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Q02004

- GP_DUGBA

UniProt

Q02004 - GP_DUGBA

Protein

Envelope glycoprotein

Gene

GP

Organism
Dugbe virus (isolate ArD44313) (DUGV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei370 – 3712Cleavage; by hostBy similarity
    Sitei893 – 8942Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiDugbe virus (isolate ArD44313) (DUGV)
    Taxonomic identifieri766194 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeNairovirus
    Virus hostiAmblyomma variegatum (Tropical bont tick) [TaxID: 34610]
    Homo sapiens (Human) [TaxID: 9606]
    Hyalomma marginatum rufipes [TaxID: 72862]
    Hyalomma truncatum [TaxID: 72855]
    Rhipicephalus [TaxID: 34630]
    Rhipicephalus annulatus [TaxID: 34611]
    Rhipicephalus decoloratus [TaxID: 60189]
    Rhipicephalus geigyi [TaxID: 136141]
    ProteomesiUP000000278: Genome

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 15511534Envelope glycoproteinPRO_0000036802Add
    BLAST
    Chaini18 – 370353Mucin-like variable regionPRO_0000369248Add
    BLAST
    Chaini371 – 893523Glycoprotein G2Sequence AnalysisPRO_0000036804Add
    BLAST
    Chaini894 – 1551658Glycoprotein G1Sequence AnalysisPRO_0000036805Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi30 – 301N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi80 – 801N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi848 – 8481N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1201 – 12011N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1258 – 12581N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1420 – 14201N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ02004.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei547 – 56721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei676 – 69621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei705 – 72521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei824 – 84421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1452 – 147221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR012487. Nairovirus_M.
    [Graphical view]
    PfamiPF07948. Nairovirus_M. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02004-1 [UniParc]FASTAAdd to Basket

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    MSKRVLIIAV VVYLVFTTQN QITGNHTTIN SSSPSTTEAS STPTVSRTPQ     50
    TTTTSTAVST TITATTTPTA SWTTQSQYFN KTTQHHWREE TMISRNPTVL 100
    DRQSRASSVR ELLNTKFLML LGFIPKGEVN HLENACNREG KNCTELILKE 150
    RIARFFSETE KESCYNTYLE KHLRSVSPEV SLTPYRVLGL REDILLKEID 200
    RRIIRFETDS QRVTCLSASL LKPDVFIREQ RIDAKPSNGP KIVPVDSVAC 250
    MNLEANVDVR SNKLVIQSLM TTVKISLKNC KVVVNSRQCI HQQTGSGVIK 300
    VPKFEKQQGG TWSSYIAGVY TATIDLLDEN NQNCKLFTEC IVKGRELVKG 350
    QSELKSFNIE VLLPRVMKTR RKLLAVTDGS TECNSGTQLI EGKSIEVHKQ 400
    DIGGPGKKLT ICNGTSVLDV PLDEGHGCYT INVITSKRAC RPKNSKLQCS 450
    IDKELKPCDS GKCLSISQKG AGHIKVSRGK TILITECKEH CQIPVPTGKG 500
    DIMVDCSGGR QHYLEVNIVD IHCPNTKFLG GIMLYFCRMS SRPTVALLLG 550
    IWIGCGYILT CIFSFLLYHL ILFFANCIKQ CRKKGERLGE ICVKCEQQTV 600
    NLMDQELHDL NCNFNLCPYC CNRMSDEGMS RHVGKCPKRL ERLNEIELYL 650
    TTSECLCLSV CYQLLISVGI FLKRTTWLVV LLVLLGLAIS PVQGAPTEVS 700
    NVKQDGDYSI CYFIFGCLVT AALLLKVKRT NSNGIVVVVD SFGRCPYCNE 750
    FTDSLFEEVL HDTLCSLCVC PFCEKQALDL VTLEEHVKEC YKVATRKDIF 800
    KILGRKFTNA LVRREKLFTT GLQLFINKTN VVVFALIMCF LLLLTGHNAS 850
    AFDSGDLPDG VWEESSQLVK SCTQFCYIEE DVCYCPAEDG VGRKLLFFNG 900
    LQNSVKRLSD SHKLLTSVSI DAPWGRINVE STWKPTLAAS NIAMSWSSTD 950
    IKGEKVILSG RSTSIIKLKE KTGVMWKLVG SGLASEKKKP FRFPIMDFAQ 1000
    VYNSVFQYIT GDRLLSEWPK AVCTGDCPHR CGCQTSTCMA KECHTQECVS 1050
    THMVLGIGTG CTCCGMDVER PFNKYLGVKW STEYLRTEVL VCVEVTEEER 1100
    HCEIVEAGTR FNIGPITITI SDPQNIGSKL PESLMTVQEI DDSNFVDIMH 1150
    VGNVISADNS CRLQSCTHGS AVTTRFTALT ALIKDDHSSG LNLAVLDPKV 1200
    NSSWLSWEGC DMDYYCNVGD WPTCTYTGVV TQKLREFLKL DQHRKRLHTT 1250
    LSFSLKKNLS KRSHTSVRLE GKTVTRMEVK VTALIEVDGM ELHSKTIRLS 1300
    GIRLTGLKCS GCFSCTSGIS CSVNAKLTSP DEFTLHLRST SPNVVVAETS 1350
    IIARKGPSAT TSRFKVFSVR DTKKICFEVV EREYCKDCTP DELTTCTGVE 1400
    LEPTKDILLE HRGTIVQHQN DTCKSKIDCW SNSISSFASG IGDFFKHYIG 1450
    SIAVGVLGTV LPFALLILFF IYGDKMLWPF KVFCRPCRRC CRKNEGYNKL 1500
    AEEEELRDII RKFSKSGELI NKDAKDKRTL ARLFMSDNPK LKKEKKLSEI 1550
    A 1551
    Length:1,551
    Mass (Da):173,355
    Last modified:July 1, 1993 - v1
    Checksum:i7C1654C63895C620
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94133 Genomic RNA. Translation: AAA42974.1.
    PIRiA43364.
    RefSeqiNP_690575.1. NC_004158.1.

    Genome annotation databases

    GeneIDi956565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94133 Genomic RNA. Translation: AAA42974.1 .
    PIRi A43364.
    RefSeqi NP_690575.1. NC_004158.1.

    3D structure databases

    ProteinModelPortali Q02004.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956565.

    Family and domain databases

    InterProi IPR012487. Nairovirus_M.
    [Graphical view ]
    Pfami PF07948. Nairovirus_M. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dugbe Nairovirus M RNA: nucleotide sequence and coding strategy."
      Marriott A.C., El-Ghorr A.A., Nuttall P.A.
      Virology 190:606-615(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 897-905.

    Entry informationi

    Entry nameiGP_DUGBA
    AccessioniPrimary (citable) accession number: Q02004
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3