
Length:173
Mass (Da):19,534
Last modified:July 1, 1993 - v1
Checksum:i79615F658A68157F
GO
Isoform 2 (identifier: Q02045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:132
Mass (Da):14,888
Checksum:iEFC8C88365F42F41
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05045988F → S.Corresponds to variant rs2228354dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264481 – 41Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03785 mRNA. Translation: AAA59890.1.
BC040050 mRNA. Translation: AAH40050.1.
CCDSiCCDS43197.1. [Q02045-1]
PIRiI54328.
RefSeqiNP_002468.1. NM_002477.1. [Q02045-1]
XP_016863734.1. XM_017008245.1. [Q02045-1]
XP_016863735.1. XM_017008246.1. [Q02045-1]
XP_016863736.1. XM_017008247.1. [Q02045-2]
XP_016863737.1. XM_017008248.1. [Q02045-2]
UniGeneiHs.410970.

Genome annotation databases

EnsembliENST00000400159; ENSP00000383023; ENSG00000215375. [Q02045-1]
ENST00000505477; ENSP00000423118; ENSG00000215375. [Q02045-2]
ENST00000506838; ENSP00000427153; ENSG00000215375. [Q02045-2]
ENST00000511290; ENSP00000425162; ENSG00000215375. [Q02045-2]
GeneIDi4636.
KEGGihsa:4636.
UCSCiuc003gav.4. human. [Q02045-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03785 mRNA. Translation: AAA59890.1.
BC040050 mRNA. Translation: AAH40050.1.
CCDSiCCDS43197.1. [Q02045-1]
PIRiI54328.
RefSeqiNP_002468.1. NM_002477.1. [Q02045-1]
XP_016863734.1. XM_017008245.1. [Q02045-1]
XP_016863735.1. XM_017008246.1. [Q02045-1]
XP_016863736.1. XM_017008247.1. [Q02045-2]
XP_016863737.1. XM_017008248.1. [Q02045-2]
UniGeneiHs.410970.

3D structure databases

ProteinModelPortaliQ02045.
SMRiQ02045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110720. 3 interactors.
IntActiQ02045. 1 interactor.
STRINGi9606.ENSP00000383023.

PTM databases

iPTMnetiQ02045.
PhosphoSitePlusiQ02045.

Polymorphism and mutation databases

BioMutaiMYL5.
DMDMi400266.

Proteomic databases

PaxDbiQ02045.
PeptideAtlasiQ02045.
PRIDEiQ02045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400159; ENSP00000383023; ENSG00000215375. [Q02045-1]
ENST00000505477; ENSP00000423118; ENSG00000215375. [Q02045-2]
ENST00000506838; ENSP00000427153; ENSG00000215375. [Q02045-2]
ENST00000511290; ENSP00000425162; ENSG00000215375. [Q02045-2]
GeneIDi4636.
KEGGihsa:4636.
UCSCiuc003gav.4. human. [Q02045-1]

Organism-specific databases

CTDi4636.
DisGeNETi4636.
GeneCardsiMYL5.
HGNCiHGNC:7586. MYL5.
HPAiHPA037381.
HPA039262.
MIMi160782. gene.
neXtProtiNX_Q02045.
OpenTargetsiENSG00000215375.
PharmGKBiPA31383.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ02045.
KOiK12753.
OMAiSQADKMT.
OrthoDBiEOG091G0QF6.
PhylomeDBiQ02045.
TreeFamiTF314218.

Enzyme and pathway databases

BioCyciZFISH:G66-31688-MONOMER.
ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

GenomeRNAii4636.
PROiQ02045.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215375.
CleanExiHS_MYL5.
ExpressionAtlasiQ02045. baseline and differential.
GenevisibleiQ02045. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYL5_HUMAN
AccessioniPrimary (citable) accession number: Q02045
Secondary accession number(s): Q8IXL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This chain binds calcium.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.