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Protein

Envelopment polyprotein

Gene

GP

Organism
Dugbe virus (isolate ArD44313) (DUGV)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 5 chains:
GP38By similarity
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G2
Non-Structural protein MBy similarity
Short name:
NSm
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G1
Gene namesi
Name:GP
OrganismiDugbe virus (isolate ArD44313) (DUGV)
Taxonomic identifieri766194 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeNairovirus
Virus hostiAmblyomma variegatum (Tropical bont tick) [TaxID: 34610]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma rufipes [TaxID: 72862]
Hyalomma truncatum [TaxID: 72855]
Rhipicephalus [TaxID: 34630]
Rhipicephalus annulatus [TaxID: 34611]
Rhipicephalus decoloratus (African blue tick) (Boophilus decoloratus) [TaxID: 60189]
Rhipicephalus geigyi [TaxID: 136141]
Proteomesi
  • UP000000278 Componenti: Genome

Subcellular locationi

Glycoprotein C :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Transmembranei676 – 696HelicalSequence analysisAdd BLAST21
Transmembranei705 – 725HelicalSequence analysisAdd BLAST21
Transmembranei824 – 844HelicalSequence analysisAdd BLAST21
Transmembranei1452 – 1472HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000003680218 – 1551Envelopment polyproteinAdd BLAST1534
ChainiPRO_000036924818 – 95Mucin-like variable regionAdd BLAST78
ChainiPRO_000043491296 – 374GP38By similarityAdd BLAST279
ChainiPRO_0000036804371 – 893Glycoprotein NSequence analysisAdd BLAST523
ChainiPRO_0000434913698 – 896Non-Structural protein MBy similarityAdd BLAST199
ChainiPRO_0000036805894 – 1551Glycoprotein CSequence analysisAdd BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi30N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi80N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi142N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi413N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi848N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi1201N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi1258N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi1420N-linked (GlcNAc...); by hostSequence analysis1

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including Glycoprotein C and Glycoprotein N.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei370 – 371Cleavage; by hostBy similarity2
Sitei893 – 894Cleavage; by host signal peptidaseBy similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ02004.

