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Q01UL9

- Q01UL9_SOLUE

UniProt

Q01UL9 - Q01UL9_SOLUE

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Protein

2-isopropylmalate synthase

Gene

Acid_5704

Organism
Solibacter usitatus (strain Ellin6076)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).SAAS annotation

Catalytic activityi

Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. 2-isopropylmalate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisSAAS annotation

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-5747-MONOMER.
UniPathwayiUPA00048; UER00070.

Names & Taxonomyi

Protein namesi
Recommended name:
2-isopropylmalate synthaseSAAS annotation (EC:2.3.3.13SAAS annotation)
Gene namesi
Ordered Locus Names:Acid_5704Imported
OrganismiSolibacter usitatus (strain Ellin6076)Imported
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
ProteomesiUP000000671: Chromosome

Interactioni

Subunit structurei

Homotetramer.SAAS annotation

Protein-protein interaction databases

STRINGi234267.Acid_5704.

Structurei

3D structure databases

ProteinModelPortaliQ01UL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0119.
HOGENOMiHOG000046859.
KOiK01649.
OMAiCKSISEP.
OrthoDBiEOG6CGCF3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTiSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF110921. SSF110921. 1 hit.
TIGRFAMsiTIGR00973. leuA_bact. 1 hit.
PROSITEiPS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q01UL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDGEQAAGT RLGSREKLII ARQLALLNVD VIEAGYPNSS PEDFDAVQRI
60 70 80 90 100
AAEIQGPAIC ALSRAVAADI EACGKALAGC PRPRIHTGIG ASDIHIAGKF
110 120 130 140 150
QDDRYGKSLA EKKRKILQMA IDAVTLARHY VAEVEFYAED AGRADPVYLY
160 170 180 190 200
EMIAAVIDAG ASVVNIPDTT GYTVPEQYGA LIAGIRTHVP GIDRAVISVH
210 220 230 240 250
CHDDLGMAVA NTLHGVLNGA RQVEGTINGL GERAGNAALE EIVMALATRA
260 270 280 290 300
DYFGVHTGVN TRELHRTSRL VADLLGVQVP PNKAVIGANA FSHSSGIHVD
310 320 330 340 350
GVLKKRETYE IMRPEDVGMT ESRVVLTART GRHGLLDRLR KLGYELSDLE
360 370 380 390 400
LDQAYRRFLS VADKKQEVFD EDLIAILRDE IHPLPAVYEL QYLHIYSGTS
410 420 430 440 450
AIPTATVRLL VSGDTREGAA IGDGPVDAVC RAISQVTATA AKLQRYEIRG
460 470 480 490 500
VTSGTEAMGE VTIQLEEAGR KVIGRGASTD IIEASAKAYL DGLNKLANIA

AASHRSAGA
Length:509
Mass (Da):54,439
Last modified:November 14, 2006 - v1
Checksum:i9E1E06EBC16D37E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000473 Genomic DNA. Translation: ABJ86651.1.
RefSeqiYP_826936.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ86651; ABJ86651; Acid_5704.
GeneIDi4426079.
KEGGisus:Acid_5704.
PATRICi32014035. VBICanSol30224_5975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000473 Genomic DNA. Translation: ABJ86651.1 .
RefSeqi YP_826936.1. NC_008536.1.

3D structure databases

ProteinModelPortali Q01UL9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234267.Acid_5704.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ86651 ; ABJ86651 ; Acid_5704 .
GeneIDi 4426079.
KEGGi sus:Acid_5704.
PATRICi 32014035. VBICanSol30224_5975.

Phylogenomic databases

eggNOGi COG0119.
HOGENOMi HOG000046859.
KOi K01649.
OMAi CKSISEP.
OrthoDBi EOG6CGCF3.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00070 .
BioCyci SUSI234267:GHSK-5747-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view ]
Pfami PF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view ]
SMARTi SM00917. LeuA_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF110921. SSF110921. 1 hit.
TIGRFAMsi TIGR00973. leuA_bact. 1 hit.
PROSITEi PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin6076Imported.

Entry informationi

Entry nameiQ01UL9_SOLUE
AccessioniPrimary (citable) accession number: Q01UL9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3