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Q02004

- GP_DUGBA

UniProt

Q02004 - GP_DUGBA

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Protein

Envelope glycoprotein

Gene
GP
Organism
Dugbe virus (isolate ArD44313) (DUGV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei370 – 3712Cleavage; by host By similarity
Sitei893 – 8942Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiDugbe virus (isolate ArD44313) (DUGV)
Taxonomic identifieri766194 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeNairovirus
Virus hostiAmblyomma variegatum (Tropical bont tick) [TaxID: 34610]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma marginatum rufipes [TaxID: 72862]
Hyalomma truncatum [TaxID: 72855]
Rhipicephalus [TaxID: 34630]
Rhipicephalus annulatus [TaxID: 34611]
Rhipicephalus decoloratus [TaxID: 60189]
Rhipicephalus geigyi [TaxID: 136141]
ProteomesiUP000000278: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei547 – 56721Helical; Reviewed predictionAdd
BLAST
Transmembranei676 – 69621Helical; Reviewed predictionAdd
BLAST
Transmembranei705 – 72521Helical; Reviewed predictionAdd
BLAST
Transmembranei824 – 84421Helical; Reviewed predictionAdd
BLAST
Transmembranei1452 – 147221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. host cell Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 15511534Envelope glycoproteinPRO_0000036802Add
BLAST
Chaini18 – 370353Mucin-like variable regionPRO_0000369248Add
BLAST
Chaini371 – 893523Glycoprotein G2 Reviewed predictionPRO_0000036804Add
BLAST
Chaini894 – 1551658Glycoprotein G1 Reviewed predictionPRO_0000036805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi30 – 301N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi80 – 801N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi142 – 1421N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi413 – 4131N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi848 – 8481N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1201 – 12011N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1258 – 12581N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1420 – 14201N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ02004.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR012487. Nairovirus_M.
[Graphical view]
PfamiPF07948. Nairovirus_M. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02004-1 [UniParc]FASTAAdd to Basket

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MSKRVLIIAV VVYLVFTTQN QITGNHTTIN SSSPSTTEAS STPTVSRTPQ     50
TTTTSTAVST TITATTTPTA SWTTQSQYFN KTTQHHWREE TMISRNPTVL 100
DRQSRASSVR ELLNTKFLML LGFIPKGEVN HLENACNREG KNCTELILKE 150
RIARFFSETE KESCYNTYLE KHLRSVSPEV SLTPYRVLGL REDILLKEID 200
RRIIRFETDS QRVTCLSASL LKPDVFIREQ RIDAKPSNGP KIVPVDSVAC 250
MNLEANVDVR SNKLVIQSLM TTVKISLKNC KVVVNSRQCI HQQTGSGVIK 300
VPKFEKQQGG TWSSYIAGVY TATIDLLDEN NQNCKLFTEC IVKGRELVKG 350
QSELKSFNIE VLLPRVMKTR RKLLAVTDGS TECNSGTQLI EGKSIEVHKQ 400
DIGGPGKKLT ICNGTSVLDV PLDEGHGCYT INVITSKRAC RPKNSKLQCS 450
IDKELKPCDS GKCLSISQKG AGHIKVSRGK TILITECKEH CQIPVPTGKG 500
DIMVDCSGGR QHYLEVNIVD IHCPNTKFLG GIMLYFCRMS SRPTVALLLG 550
IWIGCGYILT CIFSFLLYHL ILFFANCIKQ CRKKGERLGE ICVKCEQQTV 600
NLMDQELHDL NCNFNLCPYC CNRMSDEGMS RHVGKCPKRL ERLNEIELYL 650
TTSECLCLSV CYQLLISVGI FLKRTTWLVV LLVLLGLAIS PVQGAPTEVS 700
NVKQDGDYSI CYFIFGCLVT AALLLKVKRT NSNGIVVVVD SFGRCPYCNE 750
FTDSLFEEVL HDTLCSLCVC PFCEKQALDL VTLEEHVKEC YKVATRKDIF 800
KILGRKFTNA LVRREKLFTT GLQLFINKTN VVVFALIMCF LLLLTGHNAS 850
AFDSGDLPDG VWEESSQLVK SCTQFCYIEE DVCYCPAEDG VGRKLLFFNG 900
LQNSVKRLSD SHKLLTSVSI DAPWGRINVE STWKPTLAAS NIAMSWSSTD 950
IKGEKVILSG RSTSIIKLKE KTGVMWKLVG SGLASEKKKP FRFPIMDFAQ 1000
VYNSVFQYIT GDRLLSEWPK AVCTGDCPHR CGCQTSTCMA KECHTQECVS 1050
THMVLGIGTG CTCCGMDVER PFNKYLGVKW STEYLRTEVL VCVEVTEEER 1100
HCEIVEAGTR FNIGPITITI SDPQNIGSKL PESLMTVQEI DDSNFVDIMH 1150
VGNVISADNS CRLQSCTHGS AVTTRFTALT ALIKDDHSSG LNLAVLDPKV 1200
NSSWLSWEGC DMDYYCNVGD WPTCTYTGVV TQKLREFLKL DQHRKRLHTT 1250
LSFSLKKNLS KRSHTSVRLE GKTVTRMEVK VTALIEVDGM ELHSKTIRLS 1300
GIRLTGLKCS GCFSCTSGIS CSVNAKLTSP DEFTLHLRST SPNVVVAETS 1350
IIARKGPSAT TSRFKVFSVR DTKKICFEVV EREYCKDCTP DELTTCTGVE 1400
LEPTKDILLE HRGTIVQHQN DTCKSKIDCW SNSISSFASG IGDFFKHYIG 1450
SIAVGVLGTV LPFALLILFF IYGDKMLWPF KVFCRPCRRC CRKNEGYNKL 1500
AEEEELRDII RKFSKSGELI NKDAKDKRTL ARLFMSDNPK LKKEKKLSEI 1550
A 1551
Length:1,551
Mass (Da):173,355
Last modified:July 1, 1993 - v1
Checksum:i7C1654C63895C620
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94133 Genomic RNA. Translation: AAA42974.1.
PIRiA43364.
RefSeqiNP_690575.1. NC_004158.1.

Genome annotation databases

GeneIDi956565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94133 Genomic RNA. Translation: AAA42974.1 .
PIRi A43364.
RefSeqi NP_690575.1. NC_004158.1.

3D structure databases

ProteinModelPortali Q02004.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956565.

Family and domain databases

InterProi IPR012487. Nairovirus_M.
[Graphical view ]
Pfami PF07948. Nairovirus_M. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dugbe Nairovirus M RNA: nucleotide sequence and coding strategy."
    Marriott A.C., El-Ghorr A.A., Nuttall P.A.
    Virology 190:606-615(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 897-905.

Entry informationi

Entry nameiGP_DUGBA
AccessioniPrimary (citable) accession number: Q02004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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