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Q01UL9

- Q01UL9_SOLUE

UniProt

Q01UL9 - Q01UL9_SOLUE

Protein
Submitted name:

2-isopropylmalate synthase

Gene

Acid_5704

Organism
Solibacter usitatus (strain Ellin6076)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).SAAS annotation

    Catalytic activityi

    Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-isopropylmalate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    AcyltransferaseImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisSAAS annotation

    Enzyme and pathway databases

    BioCyciSUSI234267:GHSK-5747-MONOMER.
    UniPathwayiUPA00048; UER00070.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-isopropylmalate synthaseImported (EC:2.3.3.13Imported)
    Gene namesi
    Ordered Locus Names:Acid_5704Imported
    OrganismiSolibacter usitatus (strain Ellin6076)Imported
    Taxonomic identifieri234267 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
    ProteomesiUP000000671: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.SAAS annotation

    Protein-protein interaction databases

    STRINGi234267.Acid_5704.

    Structurei

    3D structure databases

    ProteinModelPortaliQ01UL9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0119.
    HOGENOMiHOG000046859.
    KOiK01649.
    OMAiCKSISEP.
    OrthoDBiEOG6CGCF3.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR005671. LeuA_bact_synth.
    IPR000891. PYR_CT.
    [Graphical view]
    PfamiPF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view]
    SMARTiSM00917. LeuA_dimer. 1 hit.
    [Graphical view]
    SUPFAMiSSF110921. SSF110921. 1 hit.
    TIGRFAMsiTIGR00973. leuA_bact. 1 hit.
    PROSITEiPS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q01UL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDGEQAAGT RLGSREKLII ARQLALLNVD VIEAGYPNSS PEDFDAVQRI    50
    AAEIQGPAIC ALSRAVAADI EACGKALAGC PRPRIHTGIG ASDIHIAGKF 100
    QDDRYGKSLA EKKRKILQMA IDAVTLARHY VAEVEFYAED AGRADPVYLY 150
    EMIAAVIDAG ASVVNIPDTT GYTVPEQYGA LIAGIRTHVP GIDRAVISVH 200
    CHDDLGMAVA NTLHGVLNGA RQVEGTINGL GERAGNAALE EIVMALATRA 250
    DYFGVHTGVN TRELHRTSRL VADLLGVQVP PNKAVIGANA FSHSSGIHVD 300
    GVLKKRETYE IMRPEDVGMT ESRVVLTART GRHGLLDRLR KLGYELSDLE 350
    LDQAYRRFLS VADKKQEVFD EDLIAILRDE IHPLPAVYEL QYLHIYSGTS 400
    AIPTATVRLL VSGDTREGAA IGDGPVDAVC RAISQVTATA AKLQRYEIRG 450
    VTSGTEAMGE VTIQLEEAGR KVIGRGASTD IIEASAKAYL DGLNKLANIA 500
    AASHRSAGA 509
    Length:509
    Mass (Da):54,439
    Last modified:November 14, 2006 - v1
    Checksum:i9E1E06EBC16D37E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000473 Genomic DNA. Translation: ABJ86651.1.
    RefSeqiYP_826936.1. NC_008536.1.

    Genome annotation databases

    EnsemblBacteriaiABJ86651; ABJ86651; Acid_5704.
    GeneIDi4426079.
    KEGGisus:Acid_5704.
    PATRICi32014035. VBICanSol30224_5975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000473 Genomic DNA. Translation: ABJ86651.1 .
    RefSeqi YP_826936.1. NC_008536.1.

    3D structure databases

    ProteinModelPortali Q01UL9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 234267.Acid_5704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ86651 ; ABJ86651 ; Acid_5704 .
    GeneIDi 4426079.
    KEGGi sus:Acid_5704.
    PATRICi 32014035. VBICanSol30224_5975.

    Phylogenomic databases

    eggNOGi COG0119.
    HOGENOMi HOG000046859.
    KOi K01649.
    OMAi CKSISEP.
    OrthoDBi EOG6CGCF3.

    Enzyme and pathway databases

    UniPathwayi UPA00048 ; UER00070 .
    BioCyci SUSI234267:GHSK-5747-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR005671. LeuA_bact_synth.
    IPR000891. PYR_CT.
    [Graphical view ]
    Pfami PF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view ]
    SMARTi SM00917. LeuA_dimer. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110921. SSF110921. 1 hit.
    TIGRFAMsi TIGR00973. leuA_bact. 1 hit.
    PROSITEi PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ellin6076Imported.

    Entry informationi

    Entry nameiQ01UL9_SOLUE
    AccessioniPrimary (citable) accession number: Q01UL9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 14, 2006
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3