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Q02002

- TRPF_LACLA

UniProt

Q02002 - TRPF_LACLA

Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-1563-MONOMER.
    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpF
    Ordered Locus Names:LL1466
    ORF Names:L0050
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154359Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272623.L0050.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02002.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 198198N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the TrpF family.Curated
    To B.subtilis YnaI in the C-terminal section.Curated

    Phylogenomic databases

    eggNOGiCOG0135.
    KOiK01817.
    OMAiNIDYHEL.
    OrthoDBiEOG6N94DF.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q02002-1 [UniParc]FASTAAdd to Basket

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    MKIKICGLST KEAVDTAVES GVTHLGFILS PSKRQVAPEK ILQITNDVPK    50
    TVKKVGVFVD EPIDFVKKAI QVAQLDLVQL HGNEDMNYIN QLDISVIKAI 100
    RPDQEFKEYE DVILLFDSPQ AGSGQAFDWD SLVTSGLKNK FFIAGGLNPE 150
    NVAAAIQHFP NAYGVDVSSG VETDGIKNLT KIKNFVQNAS LASSKQLFIE 200
    FLRITKKLNE NKIIPYLMGS LAVEQIINFP TNPDDIDIQL KTSDFENFEQ 250
    LTSLMEKLGY QLIDLHEHKF EKASIHVGFA SVETLKNYAG VDYLTIQQER 300
    MENGEKYHLP NVEQSLKIYE AAKRDEWRGG KQKDSFIFDE LIKEQKRNDN 350
    E 351
    Length:351
    Mass (Da):39,586
    Last modified:April 1, 1993 - v1
    Checksum:i698A3934C9EFD89F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M87483 Genomic DNA. Translation: AAA25227.1.
    AE005176 Genomic DNA. Translation: AAK05564.1.
    PIRiS35128.
    RefSeqiNP_267622.1. NC_002662.1.
    WP_003130430.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK05564; AAK05564; L0050.
    GeneIDi1115123.
    KEGGilla:L0050.
    PATRICi22295338. VBILacLac136773_1576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M87483 Genomic DNA. Translation: AAA25227.1 .
    AE005176 Genomic DNA. Translation: AAK05564.1 .
    PIRi S35128.
    RefSeqi NP_267622.1. NC_002662.1.
    WP_003130430.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q02002.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L0050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK05564 ; AAK05564 ; L0050 .
    GeneIDi 1115123.
    KEGGi lla:L0050.
    PATRICi 22295338. VBILacLac136773_1576.

    Phylogenomic databases

    eggNOGi COG0135.
    KOi K01817.
    OMAi NIDYHEL.
    OrthoDBi EOG6N94DF.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    BioCyci LLAC272623:GHSH-1563-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis."
      Bardowski J., Ehrlich S.D., Chopin A.
      J. Bacteriol. 174:6563-6570(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IL1403.
    2. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiTRPF_LACLA
    AccessioniPrimary (citable) accession number: Q02002
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3