Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 2 (trpG), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Anthranilate 1; via carbonyl oxygenUniRule annotation
Binding sitei79 – 791Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei87 – 871PhosphoribosylpyrophosphateUniRule annotation
Metal bindingi91 – 911Magnesium 1UniRule annotation
Binding sitei110 – 1101Anthranilate 1UniRule annotation
Binding sitei119 – 1191Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei165 – 1651Anthranilate 2UniRule annotation
Metal bindingi224 – 2241Magnesium 2UniRule annotation
Metal bindingi225 – 2251Magnesium 1UniRule annotation
Metal bindingi225 – 2251Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1565-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:LL1468
ORF Names:L0052
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Anthranilate phosphoribosyltransferasePRO_0000154452Add
BLAST

Proteomic databases

PaxDbiQ02000.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L0052.

Structurei

3D structure databases

ProteinModelPortaliQ02000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 832Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni89 – 924Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni107 – 1159Phosphoribosylpyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
KOiK00766.
OMAiHSGQAYQ.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNELEKVMS GRDMTENEMN MLANSIIQGE LSEVQIASFL VALKMKGEAA
60 70 80 90 100
SELTGLARAL QKAAIPIPTN LTNAMDNCGT GGDRSFSFNI STTAAFVLAA
110 120 130 140 150
GGVNMAKHGN RSITSKSGSA DVLEALGINL YLPAEKLAQV FDKVGLVFLF
160 170 180 190 200
AQNLHPAMKY FTPVRRQLEI PTIMNLTGPL INPIPLDTQL LGTSRPDLLE
210 220 230 240 250
LTANVLKGLG RKRALVITGE GGMDEATPFG LNHYALLEND KVTLHEFRAS
260 270 280 290 300
EVGISEVQLN DIRGGEAPEN AEILKNVLEN QPSAFLETTV LNAGLGFYAN
310 320 330
GKVDSIKSGV DLAREVISTG AALTKLHELQ AEQIG
Length:335
Mass (Da):35,845
Last modified:April 1, 1993 - v1
Checksum:iEFFF3662477357B3
GO

Sequence cautioni

The sequence AAK05566 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87483 Genomic DNA. Translation: AAA25225.1.
AE005176 Genomic DNA. Translation: AAK05566.1. Different initiation.
PIRiD86808.
S35126.
RefSeqiNP_267624.2. NC_002662.1.
WP_010905989.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05566; AAK05566; L0052.
GeneIDi1115125.
KEGGilla:L0052.
PATRICi22295342. VBILacLac136773_1578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87483 Genomic DNA. Translation: AAA25225.1.
AE005176 Genomic DNA. Translation: AAK05566.1. Different initiation.
PIRiD86808.
S35126.
RefSeqiNP_267624.2. NC_002662.1.
WP_010905989.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ02000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0052.

Proteomic databases

PaxDbiQ02000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05566; AAK05566; L0052.
GeneIDi1115125.
KEGGilla:L0052.
PATRICi22295342. VBILacLac136773_1578.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
KOiK00766.
OMAiHSGQAYQ.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.
BioCyciLLAC272623:GHSH-1565-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_LACLA
AccessioniPrimary (citable) accession number: Q02000
Secondary accession number(s): Q9CFK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.