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Q02004 (GP_DUGBA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein
Gene names
Name:GP
OrganismDugbe virus (isolate ArD44313) (DUGV) [Reference proteome]
Taxonomic identifier766194 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeNairovirus
Virus hostAmblyomma variegatum (Tropical bont tick) [TaxID: 34610]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma marginatum rufipes [TaxID: 72862]
Hyalomma truncatum [TaxID: 72855]
Rhipicephalus [TaxID: 34630]
Rhipicephalus annulatus [TaxID: 34611]
Rhipicephalus decoloratus [TaxID: 60189]
Rhipicephalus geigyi [TaxID: 136141]

Protein attributes

Sequence length1551 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Multi-pass membrane protein Potential. Host Golgi apparatus membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Sequence similarities

Belongs to the nairovirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 15511534Envelope glycoprotein
PRO_0000036802
Chain18 – 370353Mucin-like variable region
PRO_0000369248
Chain371 – 893523Glycoprotein G2 Potential
PRO_0000036804
Chain894 – 1551658Glycoprotein G1 Potential
PRO_0000036805

Regions

Transmembrane547 – 56721Helical; Potential
Transmembrane676 – 69621Helical; Potential
Transmembrane705 – 72521Helical; Potential
Transmembrane824 – 84421Helical; Potential
Transmembrane1452 – 147221Helical; Potential

Sites

Site370 – 3712Cleavage; by host By similarity
Site893 – 8942Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation251N-linked (GlcNAc...); by host Potential
Glycosylation301N-linked (GlcNAc...); by host Potential
Glycosylation801N-linked (GlcNAc...); by host Potential
Glycosylation1421N-linked (GlcNAc...); by host Potential
Glycosylation4131N-linked (GlcNAc...); by host Potential
Glycosylation8481N-linked (GlcNAc...); by host Potential
Glycosylation12011N-linked (GlcNAc...); by host Potential
Glycosylation12581N-linked (GlcNAc...); by host Potential
Glycosylation14201N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
Q02004 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 7C1654C63895C620

FASTA1,551173,355
        10         20         30         40         50         60 
MSKRVLIIAV VVYLVFTTQN QITGNHTTIN SSSPSTTEAS STPTVSRTPQ TTTTSTAVST 

        70         80         90        100        110        120 
TITATTTPTA SWTTQSQYFN KTTQHHWREE TMISRNPTVL DRQSRASSVR ELLNTKFLML 

       130        140        150        160        170        180 
LGFIPKGEVN HLENACNREG KNCTELILKE RIARFFSETE KESCYNTYLE KHLRSVSPEV 

       190        200        210        220        230        240 
SLTPYRVLGL REDILLKEID RRIIRFETDS QRVTCLSASL LKPDVFIREQ RIDAKPSNGP 

       250        260        270        280        290        300 
KIVPVDSVAC MNLEANVDVR SNKLVIQSLM TTVKISLKNC KVVVNSRQCI HQQTGSGVIK 

       310        320        330        340        350        360 
VPKFEKQQGG TWSSYIAGVY TATIDLLDEN NQNCKLFTEC IVKGRELVKG QSELKSFNIE 

       370        380        390        400        410        420 
VLLPRVMKTR RKLLAVTDGS TECNSGTQLI EGKSIEVHKQ DIGGPGKKLT ICNGTSVLDV 

       430        440        450        460        470        480 
PLDEGHGCYT INVITSKRAC RPKNSKLQCS IDKELKPCDS GKCLSISQKG AGHIKVSRGK 

       490        500        510        520        530        540 
TILITECKEH CQIPVPTGKG DIMVDCSGGR QHYLEVNIVD IHCPNTKFLG GIMLYFCRMS 

       550        560        570        580        590        600 
SRPTVALLLG IWIGCGYILT CIFSFLLYHL ILFFANCIKQ CRKKGERLGE ICVKCEQQTV 

       610        620        630        640        650        660 
NLMDQELHDL NCNFNLCPYC CNRMSDEGMS RHVGKCPKRL ERLNEIELYL TTSECLCLSV 

       670        680        690        700        710        720 
CYQLLISVGI FLKRTTWLVV LLVLLGLAIS PVQGAPTEVS NVKQDGDYSI CYFIFGCLVT 

       730        740        750        760        770        780 
AALLLKVKRT NSNGIVVVVD SFGRCPYCNE FTDSLFEEVL HDTLCSLCVC PFCEKQALDL 

       790        800        810        820        830        840 
VTLEEHVKEC YKVATRKDIF KILGRKFTNA LVRREKLFTT GLQLFINKTN VVVFALIMCF 

       850        860        870        880        890        900 
LLLLTGHNAS AFDSGDLPDG VWEESSQLVK SCTQFCYIEE DVCYCPAEDG VGRKLLFFNG 

       910        920        930        940        950        960 
LQNSVKRLSD SHKLLTSVSI DAPWGRINVE STWKPTLAAS NIAMSWSSTD IKGEKVILSG 

       970        980        990       1000       1010       1020 
RSTSIIKLKE KTGVMWKLVG SGLASEKKKP FRFPIMDFAQ VYNSVFQYIT GDRLLSEWPK 

      1030       1040       1050       1060       1070       1080 
AVCTGDCPHR CGCQTSTCMA KECHTQECVS THMVLGIGTG CTCCGMDVER PFNKYLGVKW 

      1090       1100       1110       1120       1130       1140 
STEYLRTEVL VCVEVTEEER HCEIVEAGTR FNIGPITITI SDPQNIGSKL PESLMTVQEI 

      1150       1160       1170       1180       1190       1200 
DDSNFVDIMH VGNVISADNS CRLQSCTHGS AVTTRFTALT ALIKDDHSSG LNLAVLDPKV 

      1210       1220       1230       1240       1250       1260 
NSSWLSWEGC DMDYYCNVGD WPTCTYTGVV TQKLREFLKL DQHRKRLHTT LSFSLKKNLS 

      1270       1280       1290       1300       1310       1320 
KRSHTSVRLE GKTVTRMEVK VTALIEVDGM ELHSKTIRLS GIRLTGLKCS GCFSCTSGIS 

      1330       1340       1350       1360       1370       1380 
CSVNAKLTSP DEFTLHLRST SPNVVVAETS IIARKGPSAT TSRFKVFSVR DTKKICFEVV 

      1390       1400       1410       1420       1430       1440 
EREYCKDCTP DELTTCTGVE LEPTKDILLE HRGTIVQHQN DTCKSKIDCW SNSISSFASG 

      1450       1460       1470       1480       1490       1500 
IGDFFKHYIG SIAVGVLGTV LPFALLILFF IYGDKMLWPF KVFCRPCRRC CRKNEGYNKL 

      1510       1520       1530       1540       1550 
AEEEELRDII RKFSKSGELI NKDAKDKRTL ARLFMSDNPK LKKEKKLSEI A 

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References

[1]"Dugbe Nairovirus M RNA: nucleotide sequence and coding strategy."
Marriott A.C., El-Ghorr A.A., Nuttall P.A.
Virology 190:606-615(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 897-905.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94133 Genomic RNA. Translation: AAA42974.1.
PIRA43364.
RefSeqNP_690575.1. NC_004158.1.

3D structure databases

ProteinModelPortalQ02004.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956565.

Family and domain databases

InterProIPR012487. Nairovirus_M.
[Graphical view]
PfamPF07948. Nairovirus_M. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGP_DUGBA
AccessionPrimary (citable) accession number: Q02004
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families