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Q02004

- GP_DUGBA

UniProt

Q02004 - GP_DUGBA

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Protein

Envelope glycoprotein

Gene

GP

Organism
Dugbe virus (isolate ArD44313) (DUGV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei370 – 3712Cleavage; by hostBy similarity
Sitei893 – 8942Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiDugbe virus (isolate ArD44313) (DUGV)
Taxonomic identifieri766194 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeNairovirus
Virus hostiAmblyomma variegatum (Tropical bont tick) [TaxID: 34610]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma marginatum rufipes [TaxID: 72862]
Hyalomma truncatum [TaxID: 72855]
Rhipicephalus [TaxID: 34630]
Rhipicephalus annulatus [TaxID: 34611]
Rhipicephalus decoloratus [TaxID: 60189]
Rhipicephalus geigyi [TaxID: 136141]
ProteomesiUP000000278: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 15511534Envelope glycoproteinPRO_0000036802Add
BLAST
Chaini18 – 370353Mucin-like variable regionPRO_0000369248Add
BLAST
Chaini371 – 893523Glycoprotein G2Sequence AnalysisPRO_0000036804Add
BLAST
Chaini894 – 1551658Glycoprotein G1Sequence AnalysisPRO_0000036805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi30 – 301N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi80 – 801N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi142 – 1421N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi413 – 4131N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi848 – 8481N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1201 – 12011N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1258 – 12581N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1420 – 14201N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ02004.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei547 – 56721HelicalSequence AnalysisAdd
BLAST
Transmembranei676 – 69621HelicalSequence AnalysisAdd
BLAST
Transmembranei705 – 72521HelicalSequence AnalysisAdd
BLAST
Transmembranei824 – 84421HelicalSequence AnalysisAdd
BLAST
Transmembranei1452 – 147221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR012487. Nairovirus_M.
[Graphical view]
PfamiPF07948. Nairovirus_M. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02004 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRVLIIAV VVYLVFTTQN QITGNHTTIN SSSPSTTEAS STPTVSRTPQ
60 70 80 90 100
TTTTSTAVST TITATTTPTA SWTTQSQYFN KTTQHHWREE TMISRNPTVL
110 120 130 140 150
DRQSRASSVR ELLNTKFLML LGFIPKGEVN HLENACNREG KNCTELILKE
160 170 180 190 200
RIARFFSETE KESCYNTYLE KHLRSVSPEV SLTPYRVLGL REDILLKEID
210 220 230 240 250
RRIIRFETDS QRVTCLSASL LKPDVFIREQ RIDAKPSNGP KIVPVDSVAC
260 270 280 290 300
MNLEANVDVR SNKLVIQSLM TTVKISLKNC KVVVNSRQCI HQQTGSGVIK
310 320 330 340 350
VPKFEKQQGG TWSSYIAGVY TATIDLLDEN NQNCKLFTEC IVKGRELVKG
360 370 380 390 400
QSELKSFNIE VLLPRVMKTR RKLLAVTDGS TECNSGTQLI EGKSIEVHKQ
410 420 430 440 450
DIGGPGKKLT ICNGTSVLDV PLDEGHGCYT INVITSKRAC RPKNSKLQCS
460 470 480 490 500
IDKELKPCDS GKCLSISQKG AGHIKVSRGK TILITECKEH CQIPVPTGKG
510 520 530 540 550
DIMVDCSGGR QHYLEVNIVD IHCPNTKFLG GIMLYFCRMS SRPTVALLLG
560 570 580 590 600
IWIGCGYILT CIFSFLLYHL ILFFANCIKQ CRKKGERLGE ICVKCEQQTV
610 620 630 640 650
NLMDQELHDL NCNFNLCPYC CNRMSDEGMS RHVGKCPKRL ERLNEIELYL
660 670 680 690 700
TTSECLCLSV CYQLLISVGI FLKRTTWLVV LLVLLGLAIS PVQGAPTEVS
710 720 730 740 750
NVKQDGDYSI CYFIFGCLVT AALLLKVKRT NSNGIVVVVD SFGRCPYCNE
760 770 780 790 800
FTDSLFEEVL HDTLCSLCVC PFCEKQALDL VTLEEHVKEC YKVATRKDIF
810 820 830 840 850
KILGRKFTNA LVRREKLFTT GLQLFINKTN VVVFALIMCF LLLLTGHNAS
860 870 880 890 900
AFDSGDLPDG VWEESSQLVK SCTQFCYIEE DVCYCPAEDG VGRKLLFFNG
910 920 930 940 950
LQNSVKRLSD SHKLLTSVSI DAPWGRINVE STWKPTLAAS NIAMSWSSTD
960 970 980 990 1000
IKGEKVILSG RSTSIIKLKE KTGVMWKLVG SGLASEKKKP FRFPIMDFAQ
1010 1020 1030 1040 1050
VYNSVFQYIT GDRLLSEWPK AVCTGDCPHR CGCQTSTCMA KECHTQECVS
1060 1070 1080 1090 1100
THMVLGIGTG CTCCGMDVER PFNKYLGVKW STEYLRTEVL VCVEVTEEER
1110 1120 1130 1140 1150
HCEIVEAGTR FNIGPITITI SDPQNIGSKL PESLMTVQEI DDSNFVDIMH
1160 1170 1180 1190 1200
VGNVISADNS CRLQSCTHGS AVTTRFTALT ALIKDDHSSG LNLAVLDPKV
1210 1220 1230 1240 1250
NSSWLSWEGC DMDYYCNVGD WPTCTYTGVV TQKLREFLKL DQHRKRLHTT
1260 1270 1280 1290 1300
LSFSLKKNLS KRSHTSVRLE GKTVTRMEVK VTALIEVDGM ELHSKTIRLS
1310 1320 1330 1340 1350
GIRLTGLKCS GCFSCTSGIS CSVNAKLTSP DEFTLHLRST SPNVVVAETS
1360 1370 1380 1390 1400
IIARKGPSAT TSRFKVFSVR DTKKICFEVV EREYCKDCTP DELTTCTGVE
1410 1420 1430 1440 1450
LEPTKDILLE HRGTIVQHQN DTCKSKIDCW SNSISSFASG IGDFFKHYIG
1460 1470 1480 1490 1500
SIAVGVLGTV LPFALLILFF IYGDKMLWPF KVFCRPCRRC CRKNEGYNKL
1510 1520 1530 1540 1550
AEEEELRDII RKFSKSGELI NKDAKDKRTL ARLFMSDNPK LKKEKKLSEI

A
Length:1,551
Mass (Da):173,355
Last modified:July 1, 1993 - v1
Checksum:i7C1654C63895C620
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94133 Genomic RNA. Translation: AAA42974.1.
PIRiA43364.
RefSeqiNP_690575.1. NC_004158.1.

Genome annotation databases

GeneIDi956565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94133 Genomic RNA. Translation: AAA42974.1 .
PIRi A43364.
RefSeqi NP_690575.1. NC_004158.1.

3D structure databases

ProteinModelPortali Q02004.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956565.

Family and domain databases

InterProi IPR012487. Nairovirus_M.
[Graphical view ]
Pfami PF07948. Nairovirus_M. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dugbe Nairovirus M RNA: nucleotide sequence and coding strategy."
    Marriott A.C., El-Ghorr A.A., Nuttall P.A.
    Virology 190:606-615(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 897-905.

Entry informationi

Entry nameiGP_DUGBA
AccessioniPrimary (citable) accession number: Q02004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3