Q01W10 (DCUP_SOLUE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Acid_5202

Organism

Solibacter usitatus (strain Ellin6076) [Complete proteome] [HAMAP]

Taxonomic identifier

234267 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Solibacteres › Solibacterales › Solibacteraceae › Candidatus Solibacter

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000325696
Regions
	Region	28 – 32	5	Substrate binding By similarity
Sites
	Binding site	77	1	Substrate By similarity
	Binding site	153	1	Substrate By similarity
	Binding site	208	1	Substrate By similarity
	Binding site	322	1	Substrate By similarity
	Site	77	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q01W10 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 9A09835B137C8B8B	FASTA	345	38,314
	10 20 30 40 50 60 MRVAPMTSRF LDACRRRPTD VRPVWFMRQA GRYMKQYRQI REKHGILEIC KRPDLAATVT 70 80 90 100 110 120 LQPIEVLDVD AAIIFADLLL PIEPMGLKLK YEKGEGPVIG NPVRTSDDVD SLSTTNTDEL 130 140 150 160 170 180 GYVGEAIQHV VRALAGKVPV VGFVGAPFTM ASYMIEGGAS RNFVRTKKLM YSDETLWRRL 190 200 210 220 230 240 MGKIVDVLAP FAHSQVAAGA RAIQVFDSWV GALGSDDYVR FAAPYSRALI ERIRSTGVPV 250 260 270 280 290 300 IHFGTGASGF FRELHAAGGD VMGVDWRINI DQAWMDISYR SAIQGNLDPV ALFAPLPELR 310 320 330 340 TKVQELLKRT GTRPGHIFNL GHGILPETPV ENVKAVVELV REFRP

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin6076.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000473 Genomic DNA. Translation: ABJ86155.1.
RefSeq	YP_826440.1. NC_008536.1.
3D structure databases
ProteinModelPortal	Q01W10.
ModBase	Search...
Protein-protein interaction databases
STRING	Q01W10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4426584.
GenomeReviews	Gene locus Acid_5202 in contig CP000473_GR.
KEGG	sus:Acid_5202.
NMPDR	fig|234267.9.peg.4936.
PATRIC	32012960. VBICanSol30224_5441.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0407.
HOGENOM	HBG628392.
OMA	PRIHFGV.
PhylomeDB	Q01W10.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_SOLUE

Accession

Primary (citable) accession number: Q01W10

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program