Interactioni

Subunit structurei

Glycoprotein C and Glycoprotein N interact with each other.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ02004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR012487. Nairovirus_M.
[Graphical view]
PfamiPF07948. Nairovirus_M. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRVLIIAV VVYLVFTTQN QITGNHTTIN SSSPSTTEAS STPTVSRTPQ
60 70 80 90 100
TTTTSTAVST TITATTTPTA SWTTQSQYFN KTTQHHWREE TMISRNPTVL
110 120 130 140 150
DRQSRASSVR ELLNTKFLML LGFIPKGEVN HLENACNREG KNCTELILKE
160 170 180 190 200
RIARFFSETE KESCYNTYLE KHLRSVSPEV SLTPYRVLGL REDILLKEID
210 220 230 240 250
RRIIRFETDS QRVTCLSASL LKPDVFIREQ RIDAKPSNGP KIVPVDSVAC
260 270 280 290 300
MNLEANVDVR SNKLVIQSLM TTVKISLKNC KVVVNSRQCI HQQTGSGVIK
310 320 330 340 350
VPKFEKQQGG TWSSYIAGVY TATIDLLDEN NQNCKLFTEC IVKGRELVKG
360 370 380 390 400
QSELKSFNIE VLLPRVMKTR RKLLAVTDGS TECNSGTQLI EGKSIEVHKQ
410 420 430 440 450
DIGGPGKKLT ICNGTSVLDV PLDEGHGCYT INVITSKRAC RPKNSKLQCS
460 470 480 490 500
IDKELKPCDS GKCLSISQKG AGHIKVSRGK TILITECKEH CQIPVPTGKG
510 520 530 540 550
DIMVDCSGGR QHYLEVNIVD IHCPNTKFLG GIMLYFCRMS SRPTVALLLG
560 570 580 590 600
IWIGCGYILT CIFSFLLYHL ILFFANCIKQ CRKKGERLGE ICVKCEQQTV
610 620 630 640 650
NLMDQELHDL NCNFNLCPYC CNRMSDEGMS RHVGKCPKRL ERLNEIELYL
660 670 680 690 700
TTSECLCLSV CYQLLISVGI FLKRTTWLVV LLVLLGLAIS PVQGAPTEVS
710 720 730 740 750
NVKQDGDYSI CYFIFGCLVT AALLLKVKRT NSNGIVVVVD SFGRCPYCNE
760 770 780 790 800
FTDSLFEEVL HDTLCSLCVC PFCEKQALDL VTLEEHVKEC YKVATRKDIF
810 820 830 840 850
KILGRKFTNA LVRREKLFTT GLQLFINKTN VVVFALIMCF LLLLTGHNAS
860 870 880 890 900
AFDSGDLPDG VWEESSQLVK SCTQFCYIEE DVCYCPAEDG VGRKLLFFNG
910 920 930 940 950
LQNSVKRLSD SHKLLTSVSI DAPWGRINVE STWKPTLAAS NIAMSWSSTD
960 970 980 990 1000
IKGEKVILSG RSTSIIKLKE KTGVMWKLVG SGLASEKKKP FRFPIMDFAQ
1010 1020 1030 1040 1050
VYNSVFQYIT GDRLLSEWPK AVCTGDCPHR CGCQTSTCMA KECHTQECVS
1060 1070 1080 1090 1100
THMVLGIGTG CTCCGMDVER PFNKYLGVKW STEYLRTEVL VCVEVTEEER
1110 1120 1130 1140 1150
HCEIVEAGTR FNIGPITITI SDPQNIGSKL PESLMTVQEI DDSNFVDIMH
1160 1170 1180 1190 1200
VGNVISADNS CRLQSCTHGS AVTTRFTALT ALIKDDHSSG LNLAVLDPKV
1210 1220 1230 1240 1250
NSSWLSWEGC DMDYYCNVGD WPTCTYTGVV TQKLREFLKL DQHRKRLHTT
1260 1270 1280 1290 1300
LSFSLKKNLS KRSHTSVRLE GKTVTRMEVK VTALIEVDGM ELHSKTIRLS
1310 1320 1330 1340 1350
GIRLTGLKCS GCFSCTSGIS CSVNAKLTSP DEFTLHLRST SPNVVVAETS
1360 1370 1380 1390 1400
IIARKGPSAT TSRFKVFSVR DTKKICFEVV EREYCKDCTP DELTTCTGVE
1410 1420 1430 1440 1450
LEPTKDILLE HRGTIVQHQN DTCKSKIDCW SNSISSFASG IGDFFKHYIG
1460 1470 1480 1490 1500
SIAVGVLGTV LPFALLILFF IYGDKMLWPF KVFCRPCRRC CRKNEGYNKL
1510 1520 1530 1540 1550
AEEEELRDII RKFSKSGELI NKDAKDKRTL ARLFMSDNPK LKKEKKLSEI

A
Length:1,551
Mass (Da):173,355
Last modified:July 1, 1993 - v1
Checksum:i7C1654C63895C620
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94133 Genomic RNA. Translation: AAA42974.1.
PIRiA43364.
RefSeqiNP_690575.1. NC_004158.1.

Genome annotation databases

GeneIDi956565.
KEGGivg:956565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94133 Genomic RNA. Translation: AAA42974.1.
PIRiA43364.
RefSeqiNP_690575.1. NC_004158.1.

3D structure databases

ProteinModelPortaliQ02004.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ02004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956565.
KEGGivg:956565.

Family and domain databases

InterProiIPR012487. Nairovirus_M.
[Graphical view]
PfamiPF07948. Nairovirus_M. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP_DUGBA
AccessioniPrimary (citable) accession number: Q02004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.