Q02004 (GP_DUGBA) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 72.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Envelope glycoprotein Short name=GP Alternative name(s): M polyprotein Cleaved into the following 3 chains: | ||
| Gene names |
| ||
| Organism | Dugbe virus (isolate ArD44313) (DUGV) [Reference proteome] | ||
| Taxonomic identifier | 766194 [NCBI] | ||
| Taxonomic lineage | Viruses › ssRNA negative-strand viruses › Bunyaviridae › Nairovirus ›  | ||
| Virus host | Amblyomma variegatum (Tropical bont tick) [TaxID: 34610] Homo sapiens (Human) [TaxID: 9606] Hyalomma marginatum rufipes [TaxID: 72862] Hyalomma truncatum [TaxID: 72855] Rhipicephalus [TaxID: 34630] Rhipicephalus annulatus [TaxID: 34611] Rhipicephalus decoloratus [TaxID: 60189] Rhipicephalus geigyi [TaxID: 136141] |
Protein attributes
| Sequence length | 1551 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity. |
| Subunit structure | G1 and G2 interacts with each other By similarity. |
| Subcellular location | Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity. Glycoprotein G2: Virion membrane; Multi-pass membrane protein Potential. Host Golgi apparatus membrane; Multi-pass membrane protein Potential. |
| Post-translational modification | Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2. |
| Sequence similarities | Belongs to the nairovirus envelope glycoprotein family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||
| Chain | 18 – 1551 | 1534 | Envelope glycoprotein | PRO_0000036802 | |||||
| Chain | 18 – 370 | 353 | Mucin-like variable region | PRO_0000369248 | |||||
| Chain | 371 – 893 | 523 | Glycoprotein G2 Potential | PRO_0000036804 | |||||
| Chain | 894 – 1551 | 658 | Glycoprotein G1 Potential | PRO_0000036805 | |||||
Regions | |||||||||
| Transmembrane | 547 – 567 | 21 | Helical; Potential | ||||||
| Transmembrane | 676 – 696 | 21 | Helical; Potential | ||||||
| Transmembrane | 705 – 725 | 21 | Helical; Potential | ||||||
| Transmembrane | 824 – 844 | 21 | Helical; Potential | ||||||
| Transmembrane | 1452 – 1472 | 21 | Helical; Potential | ||||||
Sites | |||||||||
| Site | 370 – 371 | 2 | Cleavage; by host By similarity | ||||||
| Site | 893 – 894 | 2 | Cleavage; by host signal peptidase By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 25 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 30 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 80 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 142 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 413 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 848 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 1201 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 1258 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 1420 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
Sequences
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References
| [1] | "Dugbe Nairovirus M RNA: nucleotide sequence and coding strategy." Marriott A.C., El-Ghorr A.A., Nuttall P.A. Virology 190:606-615(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 897-905. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M94133 Genomic RNA. Translation: AAA42974.1. |
| PIR | A43364. |
| RefSeq | NP_690575.1. NC_004158.1. |
3D structure databases | |
| ProteinModelPortal | Q02004. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR012487. Nairovirus_M. [Graphical view] |
| Pfam | PF07948. Nairovirus_M. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GP_DUGBA | ||||||||
| Accession | Primary (citable) accession number: Q02004 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |