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Q01Y56 (ASSY_SOLUE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:Acid_4448
OrganismSolibacter usitatus (strain Ellin6076) [Complete proteome] [HAMAP]
Taxonomic identifier234267 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00581

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00581

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00581

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00581.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Argininosuccinate synthase HAMAP-Rule MF_00581
PRO_1000129770

Regions

Nucleotide binding17 – 259ATP By similarity

Sites

Binding site431ATP By similarity
Binding site991Citrulline By similarity
Binding site1291ATP; via amide nitrogen By similarity
Binding site1311Aspartate By similarity
Binding site1311ATP By similarity
Binding site1351Aspartate By similarity
Binding site1351Citrulline By similarity
Binding site1361Aspartate By similarity
Binding site1361ATP By similarity
Binding site1391Citrulline By similarity
Binding site1921Citrulline By similarity
Binding site1941ATP By similarity
Binding site2011Citrulline By similarity
Binding site2031Citrulline By similarity
Binding site2801Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q01Y56 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 0485D1E0A2F54820

FASTA45350,432
        10         20         30         40         50         60 
MGNILQNLPA GEKVGLAFSG GLDTSAAIHW MRAKGAIPYS YTANLGQPDE PDYDEIPRRA 

        70         80         90        100        110        120 
LLYGAEKARL IDCRKQLVAE GIAALQSGAF HISTAGVHYF NTTPIGRAVT GTMLVIAMKE 

       130        140        150        160        170        180 
DDVHIWGDGS TFKGNDIERF YRYGLLANPA LRIYKPWLDQ TFIDELGGRK EMSEYMISHG 

       190        200        210        220        230        240 
LTYKMSVEKA YSTDSNIWGA THEAKDLEHL DKGVKIVEPI MGVASWREDV AIKPETVTIR 

       250        260        270        280        290        300 
FEEGQPVALN HVTYDDPVQL VLEANAIGGR HGLGVSDQIE NRIIEAKSRG IYEAPGLALL 

       310        320        330        340        350        360 
FIAYERLVSG IHNEDTIEQY RINGLRLGRL LYQGRWFDSQ SMMLRETAQR WVARAITGEV 

       370        380        390        400        410        420 
TVELRRGNDY SILDTTSPNL TYKPERLTME KGESTFSPQD RIGQLTMRHL DITDTRDKLL 

       430        440        450 
LYIKTGLLGP SSGNSTTLLP EPADSGTEKP PSR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000473 Genomic DNA. Translation: ABJ85409.1.
RefSeqYP_825694.1. NC_008536.1.

3D structure databases

ProteinModelPortalQ01Y56.
SMRQ01Y56. Positions 4-434.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING234267.Acid_4448.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ85409; ABJ85409; Acid_4448.
GeneID4431976.
KEGGsus:Acid_4448.
PATRIC32011390. VBICanSol30224_4660.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230094.
KOK01940.
OMAMRNLDIA.
OrthoDBEOG6K9QCV.
ProtClustDBPRK05370.

Enzyme and pathway databases

BioCycSUSI234267:GHSK-4484-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00581. Arg_succ_synth_type2.
InterProIPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_SOLUE
AccessionPrimary (citable) accession number: Q01Y56
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways