Q02002 (TRPF_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:	trpF
Ordered Locus Names:	LL1466
ORF Names:	L0050

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Lactococcus › Lactococcus lactis › Lactococcus lactis subsp. lactis

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135
Sequence similarities	In the N-terminal section; belongs to the TrpF family. To B.subtilis YnaI in the C-terminal section.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135		PRO_0000154359
Regions
	Region	1 – 198	198	N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135

Sequences

	Sequence		Length	Mass (Da)
	Q02002 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 698A3934C9EFD89F	FASTA	351	39,586
	10 20 30 40 50 60 MKIKICGLST KEAVDTAVES GVTHLGFILS PSKRQVAPEK ILQITNDVPK TVKKVGVFVD 70 80 90 100 110 120 EPIDFVKKAI QVAQLDLVQL HGNEDMNYIN QLDISVIKAI RPDQEFKEYE DVILLFDSPQ 130 140 150 160 170 180 AGSGQAFDWD SLVTSGLKNK FFIAGGLNPE NVAAAIQHFP NAYGVDVSSG VETDGIKNLT 190 200 210 220 230 240 KIKNFVQNAS LASSKQLFIE FLRITKKLNE NKIIPYLMGS LAVEQIINFP TNPDDIDIQL 250 260 270 280 290 300 KTSDFENFEQ LTSLMEKLGY QLIDLHEHKF EKASIHVGFA SVETLKNYAG VDYLTIQQER 310 320 330 340 350 MENGEKYHLP NVEQSLKIYE AAKRDEWRGG KQKDSFIFDE LIKEQKRNDN E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis." Bardowski J., Ehrlich S.D., Chopin A. J. Bacteriol. 174:6563-6570(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IL1403.
[2]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M87483 Genomic DNA. Translation: AAA25227.1. AE005176 Genomic DNA. Translation: AAK05564.1.
PIR	S35128.
RefSeq	NP_267622.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q02002.
ModBase	Search...
Protein-protein interaction databases
STRING	272623.L0050.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK05564; AAK05564; L0050.
GeneID	1115123.
KEGG	lla:L0050.
PATRIC	22295338. VBILacLac136773_1576.
Phylogenomic databases
eggNOG	COG0135.
KO	K01817.
OMA	NIDYHEL.
ProtClustDB	CLSK697758.
Enzyme and pathway databases
BioCyc	LLAC272623:GHSH-1603-MONOMER.
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00135. PRAI. Fused.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_LACLA

Accession

Primary (citable) accession number: Q02002

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program