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Q02002 (TRPF_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-(5'-phosphoribosyl)anthranilate isomerase

Short name=PRAI
EC=5.3.1.24
Gene names
Name:trpF
Ordered Locus Names:LL1466
ORF Names:L0050
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135

Sequence similarities

In the N-terminal section; belongs to the TrpF family.

To B.subtilis YnaI in the C-terminal section.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135
PRO_0000154359

Regions

Region1 – 198198N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135

Sequences

Sequence LengthMass (Da)Tools
Q02002 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 698A3934C9EFD89F

FASTA35139,586
        10         20         30         40         50         60 
MKIKICGLST KEAVDTAVES GVTHLGFILS PSKRQVAPEK ILQITNDVPK TVKKVGVFVD 

        70         80         90        100        110        120 
EPIDFVKKAI QVAQLDLVQL HGNEDMNYIN QLDISVIKAI RPDQEFKEYE DVILLFDSPQ 

       130        140        150        160        170        180 
AGSGQAFDWD SLVTSGLKNK FFIAGGLNPE NVAAAIQHFP NAYGVDVSSG VETDGIKNLT 

       190        200        210        220        230        240 
KIKNFVQNAS LASSKQLFIE FLRITKKLNE NKIIPYLMGS LAVEQIINFP TNPDDIDIQL 

       250        260        270        280        290        300 
KTSDFENFEQ LTSLMEKLGY QLIDLHEHKF EKASIHVGFA SVETLKNYAG VDYLTIQQER 

       310        320        330        340        350 
MENGEKYHLP NVEQSLKIYE AAKRDEWRGG KQKDSFIFDE LIKEQKRNDN E 

« Hide

References

« Hide 'large scale' references
[1]"Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis."
Bardowski J., Ehrlich S.D., Chopin A.
J. Bacteriol. 174:6563-6570(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IL1403.
[2]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M87483 Genomic DNA. Translation: AAA25227.1.
AE005176 Genomic DNA. Translation: AAK05564.1.
PIRS35128.
RefSeqNP_267622.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ02002.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L0050.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05564; AAK05564; L0050.
GeneID1115123.
KEGGlla:L0050.
PATRIC22295338. VBILacLac136773_1576.

Phylogenomic databases

eggNOGCOG0135.
KOK01817.
OMANIDYHEL.
OrthoDBEOG6N94DF.
ProtClustDBCLSK697758.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1563-MONOMER.
UniPathwayUPA00035; UER00042.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00135. PRAI.
InterProIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPF_LACLA
AccessionPrimary (citable) accession number: Q02002
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways