SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q01UL9

- Q01UL9_SOLUE

UniProt

Q01UL9 - Q01UL9_SOLUE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: 2-isopropylmalate synthase
Gene
Acid_5704
Organism
Solibacter usitatus (strain Ellin6076)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) By similarity.SAAS annotations

Catalytic activityi

Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.SAAS annotations

Pathwayi

GO - Molecular functioni

  1. 2-isopropylmalate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisSAAS annotations

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-5747-MONOMER.
UniPathwayiUPA00048; UER00070.

Names & Taxonomyi

Protein namesi
Submitted name:
2-isopropylmalate synthaseImported (EC:2.3.3.13Imported)
Gene namesi
Ordered Locus Names:Acid_5704Imported
OrganismiSolibacter usitatus (strain Ellin6076)Imported
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
ProteomesiUP000000671: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.SAAS annotations

Protein-protein interaction databases

STRINGi234267.Acid_5704.

Structurei

3D structure databases

ProteinModelPortaliQ01UL9.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0119.
HOGENOMiHOG000046859.
KOiK01649.
OMAiCKSISEP.
OrthoDBiEOG6CGCF3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTiSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF110921. SSF110921. 1 hit.
TIGRFAMsiTIGR00973. leuA_bact. 1 hit.
PROSITEiPS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01UL9-1 [UniParc]FASTAAdd to Basket

« Hide

MRDGEQAAGT RLGSREKLII ARQLALLNVD VIEAGYPNSS PEDFDAVQRI    50
AAEIQGPAIC ALSRAVAADI EACGKALAGC PRPRIHTGIG ASDIHIAGKF 100
QDDRYGKSLA EKKRKILQMA IDAVTLARHY VAEVEFYAED AGRADPVYLY 150
EMIAAVIDAG ASVVNIPDTT GYTVPEQYGA LIAGIRTHVP GIDRAVISVH 200
CHDDLGMAVA NTLHGVLNGA RQVEGTINGL GERAGNAALE EIVMALATRA 250
DYFGVHTGVN TRELHRTSRL VADLLGVQVP PNKAVIGANA FSHSSGIHVD 300
GVLKKRETYE IMRPEDVGMT ESRVVLTART GRHGLLDRLR KLGYELSDLE 350
LDQAYRRFLS VADKKQEVFD EDLIAILRDE IHPLPAVYEL QYLHIYSGTS 400
AIPTATVRLL VSGDTREGAA IGDGPVDAVC RAISQVTATA AKLQRYEIRG 450
VTSGTEAMGE VTIQLEEAGR KVIGRGASTD IIEASAKAYL DGLNKLANIA 500
AASHRSAGA 509
Length:509
Mass (Da):54,439
Last modified:November 14, 2006 - v1
Checksum:i9E1E06EBC16D37E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ86651.1.
RefSeqiYP_826936.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ86651; ABJ86651; Acid_5704.
GeneIDi4426079.
KEGGisus:Acid_5704.
PATRICi32014035. VBICanSol30224_5975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ86651.1 .
RefSeqi YP_826936.1. NC_008536.1.

3D structure databases

ProteinModelPortali Q01UL9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234267.Acid_5704.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ86651 ; ABJ86651 ; Acid_5704 .
GeneIDi 4426079.
KEGGi sus:Acid_5704.
PATRICi 32014035. VBICanSol30224_5975.

Phylogenomic databases

eggNOGi COG0119.
HOGENOMi HOG000046859.
KOi K01649.
OMAi CKSISEP.
OrthoDBi EOG6CGCF3.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00070 .
BioCyci SUSI234267:GHSK-5747-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view ]
Pfami PF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view ]
SMARTi SM00917. LeuA_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF110921. SSF110921. 1 hit.
TIGRFAMsi TIGR00973. leuA_bact. 1 hit.
PROSITEi PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin6076.

Entry informationi

Entry nameiQ01UL9_SOLUE
AccessioniPrimary (citable) accession number: Q01UL9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi