Q02001 (TRPE_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	LL1470
ORF Names:	L0054

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Anthranilate synthase component 1		PRO_0000154096
Experimental info
	Sequence conflict	164 – 165	2	SA → YR in AAA25223. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q02001 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 32081A7640577B06	FASTA	456	51,676
	10 20 30 40 50 60 MRKIKEISAD TMTPISVYLR LKGKNKVILE SIPRENDQSR FSIIALNPVK HIKFTDGILS 70 80 90 100 110 120 VNDEIISDEN PMEFLEKLVC QPESTDENLD LPFTSGAIGY AGFDTYGIFE GIQPELKDSI 130 140 150 160 170 180 GTPDMYFMLY ESALIFDHKR EKLIFIEDNT YSQRSEKELQ NALSANIESL SLLTEAENEL 190 200 210 220 230 240 TELSKLNFVS NMSQELFEEK VAKAKELIRN GDMFQVVLSQ RLTADFTDNP FNYYRKLRVE 250 260 270 280 290 300 NPSSYMYFME FDNFHVIGSS PERLVAVHGN QVSTNPIAGT RKRGQTEFED QALIEDLESD 310 320 330 340 350 360 PKEVAEHKML VDLGRNDIGK ISKYGSIEVP VFMKVEKYRY VMHITSEVTG ELRPEFTAMD 370 380 390 400 410 420 ALRATLPAGT LSGAPKHRAY QRIYEFETQK RGIYGGAIGY LTKNGNCDFA IAIRTMVLKD 430 440 450 KKAHVQAGAG IVYDSVPEHE YQETLNKAQG LLKVGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis." Bardowski J., Ehrlich S.D., Chopin A. J. Bacteriol. 174:6563-6570(1992) [PubMed: 1400208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IL1403.
[2]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M87483 Genomic DNA. Translation: AAA25223.1. AE005176 Genomic DNA. Translation: AAK05568.1.
PIR	F86808. S35124.
RefSeq	NP_267626.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q02001.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115127.
GenomeReviews	Gene locus LL1470 in contig AE005176_GR.
KEGG	lla:L0054.
NMPDR	fig|272623.1.peg.1511.
PATRIC	22295346. VBILacLac136773_1580.
Phylogenomic databases
HOGENOM	HBG507440.
OMA	VMHMVSD.
ProtClustDB	PRK13570.
Enzyme and pathway databases
BioCyc	LLAC272623:L0054-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_LACLA

Accession

Primary (citable) accession number: Q02001

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program