UniProtKB - Q02040 (AK17A_HUMAN)
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Protein
A-kinase anchor protein 17A
Gene
AKAP17A
Organism
Homo sapiens (Human)
Status
Functioni
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.2 Publications
Miscellaneous
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
GO - Molecular functioni
- protein kinase A binding Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- B cell activation Source: UniProtKB
- mRNA processing Source: UniProtKB-KW
- regulation of RNA splicing Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- RNA splicing Source: UniProtKB-KW
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Names & Taxonomyi
Protein namesi | Recommended name: A-kinase anchor protein 17AShort name: AKAP-17A Alternative name(s): 721P B-lymphocyte antigen Protein XE7 Protein kinase A-anchoring protein 17A Short name: PRKA17A Splicing factor, arginine/serine-rich 17A |
Gene namesi | Name:AKAP17A Synonyms:CXYorf3, DXYS155E, SFRS17A, XE7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197976.11. |
HGNCi | HGNC:18783. AKAP17A. |
MIMi | 312095. gene. 465000. gene. |
neXtProti | NX_Q02040. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 438 – 439 | LL → PP: Abolishes binding to PKA-RI; when associated with 445-P-P-446. 1 Publication | 2 | |
Mutagenesisi | 445 – 446 | KK → PP: Abolishes binding to PKA-RI; when associated with 438-P-P-439. 1 Publication | 2 |
Organism-specific databases
OpenTargetsi | ENSG00000197976. |
PharmGKBi | PA162402969. |
Polymorphism and mutation databases
BioMutai | AKAP17A. |
DMDMi | 146291102. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000022692 | 1 – 695 | A-kinase anchor protein 17AAdd BLAST | 695 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 633 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q02040. |
MaxQBi | Q02040. |
PaxDbi | Q02040. |
PeptideAtlasi | Q02040. |
PRIDEi | Q02040. |
PTM databases
iPTMneti | Q02040. |
PhosphoSitePlusi | Q02040. |
Expressioni
Tissue specificityi
Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.1 Publication
Gene expression databases
Bgeei | ENSG00000197976. |
CleanExi | HS_SFRS17A. |
ExpressionAtlasi | Q02040. baseline and differential. |
Genevisiblei | Q02040. HS. |
Organism-specific databases
HPAi | HPA043247. HPA051020. |
Interactioni
Subunit structurei
Monomer. Component of the spliceosome. Interacts with ZRANB2 and SFRS1/ASF through its Arg/Ser-rich domain. Interacts with RI and RII subunits of PKA.3 Publications
Binary interactionsi
GO - Molecular functioni
- protein kinase A binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 113860. 34 interactors. |
IntActi | Q02040. 22 interactors. |
STRINGi | 9606.ENSP00000324827. |
Structurei
3D structure databases
ProteinModelPortali | Q02040. |
SMRi | Q02040. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 147 – 256 | RRMAdd BLAST | 110 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 83 – 112 | PKA-RI and PKA-RII subunit binding domainAdd BLAST | 30 | |
Regioni | 425 – 454 | PKA-RI-alpha subunit binding domainAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 587 – 695 | Arg-richAdd BLAST | 109 |
Domaini
RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.1 Publication
Phylogenomic databases
eggNOGi | KOG2891. Eukaryota. ENOG410XQIN. LUCA. |
GeneTreei | ENSGT00440000039314. |
InParanoidi | Q02040. |
KOi | K13169. |
OMAi | AASEWMQ. |
OrthoDBi | EOG091G0DV1. |
PhylomeDBi | Q02040. |
TreeFami | TF320443. |
Family and domain databases
InterProi | View protein in InterPro IPR034355. AKAP17A. IPR035979. RBD_domain_sf. |
PANTHERi | PTHR12484:SF2. PTHR12484:SF2. 1 hit. |
SUPFAMi | SSF54928. SSF54928. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q02040-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE
60 70 80 90 100
VMERLKGMVQ NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT
110 120 130 140 150
IKLSGFSDIL KVRAAEFKID FPTRHDWDSF FRDAKDMNET LPGERPDTIH
160 170 180 190 200
LEGLPCKWFA LKESGSEKPS EDVLVKVFEK FGEIRNVDIP MLDPYREEMT
210 220 230 240 250
GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM YKGEDGKAVA
260 270 280 290 300
CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKR REKEAEERQR
310 320 330 340 350
AEERKQKELE ELERERKREE KLRKREQKQR DRELRRNQKK LEKLQAEEQK
360 370 380 390 400
QLQEKIKLEE RKLLLAQRNL QSIRLIAELL SRAKAVKLRE QEQKEEKLRL
410 420 430 440 450
QQQEERRRLQ EAELRRVEEE KERALGLQRK ERELRERLLS ILLSKKPDDS
460 470 480 490 500
HTHDELGVAH ADLLQPVLDI LQTVSSGCVS ATTLHPLGGQ PPAGAPKESP
510 520 530 540 550
AHPEADGAPK SVNGSVAEEA PCKEVQSSCR VVPEDGSPEK RCPGGVLSCI
560 570 580 590 600
PDNNQQPKGI PACEQNVSRK DTRSEQDKCN REPSKGRGRA TGDGLADRHK
610 620 630 640 650
RERSRARRAS SREDGRPRKE RRPHKKHAYK DDSPRRRSTS PDHTRSRRSH
660 670 680 690
SKDRHRRERS RERRGSASRK HSRHRRRSER SRSRSPSRHR STWNR
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 443 | L → Q in AAA36187 (PubMed:1438229).Curated | 1 | |
Sequence conflicti | 500 | P → A in AAA61303 (PubMed:1302606).Curated | 1 | |
Sequence conflicti | 500 | P → A in AAI10497 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 502 | H → P in AAA36187 (PubMed:1438229).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055353 | 194 | P → S1 PublicationCorresponds to variant dbSNP:rs17852504Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024947 | 385 – 445 | AVKLR…ILLSK → VGGSLCSRQPRPGCPQCPPL KCGRRHGAVSPPAAAVATKP ALMPRMTAPSREGVALVCRS R in isoform 3. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_004490 | 385 | A → L in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_004491 | 386 – 695 | Missing in isoform 2. CuratedAdd BLAST | 310 | |
Alternative sequenceiVSP_024948 | 446 – 695 | Missing in isoform 3. 1 PublicationAdd BLAST | 250 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03426 mRNA. Translation: AAA61303.1. L03426 mRNA. Translation: AAA61304.1. M99578 mRNA. Translation: AAA36187.1. Frameshift. AL683807 Genomic DNA. No translation available. BC028151 mRNA. Translation: AAH28151.1. BC110496 mRNA. Translation: AAI10497.1. BC110497 mRNA. Translation: AAI10498.1. |
CCDSi | CCDS14116.1. [Q02040-1] |
PIRi | A46419. I54325. |
RefSeqi | NP_005079.2. NM_005088.2. [Q02040-1] |
UniGenei | Hs.522572. |
Genome annotation databases
Ensembli | ENST00000313871; ENSP00000324827; ENSG00000197976. [Q02040-1] ENST00000474361; ENSP00000435479; ENSG00000197976. [Q02040-2] |
GeneIDi | 8227. |
KEGGi | hsa:8227. |
UCSCi | uc004cqa.4. human. [Q02040-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | AK17A_HUMAN | |
Accessioni | Q02040Primary (citable) accession number: Q02040 Secondary accession number(s): Q02832 Q8N6U9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | May 1, 2007 | |
Last modified: | March 28, 2018 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
Was originally thought to be a cell surface protein involved in B-cell activation.1 Publication